The document provides clinical audit tools and data items for monitoring acute kidney injury (AKI). It describes six clinical pathways where AKI care can be audited: acute hospital admission, elective vascular surgery, laboratory, adverse event review, primary care, and renal replacement therapy (RRT). For acute hospital admission, the pathway shows the process from presentation through risk assessment, enacting prevention/care plans, monitoring for AKI resolution or need for RRT, and outcomes of discharge, death, or ongoing RRT dependence. Standards, indicators and specific data items are defined for collecting information across the different pathways to allow comparison of AKI care and outcomes.
Basics of palliative care including symptom management: pain, dyspnea, nausea and constipation; family meetings, goals-of-care, end-of-life care, and artificial nutrition.
Basics of palliative care including symptom management: pain, dyspnea, nausea and constipation; family meetings, goals-of-care, end-of-life care, and artificial nutrition.
Communication using the SBAR tool, Patient Safety Team, NHS Improving Quality,
more at http://www.nhsiq.nhs.uk/improvement-programmes/patient-safety.aspx
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Keep your body in a straight line, with a straight back and bent knees. Your head and chest should be up and straight. Keep your feet a little wider than your shoulder width. Keep the person's head, torso, and legs in line during the transfer.
Evidence-based practice in nursing involves providing holistic, quality care based on the most up-to-date research and knowledge rather than traditional methods, advice from colleagues, or personal beliefs.
Nurses can expand their knowledge and improve their clinical practice experience by collecting, processing, and implementing research findings. Evidence-based practice focuses on what's at the heart of nursing — your patient. Learn what evidence-based practice in nursing is, why it's essential, and how to incorporate it into your daily patient care.
- American Nurses Association
Communication using the SBAR tool, Patient Safety Team, NHS Improving Quality,
more at http://www.nhsiq.nhs.uk/improvement-programmes/patient-safety.aspx
Safe transfer of unstable patient from hospital NABH ppt.pptxanjalatchi
Keep your body in a straight line, with a straight back and bent knees. Your head and chest should be up and straight. Keep your feet a little wider than your shoulder width. Keep the person's head, torso, and legs in line during the transfer.
Evidence-based practice in nursing involves providing holistic, quality care based on the most up-to-date research and knowledge rather than traditional methods, advice from colleagues, or personal beliefs.
Nurses can expand their knowledge and improve their clinical practice experience by collecting, processing, and implementing research findings. Evidence-based practice focuses on what's at the heart of nursing — your patient. Learn what evidence-based practice in nursing is, why it's essential, and how to incorporate it into your daily patient care.
- American Nurses Association
This NEHI report reviews current tech trends which will impact the future of chronic disease management. The report categorizes these technologies into 4 classes based on the significant evidence supporting clinical and financial benefits. The technologies reviewed are:
Extended Care eVisits
Home Telehealth
In-Car Telehealth
Medication Adherence Tools
Mobile Asthma Management Tools
Mobile Cardiovascular Tools
Mobile Clinical Decision Support
Mobile Diabetes Management Tools
Social Media Promoting Health
Tele-Stroke Care
Virtual Visits
Healthy Savings. Medical Technology and the Economic Burden of DiseaseRevital (Tali) Hirsch
As America ages and sedentary lifestyles and unhealthy diets become more common, experts agree the nation is suffering a sharp rise in the prevalence of chronic disease. As the 21st century unfolds, technology – in the form of advanced diagnostic and therapeutic devices -- can meet the need for early detection and more effective management of illness. Some researchers, however, have questioned whether the overall benefit of technical advances outweighs the costs -- a question this report definitively answers.
Accordingly, researchers at the Milken Institute undertook a comprehensive, quantitative documentation of medical technology's impact on the economic burden of disease. The study also projects how future innovation in this sector would affect the health care system and the larger economy -- a positive benefit of more than $23 billion a year for the United States.
The study takes a systematic approach to documenting the full costs and broader economic benefits of health care investments by examining innovations pertaining to four prevalent causes of disability and death: heart disease, diabetes, colorectal cancer, and musculoskeletal disease. The report considers therapeutics and diagnostic devices that are widely used and have substantially affected the lives of patients as well as the overall U.S. economy. Among the 10 devices or device-based procedures studied are pacemakers, insulin infusion pumps, colonoscopies, and joint replacement surgery.
The data demonstrate that the use of medical technology brings considerable economic benefits. These are seen in both aggregate savings in treatment expenditures and prevention as well as the reduction of "indirect impact" through larger contributions to the economy.
Final Progress Report on the Implementation of the Government‟s Response to the Special Commission of Inquiry into Acute Care Services in NSW Hospitals
October 2011
COBRA/Omnibus 4 Industry Day 2016- Navy Marine Corps Public Health Center (NM...Ilka T. De León, MBA
Mr. William Calvert, Deputy Director - Population Health, for the Navy Marine Corps Public Health Center (NMCPHC), provides a Command overview reflecting on his areas of foci and Omnibus participation.
Stopping over-medication of People with Learning Disabilities
(STOMPLD) 2016.
Reducing Inappropriate Psychotropic Drugs in People with a Learning Disability in General Practice and Hospitals in 2016.
Presentation slides Frailty: building understanding, empathy and the skills t...NHS Improving Quality
Frailty: building understanding, empathy and the skills to support self-care
Guest speaker:Dr Dawn Moody, Director - Fusion48
An opportunity to learn about some innovative approaches to making the health and care workforce 'Fit for Frailty'* (*British Geriatrics Society 2015).
Learning outcomes:
To explore the Frailty Fulcrum as a tool for holistic assessment and management of frailty
To hear how Virtual Reality is being used to build empathy for older people living with frailty
To learn about the impact of a county-wide, multi-agency, multi-professional training an toolkit for care professionals working with older people
Resources:www.fusion48.net
Self-management in the community and on the Internet - Presentation 22nd Marc...NHS Improving Quality
LTC Lunch & Learn webinar:- 22nd March 2016
Presenter:- Pete Moore, Educator, Author & Pain Toolkit Trainer
As pain is the most daily health problem reported to a GP-
Developing a national pain strategy- reviews from around the world
Electronic Palliative Care Coordination Systems (EPaCCS): Improving Patient C...NHS Improving Quality
Speaker slides from the national conference, 'Electronic Palliative Care Coordination Systems (EPaCCS): Improving Patient Care at End of Life', 17 March 2016
Fire service as an asset: providing telecare support in the community Webinar...NHS Improving Quality
Guest speaker: Steve Vincent - West Midlands Fire Service & Simon Brake from Coventry Council
Hosted by: Bev Matthews, Long Term Conditions Programme Lead, NHS England
Learning Outcomes:-
To better understand the role that the Fire and Rescue service can provide as a community asset to support health needs Enhancing the quality of life for people by supporting them to stay in their own home, even in a crisis
An overview of the work carried out by NHS England and NHS Improving Quality's Long Term Conditions Sustainable Improvement Team. It puts the case for why person-centred care has to be at the heart of healthcare.
Commissioning Integrated models of care
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The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
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ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. ii
Table of contents
Table of contents ............................................................................................. ii
1 Background...............................................................................................1
2 Existing data collection for AKI .................................................................3
3 Relationship between audit methods........................................................4
4 Patient reported outcome measures (PROM)...........................................5
5 Clinical pathways......................................................................................5
5.1 ACUTE HOSPITAL ADMISSION.......................................................6
5.2 ELECTIVE VASCULAR SURGERY ..................................................7
5.3 LABORATORY..................................................................................8
5.4 ADVERSE EVENT REVIEW .............................................................9
5.5 PRIMARY CARE .............................................................................10
5.6 RRT – Renal Unit or Critical Care....................................................11
6 Quality standards....................................................................................11
6.1 Acute Hospital Admission................................................................12
6.2 Elective vascular surgery.................................................................13
6.3 Laboratory .......................................................................................13
6.4 Adverse event review ......................................................................13
6.5 Primary care ....................................................................................14
6.6 RRT – Renal unit or critical care......................................................14
7 Quality indicators ....................................................................................15
7.1 Acute Hospital Admission................................................................15
7.2 Elective vascular surgery.................................................................15
7.3 Laboratory .......................................................................................16
7.4 Adverse event review ......................................................................16
7.5 Primary care ....................................................................................16
7.6 RRT – Renal unit or Critical Care ....................................................16
8 Data items...............................................................................................17
Core items for all data-sets ........................................................................18
8.1 Acute Hospital admission data items...............................................21
8.2 Elective vascular surgery data items ...............................................29
8.3 Laboratory data items......................................................................37
8.4 Adverse event review data items.....................................................38
8.5 Primary care data items...................................................................40
8.6 RRT – Renal unit or critical care......................................................42
8.7 Complete Dataset as excel file ........................................................45
9 Possible methods of collection................................................................46
9.1 Acute Hospital Admission................................................................46
9.2 Elective vascular surgery.................................................................46
9.3 Laboratory .......................................................................................46
9.4 Adverse event review ......................................................................46
9.5 Primary care ....................................................................................46
9.6 Critical care / Renal units.................................................................46
10 The future............................................................................................47
Appendix 1 Existing Quality Standards and indicators...................................48
3. iii
Appendix 2 – Other considerations from scoping document..........................57
10.1 Attributes of items in an AKI dataset................................................57
10.2 Other principles ...............................................................................57
10.3 Data collection and return to a centre..............................................58
Membership Acute Kidney Injury Delivery Board...........................................59
Membership Kidney Quality Information Partnership.....................................62
References ....................................................................................................63
Acknowledgements
This document was developed as part of the work of the Kidney Quality
Information Partnership, and the Acute Kidney Injury Delivery Group.
Members of both groups have actively participated in reviewing and refining
the document between June 2010 and February 2011. In addition we are
grateful to the comments of Dr Mark Thomas and Dr Charlie Tomson. Please
direct any comments on this document to admin@kidneycare.nhs.uk
4. iv
Introduction
There is growing recognition that acute kidney injury (AKI) is a key quality and
safety challenge for the NHS. Around one in five people who are admitted to
hospital as an emergency will get AKI to some degree and it has a significant
impact on patient outcomes and NHS resources
AKI most commonly occurs as a consequence of other acute illnesses, such
as major infection or dehydration. Indeed, AKI outcomes can be seen as
being a marker for the quality of care of all acute illness. Auditing AKI
outcomes can therefore be a powerful tool for measuring the quality of many
aspects of acute care.
