1) A 5-month-old male child presented with 5 days of fever followed by seizures and was intubated due to poor condition and raised intracranial pressure. Infectious etiologies like dengue and autoimmune encephalitis were considered.
2) Investigations like MRI, LP, and metabolic workup were normal or negative. The child had refractory seizures and raised ICP and died.
3) Causes of acute encephalopathy like infection, autoimmune, metabolic and epileptic encephalopathy were discussed. Management involves stabilization, empiric antibiotics, supportive care, preventing complications, and identifying specific causes.
Acute meningoencephalitis Powerpoint presentation.
It comprises of acute meningitis and acute encephalitis, their clinical features, physical assesment, diagnosis and treatment.
Febrile seizure / Pediatrics
Simple vs. Complex seizure
Possible explanation of febrile seizure
Risk Factors for Febrile Seizures
Risk Factors for Recurrence of Febrile Seizure
Risk Factors for Occurrence of Subsequent Epilepsy After a Febrile Seizure
Genetic Factors
Evaluation
Lumbar Puncture
Optional LP
Electroencephalogram
Blood Studies
Neuroimaging
TREATMENT
This presentation was done by Dr. Julius P. Kessy,MD. An intern Doctor at Dodoma Regional Referral Hospital (DRRH) during pediatrics unit clinical meeting and supervised by Dr. Christina K. Galabawa,MD,Mmed2, Pediatrics and Child Health, University of Dodoma (UDOM) in November, 2017.
Acute meningoencephalitis Powerpoint presentation.
It comprises of acute meningitis and acute encephalitis, their clinical features, physical assesment, diagnosis and treatment.
Febrile seizure / Pediatrics
Simple vs. Complex seizure
Possible explanation of febrile seizure
Risk Factors for Febrile Seizures
Risk Factors for Recurrence of Febrile Seizure
Risk Factors for Occurrence of Subsequent Epilepsy After a Febrile Seizure
Genetic Factors
Evaluation
Lumbar Puncture
Optional LP
Electroencephalogram
Blood Studies
Neuroimaging
TREATMENT
This presentation was done by Dr. Julius P. Kessy,MD. An intern Doctor at Dodoma Regional Referral Hospital (DRRH) during pediatrics unit clinical meeting and supervised by Dr. Christina K. Galabawa,MD,Mmed2, Pediatrics and Child Health, University of Dodoma (UDOM) in November, 2017.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. CASE
• 5months old male, first born to a 2nd degree consanguinous
parents who was previously normal brought with c/o of fever
for 5 days,followed by seizures during defervesence
period.Multiple episodes of seizures in the form of stiffening
of limbs before coming to hospital.
At ER,
Child was intubated in view of poor GCS and raised ICP
precautions were taken. No hepatosplenomegaly or rash was
present.
Provisional diagnosis was acute CNS infection. Started on
ceftriaxone,phenytoin,3% saline and other antiedema
measures.
4. Case cont….
• On day three of admission child had subtle
seizures and lid twitching hence was loaded
with phenobarbitone, leviteracetam and
midazolam infusion. Pyridoxine and folinic
acid was added for refractory seizures.
• Day 4: MRI Brain with contrast /MRA & MRS
Normal
5. CASE contd…
• Initial CSF study was normal.
• Dengue serology was sent on day 3 since
encephalopathy occurred during defervescence
period. Igm and Ig G reported as positive. But
classical features of dengue were not present
• EEG showed epileptiform activity for which
midazolam infusion was continued.
• S.Ammonia – Normal
• HIV- Non reactive
6. Contd..
• Since child was refractory to supportive
management and definite diagnosis could not
be achieved ,suspecting autoimmune
encephalitis- Methylprednisolone was added.
• Possibilities kept at this point were
• 1.Infection triggered Encephalopathy ? Viral
(FIRES)
• 2.Metabolic
• 3.Autoimmune encephalitis
7. CASE Contd…
• By day 8 – GCS dropped. Pupils SRL.Child had
refractory raised ICP and subsequently pupils
became dilated ,absent gag reflex and
spontaneous triggers .
• On 19.5.2017, baby went in for cardiac arrest.
Declared dead on 19.5.2017 at 11.30am
• Postmortem LP done
• CSF Dengue,HSV,JE and encephalitis panel –
Negative
• DNA has been separated for genetic studies(
Epileptic encephalopathy panel)
9. What else could have been done
• Continuous EEG monitoring
• Continous ETCO2 monitoring
10. IMPORTANT DEFINITIONS
1) Encephalopathy : Encephalopathy describes a
clinical syndrome of altered mental status,
manifesting as reduced consciousness or
altered behavior.
2) Encephalitis : Encephalitis means
inflammation of the brain.
11. IMPORTANT DEFINITIONS
3) Acute Encephalitis Syndrome : A person of
any age, at any time of year with the acute
onset of fever and a change in mental status.
