This document discusses clinical pharmacokinetics, which involves applying pharmacokinetic principles to optimize drug therapy for individual patients. It covers topics like absorption, distribution, metabolism, and excretion of drugs. Key concepts explained include clearance, which determines maintenance dosing to achieve steady-state concentrations, and volume of distribution, which is used to calculate loading doses based on a target plasma concentration. Clinical pharmacokinetics aims to achieve predictable drug concentrations at receptor sites based on measurable plasma levels.
Population pharmacokinetics is the study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug of interest
various measures for the measurement of outcome such as incidence prevalence and other drug us measures are briefly discussed here with suitable examples and equations
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
Population pharmacokinetics is the study of the sources and correlates of variability in drug concentrations among individuals who are the target patient population receiving clinically relevant doses of a drug of interest
various measures for the measurement of outcome such as incidence prevalence and other drug us measures are briefly discussed here with suitable examples and equations
breif notes on what is pharmacoepidemiology, why do we need pharmacoepidemiology, whats is its aim and its main applications, advantages and disadvantages
Nomograms and tabulations in design of dosage regimens pavithra vinayak
Nomograms and tabulations in the design of dosage regimens --- NOMOGRAM IN UREMIC PATIENTS: NOMOGRAM FOR RELATIONSHIP BETWEEN CREATININE CLEARANCE AND ELIMINATION RATE CONSTANT FOR FOUR DRUGS clinical pharmacokinetics and therapeutic drug monitoring ---fifth PharmD notes
In this presentation i have tried to explain in detail about the measurements of the outcomes which are used in epidemiology such as prevalence, incidence, fatality rate, crude death rate etc.
adaptive methods are doing with feedback in population pharmacokinetics---- clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Nomograms and tabulations in design of dosage regimens pavithra vinayak
Nomograms and tabulations in the design of dosage regimens --- NOMOGRAM IN UREMIC PATIENTS: NOMOGRAM FOR RELATIONSHIP BETWEEN CREATININE CLEARANCE AND ELIMINATION RATE CONSTANT FOR FOUR DRUGS clinical pharmacokinetics and therapeutic drug monitoring ---fifth PharmD notes
In this presentation i have tried to explain in detail about the measurements of the outcomes which are used in epidemiology such as prevalence, incidence, fatality rate, crude death rate etc.
adaptive methods are doing with feedback in population pharmacokinetics---- clinical pharmacokinetics and therapeutic drug monitoring-- fifth pharm D notes
Understanding Therapeutic drug monitoring (TDM) at a glanceAI Publications
This paper gives an overview of therapeutic drug monitoring. The primary objectives of TDM are to prevent therapeutic failures carried on by poor compliance or prescribing a drug at a dose that is too low, as well as negative or toxic effects brought on by an excessive dose. Moreover, it gives information about when and what type of drug needs therapeutic drug monitoring. Like the drug which has a short therapeutic window they require therapeutic monitoring because it can cause toxicity or no therapeutic effect. However, the appropriate use of TDM is not only the simple measurement of patient blood drug concentration and the comparison of its target range but also TDM plays an important role in the therapeutic medication by ensuring safety and effectiveness also with individualization of these medications, desired clinical targets, dosage history, sampling time in relation to the dose patient’s response these factors needed to be considered while interpreting drug concentration measurements to achieve the optimal response with minimal toxicity. So TDM can be considered as a combined approach encompassing pharmaceutical, pharmacokinetic, pharmacodynamic techniques and analyses.
Introduction to dosage regimen and Individualization of dosage regimenKLE College of pharmacy
Introduction of Dosage regimen, Approaches for design of dosage regimen, Individualization, Advantages, Dosage in neonates, Geriatrics, Renal and Hepatic impaired Patients.
Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Primary goals of clinical pharmacokinetics include enhancing efficacy and decreasing toxicity of a patient's drug therapy.
The success of drug therapy is highly dependent on the choice of the drug, the drug product, and the design of the dosage regimen. The choice of the drug is generally made by the physician after careful patient diagnosis and physical assessment.
Similar to 1. Introduction to clinical pharmacokinetics (20)
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Organization and objectives of ICH, expedited reporting, ICSR, PSURs, post approval expedited reporting, pharmacovigilance Planning, good clinical practices
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
7. Dr.RameshBhandari
NO
Because of SINK
Condition Diluted in blood
Distributed in tissues
Protein bound
Metabolized &
Excreted
So, the concentration of the GIT is always greater
than the concentration of the drug in blood.