The monitoring of quality standards in AKI is at an early stage. Some centres
have attempted to adopt the previous and current illustrative CQUINs for AKI,
whilst others are choosing to monitor the quality of care through a range of
other means. In addition, some centres in the UK are pioneering work on the
identification and management of people in hospital with AKI through a variety
of innovative systems.
As work in this area gathers pace, there are significant gains to be had from
the development of a standardised set of metrics to measure patient
outcomes and care quality to compare the effectiveness of different processes
and interventions. The recent international agreement on a definition of AKI
and its stages, which has been adopted in the UK, marks a major step
towards achieving this goal.
This AKI clinical audit tools document aims to support clinicians and hospital
improvement teams who are working to improve the prevention, identification,
management and care for people who develop AKI. It identifies a series of
established markers which can be used to measure the quality of care for
5. v
acutely unwell patients. It has been produced by the AKI Delivery Group and
the Kidney Quality Information Partnership.
The document describes the background to the problem and sets out the key
points in six common clinical pathways at which the quality of care for AKI can
be monitored. It brings together the existing quality standards for each
pathway, identifies indicators which could be considered for monitoring those
standards and details the data items which need to be collected to construct
these indicators.
However, the document is not expected to remain static; it will need to adapt
to the learnings and experiences of centres as they begin to develop and
implement AKI quality measures. It is possible that the patient pathways will
alter and highly likely that more refined standards will be developed (as part of
the NICE AKI guidance, for instance).
In the meantime, we hope that units will find the tools contained in this
document useful and will use them to carry out quality audits for AKI care.
Any comments on the tools are welcome and we would like to hear about the
experiences of individuals and units who have tried to implement them.
Please email admin@kidneycare.nhs.uk.
6. 1
1 Background
This paper proposes the development of a set of clinical audit tools and
observations (“data items”) important in monitoring the identification and
treatment of patients with Acute Kidney Injury (AKI). At present few nationally
agreed AKI measures exist, which makes comparison between different
services difficult or impossible. However, in order to improve quality of care
and outcomes in AKI it is crucial to be able to identify variation in outcomes
between areas, because in the causes of this variation are the keys to
improving outcomes in AKI for all.
AKI is an illness with a rapid reduction in kidney function over days or weeks
and has many causes but is most commonly associated with episodes of
acute illness, changes in medication or following diagnostic procedures. Care
pathways for patients with AKI are often not linear; they commonly span
different care sectors (primary and secondary) and different disciplines
(general practice, acute and elective secondary care medicine and surgery,
critical care, renal unit, and support disciplines such as chemical pathology
diagnostic imaging and pharmacy). The monitoring and improvement of care
in AKI will therefore require a dataset to effectively span these different areas.
AKI is common amongst acute admissions to hospital, with approximately 5-
20% of acutely admitted patients experiencing an episode of AKI during the
course of their illness1
. Mortality from AKI varies between study, setting and
disease severity but is significant (over 50% in the setting of sepsis and multi-
organ failure)2
. More recently it has become clear that even a small change in
serum creatinine in admitted patients is a marker for worse long-term
outcome, although the exact mechanism is unclear3,4,5
. Currently the
prevalence of such changes in creatinine in a UK admitted or ambulatory
population is not known as the majority of studies have focused on more
severe (but less common) AKI.
The recent National Confidential Enquiry into Patient Outcome and Death
(NCEPOD) which reviewed care in patients who had died following AKI in
hospital concluded that AKI could have been avoided in 14% of the cases
7. 2
examined, and care was good in only 50%6
. NCEPOD also criticised the poor
implementation of the NICE guidance on acute admission to hospital (CG50)7
,
and poor patient / carer involvement in decision making regarding escalation
of care. This is disappointing because it is known that early application of
simple interventions such as screening for and treatment of sepsis and
assessment of volume status can potentially ameliorate and reverse AKI and
improve outcome8
.
Monitoring outcomes in AKI therefore fulfils two of key outcomes in the recent
NHS white paper9
– namely improving patient safety and reducing
preventable deaths. In addition AKI is expensive as it associated with a
longer stay in an intensive care unit10
, and a longer in-patient stay11
. Length
of stay in intensive care is longer in patients with each increase in severity of
AKI based on the RIFLE criteria, with an average stay rising from six days in
patients without AKI, through eight, 10 and 16 days for AKI stages “risk”,
“injury” and “failure” respectively12
. Patients who survive but continue to
require dialysis incur the on-going costs as well as burden of long-term
dialysis. The AKI dataset therefore needs to consider patient survival as the
major outcome following AKI, but should also cover other outcomes such as
effective re-enablement, development of CKD or an ongoing requirement on
dialysis.
In the future the monitoring of care outcomes will be through the development
of Indicators for Quality Improvement (IQI), and Nice Quality Standards (the
quality standard for CKD contains one standard for those with CKD acutely
unwell13
). However, the development of IQI and quality standards in AKI is
currently hampered by different terminology, different coding practices, poor
understanding of AKI across healthcare teams, and not having either agreed
key data items or a consistent means of collecting national information on AKI
care or outcomes. The development and flow of an AKI dataset could be
directly linked to the refinement of such measures.
This data-set is designed to support the collection of current and likely quality
indicators including the Acute Services Illustrative CQUIN14
, the UK Renal
8. 3
Association AKI module audit measures15
, the shortly to be published KDIGO
quality standards16
, and the vascular surgical society of Great Britain and
Ireland AKI audit (pilot in progress)17
. The NICE guidance on AKI (currently
recruiting committee members) will inform further iterations of this work, but is
currently out of the scope of this document. This document makes explicit
areas where expert guidance is still required in order to define the operational
definitions of some of the clinical concepts.
2 Existing data collection for AKI
Codes exist within ICD-10 (section N17 “Acute renal failure” and N19
“Unspecified renal failure”) which could allow collection of basic information on
the incidence of AKI within acute hospital settings in particular, and these are
available for national comparison via HES. However the codes are
insufficiently refined to allow investigation or monitoring of the appropriate
detection of AKI, the standard of care of those with AKI, or any outcome
except discharge alive from hospital. In addition it is very unlikely that a small
(but significant) change in serum creatinine would be clinically coded as AKI.
Renal units in the UK commonly provide renal replacement treatments for
patients both with end-stage renal disease (ESRD) and also AKI. Information
on those patients with ESRD is collected for national audit and quality
improvement by the UK Renal Registry (UKRR)18
. At present the UKRR does
not collect information on patients treated in renal units for AKI and it is likely
that only a proportion of renal units collect sufficient electronic information
about the patients they treat with AKI to allow analysis.
The Intensive Care National Audit and Research Centre (ICNARC) co-
ordinates national collection of patient identifiable information about all
patients who are admitted to critical care units. In addition to APACHE II
physiological scores for the first 24hrs of admission, this dataset includes
subsequent care items in the daily critical care minimum dataset which would
allow for the identification of patients who receive RRT during the course of a
critical care stay and their outcome at critical care discharge. However this
9. 4
dataset does not contain information about care which could have prevented
AKI in the first place.
The Vascular Society of GB and Ireland is currently working with NHS kidney
Care to test the collection of items pertaining to AKI in patients undergoing
abdominal aortic surgery17
. This work could also inform data collection in
other related areas such as cardio-thoracic or orthopaedic surgery. The
intelligence which refined these items, and the learning which will emerge
from their testing in practice, will be incorporated into the development of this
broad AKI dataset wherever applicable.
3 Relationship between audit methods
At present it is postulated that there are six related, but different project
methods which either have been used previously, are currently involved in
pilot projects, or have active plans to pilot. Each method reflects a different
care pathway or part of the care pathway (and hence each merits its own
description). However, the pathways will also share some common concepts
which are best defined in common and shared than developed in isolation. It
is anticipated that the relationship between data items could look like figure 1.
Figure 1: Relationship between AKI audit group’s data items
CORE
Patient identifiers
Demographics
EMERGENCY
ADMISSION
ELECTIVE
VASCULAR
SURGERY
PRIMARY
CARE
LABORATORY
PROM
PROM
ADVERSE
EVENT
REVIEW
(e.g. NCEPOD)
RRT
CORE
Patient identifiers
Demographics
EMERGENCY
ADMISSION
ELECTIVE
VASCULAR
SURGERY
PRIMARY
CARE
LABORATORY
PROM
PROM
ADVERSE
EVENT
REVIEW
(e.g. NCEPOD)
RRT
10. 5
4 Patient reported outcome measures (PROM)
No patient reported outcome measures have been validated or tested
amongst patients specifically with AKI. Such measures would need to be
tailored to fit with the different clinical contexts and varying clinical pathways
for those patients who develop AKI. It could be imagined that the patient
experience relating to the quality of information relating to AKI might be
considered a useful measure. In the current absence of an agreed AKI
PROM the current AKI dataset contains a placeholder in figure 1, but no
standards or items.
5 Clinical pathways
In order to describe in informatics terms the quality standards, indicators and
data items, each audit method needs to start with an illustration of the
pathway being evaluated. Any step which is considered important to measure
must be present in the pathway. In this way it becomes clear which items
need to be collected, where they are in the pathway, and an indication of how
they might be collected. Any step which cannot be drawn in the pathway is
not (self evidently) possible to measure. The clinical pathways subject to
audit are drawn using unified mark-up language (UML) as this could be
understood by informatics professionals as well as clinicians. This could allow
early consideration to develop an AKI “dashboard” of key quality indicators.
