Acromegaly
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Acromegaly is caused by excess growth hormone secretion from a pituitary tumor, usually a macroadenoma, leading to elevated GH and IGF-1 levels in adults. Common complaints are headaches and sweating. Diagnosis involves elevated levels of GH, IGF-1, and sometimes prolactin. Treatment aims to normalize GH and IGF-1 using somatostatin analogues like octreotide or lanreotide, or the GH receptor antagonist pegvisomant.
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Acromegaly
Acromegaly is a hormonal disorder that develops when your pituitary gland produces too much growth hormone during adulthood
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When the pituitary Gland it' s function is increased whether the cause are?
Both anterior and Posterior gland secretions are increased the most causes are ADENOMAS
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Acromegaly
- 2. INTRODUCTION • caused by excess growth hormone (GH) secretion from a pituitary tumor • usually a macroadenoma • GH stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland • Excess GH in children leads to Gigantism • Excess GH in adults is leads to Acromegaly
- 4. • most common complaints are headache and sweating
- 6. Investigations • Plasma GH > 0.5 μg/L • IGF-1 is also elevated • Prolactin concentrations are elevated in about 30% of patients due to co- secretion of prolactin from the tumor
- 7. Treatment • Aim: Normalize serum GH and IGF-1 • Somatostatin analogues- Octreotide, lanreotide or pasireotide • Pegvisomant is a peptide GH receptor antagonist administered by daily self-injection (Trans-sphenoidal) (Less eff)