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SARS
Dr. Sushrit A. Neelopant
Assistant Professor,
Department of Community Medicine
RIMS, Raichur
• Coronavirus
• Fever, malaise, chills, headache, myalgia, dizziness,
cough, sore throat, running nose
• Rapid deterioration with low oxygen saturation,
ARD ventilator
• CFR- 10%
• Majority- health care providers
• Children- rare
PROBLEM STATEMENT
• 2002- China- health care worker
• Rapid spread- Hong Kong, Singapore, Vietnam,
Taiwan, Toranto
• 2003- 8422 cases, 916 deaths
• IP: 2-7 days
• TRANSMISSION
– Close contact with patient and infected material-
respiratory droplets.
– Portal of entry- eyes, nose and mouth.
– No evidence of airborne transmission.
– Maximum virus excretion from respiratory tract
– Around day ten of illness.
CASE DEFINITION: IHR-2005
• Notifiable case- individual with lab confirmation +
clinical case def.or worked in lab handling live SARS-
CoV or storing clinical specimens infected with SARS
• Clinical case defn.-
1. H/o fever
2. One or more symp. of LRTI
3. Radiographic evidence- lung infiltrates- pneumonia,
ARDS or Autopsy findings- pneumona, ARDS
4. No alternative diagnosis
DIAGNOSTIC TESTS FOR CONFIRMATION
1. Conventional RT-PCR/ rt RT-PCR- viral RNA-
a. At least 2 diff. specimens- nasoph & stool
b. Same specimen collected – 2 or more occassions
c. New extract- +ve by 2 assays
d. Virus culture
2. ELISA & IFA
a. -ve AB test  +ve test
b. 4 fold or more rise in AB titre
TREATMENT
• Intensive support
• Ribavirin, Lopinavir/ritonavir, Inf type 1, IVIG,
systemic Corticosteroids
PREVENTION & CONTROL
• Identification of cases and their contacts
• Effective isolation in hospitals
• Protection of medical staff with PPE
• Identification of suspected cases & isolation
• Screening of international travelers
• Timely & accurate sharing of information with
other authorities

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20160725 sars

  • 1. SARS Dr. Sushrit A. Neelopant Assistant Professor, Department of Community Medicine RIMS, Raichur
  • 2. • Coronavirus • Fever, malaise, chills, headache, myalgia, dizziness, cough, sore throat, running nose • Rapid deterioration with low oxygen saturation, ARD ventilator • CFR- 10% • Majority- health care providers • Children- rare
  • 3. PROBLEM STATEMENT • 2002- China- health care worker • Rapid spread- Hong Kong, Singapore, Vietnam, Taiwan, Toranto • 2003- 8422 cases, 916 deaths
  • 4. • IP: 2-7 days • TRANSMISSION – Close contact with patient and infected material- respiratory droplets. – Portal of entry- eyes, nose and mouth. – No evidence of airborne transmission. – Maximum virus excretion from respiratory tract – Around day ten of illness.
  • 5. CASE DEFINITION: IHR-2005 • Notifiable case- individual with lab confirmation + clinical case def.or worked in lab handling live SARS- CoV or storing clinical specimens infected with SARS • Clinical case defn.- 1. H/o fever 2. One or more symp. of LRTI 3. Radiographic evidence- lung infiltrates- pneumonia, ARDS or Autopsy findings- pneumona, ARDS 4. No alternative diagnosis
  • 6. DIAGNOSTIC TESTS FOR CONFIRMATION 1. Conventional RT-PCR/ rt RT-PCR- viral RNA- a. At least 2 diff. specimens- nasoph & stool b. Same specimen collected – 2 or more occassions c. New extract- +ve by 2 assays d. Virus culture 2. ELISA & IFA a. -ve AB test  +ve test b. 4 fold or more rise in AB titre
  • 7. TREATMENT • Intensive support • Ribavirin, Lopinavir/ritonavir, Inf type 1, IVIG, systemic Corticosteroids
  • 8. PREVENTION & CONTROL • Identification of cases and their contacts • Effective isolation in hospitals • Protection of medical staff with PPE • Identification of suspected cases & isolation • Screening of international travelers • Timely & accurate sharing of information with other authorities