11. 6
5.1 ACUTE HOSPITAL ADMISSION
Acute admission to hospital and the subsequent days are a high risk period
for AKI. Standards of care in this pathway are listed in the Renal Association
Clinical Practice guidelines15
, and the recommendations of the NCEPOD
report “Adding insult to injury”6
. Audit of this care-pathway is currently being
piloted using the DH illustrative CQUIN in some UK regions. Operational
definitions need to be developed with relation to a definition of AKI, “recovery
to baseline”. Ultrasound indications are in section 6.1.5
[N][Y]
Presentation at hospital
Clinical Assessment
AKI Risk Assessment
Test serum creatinine
and look up baseline value
Enact AKI care plan
AKI prevention care plan
[Fulfils definition AKI] [Does not fulfil definition AKI]
[High risk of AKI][Low risk of AKI]
US within 24hrs
Senior review 12hrsRepeat creat within 24hrs
[AKI resolves] [requires RRT]
[Dies as IP] [Disch alive]
[Baseline eGFR]
Enact Standard Care
[AKI does not resolve][AKI resolves]
[Disch alive]
[Loss of eGFR]
[Dies as IP]
[RRT dependent]
[Discharged Alive]
[RRT dependent]
………
Medication review
Repeat creat 24hrsUS clinically indicated?*
* See text for definition
[N][Y]
Presentation at hospital
Clinical Assessment
AKI Risk AssessmentAKI Risk Assessment
Test serum creatinine
and look up baseline value
Enact AKI care planEnact AKI care plan
AKI prevention care planAKI prevention care plan
[Fulfils definition AKI] [Does not fulfil definition AKI]
[High risk of AKI][Low risk of AKI]
US within 24hrsUS within 24hrs
Senior review 12hrsRepeat creat within 24hrsRepeat creat within 24hrs
[AKI resolves] [requires RRT]
[Dies as IP] [Disch alive]
[Baseline eGFR]
Enact Standard Care
[AKI does not resolve][AKI resolves]
[Disch alive]
[Loss of eGFR]
[Dies as IP]
[RRT dependent]
[Discharged Alive]
[RRT dependent]
………
Medication reviewMedication review
Repeat creat 24hrsRepeat creat 24hrsUS clinically indicated?*US clinically indicated?*
* See text for definition
12. 7
5.2 ELECTIVE VASCULAR SURGERY
This is based on the pilot study currently underway by the Vascular Society of
Great Britain and Ireland17
Pre-assessment by HCP
Test serum creatinine
Admission for procedure
Undergoes procedure
[Does not require RRT] [requires RRT]
[Dies as IP]
[AKI does not resolve][AKI resolves]
[Disch alive]
[Alive at 1 year]
Urine observations Serum biochemistryBlood pressure
Urine observations Serum biochemistryBlood pressure
Urine observations Serum biochemistryBlood pressure
[Dead at 1 year]
[Dies as IP]
[RRT dependent]
[Dies as IP]
[Disch alive on RRT]
0-24hrs
24-48hrs
48-72hrs
Pre-assessment by HCP
Test serum creatinineTest serum creatinine
Admission for procedureAdmission for procedure
Undergoes procedure
[Does not require RRT] [requires RRT]
[Dies as IP]
[AKI does not resolve][AKI resolves]
[Disch alive]
[Alive at 1 year]
Urine observations Serum biochemistryBlood pressure
Urine observations Serum biochemistryBlood pressure
Urine observations Serum biochemistryBlood pressure
[Dead at 1 year]
[Dies as IP]
[RRT dependent]
[Dies as IP]
[Disch alive on RRT]
0-24hrs0-24hrs
24-48hrs24-48hrs
48-72hrs48-72hrs
13. 8
5.3 LABORATORY
The incidence of AKI between hospitals and regions in the UK is unknown.
The purpose of this dataset is to allow reliable, repeated interrogation of
pathology laboratories to compare the incidence of AKI and assess the impact
of any detection or prevention interventions in the future. It will also allow
international comparison and allow national identification of inequality.
Comparisons between results and centres may be limited until standardisation
of assays to an enzymatic method.
In addition to these proposed data items for audit these same data items
could be used to identify individuals with AKI locally and alert clinicians to this.
Finally, if linked either locally or centrally to HES it would be possible to report
AKI in hospitalised and non-hospitalised patients, and audit the recommended
repeat creatinine check within 24hrs. Linkage to the NRD would allow the
exclusion of patients on RRT which is generally not possible within local
pathology or PAS systems.
Serum creatiinine assayed
Compared to previous result
[No previous results]
[Report result]
[No other action]
Warning “poss AKI” on report
[Report result]
[No other action]
[Does not fulfil definition AKI]
[Fulfils definition AKI]
Serum creatiinine assayed
Compared to previous result
[No previous results]
[Report result]
[No other action]
Warning “poss AKI” on report
[Report result]
[No other action]
[Does not fulfil definition AKI]
[Fulfils definition AKI]
14. 9
5.4 ADVERSE EVENT REVIEW
This approach to audit of care of patients with AKI was adopted in the
NCEPOD “adding insult to injury report”6
.
Patient dies as IP with ICD-10 code for ARF
[Does not fulfil definition AKI][Fulfils definition AKI]
Review of notes by responsible consultant
Independent expert
Notes review to
template
Organisational questionnaire
To host acute NHS Trust
[Good care] [AKI avoidable][Some omissions]
Recognition of AKI
Overall assessment
[Within 48hrs] [> 48hrs]
Patient dies as IP with ICD-10 code for ARF
[Does not fulfil definition AKI][Fulfils definition AKI]
Review of notes by responsible consultant
Independent expert
Notes review to
template
Organisational questionnaire
To host acute NHS Trust
[Good care] [AKI avoidable][Some omissions]
Recognition of AKIRecognition of AKI
Overall assessmentOverall assessment
[Within 48hrs] [> 48hrs]
15. 10
5.5 PRIMARY CARE
The prevalence of AKI in a population managed by primary care in the UK is
not known.
16. 11
Patient admitted to renal unit or critical care
[Yes][No]
Does patient has ESRF on dialysis requiring RRT ?
Collect information on;
Max no. organ failures
Pre-existing CKD
Hosp / community aquired AKI
Insertion of vascular catheter for RRT
[Died]
[Alive on RRT][Alive off RRT]
[Exit]
Patient requires RRT for removal of metabolic
waste, water or correction of metabolic acidosis
[No][Yes]
[Exit]
MSSA or MRSA Bacteraemia whilst has vascular catheter?
[No][Yes]
Discharged from renal unit or critical care
Discharged from hospital
[Died]
[Alive off RRT]
[Alive on RRT]
Agreed transfer to renal unit or critical carePatient referred to renal unit or critical care
Patient admitted to renal unit or critical care
[Yes][No]
Does patient has ESRF on dialysis requiring RRT ?
Collect information on;
Max no. organ failures
Pre-existing CKD
Hosp / community aquired AKI
Insertion of vascular catheter for RRT
[Died]
[Alive on RRT][Alive off RRT]
[Exit]
Patient requires RRT for removal of metabolic
waste, water or correction of metabolic acidosis
[No][Yes]
[Exit]
MSSA or MRSA Bacteraemia whilst has vascular catheter?
[No][Yes]
Discharged from renal unit or critical care
Discharged from hospital
[Died]
[Alive off RRT]
[Alive on RRT]
Agreed transfer to renal unit or critical carePatient referred to renal unit or critical care
5.6 RRT – Renal Unit or Critical Care
6 Quality standards
Within each patient pathway there are key quality standards which are
expected in the care pathway. Examples of quality standards for other
disease areas such as dementia, venous thrombo-embolism and the CKD
standards13
are available for comparison on the NICE website. A plethora of
different standards are confusing, can result in barriers to implementation, and
represent an undue burden of collection to the NHS. Where-ever possible
therefore existing quality standards have been adopted before considering
new standards.
In some instances the quality standards could be the same in several different
pathways, with the difference being the method of audit rather than the
standard (for instance between 5.1 and 5.5). As this constrains the overall
17. 12
number of different standards this approach is to be encouraged. Examples
of draft standards for discussion are listed under each heading.
6.1 Acute Hospital Admission
Adapted from NCEPOD6
, RA AKI guidelines15
, and NICE CKD quality
standard13
.
6.1.1 All patients admitted as an emergency, regardless of specialty, should
have their electrolytes and creatinine checked routinely on admission
and appropriately thereafter. Exception will need to be made for
patients admitted for end-of-life care.
6.1.2 For those in-patients who develop AKI there should be both a robust
assessment of contributory risk factors, identification of reversible and
treatable causes and appropriate examination and investigations for
the possible complications that may arise.
6.1.3 All acute admissions should receive adequate senior reviews (with a
consultant review within 12 hours of admission)
6.1.4 All non-anuric patients who have AKI should have multistix reagent
strip urinalysis performed and recorded in the care-plan.*
*
A care-plan in this context is a clinical record of patient care (medical, nursing or shared) which
includes a record of observations, but also an appropriate clinical plan based on that observation. This
should include frequency of repeating observations, and a threshold which would trigger further
assessment.
18. 13
6.1.5 People presenting with acute kidney injury have their medication
reviewed, an assessment of volume status, and an ultrasound scan for
renal morphology and the presence or absence of obstruction if the
later is clinically indicated. Indications for an renal tract ultrasound
include;
• Patients with unexplained AKI
• Patients whose renal function has failed to improve after correction
of initial presumed cause (eg after fluid replacement and removal of
nephrotoxins)
• Patients with a history of urinary tract pathology eg bladder tumour
• Patients with a single kidney
• Patients with evidence of previously un-investigated CKD
• Patients with unexplained haematuria
6.2 Elective vascular surgery
These are currently engineered from the Vascular Society GB and Ireland
data items17
, and the quality requirements of the renal NSF19
.
6.2.1 All patients undergoing elective surgery where there is a risk of peri-
operative AKI should have their creatinine checked as part of a pre-
surgery assessment. Threshold for degree of risk and the named
procedures will need to be developed.
6.2.2 Patients undergoing AAA repair are to receive regular physiological
monitoring over the at-risk period following their operation. This will
require further operational definition of “regular” and the “at risk period”,
and might include a protocolised early warning system (EWS).
6.3 Laboratory
6.3.1 All laboratories measuring serum creatinine will work towards adopting
an alert system based on changes in serum creatinine to warn the
requester of the possibility of acute kidney injury.
6.4 Adverse event review
As section 6.1 plus
19. 14
6.4.1 Predictable and avoidable AKI should never occur. This standard
requires an operational definition to allow comparisons between audits,
but could include a failure to identify the patient at risk, the risk of any
procedure, and an appropriate management plan.
