This document discusses aminoglycoside and spectinomycin antibiotics. It describes that aminoglycosides like streptomycin are produced by Streptomyces bacteria and inhibit protein synthesis in bacteria. Their mechanism of action involves binding to the bacterial ribosome. Common adverse effects are nephrotoxicity and ototoxicity. Spectinomycin also inhibits bacterial protein synthesis and is used as an alternative treatment for drug-resistant gonorrhea.