Designing a Clinical Trial
Dr.Ramakrishna HK
MS, DNB, FMAS
Lakshmi Nursing Home
Bhadravathi
E mail: swarama@hotmail.com
BASIC AIRWAY
MANAGEMENT
Rafal Banek CRNA
Learning Objectives
● Anatomy of the airway and respiratory
system
● Fundamentals of Airway Management
● Familiarity with airway adjuncts
IF YOU CAN’T BREATH,
NOTHING ELSE MATTERS !!!
● Airway management is one of the most
critical aspect of trauma care.
● Airway compromise may quickly result in
fatality yet, it may be easy to treat
● Unrecognized airway compromise may lead
to patient deterioration and death within
minutes.
● No trauma interventions should be
undertaken before addressing the airway
status……….ANY EXCEPTIONS TO THIS
?
AIRWAY ANATOMY
TWO MAJOR
COMPONENTS
1.Upper airway
 Humidification, filtration and warming of
the inhaled air
 Filtration of bacteria (Tonsils/Adenoids)
 Phonation
2.Lower airway
 Exchange of O2, CO2 with blood
 Phonation
UPPER AIRWAY
1. Nasal cavity
 Warms, filters,
humidifies air
2. Nasopharynx
 From the internal
nostrils to lower edge of
soft palate
3. Oral cavity,
4. Oropharynx
 Soft palate to epiglottis
5. Laryngopharynx
(hypopharynx)
 From epiglottis to
cricoid cartilage
Nasal Cavity
Oral
Cavit
y
Oral cavity
LOWER AIRWAY
1. Trachea
2. Bronchi
 Two mainstem
 Secondary, tertiary
3. Bronchioles
4. Alveolar ducts
5. Alveolar sacs
4. Alveoli
 “Balloon-like” clusters
 Actual sites of gas
exchange
Carina
Basic Airway Techniques
• Everyone involved in trauma care should be
familiar with and proficient in their use
• These should be executed before advanced
airway management is undertaken
1. Head tilt/chin lift
2. Jaw thrust (known or suspected c-spine injury)
3. Nasopharyngeal airway
4. Oropharyngeal airway
5. Bag valve mask assist or PPV
Key points to remember
during initial airway evaluation
 Airway is patent if the victim is able to speak
 Muscular tone of the head and neck muscles keeps the
airway open in awake conscious patient
 As LOC decreases, the airway muscle tone decreases
leading to partial or complete obstruction
 The tongue is the most common cause of airway
obstruction in an unconscious adult.
 Unconscious victim’s respirations may be sufficient to
maintain life but death may result from airway
obstruction
 Patients with head, face, neck, chest and inhalational
injury have higher likelihood of airway compromise
Conscious victim
Airway obstruction in
unconscious victim
Obstruction
Types of airway
obstruction
Partial
Snoring
Stridor
Abnormal phonation
Paradoxical motion of
the abdominal and
Complete
Absent air movement
Aphonia
Rapidly ensuing
hypoxia
Paradoxical motion may
Airway Evaluation
• If patient is conscious and speaking
normally-provide supplemental 02, assess
BS, continue close monitoring
• If patient is unconscious
 Head tilt/chin lift or forward thrust the
mandible if known or suspected c-spine
trauma
 If facial trauma present, may need to
inspect the mouth for blood, bone
fragments and other foreign objects-
remove or suction if necessary
Head tilt/chin lift
Jaw thrust
• One hand on forehead
• Second grasping the
bony portion of
mandible
• Avoid pressing on the
soft tissue !!!
• Tilt the head and lift the
chin at the same time.
• This lifts the tongue
and creates a pocket
for oxygen to travel.
• Assess for air
movement
Jaw thrust
• Safest maneuver if c-
spine injury is
suspected
• Avoids c-spine
extension
• Stand behind the
patient
• Heels of the hands on
the temporal areas
• Locate angle of the
mandible
Nasopharyngeal Airway
(NPA)
• Better tolerated in semi-
conscious patient with
intact airway reflexes
• Properly sized from NPA
extends from the nostril
to the angle of the
mandible
• Do not use with facial
trauma or suspected
skull fracture
• Epistaxis not uncommon
from NPA use
(coagulopathic patients???)