6.4.2 AKI should be recognised within 48hrs (RA audit draft measure 4)
6.5 Primary care
Based on the NICE guidance on the detection and treatment of CKD20
.
6.5.1 All patients who have a serum creatinine checked in which no previous
result is available will have the result rechecked within 2 weeks to
differentiate between AKI and CKD.
6.6 RRT – Renal unit or critical care
6.6.1 Transfer to the renal unit or critical care should occur within 24 hours of
the transfer being agreed as clinically indicated.
6.6.2 Vascular access should be placed by experienced or appropriately
supervised staff. Real-time ultrasound guidance should be used to aid
placement of upper body access. Incidence of vascular access
bacteraemia should be reduced to a minimum, and should work
towards a zero incidence of MRSA bacteraemia.
20. 15
7 Quality indicators
Quality indicators are the specific questions which measure whether each
quality standard is being achieved. Nationally the NHS Information centre for
health and social care (NHSIC) is defining such Indicators for Quality
Improvement (IQI) in other areas of care which are expected to match with the
NICE defined quality standards wherever possible. Therefore, when defining
AKI care IQI for each pathway wherever possible existing quality indicators
have been adopted which have already been endorsed. Examples of draft
indicators are listed under each heading. These must be carefully considered
to ensure they are collectable and represent an acceptable burden on the
NHS.
7.1 Acute Hospital Admission
These are based on the illustrative CQUIN for AKI 2011-12 (appendix 1).
7.1.1 Percentage of emergency admissions to have
• Physiological scoring performed to identify patients at high risk of
clinical deterioration (e.g. MEWS Score)
• Consultant review within 12 hours of admission
7.1.2 Percentage of emergency admissions with a major risk factor for AKI to
have:
• Medication review
• Serum creatinine rechecked within 24 hours of admission
7.2 Elective vascular surgery
7.2.1 Percentage of patients undergoing elective surgery where there is a
risk of peri-operative AKI (requires operations definition) who have their
creatinine checked as part of a pre-surgery assessment.
7.2.2 Percentage of patients undergoing AAA repair who receive the
following interventions over the first 72 hours post-operatively
(a) daily re-measurement of serum creatinine
(b) continuous monitoring of urine volume
(c) regular (minimum 4 hourly) physiological measurements including
blood pressure.
21. 16
7.3 Laboratory
7.3.1 Percentage of serum creatinine checks which fulfil the criteria for AKI
(requires operational definition including the presence or absence of
any previous creatinine value, the time-frame since last measurement,
and the absolute or percentage change in creatinine required).
7.3.2 Refinement of 7.3.1 to include stage of AKI.
7.3.3 Percentage of the reports of those fulfilling the criteria which include
and alert to the possibility of AKI.
7.4 Adverse event review
As 7.2 plus;
7.4.1 Percentage of cases in where AKI was considered to be predictable
and avoidable. An operational definition of this is required.
7.5 Primary care
7.5.1 Percentage of patients who have a serum creatinine checked in which
no previous result in that patients primary care record who have a
second measurement of GFR within 2 weeks of the first.
7.6 RRT – Renal unit or Critical Care
7.6.1 Number of people and percentage of total acute hospital admissions
who require RRT for AKI during their admission to hospital. This
should be separated by setting between critical care and renal unit
where one exists.
7.6.2 Number of people and percentage of people who require RRT for AKI
who are alive at discharge from a renal unit / critical care and discharge
from hospital.
7.6.3 Number of people and percentage of people who undergo RRT for AKI
who have independent kidney function on hospital discharge or still
require ongoing RRT.
7.6.4 Proportion of patients who were transferred to a critical care or renal
unit setting > 24hrs after it was agreed to be clinically appropriate to
transfer as a proportion of all renal unit or critical care admissions.
22. 17
8 Data items
This section defines the items which are required to be collected in order to
construct the IQI. An example set of data items which could be used to drive
the existing audits are attached below, and sub divided by AKI audit
methodology. Wherever possible the same data item is used in several
different pathways. There are examples of where a data item is present
within a care-pathway but does not directly drive a current quality standard or
quality indicator. These are currently retained because they are present in
on-going audits (for example the current 2010/11 illustrative CQUIN) and their
collectability and utility as a measure of quality is still under assessment.
Please interpret these currently “aspirational” items with care; they are
retained because they represent likely future care quality markers. However
until electronic and/or clinical assessment tools to collect them are developed,
they are unlikely to be collectable without undue burden.
To help with the assessment of data items these will be scored by the two
domains:
A: importance to quality
0 – No utility for monitoring quality
1 – Some value in monitoring quality
2 – Good measure of quality
3 – Essential quality measure
B: ease of collection
0 – Impossible to collect now or in foreseeable future
1 – Could be collected in the future using tools currently under development
2 – Could be collected now with modest impact on burden.
3 – Routine collected already
It could be anticipated that items which score 3:3 would be taken forward
without delay, those 0:0 rejected, and those in between retained for future
development.
23. 18
Core items for all data-sets
Row Section
Item
no Description Definition Purpose Importance Collection
2 EpisodeCare 2
Date fulfilled definition
of AKI
Date that the patient
fulfilled the KDIGO /
RA definition for AKI 3 1
5 EpisodeCare 5
End of care episode
date
Discharge date from
hospital if inpatient, or
date routine monitoring
of kidney function re-
established if in
primary care
Calculation of Length of
stay as marker of
additional resources
consumed 2 2
EpisodeCare 6
Site where audit is
being undertaken
The site and setting
where the audit is
taking place
To allow comparison
between care sites and
settings. 2 2
19 Demographics 1 Traced NHSnumber Patient NHSnumber
Allows linkage to ONS
caused of death, and HES
episodes to compare
associated diagnoses and
procedures 2 3
20 Demographics 2 Surname Patient Surname
Allows linkage to ONS
caused of death, and HES
episodes to compare
associated diagnoses and
procedures 2 3
21 Demographics 3 Date of birth Patient Date of Birth
Allows calculation of stage
of CKD and eGFR to 2 3
24. 19
differentiate AKI and CKD
22 Demographics 4 Sex Patient Sex
Allows calculation of stage
of CKD and eGFR to
differentiate AKI and CKD 2 3
23 Demographics 5 Ethnic Group
Patient self reported
ethnic group
Allows calculation of stage
of CKD and eGFR to
differentiate AKI and CKD.
Reassurance of equity of
access to high quality
treatment and outcome 2 3
24 Demographics 6 Postcode
Patient postcode at
normal place of
residence
Reassurance of equity of
access to high quality
treatment and outcome 2 3
25 Demographics 7 GP practice identifier
Identifier of GP practice
with whom the patient
is registered for long-
term care.
Reassurance of equity of
access to high quality
treatment and outcome 2 3
62 Organisation 1 Denominator
Number of individuals
from whom the patient
was drawn
To allow calculation of
prevalence 3 3
63 Organisation 2
Denominator
Description
Text description of the
definition of the
denominator population
For example; "all patients
referred to renal services",
"all acute medical
admission" 3 3
64 Organisation 3
Date of first day of audit
period
Date of the first day of
the period audited 3 3
65 Organisation 4
Date of last day of audit
period
Date of the last day of
the period audited 3 3
25. 20
66 Organisation 5 Sampling percentage
If patient is part of a
sample from the
population with AKI
rather than then entire
population with AKI
what proportion was
sampled.
To allow calculation of
prevalence 3 3
26. 21
8.1 Acute Hospital admission data items
Row Section
Item
no Description Definition Purpose Importance Collection
1 EpisodeCare 1
Date of start episode of
care
Admission date if
emergency admission
to hospital. 1st
Consultation where
kidney function
assessed during this
illness if in primary
care. Date of
intervention or
procedure if elective
admission or daycase
attendance 2 3
3 EpisodeCare 3
OPCS code of
procedure if elective
admission
OPCS code of primary
procedure for which the
patient was admitted
Identification of procedures
as examples of high and
poor quality AKI care 2 3
4 EpisodeCare 4 Admission date
Date of inpatient
admission if different to
EC1
Separation of community
and hospital acquired AKI 2 3
6 DefinitionAKI 1
Observation of patient
serum creatinine value
at baseline
Closest Serum
Creatinine >30days
and <365days to EC1
Differentiating AKI from
Acute on Chronic Kidney
disease 2 2
7 DefinitionAKI 2
Date of observation of
patient serum
creatinine value at
Date of closest serum
creatinine >30days and
<365days to EC1 2 2
27. 22
baseline
8 DefinitionAKI 3
Observation of patient
closest prior serum
creatinine value
Serum creatinine
checked immediately
prior to this episode of
care
See definition of AKI; 1.5x
increase in creatinine over
7days, or 26umol/L
increase over 2 days 3 2
9 DefinitionAKI 4
Date of observation of
patient closest prior
serum creatinine value
Date of serum
creatinine measured
immediately prior to this
episode of care 3 2
10 DefinitionAKI 5
Observation of patient
first serum creatinine
value
First serum creatinine
checked this episode of
care Defines episode of AKI 3 2
11 DefinitionAKI 6
Date of observation of
patient first serum
creatinine value
Date of First serum
creatinine checked this
episode of care 3 2
12 DefinitionAKI 7
Observation of patient
second serum
creatinine value
Second serum
creatinine checked this
episode of care
Marker of quality (standard
to re-check serum
creatinine within 24hrs of
abnormal). Measure of
success of initial care 3 2
13 DefinitionAKI 8
Date of observation of
patient second serum
creatinine value
Date of Second serum
creatinine checked this
episode of care 2 2
14 DefinitionAKI 9
Observation of patient
highest serum
creatinine value
Highest serum
creatinine value during
this episode of care
Stage of AKI (see AKIN
definition) 2 2
15 DefinitionAKI 10
Date of observation of
patient highest serum
creatinine value
Date of highest serum
creatinine value during
this episode of care 3 2
28. 23
16 DefinitionAKI 11
Urine volume
measured first 24hrs
Is there sufficient
information available to
establised urine volume
for 6 consecutive hours
during the first 24 hours
of episode of care?