14. EVALUATION AND MANAGEMENT
Step I: Rapid assessment and stabilization
Step II: Clinical evaluation: History and
Examination
Step III: Investigation/Samples to be collected
Step IV: Empirical Treatment
Step V: Supportive care and treatment
Step VI: Prevention/treatment of complications
and rehabilitation
15. Step I: Rapid assessment and
stabilization
• Establish and maintain airway
• Ventilation, Oxygenation
• Circulation
• Identify signs of cerebral herniation or raised
ICP.
• Temperature: treat fever and hypothermia
• Treat ongoing seizures- Benzodiazepine,
followed by phenytoin loading
16. Step II: Clinical evaluation: History
and Examination
• There may be a prodrome of upper respiratory
illness, flu-like illness or diarrhea.
• Altered behavior, cognition, personality
changes, altered consciousness.
• History of recurrent episodes of
encephalopathy.
• Family history of previous infant/child deaths.
• Recent history of travel
17. Etiological Clues
• Pallor : Cerebral malaria, or IC bleed
• Icterus : Leptospirosis, hepatic
encephalopathy, or cerebral malaria.
• Skin rashes : dengue, measles, varicella,
rickettsial diseases
• Petechiae : dengue and viral hemorrhagic
fevers
• Parotid swelling and orchitis : Mumps
18. Examination
• GCS
• Pupillary size, shape, symmetry and response
to light provide valuable clues to brainstem
and third nerve dysfunction.
• Special attention should be given to posturing
because it often signals a brainstem
herniation syndrome.
• Fundus examination must be performed to
look for papilledema and retinal hemorrhages.
19. Step III: Investigation
• Basic investigations :
CBC, RFT, Electrolytes, LFT, Blood Culture, CXR
• Lumbar puncture :
In Patients who are hemodynamically stable, and no
features of raised intracranial pressure.
CSF analysis is an important investigation in children
with AES (Should include full viral panel)
• Neuroimaging:
May give valuable information such as presence of bleed,
cerebral edema etc
MRI should be obtained, as soon as the patient is stable.
20. Investigation
• Other microbiological investigations:
These samples include urine, throat swab,
nasopharyngeal aspirate, swab from vesicles or
rash, if present.
• Unexplained encephalopathy with fever and
rash : Weil- Felix test, rickettsial serology
• Unexplained encephalitis : HIV testing
21. Investigation
• Other tests
• EEG is not routinely needed .
It must be performed in children with
unexplained altered sensorium to look for
suspected non-convulsive status epilepticus.
Metabolic.
Autoimmune encephalitis panel.
22. Step IV: Empirical Treatment
Must be started if CSF cannot be done/report
will take time and patient sick.
• Ceftriaxone
{100mg/kg/day}
• Acyclovir (use in all suspected sporadic viral
encephalitis)
3mt – 12yr : 500mg/m2 Q8H
> 12yr : 100mg/kg Q8H
23. Step V: Supportive care and treatment
(a) Maintenance intravenous fluids :
• Isotonic fluids are preferred
(b) Management of raised intracranial pressure:
• Head elevation,
• Minimal disturbance,
• Normothermia,
• Hyperventilation,
24. Supportive care and treatment
(c) Maintain euglycemia
(d) Treatment and prevention of seizures:
(Lorazepam 0.1 mg/kg, diazepam 0.3 mg/kg, or
midazolam 0.1 mg/kg)
(e) Other drugs : Corticosteroids
(f) Other measures: Acid-base and electrolyte
abnormalities should be corrected.
25. Step VI: Prevention/treatment of
complications and rehabilitation
• Physiotherapy, posture change, Prevent bed
sores and exposure keratitis.
• Complications: aspiration pneumonia,
nosocomial infections, coagulation
disturbances
• Nutrition: early feeding
• Psychological support to patient and family
27. ACUTE ENCEPHALOPATHY IN CHILDREN
WITH INBORN ERRORS OF METABOLISM
• Acute encephalopathy is a common and
potentially medical emergency in patients
with inborn errors of metabolism.
• In young children with unexplained altered
sensorium, especially with pre-morbid
developmental delay, investigations for inborn
errors of metabolism plasma must be carried
out.
28. Contd..
• Lactate, ketones.
• Serum ammonia,
• Blood tandem mass spectroscopy,
• Urine gas chromatography mass spectroscopy
29.
30. Autoimmune Encephalitis
In older children, the possibility of autoimmune
disorders such as
SLE (anti-nuclear antibodies, anti-ds-DNA
antibodies),
Hashimoto encephalopathy (anti-TPO
antibodies), and
Anti-NMDA receptor and Anti-VKGC antibody-
mediated encephalitis may be considered.
31. • In this case infectious etiology has been
reasonably worked up and ruled out.
Metabolic & autoimmune encephalitis was
not completely worked up.
• Also there is a subgroup of disorders which
can have infantile epileptic encephalopathy
which can cause refractory raised ICP.
32. Take home message
• Early stabilization and institution of non-
specific supportive measures is the
cornerstone of management.
• Investigations are aimed at recognition of
etiological agent for specific therapeutic and
control measures.