NPA insertion
• Lubricate-KY or
Lidocaine jelly
• Perpendicular to the
face
• Twisting motion
• Avoid forcing in the
device
• Once placed, reassess
the airway patency
Oropharyngeal airway
(OPA)
• Do not use in semiconscious
patient with intact airway reflexes
(vomiting, aspiration,
laryngospasm !!!)
•Properly sized from OPA extends
from the mouth to the angle of the
mandible
OPA insertion
•Begin inserting from the
inverted position
•When advancing, gently
rotate the device 180
degrees
•Tongue blade may be
used to aid the passage of
the OPA
•Reassess airway patency
Oxygenation and ventilation must be reassessed
after airway patency has been re-established
Indicators of inadequate ventilation and
oxygenation
Central cyanosis
Rapid shallow respirations
Accessory muscle use
Retractions
Abdominal paradoxical respirations
SpO2<90%
Bag-Valve mask (BVM) ventilation
(“bagging”)
• Critically important airway skill
• Always the first response to inadequate
oxygenation and ventilation
• The first “bail-out” maneuver to a failed
intubation attempt
• Attenuates the urgency to intubate
Golden Rules of “Bagging”
• Almost anybody can be oxygenated
and ventilated with a bag and a mask
• Manual ventilation skill with proper
equipment is a fundamental premise of
basic and advanced airway
management
• The art of bagging should be mastered
before the learning advanced airway
skills
BVM Ventilation
• Requires practice to master
• One hand to
– maintain face seal
– position head
– maintain patency
• Sniffing position if c-spine
clear
• Thumb + index to maintain
face seal
• Middle finger under
mandibular symphysis
• Ring/little finger under angle
of mandible
• Other hand ventilates
ALL fingers rest on the bony
portion of the mandible
“Bagging” with C-spine
precautions
• Two person maneuver
• Primary maintains the
seal and neutral head
postition
• Assistant provides jaw
thrust
• NPA or OPA may be
helpful
Predictors of difficult “bagging”
•Upper airway obstruction
•Lack of dentures
•Beard
•Midfacial trauma
•Facial burns, dressings, scarring
•Poor lung mechanics-resistance or
compliance
Algorithm for difficulty
“Bagging”
• Reassess for blood, fractured teeth
and foreign bodies –suction or
remove if applicable
• Triple maneuver if c-spine clear
– Head tilt, jaw thrust, mouth
opening
• Nasal or/and oropharyngeal airways
• Two-person, four-hand technique
Two-person, four-hand
technique
OPA and 2 NPA’s in place
Two hands on the mask and face for
optimal seal/position
Two hands on the bag to ventilate
Excessive gastric distention from
“bagging”
• Possible consequences
Gastric contnents regurgitation and aspiration
Restricted diaphragmatic movement
In rare cases gastric rupture
• Minimizing the risks
Minimize the duration of “bagging”
Avoid excessive tidal volumes
Minimize the positive pressure (<20 cm H2O) if possible
Consider cricoid pressure
Decompress the stomach with NGT or OGT after the
airway is secured
What if “bagging” is difficult
or impossible????
• Rescue devices
Laryngeal Mask Airway (LMA)
Combitube
LMA
• Can be inserted blindly by
unskilled personnel
• Creates seal around the
laryngeal inlet, enabling
ventilation from immediately
above the cords,
• Bypasses proximal upper
airway obstruction- mostly
tongue
• >90% rescue success rate in
impossible or difficult face
mask ventilation situations
LMA placement
1. Lubricate posterior part of
the cuff
2. Place the tip behind pt’s
upper teeth
3. Place the finger in pt’s
mouth, while advancing
push your finger against the
palate and forward against
the cuff
4. Continue advancing till
resistant is felt
5. Inflate the cuff
Combitube
• Inserted blindly
• Easy to use by the
unskilled rescuers
• Esophageal
placement is most
likely (90% of the
insertions)
• Easy to use by the
unskilled rescuers
• Provides better
esophageal seal
Combitube insertion
• Head tilt (clear C-spine?)