Marker of quality (standard
is to monitor input and
output in any patient with
or at risk of AKI) 2 1
17 DefinitionAKI 12
Urine volume passed
during 6hrs of first
24hrs
Volume of urine passed
during the first
consecutive 6hour
period measured during
the first 24 hours
See definition of AKI; small
urine volume or no urine
volume 2 1
18 DefinitionAKI 13
Renal Replacement
therapy required
Renal replacement
therapy (HD, CRRT,
PD) required for the
purpose of removal of
fluid or electrolytes.
Stage of AKI (see AKIN
definition) 3 3
26 Demographics 7
Observation of patient
weight
Measure of patient
weight within 30days of
episode of care and the
first 48hrs of episode of
care
Allows calculation of urine
volume per kg body weight,
and BSA for the
adjustment of eGFR 2 2
27 Demographics 8
Observation of patient
height
Any measure of adult
height within the last
10years measured or
reported by person
Calculation of BSA for the
adjustment of eGFR 1 1
28 Comorbidity 1 Diabetes Mellitus
Does the patient have a
pre-existing diagnosis
of type 1 or type 2
diabetes
Differentiation of outcomes
in those with and without
pre-existing conditions
likely to directly affect risk 2 2
29. 24
of AKI and outcome
29 Severity 1 Number organ failures
Maximum concurrent
number of organs
which have "failed"
during this episode of
care (not including
kidney failure)
Differentiation of outcomes
in those with different
severity of illness 2 3
30 Severity 2
Highest Level of care
received
Highest level of care
(as defined by Critical
Care "bed levels 1-3"
Marker of quality of care.
Marker of appropriate use
of resources 2 3
31 AKIcause 1
Contrast media prior to
episode
Patient administered
contrast media during
the 7 days prior to EC1
Marker of quality as this
should be a largely
preventable cause of AKI 2 1
33 AKIcause 3
Observation of the
reagent stick urinalysis
for blood
Urinalysis for blood
recorded on patient
urine sample produced
during first 24hrs of
care episode
Differentiation of those with
intrinsic renal disease
(different likelihood of
recovery) 1 1
34 AKIcause 4
Observation of the
reagent stick urinalysis
for protein
Urinalysis for protein
recorded on patient
urine sample produced
during first 24hrs of
care episode
Differentiation of those with
intrinsic renal disease
(different likelihood of
recovery) 1 1
30. 25
35 AKIcause 5
Urinary tract
obstruction
Ultrasound scan /
bladder scan shows
obstruction of urinary
tract (uni or bilateral
hydro-ureter, bladder
outflow obstruction), or
evidence of relieved
obstruction (resolving
hydro-ureter)
Differentiation of those with
obstructive renal disease
(different likelihood of
recovery) 3 2
36 AKIcause 6
Observation of the
patients fluid balance
assessment
Was the patient
considered to be
hypovolaemic,
euvolaemic or
hypervolaemic at there
first fluid balance
assessment within
24hours of EC1 Marker of care quality 3 2
37 CareQuality 1
U&E checked on
admission
Was a sample of blood
measured for
concentrations of urea,
creatinine, sodium and
potassium ("U&E") on
admission Marker of care quality 3 2
38 CareQuality 2
U&E rechecked within
24hrs
Was a second sample
of blood measured for
concentrations of urea,
creatinine, sodium and
potassium ("U&E")
within the first 24 hours Marker of care quality 3 2
31. 26
39 CareQuality 3 Urinalysis performed
Was a sample of urine
produced during the
first 24hours of care
episode tested with a
reagent stick for blood
and protein and the
result recorded. Marker of care quality 2 1
40 CareQuality 4
Senior Review
occurred
Was the patient
reviewed by a senior
doctor within 12 hours
of the beginning of this
episode of care Marker of care quality 3 2
41 CareQuality 5 Ultrasound performed
Did the patient undergo
an ultrasound scan
within 24hous of EC1 Marker of care quality 2 2
42 CareQuality 6
Fluid balance
assessment performed
Was an assessment
made and a conclusion
recorded as the patient
fluid status within 24
hours of EC1 Marker of care quality 3 2
43 CareQuality 7 AKI Risk assessment
Was an AKI risk
assessment
undertaken within 24
hours of EC1 Marker of care quality 3 2
44 CareQuality 8
Physiological scoring
performed
Was physiological
scoring performed to
identify patients at high
risk of clinical
deterioration (e.g. Marker of care quality 3 2
32. 27
MEWS Score)
45 CareQuality 9
Presence of "major risk
factor for AKI"
Is the patient assessed
using items CQ-7 and
CQ-8 found to have a
major risk factor for AKI
Marker of care quality.
Required to identify
denominator at risk group
for items CQ-2 and CQ-10
when used in the 2011-12
CQUIN 2 2
46 CareQuality 10 Review of medication
Was the patients
medication reviewed Marker of care quality 2 2
47 CareQuality 11 Care plan
Was the result of a AKI
risk assessment used
to create a care plan
which included the
stated intention to re-
check Creatinine within
24hrs, and to monitor
fluid balance Marker of care quality 2 2
51 Outcome 1
Patient alive at
discharge
Was the patient
discharged from
hospital alive if an
inpatient Measure of care outcome 3 3
52 Outcome 2 Dialysis at discharge
Was the patient
discharged from
hospital without
independent kidney
function (Did the patient
either have plans for
ongoing dialysis or
Measure of care outcome -
non recovery of AKI 3 2
33. 28
dialysis withdrawn for
palliative care)
53 Outcome 3
Observation of patient
serum creatinine at
discharge from hospital
Last serum creatinine
measurement prior to
hospital discharge if
hospital inpatient, and
patient not planned for
ongoing dialysis
treatment
Measure of care outcome -
persistent kidney damage 2 2
54 Outcome 4 Patient alive at day 90
Was the patient alive at
90days following EC1 Measure of care outcome 2 2
55 Outcome 5 Dialysis at day 90
Did the patient not have
independent kidney
function at day 90 (Did
the patient either have
plans for ongoing
dialysis or dialysis
withdrawn for palliative
care)
Measure of care outcome -
non recovery of AKI 2 2
56 Outcome 6
Observation of patient
serum creatinine at day
90
Last serum creatinine
measurement prior to
day 90 in patient not
planned for ongoing
dialysis treatment
Measure of care outcome -
persistent kidney damage 2 2
34. 29
8.2 Elective vascular surgery data items
Row Section
Item
no Description Definition Purpose Importance Collection
1 EpisodeCare 1
Date of start episode of
care
Admission date if
emergency admission
to hospital. 1st
Consultation where
kidney function
assessed during this
illness if in primary
care. Date of
intervention or
procedure if elective
admission or daycase
attendance 2 3
3 EpisodeCare 3
OPCS code of procedure
if elective admission
OPCS code of primary
procedure for which
the patient was
admitted
Identification of procedures
as examples of high and
poor quality AKI care 2 3
4 EpisodeCare 4 Admission date
Date of inpatient
admission if different to
EC1
Separation of community
and hospital acquired AKI 2 3
8 DefinitionAKI 3
Observation of patient
closest prior serum
creatinine value
Serum creatinine
checked immediately
prior to this episode of
care
See definition of AKI; 1.5x
increase in creatinine over
7days, or 26umol/L
increase over 2 days 3 2
35. 30
9 DefinitionAKI 4
Date of observation of
patient closest prior
serum creatinine value
Date of serum
creatinine measured
immediately prior to
this episode of care 3 2
10 DefinitionAKI 5
Observation of patient
first serum creatinine
value
First serum creatinine
checked this episode
of care Defines episode of AKI 3 2
11 DefinitionAKI 6
Date of observation of
patient first serum
creatinine value
Date of First serum
creatinine checked this
episode of care 3 2
18 DefinitionAKI 13
Renal Replacement
therapy required
Renal replacement
therapy (HD, CRRT,
PD) required for the
purpose of removal of
fluid or electrolytes.
