Surfactants and their applications in pharmaceutical dosage formMuhammad Jamal
This presentation is very much helpful for the medical students,pharmacists, researchers and other health care providers. i hope it will provide important information regarding surfactants and their applications in pharmaceutical dosage forms.
Surfactant is a surface active agent which are used to prevent surface tension and interfacial tension. It is important prevent interfacial fluidity, it is amphiphilic molecule having Hydrophilic head and Lipophilic tail. It is important for poorly water soluble drug and it is important to influencing water solubility of poorly water soluble drug. It is important to prevent the inter and intra subject variability.
It act as solubilizing agent, suspending and emulsifying agent, stabilizing agent, wetting agent, detergent, Foaming agent.
It is important for preparation of Nanoemulsion, Nanosuspension, Microemulsion.
It is important to show antibacterial as well as antimicrobial activity.
It is important for Novel drug delivery system, oral drug delivery system, Targeted drug delivery system.
It is important to influencing oral bioavailability of poorly water soluble drug.
KINETICS OF STABILITY , ACCELERATED STABILITY STUDY, AND ICH STABILITY GUIDEL...Akhila Anil
CHEMICAL KINETICS
ORDER OF REACTION
DETERMINATION OF ORDER
SALIENT FEATURES OF ACCELERATED DRUG STABILITY
STABILITY METHOD
LIMITATIONS OF ACCELERATED DRUG STABILITY
ICH GUIDELINES ON STABILITY
Surfactants and their applications in pharmaceutical dosage formMuhammad Jamal
This presentation is very much helpful for the medical students,pharmacists, researchers and other health care providers. i hope it will provide important information regarding surfactants and their applications in pharmaceutical dosage forms.
Surfactant is a surface active agent which are used to prevent surface tension and interfacial tension. It is important prevent interfacial fluidity, it is amphiphilic molecule having Hydrophilic head and Lipophilic tail. It is important for poorly water soluble drug and it is important to influencing water solubility of poorly water soluble drug. It is important to prevent the inter and intra subject variability.
It act as solubilizing agent, suspending and emulsifying agent, stabilizing agent, wetting agent, detergent, Foaming agent.
It is important for preparation of Nanoemulsion, Nanosuspension, Microemulsion.
It is important to show antibacterial as well as antimicrobial activity.
It is important for Novel drug delivery system, oral drug delivery system, Targeted drug delivery system.
It is important to influencing oral bioavailability of poorly water soluble drug.
KINETICS OF STABILITY , ACCELERATED STABILITY STUDY, AND ICH STABILITY GUIDEL...Akhila Anil
CHEMICAL KINETICS
ORDER OF REACTION
DETERMINATION OF ORDER
SALIENT FEATURES OF ACCELERATED DRUG STABILITY
STABILITY METHOD
LIMITATIONS OF ACCELERATED DRUG STABILITY
ICH GUIDELINES ON STABILITY
Chemical equilibrium is about reversible reaction, how equilibrium set up n physical and chemical processes,equilibrium constant, its application and Le Chatlier's principle and factors altering the composition of equilibrium
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
9.2Physical Science SHS Measurement of Reaction Ra.pptxgoddesshera
It tells how fast or slow a certain chemical reaction occur.
There are two factors that can be used to determine reaction rates: concentration and rate constant.
It can simply be determined by measuring the changes in the concentrations of the reactants or products within a particular time frame.
Generally, a chemical reaction is represented in the following format.
As the chemical reaction takes place, the amount of reactants decrease as the amount of the products increase.
Δ[A], Δ[B], Δ[C], and Δ[D] are the measures of the change in respective concentrations over a period of time, Δt.
Reaction rates are always positive.
In terms of appearance of a product in a reaction, the expression is positive since the change in concentration is positive.
In term of disappearance of a reactant, the case is opposite; hence the expression is appended by a negative sign.
The rate law expresses the relationship of the rate of reaction to the rate constant and the concentration of the reactants raised to certain exponents.
The rate constant, k, is a constant of proportionality between the reaction rate and the concentration of the reactants.
Rate laws are always determined experimentally.
Navigating the Health Insurance Market_ Understanding Trends and Options.pdfEnterprise Wired
From navigating policy options to staying informed about industry trends, this comprehensive guide explores everything you need to know about the health insurance market.
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Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
QA Paediatric dentistry department, Hospital Melaka 2020Azreen Aj
QA study - To improve the 6th monthly recall rate post-comprehensive dental treatment under general anaesthesia in paediatric dentistry department, Hospital Melaka
India Clinical Trials Market: Industry Size and Growth Trends [2030] Analyzed...Kumar Satyam
According to TechSci Research report, "India Clinical Trials Market- By Region, Competition, Forecast & Opportunities, 2030F," the India Clinical Trials Market was valued at USD 2.05 billion in 2024 and is projected to grow at a compound annual growth rate (CAGR) of 8.64% through 2030. The market is driven by a variety of factors, making India an attractive destination for pharmaceutical companies and researchers. India's vast and diverse patient population, cost-effective operational environment, and a large pool of skilled medical professionals contribute significantly to the market's growth. Additionally, increasing government support in streamlining regulations and the growing prevalence of lifestyle diseases further propel the clinical trials market.