with lower jaw lift
• Advance gently with other
hand trying to follow
curvature of the tongue,
until transverse lines are
adjacent to the teeth
• If this is emergency
airway, inflate both lumens
•
Combitube insertion
• Inflate proximal cuff (#1) first (80-10mL) then distal
(5-15mL)
• Attempt ventilation via #1, assess for CO2, BS,
chest movement
• If no CO2 return and no breathsounds are present
>90% placements <10% placements
#1
#2
Combitube troubleshooting
• If ventilations are ineffective, through
either lumen, the tube is to deep in
esophagus
• Withdraw at 1cm increments
• Reassess BS, CO2, chest movement as
you withdraw
Exhaled CO2
(ETCO2)monitoring
• Golden standard to ascertain patent airway and correct
placement of advance airway device
• 2 types of monitors
 Capnograph – bedside monitoring
 “Easy cap”-Responds quickly to exhaled CO2 with a
simple color change, breath-to-breath response, highly
portable,
What color
if CO2 is
present?
• Golden standard to ascertain patent airway and correct
placement of advance airway device
• 2 types of monitors
 Capnograph – bedside monitoring
 “Easy cap”-Responds quickly to exhaled CO2 with a simple
color change, breath-to-breath response, highly portable,
Key points
• Airway compromise can be quickly fatal but
in most cases is easy to correct
• Tongue is the most frequent cause of airway
obstruction
• In the absence of severe extremity
hemorrhage, airway is evaluated and treated
first, regardless of severity of other injuries
• Bag-valve mask ventilation is the most critical
airway management skill set, the first
responders must learn
• ETCO2 monitoring is the golden standard for
ascertaining the airway patency
References
1. Kovacs G, Law JA. Airway
Management in Emergencies.
McGraw Hill Medical; 2008:33-51
??????????????
Why?
• To answer a clinical problem
• To gain new knowledge about a new or
existing treatment
• To support a claim
To get govt. regulatory approval
To market a drug, device or technique
“ I don’t teach my children.
I create condition for them to
learn”.
-Albert Einstein
Thank You

Clinical trial in surgery design protocol

  • 1.
    Designing a ClinicalTrial Dr.Ramakrishna HK MS, DNB, FMAS Lakshmi Nursing Home Bhadravathi E mail: swarama@hotmail.com
  • 2.
  • 3.
    Learning Objectives ● Anatomyof the airway and respiratory system ● Fundamentals of Airway Management ● Familiarity with airway adjuncts
  • 4.
    IF YOU CAN’TBREATH, NOTHING ELSE MATTERS !!! ● Airway management is one of the most critical aspect of trauma care. ● Airway compromise may quickly result in fatality yet, it may be easy to treat ● Unrecognized airway compromise may lead to patient deterioration and death within minutes. ● No trauma interventions should be undertaken before addressing the airway status……….ANY EXCEPTIONS TO THIS ?
  • 5.
    AIRWAY ANATOMY TWO MAJOR COMPONENTS 1.Upperairway  Humidification, filtration and warming of the inhaled air  Filtration of bacteria (Tonsils/Adenoids)  Phonation 2.Lower airway  Exchange of O2, CO2 with blood  Phonation
  • 6.
    UPPER AIRWAY 1. Nasalcavity  Warms, filters, humidifies air 2. Nasopharynx  From the internal nostrils to lower edge of soft palate 3. Oral cavity, 4. Oropharynx  Soft palate to epiglottis 5. Laryngopharynx (hypopharynx)  From epiglottis to cricoid cartilage Nasal Cavity Oral Cavit y Oral cavity
  • 7.
    LOWER AIRWAY 1. Trachea 2.Bronchi  Two mainstem  Secondary, tertiary 3. Bronchioles 4. Alveolar ducts 5. Alveolar sacs 4. Alveoli  “Balloon-like” clusters  Actual sites of gas exchange Carina
  • 8.