Stage of AKI (see AKIN
definition) 3 3
31 AKIcause 1
Contrast media prior to
episode
Patient administered
contrast media during
the 7 days prior to EC1
Marker of quality as this
should be a largely
preventable cause of AKI 2 1
32 AKIcause 2
Contrast media following
episode
Patient administered
contrast media during
the 3 days following to
EC1
Risk factor for non-
recovery of AKI 2 1
51 Outcome 1 Patient alive at discharge
Was the patient
discharged from
hospital alive if an
inpatient Measure of care outcome 3 3
36. 31
52 Outcome 2 Dialysis at discharge
Was the patient
discharged from
hospital without
independent kidney
function (Did the
patient either have
plans for ongoing
dialysis or dialysis
withdrawn for palliative
care)
Measure of care outcome -
non recovery of AKI 3 2
67
Definition
AKI 14
Highest serum potassium
(9-15 months pre EC1) 1 1
68
Definition
AKI 15
Highest serum potassium
(3-9 months pre EC1) 1 1
69 Severity 3
Highest serum potassium
(0-24hrs post EC1) 1 1
70 Severity 4
Highest serum potassium
(24-48hrs post EC1) 1 1
71 Severity 5
Highest serum potassium
(48-72hrs post EC1) 1 1
72
Definition
AKI 16
Highest serum urea (9-15
months pre EC1) 1 1
73
Definition
AKI 17
Highest serum urea (3-9
months pre EC1) 1 1
74 Severity 6
Highest serum urea (0-
24hrs post EC1) 1 1
75 Severity 7
Highest serum urea (24-
48hrs post EC1) 1 1
37. 32
76 Severity 8
Highest serum urea (48-
72hrs post EC1) 1 1
77
Definition
AKI 18
Highest serum creatine
(9-15 months pre EC1) 2 2
78
Definition
AKI 19
Highest serum creatinine
(3-9 months pre EC1) 2 2
79 Severity 9
Highest serum creatinine
(0-24hrs post EC1) 2 2
80 Severity 10
Highest serum creatinine
(24-48hrs post EC1) 2 2
81 Severity 11
Highest serum creatinine
(48-72hrs post EC1) 2 2
82 Severity 12
Lowest haemoglobin (0-
24hrs post EC1) 1 1
83 Severity 13
Lowest haemoglobin (24-
48hrs post EC1) 1 1
84 Severity 14
Lowest haemoglobin (48-
72hrs post EC1) 1 1
85
Definition
AKI 20
Total urine volume during
surgery 2 1
86
Definition
AKI 21
Total urine volume (0-
24rs post EC1) 2 1
87
Definition
AKI 22
Total urine volume (24-
48hrs post EC1) 2 1
88
Definition
AKI 23
Total urine volume (48-
72rs post EC1) 2 1
89
Definition
AKI 24
Lowest 6hr urine volume
(0-24hrs post EC1) 1 1
38. 33
90
Definition
AKI 25
Lowest 6hr urine volume
(24-48hrs post EC1) 1 1
91
Definition
AKI 26
Lowest 6hr urine volume
(48-72hrs post EC1) 1 1
92 AKIriskfactor 3 SBP pre-EC1
Pre-assessment SBP
value if available,
otherwise closest prior
to EC1 2 2
93 AKIriskfactor 4 DBP pre-EC1
Pre-assessment DBP
value if available,
otherwise closest prior
to EC1 2 2
94 Severity 15
Lowest recorded SBP (0-
24hrs post EC1) 1 1
95 Severity 16
Lowest recorded SBP
(24-72hrs post EC1) 1 1
96 Severity 17
Lowest recorded SBP
(48-72hrs post EC1) 1 1
97 Severity 18
Patient on
inotrope/vasopressor
infusion at any time (0-
24hrs post EC1) 1 2
98 Severity 19
Patient on
inotrope/vasopressor
infusion at any time (24-
48hrs post EC1) 1 2
99 Severity 20
Patient on
inotrope/vasopressor
infusion at any time (48- 1 2
39. 34
72hrs post EC1)
100 Outcome 7
Alive at one year post
EC1 2 1
101 AKIriskfactor 5 Aspirin/Dipyridamole
Patient taking aspirin
and/or dipyridamole
during the week prior
to EC1 1 1
102 AKIriskfactor 6 Clopidogrel
Patient taking
clopidogrel during the
week prior to EC1 1 1
103 AKIriskfactor 7 Beta blocker
Patient taking beta
blocker during the
week prior to EC1 1 1
104 AKIriskfactor 8 Statin
Patient taking statin
during the week prior
to EC1 1 1
105 AKIriskfactor 9 ACE inhibitor
Patient taking ACE
inhibitor during the
week prior to EC1 1 1
106 AKIriskfactor 10 ARB
Patient taking ARB
during the week prior
to EC1 1 1
107 AKIriskfactor 11 Loop diuretic
Patient taking loop
diuretic during the
week prior to EC1 1 1
108 AKIriskfactor 12 NSAID
Patient taking NSAID
during the week prior
to EC1 1 1
40. 35
109 AKIriskfactor 13 Top clamp position 1 1
110 AKIriskfactor 14 Clamp duration (minutes) 1 1
111 AKIriskfactor 15
Left Renal Vein ligated /
divided
Was the left renal vein
ligated or divided? 1 1
112 AKIriskfactor 16 Renal Artery Occlusion
If EVAR was there a
Renal Artery Occlusion 1 1
113 AKIriskfactor 17
Volume 0.9% saline
infused during operation
(ml) 1 1
114 AKIriskfactor 18
Volume Hartmans /
Ringers infused during
operation (ml) 1 1
115 AKIriskfactor 19
Volume colloid infused
during operation (ml) 1 1
116 AKIriskfactor 20
Volume bank blood
infused during operation
(ml) 1 1
117 AKIriskfactor 21
Volume bank FFP
infused during operation
(ml) 1 1
118 AKIriskfactor 22
Volume salvaged blood
infused during operation
(ml) 1 1
119 AKIriskfactor 23
Did the patient develop
intestinal ischemia? 1 1
120 AKIriskfactor 24
Did the patient require
surgery for intestinal
ischemia? 1 1
42. 37
8.3 Laboratory data items
Row Section
Item
no Description Definition Purpose Importance Collection
8 DefinitionAKI 3
Observation of patient
closest prior serum
creatinine value
Serum creatinine
checked immediately
prior to this episode of
care
See definition of AKI; 1.5x
increase in creatinine over
7days, or 26umol/L
increase over 2 days 3 2
9 DefinitionAKI 4
Date of observation of
patient closest prior
serum creatinine value
Date of serum
creatinine measured
immediately prior to this
episode of care 3 2
10 DefinitionAKI 5
Observation of patient
first serum creatinine
value
First serum creatinine
checked this episode of
care Defines episode of AKI 3 2
11 DefinitionAKI 6
Date of observation of
patient first serum
creatinine value
Date of First serum
creatinine checked this
episode of care 3 2
43. 38
8.4 Adverse event review data items
Row Section
Item
no Description Definition Purpose Importance Collection
8 DefinitionAKI 3
Observation of patient
closest prior serum
creatinine value
Serum creatinine
checked immediately
prior to this episode of
care
See definition of AKI; 1.5x
increase in creatinine over
7days, or 26umol/L
increase over 2 days 3 2
9 DefinitionAKI 4
Date of observation of
patient closest prior
serum creatinine value
Date of serum
creatinine measured
immediately prior to this
episode of care 3 2
10 DefinitionAKI 5
Observation of patient
first serum creatinine
value
First serum creatinine
checked this episode of
care Defines episode of AKI 3 2
11 DefinitionAKI 6
Date of observation of
patient first serum
creatinine value
Date of First serum
creatinine checked this
episode of care 3 2
17 DefinitionAKI 12
Urine volume passed
during 6hrs of first 24hrs
Volume of urine passed
during the first
consecutive 6hour
period measured during
the first 24 hours
See definition of AKI; small
urine volume or no urine
volume 2 1
57 Outcome 7 Date of death Date that patient died
Identification of in-hospital
mortality for adverse event
review inclusion 3 3
58 Outcome 8
Coded within hospital
episode statistics as
Clinical coding of
episode includes ICD-
Identification of those who
could have had AKI for 2 3
44. 39
having had AKI during
this episode of care
10 code consistent with
AKI
adverse event review
inclusion
59 Outcome 9 AKI predictable
NCEPOD assessment
criteria: Predictable,
unpredictable or
unknown
Retrospective assessment
of predictability of the AKI 2 1
60 Outcome 10 AKI avoidable
NCEPOD assessment
criteria: Avoidable or un-
avoidable
Retrospective assessment
of avoidance of AKI 2 1
61 Outcome 11 AKI quality of care
NCEPOD assessment
criteria: Good practice,
Room for improvement -
clinical care, Room for
improvement -
Organisational care,
Room for improvement
Clinical and
Organisational care,
Less than satisfactory
care, Insufficient data
Retrospective assessment
of care quality in AKI 2 1
45. 40
8.5 Primary care data items
Row Section
Item
no Description Definition Purpose Importance Collection
8 DefinitionAKI 3
Observation of patient
closest prior serum
creatinine value
Serum creatinine
checked immediately
prior to this episode of
care
See definition of AKI; 1.5x
increase in creatinine over
7days, or 26umol/L
increase over 2 days 3 2
9 DefinitionAKI 4
Date of observation of
patient closest prior
serum creatinine value
Date of serum
creatinine measured
immediately prior to this
episode of care 3 2
10 DefinitionAKI 5
Observation of patient
first serum creatinine
value
First serum creatinine
checked this episode of
care Defines episode of AKI 3 2
11 DefinitionAKI 6
Date of observation of
patient first serum
creatinine value
Date of First serum
creatinine checked this
episode of care 3 2
28 Comorbidity 1 Diabetes Mellitus
Does the patient have a
pre-existing diagnosis
of type 1 or type 2
diabetes
Differentiation of outcomes
in those with and without
pre-existing conditions
likely to directly affect risk
of AKI and outcome 2 2
39 CareQuality 3 Urinalysis performed
Was a sample of urine
produced during the
first 24hours of care
episode tested with a
reagent stick for blood Marker of care quality 2 1
46. 41
and protein and the
result recorded.
47 CareQuality 11 Care plan
Was the result of a AKI
risk assessment used to
create a care plan
which included the
stated intention to re-
check Creatinine within
24hrs, and to monitor
fluid balance Marker of care quality 2 2
47. 42
8.6 RRT – Renal unit or critical care
Row Section
Item
no Description Definition Purpose Importance Collection
3 EpisodeCare 3
OPCS code of
procedure if elective
admission
OPCS code of primary
procedure for which the
patient was admitted
Identification of procedures
as examples of high and
poor quality AKI care 2 3
4 EpisodeCare 4 Admission date
Date of inpatient
admission if different to
EC1
Separation of community
and hospital acquired AKI 2 3
18 DefinitionAKI 13
Renal Replacement
therapy required
Renal replacement
therapy (HD, CRRT,
PD) required for the
purpose of removal of
fluid or electrolytes.
Stage of AKI (see AKIN
definition) 3 3
29 Severity 1 Number organ failures
Maximum concurrent
number of organs which
have "failed" during this
episode of care (not
including kidney failure)
Differentiation of outcomes
in those with different
severity of illness 2 3
30 Severity 2
Highest Level of care
received
Highest level of care (as
defined by Critical Care
"bed levels 1-3"
Marker of quality of care.
Marker of appropriate use
of resources 2 3
31 AKIcause 1
Contrast media prior to
episode
Patient administered
contrast media during
the 7 days prior to EC1
Marker of quality as this
should be a largely
preventable cause of AKI 2 1
48. 43
48 CareQuality 12
Ultrasound used to
place vascular access
catheter for RRT
Was real time
ultrasound guidance
used to insert vascular
access catheter for RRT Marker of care quality 2 1
49 CareQuality 13
Date or MRSA or MSSA
bacteraemia
Date of an MRSA or
MSSA bacteraemia
whilst patient has
vascular catheter in-situ
for purposes of RRT
Marker of care quality.
Major patient safety marker 3 2
50 CareQuality 14 MRSA or MSSA
Organism causing
bacteraemia
Marker of care quality.
