This document defines acids, bases, and salts according to three theories:
1) Arrhenius defines acids as substances that yield hydrogen ions in water and bases as substances that yield hydroxide ions in water. Neutralization produces salt and water.
2) Bronsted-Lowry defines acids as proton donors and bases as proton acceptors. Neutralization involves the transfer of a proton from an acid to a base.
3) Lewis defines acids as electron pair acceptors and bases as electron pair donors. Neutralization involves the sharing of an electron pair between an acid and base.
The three main categories of chemical compounds are acids, bases and salts. These compounds are always part of our daily lives in terms of what we eat and use. The human body contains some very common acids like dilute hydrochloric acid in the stomach, which aids in digestion of food. If the contents of our stomach become too acidic, it results to a burning sensation in the stomach. Acids and bases also regulate metabolic activities in the human body through equilibrium processes. Acids contain hydrogen ions (H+). A base is a substance, which on dissolving in water yields hydroxyl ions (OH-) as the only negative ions. Salts are formed by the combination of an acid and base.
THIS PRESENTATION IS FOR THE STUDENTS STUDYING IN SENIOR CLASSES .IT WILL HELP THE CHILD TO RECALL THE CONTENT IN SHORT TIME IT WILL HELP TO BUILD THE STRONG AND CLEAR CONCEPT KNOWLEDGE.
The three main categories of chemical compounds are acids, bases and salts. These compounds are always part of our daily lives in terms of what we eat and use. The human body contains some very common acids like dilute hydrochloric acid in the stomach, which aids in digestion of food. If the contents of our stomach become too acidic, it results to a burning sensation in the stomach. Acids and bases also regulate metabolic activities in the human body through equilibrium processes. Acids contain hydrogen ions (H+). A base is a substance, which on dissolving in water yields hydroxyl ions (OH-) as the only negative ions. Salts are formed by the combination of an acid and base.
THIS PRESENTATION IS FOR THE STUDENTS STUDYING IN SENIOR CLASSES .IT WILL HELP THE CHILD TO RECALL THE CONTENT IN SHORT TIME IT WILL HELP TO BUILD THE STRONG AND CLEAR CONCEPT KNOWLEDGE.
Acids and bases buffers ARRHENIUS CONCEPT
THE LEWIS CONCEPT-THE ELECTRON DONOR ACCEPTOR SYSTEM
BRONSTED-LOWRY CONCEPT (PROTON TRANSFER
THEORY
buffer action
ph scale
buffer capacity
acid base balance
isotonicity method
isotonic soltions
buffer solutions in pharmaceutical preparations
Acids and bases buffers ARRHENIUS CONCEPT
THE LEWIS CONCEPT-THE ELECTRON DONOR ACCEPTOR SYSTEM
BRONSTED-LOWRY CONCEPT (PROTON TRANSFER
THEORY
buffer action
ph scale
buffer capacity
acid base balance
isotonicity method
isotonic soltions
buffer solutions in pharmaceutical preparations
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
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Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
2. Facts About Acids
Have sour taste;
Turn blue litmus dye to red;
Colorless with phenolphthalein (often used as an indicator
in acid–base titrations);
Corrosive, can dissolve metals; and
React with metals to liberate hydrogen gas.
3. Facts About Bases
Have bitter taste;
Feel slippery or greasy to touch;
Turn red litmus dye to blue;
Magenta red color with phenolphthalein; and
Strong bases liberate NH3 from ammonium salts.
5. A. The Arrhenius concept is based on the type of ions produced
in aqueous solution.
Acid is a substance which yields hydrogen ions (H+) or
hydronium ions (H3O+) in aqueous solution.
Example of Arrhenius acids are HCl, NHO3, H2SO4,
HC2H3+O2.
Base is a substance which yields hydroxide ions (OH-) in
aqueous solution.
Example of Arrhenius bases are KOH, NaOH, Mg(OH)2.
6. • Neutralization refers to the reaction between an acid and a
base. When an Arrhenius acid reacts with an Arrhenius base,
salt and water are produced as shown in the following
equation.
HCl + NaOH → NaCl + H2O
Acid Base Salt Water
• Salt are ionic compounds made up of a negative ion, except OH
and any positive ion, Except H+. Example are KNO3, Na2CO3,
AlPO4 and CaSO4.
7. B. The Bronsted-Lowry concept is based on wherever a
proton, H+ is donated or accepted.
Acid is a proton donor.
Bases is a proton acceptor.
• According to the Bronsted-Lowry concept, neutralization
involves the transfer of a proton (H+) from a Bronsted-Lowry
acid to a Bronsted-Lowry base as shown in the following
equation.
HC2H3O2 + HOH → C2H3O2
- + H3O+
Acid1 Base2 Base1 Acid2
8. • Conjugate acids and Bases
Reactioon between a Bronsted-Lowry acid and a
Bronsted_Lowry base result in the formation of another Bronsted-Lowry
acid and base. For each reaction, there are two pairs of acids and bases,
where each pair differ only in the number of H+ or protons. The species
with one proton more is the acid while the species with has one proton
less is the base. Each pair is called conjugate acid-base pair. The
conjugate acid-base pairs in this particular neutralization reaction are:
HC2H3O2 – C2H3O2
- or ascetic acid – acetate ion
H3O+ − HOH or hydronium ion – water
• Water is said to be amphiprotic, which means it can act as an acid in
the presence of a strong base, and as a base in the presence of a strong
acid.
9. C. The Lewis concept is based on the shared electron pair.
Acid is an electron pair acceptor.
Base is an electron pair donor.
Example of Lewis acids are Ag+, BF3, AlCl3 while NH3
(ammonia) and RNH2 (amines) are classified as Lewis bases.
: NH3 + HCl → [H: NH3]+ Cl-
Base Acid Salt
10. Summary of definitions of acids and bases
Theory Acid Base
Arrhenius Release H+ in aqueous
solution
Release OH+ in
aqueous solution
Bronsted-Lowry Proton donor Proton acceptor
Lewis Electron pair acceptor Electron pair donor