    Basic Airway Techniques •Everyone involved in trauma care should be familiar with and proficient in their use • These should be executed before advanced airway management is undertaken 1. Head tilt/chin lift 2. Jaw thrust (known or suspected c-spine injury) 3. Nasopharyngeal airway 4. Oropharyngeal airway 5. Bag valve mask assist or PPV
  • 9.
    Key points toremember during initial airway evaluation  Airway is patent if the victim is able to speak  Muscular tone of the head and neck muscles keeps the airway open in awake conscious patient  As LOC decreases, the airway muscle tone decreases leading to partial or complete obstruction  The tongue is the most common cause of airway obstruction in an unconscious adult.  Unconscious victim’s respirations may be sufficient to maintain life but death may result from airway obstruction  Patients with head, face, neck, chest and inhalational injury have higher likelihood of airway compromise
  • 10.
  • 11.
  • 12.
    Types of airway obstruction Partial Snoring Stridor Abnormalphonation Paradoxical motion of the abdominal and Complete Absent air movement Aphonia Rapidly ensuing hypoxia Paradoxical motion may
  • 13.
    Airway Evaluation • Ifpatient is conscious and speaking normally-provide supplemental 02, assess BS, continue close monitoring • If patient is unconscious  Head tilt/chin lift or forward thrust the mandible if known or suspected c-spine trauma  If facial trauma present, may need to inspect the mouth for blood, bone fragments and other foreign objects- remove or suction if necessary
  • 14.
    Head tilt/chin lift Jawthrust • One hand on forehead • Second grasping the bony portion of mandible • Avoid pressing on the soft tissue !!! • Tilt the head and lift the chin at the same time. • This lifts the tongue and creates a pocket for oxygen to travel. • Assess for air movement
  • 15.
    Jaw thrust • Safestmaneuver if c- spine injury is suspected • Avoids c-spine extension • Stand behind the patient • Heels of the hands on the temporal areas • Locate angle of the mandible
  • 16.
    Nasopharyngeal Airway (NPA) • Bettertolerated in semi- conscious patient with intact airway reflexes • Properly sized from NPA extends from the nostril to the angle of the mandible • Do not use with facial trauma or suspected skull fracture • Epistaxis not uncommon from NPA use (coagulopathic patients???)
  • 17.
    NPA insertion • Lubricate-KYor Lidocaine jelly • Perpendicular to the face • Twisting motion • Avoid forcing in the device • Once placed, reassess the airway patency
  • 18.
    Oropharyngeal airway (OPA) • Donot use in semiconscious patient with intact airway reflexes (vomiting, aspiration, laryngospasm !!!) •Properly sized from OPA extends from the mouth to the angle of the mandible
  • 19.
    OPA insertion •Begin insertingfrom the inverted position •When advancing, gently rotate the device 180 degrees •Tongue blade may be used to aid the passage of the OPA •Reassess airway patency
  • 20.
    Oxygenation and ventilationmust be reassessed after airway patency has been re-established Indicators of inadequate ventilation and oxygenation Central cyanosis Rapid shallow respirations Accessory muscle use Retractions Abdominal paradoxical respirations SpO2<90%
  • 21.
    Bag-Valve mask (BVM)ventilation (“bagging”) • Critically important airway skill • Always the first response to inadequate oxygenation and ventilation • The first “bail-out” maneuver to a failed intubation attempt • Attenuates the urgency to intubate
  • 22.
    Golden Rules of“Bagging” • Almost anybody can be oxygenated and ventilated with a bag and a mask • Manual ventilation skill with proper equipment is a fundamental premise of basic and advanced airway management • The art of bagging should be mastered before the learning advanced airway skills
  • 23.
    BVM Ventilation • Requirespractice to master • One hand to – maintain face seal – position head – maintain patency • Sniffing position if c-spine clear • Thumb + index to maintain face seal • Middle finger under mandibular symphysis • Ring/little finger under angle of mandible • Other hand ventilates ALL fingers rest on the bony portion of the mandible
  • 24.
    “Bagging” with C-spine precautions •Two person maneuver • Primary maintains the seal and neutral head postition • Assistant provides jaw thrust • NPA or OPA may be helpful
  • 25.