Major patient safety marker 2 2
51 Outcome 1
Patient alive at
discharge
Was the patient
discharged from
hospital alive if an
inpatient Measure of care outcome 3 3
52 Outcome 2 Dialysis at discharge
Was the patient
discharged from
hospital without
independent kidney
function (Did the patient
either have plans for
ongoing dialysis or
dialysis withdrawn for
palliative care)
Measure of care outcome -
non recovery of AKI 3 2
53 Outcome 3
Observation of patient
serum creatinine at
discharge from hospital
Last serum creatinine
measurement prior to
hospital discharge if
hospital inpatient, and
patient not planned for
Measure of care outcome -
persistent kidney damage 2 2
49. 44
ongoing dialysis
treatment
54 Outcome 4 Patient alive at day 90
Was the patient alive at
90days following EC1 Measure of care outcome 2 2
55 Outcome 5 Dialysis at day 90
Did the patient not have
independent kidney
function at day 90 (Did
the patient either have
plans for ongoing
dialysis or dialysis
withdrawn for palliative
care)
Measure of care outcome -
non recovery of AKI 2 2
50. 45
8.7 Complete Dataset as excel file
Contact admin@kidneycare.nhs.uk for a copy of the complete dataset
as an excel file
51. 46
9 Possible methods of collection
This document does not define exactly how that data items would be collected
for each audit as in some cases pilots are underway, or would be required to
establish the most practicable methods.
9.1 Acute Hospital Admission
The 2010/11 illustrative CQUIN is being piloted in the East Midlands
Specialised commissioning group. It is anticipated that this audit would be
performed as a snap-shot of all emergency admissions over a fixed period.
9.2 Elective vascular surgery
This audit is currently ongoing and uses data entry by vascular surgeons
using a secure on-line data-entry tool.
9.3 Laboratory
Local units are currently piloting different methods to extract and analyse this
data. In units where the data is “warehoused” it is anticipated that it would be
a relatively straightforward task to collect this basic data-set on the prevalence
of a change in serum creatinine.
9.4 Adverse event review
The detailed methodology of the NCEPOD audit methodology including the
assessment forms is available from the NCEPOD website6
.
9.5 Primary care
Pilots would be required to demonstrate that this data could be collected from
primary care, although the shortly to be operational GPES would appear to
make such an audit technically possible.
9.6 Critical care / Renal units
The ICNARC initial assessment on presentation to critical care (incorporating
APACHE2 physiology score) does not include sufficient information to allow
collection of the incidence of RRT in patients admitted to critical care.
However the Critical Care Minimum Data Set (CCMDS) does establish the
need for RRT on a daily basis during a critical care episode.
52. 47
Most UK renal units collect information on outpatient haemodialysis treatment
sessions, but many units do not routinely collect this for inpatients or those
with acute rather than chronic kidney disease. However, if units could be
enabled to collect this information it is likely collectable via existing routes to
the UKRR for comparison of outcomes for those who receive RRT for AKI
between units. Linkage to HES would be required in order to establish the
proportion of admitted patients who underwent RRT for AKI, and possibly to
establish outcome.
10 The future
This document represents a first step in defining tools to audit AKI. Over the
next 6-12 months it is hoped that other groups will take parts of this work and
establish whether it can be used as a framework to drive local quality
improvement. Current pilot projects will also report during this time (such as
the National Vascular Society and also groups who implemented the first
illustrative CQUIN) which will further guide the practicality of this data
collection. It is highly likely that these audit tools will need to be revised in the
light of these developments.
In the future it will be increasingly important that items for quality monitoring
and improvement are firmly grounded in items which would be routinely
collected during high quality AKI care (either directly or derived from them).
This might also necessitate changes to the items or their collection method.
Provided at least some of these audit tools have proved practicable and useful
then consideration should be given in the future to further refine and minimise
to the dataset to enable monitoring of standards with the minimum of burden.
53. 48
Appendix 1 Existing Quality Standards and indicators
National Service framework (part 2)19
The NSF part 2 identifies “Acute Renal Failure” (AKI) as one of the four quality
requirements. The current nationally mandated national renal dataset does
not include the measurement of outcomes in AKI. The AKI dataset would
need to enable the monitoring of the following markers of good practice;
1. Timely identification and referral to renal and critical care services for
specialist, culturally appropriate advice and assessment. (Level 3)
2. Appropriate pre-operative testing and interventions, in accordance with
the NICE guideline on pre-operative testing.
3. Involvement of local critical care networks in planning, commissioning
and monitoring the delivery of critical care services to acutely ill renal
patients. (Level 4)
4. Liaison with specialist renal services to facilitate optimal management
of people with ARF in the most clinically appropriate setting. (Level 4)
For children and young people
5. Treatment and care in accordance with Getting the right start: National
Service Framework for Children, Young People and Maternity Services.
54. 49
National Confidential Enquiry into Patient Outcome and Death
(NCEPOD)6
The NCEPOD highlighted the poor care received by some patients who died
in hospital following AKI. The AKI dataset would need to enable the
monitoring of the key recommendations;
1. All patients admitted as an emergency, regardless of specialty, should
have their electrolytes checked routinely on admission and
appropriately thereafter. This will prevent the insidious and
unrecognised onset of AKI.
2. Predictable and avoidable AKI should never occur. For those in-
patients who develop AKI there should be both a robust assessment of
contributory risk factors and an awareness of the possible
complications that may arise.
3. All acute admissions should receive adequate senior reviews (with a
consultant review within 12 hours of admission as previously
recommended by NCEPOD3).
4. NCEPOD recommends that the guidance for recognising the acutely ill
patient (NICE CG 50) is disseminated and implemented. In particular
all acute patients should have admission physiological observations
performed and a written physiological monitoring plan made, taking into
account the degree of illness and risk of deterioration.
5. There should be sufficient critical care and renal beds to allow rapid
step up in care if appropriate.
6. All level 3 units should have the ability to deliver renal replacement
therapy; and where appropriate these patients should receive clinical
input from a nephrologist.
7. All acute admitting hospitals should have access to either onsite
nephrologists or a dedicated nephrology service within reasonable
distance of the admitting hospital.
8. All acute admitting hospitals should have access to a renal ultrasound
scanning service 24 hours a day including the weekends and the ability
to provide emergency relief of renal obstruction.
55. 50
Renal Association current AKI Audit Measures15
1. Incidence of acute admissions/patients undergoing major surgery who
had
• the risk of AKI assessed on admission/pre-surgery
• electrolytes checked on admission/pre-surgery and rechecked
within 24 hours
2. Incidence and outcomes of patients diagnosed with
• community-acquired AKI
• hospital acquired AKI
3. Incidence and outcomes of patients with different causes of AKI
4. Proportion of patients where there has been a delay of >48 hours in
recognising the diagnosis of AKI
6. Proportion of patients with or at risk of AKI who are prescribed
intravenous fluids without an assessment of volume status
7. Proportion of patients with AKI who did not have the appropriate
adjustment of medication doses
8. Proportion of patients with or at risk of AKI who receive nephrotoxic
medications
9. Proportion of patients who had a urinalysis performed within 24 hours
of the diagnosis of AKI unless anuric
10.Proportion of patients developing AKI secondary to obstruction who
had a renal ultrasound examination < 24 hrs after a diagnosis of AKI
established.
11.Proportion of patients at high risk of contrast induced AKI (CI-AKI) who
developed AKI and did not
• receive pre-procedure volume assessment
• receive appropriate volume expansion
• have appropriate adjustments to medications
12.Incidence of delays of transfer of patients with AKI >24 hours following
referral to renal services due to a lack of resources on renal unit
13.Incidence of patients with single organ AKI admitted to ICU for RRT
due to a lack of resources on the renal unit
56. 51
14.Number of AKI inpatient transfers requiring escalation of care within 24
hours of arrival on renal unit
15.Proportion of AKI survivors with residual chronic kidney disease with
post discharge CKD planning
16.Incidence of dialysis catheter-related bacteraemia and sepsis in
patients with AKI
17.Incidence of heparin induced thrombocytopenia
18.Proportion of critically ill patients with AKI treated with alternate day
haemodialysis who receive Kt/V ≥ 1.2 per session
19.Proportion of critically ill patients with AKI treated with continuous renal
replacement therapy who receive > 25 mls/kg/hr post dilution
ultrafiltration
20.Proportion of patients with AKI receiving renal replacement therapy
reviewed by dietician within 24 hours
21.Proportion of patients with AKI receiving renal replacement therapy
prescribed the recommended nutritional support
22.Proportion of patients with AKI who recover kidney function within 90
days of episode as defined by return of serum creatinine to within 20%
of baseline value (most recent value within 3 months but accepting
value up to one year)
• dialysis independence (if previously requiring dialysis)
23.Outcome measures for patients developing AKI should include
• length of hospital stay
• hospital mortality
• 90 day mortality
• one year mortality
59. 54
2011-12 Department of Health Commissioning for Quality (CQUIN)
Description of goal Improving the prevention, detection and
management of Acute Kidney Injury (AKI) in
patients admitted as an emergency to hospital
Rationale for Inclusion Acute Kidney Injury (AKI) is a common
consequence of acute illness, affecting up to 20%
of emergency hospital admissions. It is associated
with significant excess morbidity and mortality, and
the NCEPOD report published in June 2009
documented widespread substandard care of
people with AKI. Up to 30% of cases of AKI are
estimated to be avoidable through better medical
management of acutely unwell patients and NICE
Clinical Guideline 50 has endorsed the importance
of physiological monitoring and scoring to identify
patients at risk of clinical deterioration. Improving
the recognition of acute illness and AKI risk has the
potential to significantly improve the quality of care
for patients with acute illness and lead to significant
productivity improvements.
Recent local audits have shown that the recording
and documentation of physiological observations is
not being performed for all patients and that many
cases of avoidable AKI are still occurring. This has
been linked locally to above average lengths of
stay at the Trust and therefore this indicator is a
key driver of improved productivity as well as
quality.
The final indicator values and rules for partial
achievement have been agreed by the Trust clinical
reference group as realistic and clinically
appropriate.
