The conjunctiva is a mucous membrane that lines the inner surface of the eyelids and covers the anterior portion of the eye. It has three parts - the marginal, tarsal, and orbital conjunctiva. The marginal conjunctiva extends from the eyelid margin to the subtarsal fold. The tarsal conjunctiva is firmly attached to the tarsal plate. The orbital conjunctiva lies loosely over underlying structures. Histologically, the conjunctiva has an epithelial layer, adenoid layer, and fibrous layer. The epithelial layers vary between regions from stratified squamous to columnar epithelium. The adenoid layer contains lymphocytes and the fibrous layer consists of collagen and elastic fibers with blood vessels and nerves
1. Introduction Gross anatomy Layers Blood supply, drainage and nerve supply
2. INTRODUCTION • Sclera forms posterior 5/6th of external tunic , connective tissue coat of eyeball. • it continues with duramater and cornea • Its whole surface covered by tenon’s capsule • Anteriorly covered by- bulbar conjunctiva • Inner surface lies in contact with choroid • With a potential suprachoroidal space in between
3. Equa THICKNESS OF SCLERA
4. • Thickness varies with individual, with age • Thinner- children, elder, F> M • Thickest posteriorly • Gradually becomes thinner when traced anteriorly • Thin at insertion of extraocular muscle
1. Introduction Gross anatomy Layers Blood supply, drainage and nerve supply
2. INTRODUCTION • Sclera forms posterior 5/6th of external tunic , connective tissue coat of eyeball. • it continues with duramater and cornea • Its whole surface covered by tenon’s capsule • Anteriorly covered by- bulbar conjunctiva • Inner surface lies in contact with choroid • With a potential suprachoroidal space in between
3. Equa THICKNESS OF SCLERA
4. • Thickness varies with individual, with age • Thinner- children, elder, F> M • Thickest posteriorly • Gradually becomes thinner when traced anteriorly • Thin at insertion of extraocular muscle
The tear film is a complex mixture of substances secreted from multiple sources on the ocular surface, including the lacrimal gland, the accessory lacrimal glands, the meibomian glands, and the goblet cells.
LIMBUS… • The limbus forms the border between the transparent cornea and opaque sclera, contains the pathways of aqueous humour outflow, and is the site of surgical incisions for cataract and glaucoma
2. Anatomical Limbus: Circumcorneal transitional zone of the conjunctivocorneal & corneoscleral junction Conjunctivo-corneal junction: • Bulbar conjunctiva is firmly adherent to underlying structures • Substantia propria of the conjunctiva stops here but its epithelium continues with that of the cornea. Sclero-corneal junction: • Transparent corneal lamellae become continuous • With the oblique, circular and opaque fibres of sclera
3. CONTINUE…. • In the area near limbus, the conjunctiva, tenon’s capsule & the episcleral tissue are fused into a dense tissue which is strongly adherent to corneo scleral junction.It is preferred site for obtaining a firm hold of the eyeball during ocular surgery. • The limbus is a common site for the occurrence of corneal epithelial neoplasm. • The Limbus contains radially oriented fibrovascular ridge known as the palisades of Vogt that may harbour a stem cell population. The palisades of Vogt are more common in the superior and inferior quadrants around the eye
The tear film is a complex mixture of substances secreted from multiple sources on the ocular surface, including the lacrimal gland, the accessory lacrimal glands, the meibomian glands, and the goblet cells.
LIMBUS… • The limbus forms the border between the transparent cornea and opaque sclera, contains the pathways of aqueous humour outflow, and is the site of surgical incisions for cataract and glaucoma
2. Anatomical Limbus: Circumcorneal transitional zone of the conjunctivocorneal & corneoscleral junction Conjunctivo-corneal junction: • Bulbar conjunctiva is firmly adherent to underlying structures • Substantia propria of the conjunctiva stops here but its epithelium continues with that of the cornea. Sclero-corneal junction: • Transparent corneal lamellae become continuous • With the oblique, circular and opaque fibres of sclera
3. CONTINUE…. • In the area near limbus, the conjunctiva, tenon’s capsule & the episcleral tissue are fused into a dense tissue which is strongly adherent to corneo scleral junction.It is preferred site for obtaining a firm hold of the eyeball during ocular surgery. • The limbus is a common site for the occurrence of corneal epithelial neoplasm. • The Limbus contains radially oriented fibrovascular ridge known as the palisades of Vogt that may harbour a stem cell population. The palisades of Vogt are more common in the superior and inferior quadrants around the eye
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The Atlas of the eye is a B.sc. degree research
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VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
3. IT is a translucent mucous membrane which lines the posterior surface of the
eyelids & anterior aspect of eyeball.
