Acute pancreatitis is an inflammation of the pancreas that can result in its self-digestion. It is commonly seen in middle-aged men and women, with about 5000 cases per year in the US. Risk factors include abdominal trauma, alcohol use, gallstones, hyperlipidemia, and certain medications. The pancreas releases enzymes that normally break down food but in pancreatitis can damage the pancreas itself. Treatment focuses on pain relief, preventing shock, and suppressing pancreatic enzymes through NPO, NG suction and medications while correcting electrolyte imbalances and maintaining hydration.