Description of indicator This is a composite indicator (C1 and C2)
incorporating metrics relating to the recognition of
acute illness in emergency admissions and to the
prevention and detection of AKI
Numerator
C1. % of emergency admissions to have:
• Physiological scoring performed to identify
patients at high risk of clinical deterioration
(e.g. MEWS Score)
• Consultant review within 12 hours of
admission
C2. % of emergency admissions with a major risk
60. 55
factor for AKI to have:
• Medication review
• Serum creatinine rechecked within 24 hours
of admission
Denominator Total number of adult emergency admissions
Data source and
frequency of collection
C1 and C2. Local audit of case records and
interrogation of laboratory results relating to all
adult emergency admissions for two days each
quarter in 2010/2011 (dates to be specified
retrospectively by commissioner).
Organisation
responsible for data
collection
Provider
Frequency of reporting
to commissioner
Quarterly
61. 56
Other quality indicators
In addition there are published guidelines from the international KDIGO
group16
which are reflected in the final version of the update of the UK Renal
Association AKI guidance (2011).
62. 57
Appendix 2 – Other considerations from scoping document
10.1 Attributes of items in an AKI dataset
10.1.1 Specific and Defined unambiguously in clinical and in informatics
terms.
10.1.2 Measurable
10.1.3 Agreed to be useful to share
10.1.4 Agreed to be a key determinant of either patient outcome in AKI, or a
surrogate for quality of care in AKI care pathway.
10.1.5 Realistic means of getting the data into a central (or regional) place to
allow comparison between settings or centres.
10.1.6 Timely – could be done repeatedly without undue burden to
demonstrate improvement in quality with time.
10.2 Other principles
10.2.1 Where-ever possible items in the dataset should be capable of fulfilling
both primary uses (i.e. to directly facilitate patient care) and also be
useful to measure outcome (secondary uses).
10.2.2 Ideally the dataset should be setting independent even if it is initially
only deployed and collected in a sub-set of all the possible settings
10.2.3 Ideally the dataset would cover quality in all the aspects of the AKI
pathway (Prevention, Detection, Referral, Initial Management, Ongoing
management, dealing with sequelae.)
10.2.4 The dataset should be a small as possible to be effective thereby
simplifying the task of its deployment and maintenance and the
minimising burden of collection to the NHS.
10.2.5 The data-set should almost exclusively use items previously validated
by the work of national and international guideline groups and from
clinical and epidemiological research. Exceptions might include data
on administrative boundaries or care structures unique to the NHS but
thought to important in AKI outcome. An exceptional item might be
considered if of a speculative nature but with consensus of professional
assurance of its value versus the burden of collection to the NHS.
10.2.6 There would need to be a tight definition of who to include in the first
place (“the denominator”) in order for the data-set to accurately cover
the subsequent entire care pathway of such people.
10.2.7 The data in the dataset should be patient-identifiable to allow linkage
with other data-sets unless the benefit of so-doing is considered
insufficient to justify this by NIGB.
63. 58
10.3 Data collection and return to a centre.
10.3.1 Items relating to hospital admission, discharge, procedures, associated
diagnosis and in hospital death are routinely collected in hospital PAS
and returned to the SUS to generate HES. As discussed above this
data is insufficient alone to allow quality improvement.
10.3.2 Information relating to AKI in primary care could be available
electronically in the future (2012) via services such as the GPES.
10.3.3 Information relating to an ongoing dialysis requirement is collected
electronically through renal unit computer systems. This information is
contained in the existing NRD with established flows to the UK renal
registry and proposed flow to the IC. Information on the acute
requirement for dialysis within renal units could be collected in this way
with several renal units recording all dialysis sessions delivered
already.
10.3.4 Intensive Care National Audit and Research Centre (ICNARC)21
collect
information central on outcomes in patients admitted to intensive care
unit.
10.3.5 Items relating to the identification of cases of AKI, and clinical
management in hospitals are currently not recorded electronically. This
is likely to represent the greatest burden of collection to the NHS and
will likely need the establishment of an electronic data-collection tool to
enable electronic central returns using existing connections to the IC.
64. 59
Membership Acute Kidney Injury Delivery Group
Title
Mr, Dr,
Prof
etc
Name Organisation (s) Position (s) held e.g. Please list here
relevant positions in other organisations
Dr Ian Barnes Department of Health National Clinical Director for Pathology
Dr Gifford
Batstone
NHS Connecting for
Health
National Clinical Lead for Pathology, Office
of the Chief Clinical Officer
Dr Benjamin Bray NHS Kidney Care Clinical Advisor to NHS Kidney Care
Ms Anne Casey Royal College of
Nursing
Advisor on Information Standards
Dr Mike Cheshire NHS North West Medical Director
Dr Erika Denton Norwich Radiology
Academy
Consultant Radiologist
Medical
Director PACS Programme, Connecting for
Health
National Clinical Lead for Diagnostic
Imaging, Department of Health
Dr Donal
O’Donoghue
(Chair)
Department of Health National Clinical Director for Kidney Care
Ms Lesley Durham North of England
Critical Care Network
(NoECCN)
Chair NOrF
Network Director
Dr Sian Finlay Dumfries and
Galloway Royal
Infirmary
Acute Medicine Consultant,
Member of Society for Acute Medicine
Member of Renal Association
Member of AKI Competencies Group (led
by Andrew Lewington)
Dr Paul Glynne UCLH Medical Director
Dr Tim Gould Intensive Care
Society
Consultant ICM
Bristol Royal Infirmary
Consultant ICM
Examiner DICM
Regional Education Adviser ICM
65. 60
Title
Mr, Dr,
Prof
etc
Name Organisation (s) Position (s) held e.g. Please list here
relevant positions in other organisations
Previous Clinical Director
Mr Tom Gray NHS East Midlands
Royal Derby Hospital
Pharmacy Lead
Chief Pharmacist
Dr Mike C Jones Royal Infirmary of
Edinburgh
The Royal College of
Physicians
The Academy of
Royal Medical
Colleges
Consultant Physician
Ms Monica Jones NHS Information
Centre
Head of Architecture and Standards
Dr Andrew
Lewington
Renal Association Consultant Renal Physician/Honorary
Senior Lecturer
Leeds Teaching Hospitals
Ms Beverley
Matthews
NHS Kidney Care Director
Ms Jane McDonald British Renal
Association (BRS)
Salford Royal NHS
Trust
President BRS
Lead Nurse
Salford Royal NHS Trust
Dr Rajib Pal Royal College of
General Practitioners
General Practitioner
Clinical Director (Cardiac/Stroke/Renal)
South Birmingham PCT
GP Trainer
Ms Joanne Pope London Specialised
Commissioning
Group
London Kidney Care
Network
Network Managers Forum
Network Manager
Mr John
Sedgewick
Royal College of
Nursing
Nephrology Nursing
Forum
Executive Committee Member RCN
Nephrology Forum
Chair – Education & Research Board,
European Dialysis & Transplant Nurses
Association/ European Renal Care
Association
Programmes Director & Principal Lecturer
66. 61
Title
Mr, Dr,
Prof
etc
Name Organisation (s) Position (s) held e.g. Please list here
relevant positions in other organisations
(Nephrology Nursing)
Dr Paul
Stevens
Royal College of
Physicians
BRS immediate past President
Dr Duncan
Watson
University Hospitals
Coventry and
Warwickshire NHS
Trust
Critical Care
Networks
Consultant in Critical Care Medicine
Chair of Critical Care Clinical Leads Forum
67. 62
Membership Kidney Quality Information Partnership
Title
Mr, Dr,
Prof etc
Name Organisation (s)
Dr Donal O’Donoghue National Clinical Director, DH
Ms Beverley Matthews NHS Kidney Care
Ms Cherry Bartlett
Dr Paul Roderick Renal Advisory Group
Dr Mark Davies NHS Information Centre
Ms Jane Pearson Moore
Dr Damian Fogarty Renal Association (UKRR)
Dr Dave Collett NHS Blood and Transplant
Ms Rachel Johnson
Professor John Feehally Renal Information Exchange Group
Dr Grant Kelly Primary Care
Dr Rick Jones Pathology IT
Dr David Meechan East Midlands Public Health
ObservatoryJames Hollinshead
Mr Mike Catchpole Health Protection Agency
Ms Catherine Turner Specialised Commissioners Forum
Mr Peter Knight Research CapabilityNetworks
Mr Andrew Jackson Programme Budgeting
Ms Dawn Mankin
Mr David Mitchell National Vascular Society
Dr James Medcalf Clinical Lead KQIP
68. 63
References
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Ali T, Khan I, Simpson W, Prescott G, Townend J, Smith W, and
MacLeod A. Incidence and Outcomes in Acute Kidney Injury: A
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Liano F, Junco E, Pascual J, Madero R, Verde E. The spectrum of
acute renal failure in the intensive care unit compared with that seen in
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3
Lassus JPE, Nieminen MS, Peuhkurinen K, Pulkki K, Siirilä-Wairs K,
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4
Levy et al. The Effect of Acute Renal Failure on Mortality: A Cohort
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5
Lassnigg et al. Minimal Changes of Serum Creatinine Predict
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10
Mangano CM, Diamondstone LS, Ramsay JG, Aggarwal A,
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11
Durmaz I, Buket S, Atay Y, Yagdi T, Ozbaran M, Boga M, et al.
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12
Hoste EAJ, Clermont G, Kersten A, Venkataraman R, Angus DC,
De Bacquer D and Kellum JA. RIFLE criteria for acute kidney injury
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13
NICE quality standard for Chronic Kidney disease.
http://www.nice.org.uk/guidance/qualitystandards/chronickidneydisease
/ckdqualitystandard.jsp
14
Commissioning for Quality (CQUIN) Acute Services Illustrative
example. www.dh.gov.uk
15
Clinical Practice Guidelines. Acute Kidney Injury. 5th
Edition (2011)
UK Renal Association.
http://www.renal.org/Clinical/GuidelinesSection/AcuteKidneyInjury.aspx
16
Kidney Disease Global Outcomes Collaborative. www.kdigo.org
17
The Vascular Society of Great Britain and Ireland.
www.vascularsociety.org.uk/
18
UK Renal Registry. www.renalreg.com
19
The National Service Framework for Renal Services. Part 2: Chronic
Kidney Disease, Acute Renal Failure and End of Life Care (2005).
20
Chronic kidney disease. National clinical guideline for early
identification and management in adults in primary and secondary care.
www.NICE.org.uk/
21
Intensive Care National Audit and Research Centre.
https://www.icnarc.org