The normal conjunctiva is-
o pink
o Smooth
o Thin
o Transparent
There are normally large deep blood vesells that run vertically.
4. The conjunctiva helps lubricate the eye by producing mucus and tears, although a
smaller volume of tears than the lacrimal gland.
It also contributes to immune surveillance and helps to prevent the entrance of
microbes into the eye.
5.
6. It is richly vascular, extremely thin and strongly bounded to the tarsal plate.
It is subdivided into 3 parts-
A. Marginal
B. Tarsal
C. orbital
7. o Extends from the lid margin to about 2 mm back of the lid upto the sulcus
subtarsalis.
o Actually a transitional zone between skin & the conjunctiva proper.
o Lacrimal puncta open in the marginal zone.
8. o Thin , transparent & highly vascular
o Firmly adherent to the whole tarsal plate in the upper lid and only to half width of
the tarsus in the lower lid.
o The tarsal glands are seen through it as yellow streaks.
9. It lies loose between the tarsal plate & the fornix.
Orbital margin of the upper eyelid is loose and lies over the muller’s muscle.
10. o It is transparent and lies loose over the underlying structures and thus can be
moved easily.
o It is separated from the anterior sclera by episcleral tissue & tenon’s capsule.
o The average thickness is 33 microns
o It is also known as ocular conjunctiva
o It is further of two types.- limbal, sclera
11. A 3mm ridge of bulbar conjunctiva around the cornea is called limbal conjunctiva.
Strongly adherent to sclero-corneal junction
12. COVERS the eyeball above the anterior sclera & hence known as scleral
conjunctiva.
Thin, transparent & loosely attached to underlying sclera
Separated from the sclera by episcleral vessels and tenon’s capsule.
13. It is thin, transparent, continuous circular cui-de-sac
It is broken only on the medial side by caruncle and the plica semilunaris.
It joins the bulbar conjunctiva with the palpebral conjunctiva.
It is further of four types-
1. Superior
2. Lateral
3. Medial
4. inferior
18. The layers of epithelial cells in the conjunctiva vary from region to region and its
different parts are
oMARGINAL CONJUNCTIVA:-
have 5layers non-keratinised stratified squamous type of epithelium.
Superficial layer- squamous cells
Intermediate 3 layers- polyhedral cells.
Deepest layer- globlet cells.
19. oTARSAL CONJUNCTIVA-
Has 2 layers epithelium in the upper eyelid.
Superficial layer-cylindrical cells.
Deep layers- cubical cells
Lower tarsal conjunctiva is made of 3-4 layers of cells like the cubical, polygonal, elongated
wedge shaped and cone shaped cells.
oFORNIX & BULBAR CONJUCTIVA-
3 layered epithelium
Superficial layer-cylindrical cells
Middle layer- polyhedral cells
Deep layer- cuboidal cells
20. 8-10 LAYERS of stratified squamous epithelium
Most superficial 1-2 layers squamous cells.
Intermediate several layers-polygonal cells.
Basal layer- cylindrical or cubical cells.
21. a. Goblet cells
b. Melanocytes
c. Langerhans cells
d. Conjunctival associated lymphoid tissue.
e. Mucosal associated lymphoid tissue.
22. Also called as lymphoid layer
Consists of fine connective tissue reticulum in the meshes of which lie the
lymphocytes
Most developed in the fornices and ends at the subtarsal fold.
Develops after 2-3 months of life.
23. Consists of a meshwork of collagenous and elastic fibres.
Thicker than the adenoid layer
Except in the tarsal conjunctiva where it is very thin.
This layers consist vessels and nerves of the conjunctiva.
The adenoid layer & the fibrous layer are collectively called as substantia propia.