    Predictors of difficult“bagging” •Upper airway obstruction •Lack of dentures •Beard •Midfacial trauma •Facial burns, dressings, scarring •Poor lung mechanics-resistance or compliance
  • 26.
    Algorithm for difficulty “Bagging” •Reassess for blood, fractured teeth and foreign bodies –suction or remove if applicable • Triple maneuver if c-spine clear – Head tilt, jaw thrust, mouth opening • Nasal or/and oropharyngeal airways • Two-person, four-hand technique
  • 27.
    Two-person, four-hand technique OPA and2 NPA’s in place Two hands on the mask and face for optimal seal/position Two hands on the bag to ventilate
  • 28.
    Excessive gastric distentionfrom “bagging” • Possible consequences Gastric contnents regurgitation and aspiration Restricted diaphragmatic movement In rare cases gastric rupture • Minimizing the risks Minimize the duration of “bagging” Avoid excessive tidal volumes Minimize the positive pressure (<20 cm H2O) if possible Consider cricoid pressure Decompress the stomach with NGT or OGT after the airway is secured
  • 29.
    What if “bagging”is difficult or impossible???? • Rescue devices Laryngeal Mask Airway (LMA) Combitube
  • 30.
    LMA • Can beinserted blindly by unskilled personnel • Creates seal around the laryngeal inlet, enabling ventilation from immediately above the cords, • Bypasses proximal upper airway obstruction- mostly tongue • >90% rescue success rate in impossible or difficult face mask ventilation situations
  • 31.
    LMA placement 1. Lubricateposterior part of the cuff 2. Place the tip behind pt’s upper teeth 3. Place the finger in pt’s mouth, while advancing push your finger against the palate and forward against the cuff 4. Continue advancing till resistant is felt 5. Inflate the cuff
  • 32.
    Combitube • Inserted blindly •Easy to use by the unskilled rescuers • Esophageal placement is most likely (90% of the insertions) • Easy to use by the unskilled rescuers • Provides better esophageal seal
  • 33.
    Combitube insertion • Headtilt (clear C-spine?) with lower jaw lift • Advance gently with other hand trying to follow curvature of the tongue, until transverse lines are adjacent to the teeth • If this is emergency airway, inflate both lumens •
  • 34.
    Combitube insertion • Inflateproximal cuff (#1) first (80-10mL) then distal (5-15mL) • Attempt ventilation via #1, assess for CO2, BS, chest movement • If no CO2 return and no breathsounds are present >90% placements <10% placements #1 #2
  • 35.
    Combitube troubleshooting • Ifventilations are ineffective, through either lumen, the tube is to deep in esophagus • Withdraw at 1cm increments • Reassess BS, CO2, chest movement as you withdraw
  • 36.
    Exhaled CO2 (ETCO2)monitoring • Goldenstandard to ascertain patent airway and correct placement of advance airway device • 2 types of monitors  Capnograph – bedside monitoring  “Easy cap”-Responds quickly to exhaled CO2 with a simple color change, breath-to-breath response, highly portable, What color if CO2 is present? • Golden standard to ascertain patent airway and correct placement of advance airway device • 2 types of monitors  Capnograph – bedside monitoring  “Easy cap”-Responds quickly to exhaled CO2 with a simple color change, breath-to-breath response, highly portable,
  • 37.
    Key points • Airwaycompromise can be quickly fatal but in most cases is easy to correct • Tongue is the most frequent cause of airway obstruction • In the absence of severe extremity hemorrhage, airway is evaluated and treated first, regardless of severity of other injuries • Bag-valve mask ventilation is the most critical airway management skill set, the first responders must learn • ETCO2 monitoring is the golden standard for ascertaining the airway patency
  • 38.
    References 1. Kovacs G,Law JA. Airway Management in Emergencies. McGraw Hill Medical; 2008:33-51
  • 39.
  • 40.
    Why? • To answera clinical problem • To gain new knowledge about a new or existing treatment • To support a claim To get govt. regulatory approval To market a drug, device or technique
  • 41.
    “ I don’tteach my children. I create condition for them to learn”. -Albert Einstein
  • 42.