Growing Prevalence of Lifestyle Diseases
The rising incidence of lifestyle diseases such as diabetes, cardiovascular diseases, and cancer is a major trend driving the clinical trials market in India. These conditions necessitate the development and testing of new treatment methods, creating a robust demand for clinical trials. The increasing burden of these diseases highlights the need for innovative therapies and underscores the importance of India as a key player in global clinical research.
R3 Stem Cells and Kidney Repair A New Horizon in Nephrology.pptxR3 Stem Cell
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Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
Artificial Intelligence to Optimize Cardiovascular Therapy
4 chemical kinetics and stability
1.
2.
3. At the end of the lesson, students are expected to
understand the following concepts:
•General Introduction to Chemical Kinetics and Stability
•Determination of Reaction Order
•Zero-Order Reactions
•First-Order Reactions
•Factorial Effects on Stability
•Accelerated Stability Testing
4.
5.
6. • Suppose that in this reaction, sodium hydroxide as well as
water was in great excess and ethyl acetate was in a relatively
low concentration. As the reaction proceeded, ethyl acetate
would change appreciably from its original concentration,
whereas the concentrations of NaOH and water would
remain essentially unchanged because they are present in
great excess. In this case, the contribution of sodium
hydroxide to the rate expression is considered constant and
the reaction rate can be written as
• where k′ = k[NaOH]. The reaction is then said to be a
pseudo–first-order reaction because it depends only on the
first power (a = 1) of the concentration of ethyl acetate. In
general, when one of the reactants is present in such great
excess that its concentration may be considered constant or
nearly so, the reaction is said to be of pseudo-order.
7. • “Apparent” or “pseudo”-order describes a
situation where one of the reactants is present in
large excess or does not affect the overall reaction
and can be held constant - For example, many
hydrolysis decomposition reactions of drug
molecules are second order.
• Usually the amount of water present is in excess of
what is needed for the reaction to proceed. In
other words, the concentration of water is
essentially constant throughout the reaction.
• In this case, the second-order reaction behaves like
a first-order reaction and is called an apparent or
pseudo–first-order reaction.
8.
9. Specific Rate Constant:
• The constant, k, appearing in the rate law associated
with a single-step (elementary) reaction is called the specific
rate constant for that reaction.
• Any change in the conditions of the reaction, for
example, in temperature or solvent, or a slight change in one
of the reacting species, will lead to a rate law having a
different value for the specific rate constant. Experimentally,
a change of specific rate constant corresponds simply to a
change in the slope of the line given by the rate equation.
Variations in the specific rate constant are of great physical
significance because a change in this constant necessarily
represents a change at the molecular level as a result of a
variation in the reaction conditions.
10.
11. Half-Life and Shelf Life:
• The half-life is the time required for one-half of the
material to disappear; it is the time at which A has
decreased to ½ A.
• The shelf life is the time required for 10% of the material
to disappear; it is the time at which A has decreased to
90% of its original concentration (i.e., 0.9 A).
• Shelf life (also referred to as the expiration dating period)
is the time period during which a drug product is
expected to remain within the approved specification for
use, provided that it is stored under the conditions
defined on the container label and after which it must not
be used.
14. Example 14-2
• A prescription for a liquid aspirin preparation is called for - It is
to contain 325 mg/5 mL or 6.5 g/100 mL.
• The solubility of aspirin at 25°C is 0.33 g/100 mL; therefore, the
preparation will definitely be a suspension.
• The other ingredients in the prescription cause the product to
have a pH of 6.0.
• The first-order rate constant for aspirin degradation in this
solution is 4.5 × 10-6 sec-1.
• Calculate the zero-order rate constant, Determine the shelf life,
t90, for the liquid prescription, assuming that the product is
satisfactory until the time at which it has decomposed to 90%
of its original concentration (i.e., 10% decomposition) at 25°C.
• Answer: k0 = k × [Aspirin in solution], from equation (14-9).
16. Determination of Reaction Order
1-Substitution Method:
• The data accumulated in a kinetic study can be substituted in the integrated form of the
equations that describe the various orders.
• When the equation is found in which the calculated k values remain constant within the limits
of experimental variation (for different Ct), the reaction is considered to be of that order.
2-Graphic Method:
• A plot of the data in the form of a graph as shown in Figure 14-2 can also be used to ascertain
the order.
• If a straight line results when concentration is plotted against t, the reaction is zero order.
• The reaction is first order if log (a - x) (log concentration remaining) versus t yields a straight
line,
• and it is second order if 1/(a - x) versus t gives a straight line (in the case in which the initial
concentrations are equal).
3-Half-Life Method:
• In a zero-order reaction, the half-life is proportional to the initial concentration, a, as
observed in Table 14-2.
