3. From Medical Microbiology, 5 th ed., Murray, Rosenthal & Pfaller, Mosby Inc., 2005, Fig. 53-1. Adenovirus Structure www.freelivedoctor.com
4. E1 E2 E4 E3 Late genes Adenovirus Genome 36 kb linear ds DNA Early genes for host and viral transcription control, viral DNA replication Late genes for virion structure www.freelivedoctor.com
13. Helper dependent parvovirus (AAV) replication Infection without adenovirus Infection with adenovirus Superinfect with adenovirus Lytic replication www.freelivedoctor.com AAV DNA integrates into chromosome 19
20. Replication cycle of polyomaviruses. Steps in the replication cycle are indicated by numbers as follows: 1, adsorption of virions to the cell surface; 2, entry by endocytosis; 3, transport to the cell nucleus (route and mechanism not yet known); 4, uncoating; 5, transcription to produce early region mRNAs; 6, translation to produce early proteins (T antigens); 7, viral DNA replication; 8, transcription to produce late region mRNAs; 9, translation to produce late proteins (capsid proteins); 10, assembly of progeny virions in the nucleus; 11, entry of virions into cytoplasmic vesicles (mechanism unknown); 12, release of virions from the cell by fusion of membrane vesicles with the plasma membrane; 13, released virion. Polyomavirus replication www.freelivedoctor.com
