1. Tablet compression involves several mechanisms including particle rearrangement, deformation through elastic or plastic flow, fragmentation, and bonding through mechanical interlocking or intermolecular forces under pressure.
2. As pressure increases, particles first rearrange then deform through elastic and plastic mechanisms, which can lead to fragmentation and new surfaces for bonding.
3. Further increases in pressure cause consolidation through plastic deformation and bonding until ejection, where problems like capping, lamination, or sticking can occur if tablets do not release from the punch properly.
This presentation includes the detail information about the physics of tablet compression and compaction, Compression, Effect of friction, distribution of forces, compaction profiles,solubility.
This presentation includes the detail information about the physics of tablet compression and compaction, Compression, Effect of friction, distribution of forces, compaction profiles,solubility.
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
WHAT IS COMPRESSION ?
Compression means reduction of bulk volume of material as a result of the removal of gaseous phase (air) by applied pressure
WHAT IS CONSOLIDATION?
Consolidation is an increase in mechanical strength of material resulting from particle - particle interactions.
M.pharm (Pharmaceutics) modern pharmacy unit-5 Study of consolidation parameters; Diffusion parameters, Dissolution
parameters and Pharmacokinetic parameters, Heckel plots, Similarity factors – f2
and f1, Higuchi and Peppas plot, Linearity Concept of significance, Standard
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As per the syllabus of M.Pharma (1st sem.) I have presented the topic pH-activated and Enzyme-activated. This comes under rate-controlled drug delivery system under the subject Drug delivery system. Best wishes from Sakshi Sharma
Physics of Tablet compression is very useful during study of the tablet. It contains the mechanism of tablet compression. It also contains the process of tablet compression.
WHAT IS COMPRESSION ?
Compression means reduction of bulk volume of material as a result of the removal of gaseous phase (air) by applied pressure
WHAT IS CONSOLIDATION?
Consolidation is an increase in mechanical strength of material resulting from particle - particle interactions.
M.pharm (Pharmaceutics) modern pharmacy unit-5 Study of consolidation parameters; Diffusion parameters, Dissolution
parameters and Pharmacokinetic parameters, Heckel plots, Similarity factors – f2
and f1, Higuchi and Peppas plot, Linearity Concept of significance, Standard
deviation , Chi square test, students T-test , ANOVA test
pH-activated and Enzyme-activated drug delivery systemSakshiSharma250807
As per the syllabus of M.Pharma (1st sem.) I have presented the topic pH-activated and Enzyme-activated. This comes under rate-controlled drug delivery system under the subject Drug delivery system. Best wishes from Sakshi Sharma
COMPRESSION AND COMPACTION , physics of tablet compression, compression, consolidation, effects of friction, distribution of forces, compaction profiles, solubility.
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This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
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Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
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The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
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Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
2. Content
1. Introduction
2. Mechanism of tablet compression
Particle rearrangement
Deformation
Fragmentation
Bonding
Deformation of solid bonding
Decompression
Ejection
3. Problem during ejection
3. INTRODUCTION
• COMPRESSION: Compression means a reduction in the
bulk volume of a material as a result of the removal of the
gaseous phase (air) by applied pressure.
• COMPACTION: Compaction of powder is the general term
used to describe the situation in which these materials are
subjected to some level of mechanism force.
The physics of compaction may be simply stated as “the
compression and consolidation of a two phase (solid-gas)
system due to the applied force’’
5. • CONSOLIDATION: An increase in the mechanical strength of the
material resulting from particle or particle interaction
• Consolidation Process
cold welding: When the surface of two particles approach each
other closely enough their free surface energies result in strong
attractive force.
Fusion bonding: Contact of particles at multiple points upon
application of load, produces heat which causes fusion or melting. If
this heat is not dissipated the local rise in temperature could be
sufficient to cause melting of the contact area of the particles.
7. PARTICLE REARRANGEMENT
• Generally it occures at low pressures.
• It depends on particle size of distribution and shape.
• Reduction in relative volume of powder bed into closure
packing structures.
• the granules flow with respect to each other with the final
particles entering the void between the larger particles and
the bulk density of the granulation is increased.
• As pressure increases , relative particle movement
becomes impossible , inducing deformation.
9. DEFORMATION
• When the particles of the granulation are so closely
packed that no further fillings of the voids can occur , a
further increase of compression force causes
deformation at the point of contact.
• change in the shape of material occurs.
• At a certain point , the packing characteristics of the
particles, reduced space or porosity of inter-
particulate friction will prevent any further
rearrangement of particles
10. 1. ELASTIC DEFORMATION
Removal of upload act like rubber comes to original
place, usually all solids undergo deformation
example: Acetyl salicylic acid
2. PLASTIC DEFORMATION
They would not come back to its original volume,
completely reduction in bulk volume.
example: Sucrose
11.
12. FRAGMENTATION
• Under high pressure the deformed particles may fragment
resulting in new clean surfaces that have potential bonding
areas.
• Fragmentation leads to further densification with the
infiltration of the smaller particles in the voids.
• The mechanism of fragmentation and plastic deformation
are not independent because both the phenomena modify
particle size distribution.
• With some materials fragmentation doesn’t occurs because
the stresses are released by plastic deformation.
13. Fragmentation do not occur when applied
stress:
•Is balanced by a plastic deformation.
•Change in shape
•Sliding of groups of particle (viscoelastic flow)
14. BONDING OF PARTICLES
THE MECHANICAL THEORY:
It occures between irregularly shaped particles .
Also Increases the number of contact points Between the particles
The mechanical theory proposes that under pressure the individual
particles undergo Elastic / Plastic Deformation & that the Edges of
the particle intermesh deforming a mechanical Bond.
Mechanical interlocking is not a major mechanism of bonding in
pharmaceutical tableting.
15. INTERMOLECULAR THEORY
The Molecules at surface at the surface of solids have unsatisfied
forces which interact with the other particle in true contact
Under Pressure Molecules in true contact between new clean
surface of the granule are close enough so that vanderwal forces
interact to consolidate the particles.
Material containing plenty OH group may also creat hydrogen bond
between molecule.
16. DEFORMATION OF THE SOLID
BODY
• On further increases of the pressure , the non-
bonded Solid is consolidated towards a
limiting density by plastic/elastic deformation.
17. EJECTION
Rising of lower punch
Continuation of residual die wall pressure
Energy expansion due to die wall friction.
Removal of tablet relief of lateral pressure
2 to 10% increase in volume of the portion removed
18. PROBLEM DURING
DECOMPISSION/EJEC
TION
•Capping: deep concave
punches may expand radially,
while the cylindrical part
cannot
•Lamination : Elastic
expansion of some particles
and divided in layers
•Sticling: too much adhesion
on the punch