• The half-life of a first-order reaction is independent of initial concentration a;
• t1/2 for a second-order reaction, in which a = b, is proportional to 1/a.
21. Factorial Effects on Stability
1 - Temperature Effects:
• A number of factors other than concentration may affect the reaction velocity.
Among these are temperature, solvents, catalysts, and light.
Collision Theory:
• Reaction rates are expected to be proportional to the number of collisions per
unit time.
• Because the number of collisions increases as the temperature increases, the
reaction rate is expected to increase with increasing temperature.
• In fact, the speed of many reactions increases about two to three times with
each 10° rise in temperature.
• As a reaction proceeds from reactants to products, the system must pass
through a state whose energy is greater than that of the initial reactants.
• This “barrier” is what prevents the reactants from immediately becoming
products. The activation energy, Ea, is a measure of this barrier.
• The effect of temperature on reaction rate is given by the equation, first
suggested by Arrhenius,
22.
23.
24. Accelerated Stability Testing
• Stability
The stability of drug products needs to be evaluated over time in the same container-
closure system in which the drug product is marketed.
In some cases, accelerated stability studies can be used.
They are designed to increase the rate of chemical degradation or physical change of a
drug substance or drug product by using exaggerated storage.
• Method Acceleration
The method of accelerated testing of pharmaceutical products based on the principles
of chemical kinetics was demonstrated by Garrett and Carper.
According to this technique, the k values for the decomposition of a drug in solution at
various elevated temperatures are obtained by plotting some function of concentration
against time (log C), as shown in Figure 14-19. K = slope × –2.303
25. 2 - Medium Effects (Solvent, Ionic Strength, Dielectric Constant):
A - Effect of the Solvent:
• The influence of the solvent on the rate of decomposition of drugs is a topic of great importance to the
pharmacist.
• It appears that the reaction of nonelectrolytes is related to the relative internal pressures or solubility
parameters of the solvent and the solute.
• In summary, the polarity of the solvents affects the rate of reactions depending on the polarity of the
reactant.
26. C- Influence of Dielectric Constant:
• The dielectric constant affects on the rate constant of an ionic
reaction.
• For a reaction between ions of opposite sign, an increase in
dielectric constant of the solvent results in a decrease in the
rate constant. For ions of like charge, on the other hand, an
increase in dielectric constant results in an increase in the rate
of the reaction.
27. 3 – Catalysis (Specific and general acid–base & pH effects):
The rate of a reaction is frequently influenced by the presence of a catalyst.
• A catalyst is therefore defined as a substance that influences the speed of
a reaction without itself being altered chemically.
• Solutions of a number of drugs undergo accelerated decomposition on the
addition of acids or bases.
• If the drug solution is buffered, the decomposition may not be
accompanied by an appreciable change in the concentration of acid or
base so that the reaction can be considered to be catalyzed by hydrogen
or hydroxyl ions.
• When the rate law for such an accelerated decomposition is found to
contain a term involving the concentration of hydrogen ion or the
concentration of hydroxyl ion, the reaction is said to be subject to specific
acid–base catalysis.
• As an example of specific acid–base catalysis, consider the pH
dependence for the hydrolysis of esters.
28.
29.
30. Example 14-12
• A sample of glucose was decomposed at 140°C
in a solution containing 0.030 M HCl. The
velocity constant, k, was found to be 0.0080 hr-1
If the spontaneous rate constant, k0, is 0.0010
hr-1, compute the catalytic coefficient, kH.
• The catalysis due to hydroxyl ions in this acidic
solution can be considered as negligible.
31.
32. Decomposition and stabilization of medicinal agents
• Pharmaceutical decomposition can be classified as : hydrolysis,
oxidation, isomerization, epimerization, and photolysis.
• These processes may affect the stability of drugs in liquid, solid
and semisolid products.
33. Reference:
1. Dosage Calculations: A Ratio-Proportion Approach, Gloria D. Pickar, EdD, RN 2007, 2nd Edition
2. Pharmaceutical and Clinical Calculations, Mansoor A.Khan. and Indra K. Reddy, 2000, 2nd Ed.
36. Study Questions
Define the following terms:
[molecularity, exponent, mole, molar, half-life, shelf-life, suspension, solution,
emulsion, concentration, prescription, decomposition, stability, acceleration, dielectric,
catalyst, hydrolysis, decomposition, stabilization, etc]
Respond to the following questions:
Give a descriptive account of the following characteristics of chemical reaction
process, rates, order and molecularity
Illustrate the practical differences between the half-life and shelf-life of
pharmaceutical substance that can be chemical or physical in nature
Give a descriptive account of how reaction order can be determined
State and explain the factors that have the effect on the stability of chemical
stature and reactions
Group work discussional questions:
Give a detailed descriptive account of of the following characteristics of chemical reaction
process, rates, order and molecularity
Give a descriptive account of how reaction order can be determined
Identify and explain various factors that have the effect on the stability of chemical stature
and reactions
Explain the of chemical reaction process in given favourable environment