12. Dr.RameshBhandari
Excretion
Excretory
Route
Mechanism Drug Excreted
Urine Free, Hydrophilic, Unchanged Drugs or
metabolites of MW < 300
Bile Active Secretion Hydrophilic, Unchanged Drugs or
metabolites of MW > 500
Lung Passive
Diffusion
Gaseous and volatile, Blood and tissue
insoluble drugs
Saliva Passive
Diffusion
Active Transport
Free, unionized, lipophilic drugs, some
polar drugs
Milk Passive
Diffusion
Free, unionized, lipophilic drugs (basic)
13. Dr.RameshBhandari
A drug’s effect its concentration
at the SITE OF ACTION
Is it PRACTICABLE to measure the
drug concentration in the
RECEPTOR SITES / TISSUES??
Depends on
15. Dr.RameshBhandari
Then, How to Measure
Drug Concentration??
Answer is:
Kinetic Homogeneity
It describes the predictable relationship
between plasma drug concentration and
concentration at the receptor site.
16. Dr.RameshBhandari
Changes in the plasma drug
concentration reflect
Proportional changes in the
drug concentration in other
tissues.
20. Dr.RameshBhandari
Pharmacokinetic homogeneity is the foundation
on which all therapeutic and toxic plasma drug
concentrations are established.
When studying concentration of drug in plasma,
we assume that these plasma concentrations
directly relate to concentrations in tissues where
the disease is to be modified by the drug. (e.g.
CNS in parkinson’s disease and bone in
osteomyelitis)
However this may not be true for all drugs.
21. Dr.RameshBhandari
Clinical Correlation
Drugs concentrate in some tissues because
of physical or chemical properties.
Examples: digoxin, which concentrates in
the myocardium,
and
lipid-soluble drugs such as benzodiazepines,
which concentrate in fat.
22. Dr.RameshBhandari
Pharmacodynamics
It refers to the relationship
between drug concentration at the
site of action and the resulting
effect, including the time course
and intensity of therapeutic and
adverse effects.
23. Dr.RameshBhandari Pharmacodynamics in relation with
Pharmacokinetics
50%
100%
1
0
100
Fig: Plasma Drug Concentration at the receptor site to effect
Plasma Drug Concentration
(mg/ml)
Effect(%)
24. Dr.RameshBhandari
Clinical Pharmacokinetics
Clinical Pharmacokinetics is the application of the
pharmacokinetic principles, using drug
concentration and pharmacodynamic criteria to
optimize drug therapy in individual patient.
Application of pharmacokinetic principles to the safe
and effective therapeutic management of the drugs in
patient.
Applied pharmacokinetics is a broader term.
25. Dr.RameshBhandari Applications of Clinical
Pharmacokinetics
TDM
Dosage Adjustment in an individual patient
Formulation development: BA/BE, ADME
studies
Drug development process: Deciding Dosage
regimen
Rational Drug design
26. Dr.RameshBhandari Linear versus Nonlinear
Pharmacokinetics
When drugs are given in a constant
basis, such as continuous intravenous
infusion or an oral medication given
every 12 hours, serum drug
concentrations increases until the rate
of drug administration equals the rate
of drug elimination.
27. Dr.RameshBhandari
When the rate of drug administration
equals the rate of drug elimination, the
amount of drug contained in the body
reaches a constant value. This
equilibrium condition is known as
steady state.
28. Dr.RameshBhandari
If a steady state concentration versus
dose yields a straight line, the drug is
said to follow Linear pharmcokinetics.
In this situation steady state serum
concentration increases or decreases
proportionally with dose.
29. Dr.RameshBhandari
When steady state concentration
change in a disproportionate fashion
after the dose is altered, a plot of steady
state concentration versus dose is not a
straight line and the drug is said to
follow non-linear pharmacokinetics.
34. Dr.RameshBhandari If patient has no drug in the body then can
administer an amount called loading dose to
achieve a given Atarget and Dp(target).
Since loading dose must provide Atarget
amount of drug in body, since not all
administered dose is absorbed.
LD*B = Atarget then LD = Atarget / B
LD = Vd * Dp / B
35. Dr.RameshBhandari
LD = Vd * Dp
B
The amount of drug that must be
given to achieve rapidly a target
concentration of the drug in the
plasma is solely depends on Vd, B
and Dp.
36. Dr.RameshBhandari Vd is easily obtained
Give bolus of
drug.
Measure plasma
levels overtime.
Extrapolate to
find plasma level
at time 0.
Vd = DoseIV / Dp
0
Dp
0
1
2
3
4
5
6
4 8 12 16 20 24
Time (in hours)LogDp(mcg/ml)
37. Dr.RameshBhandari Examples of using Vd to calculate
LD
Pharmacokinetic Parameter
for digoxin
Dp(target) = 1.5 mcg
Vd = 580 L
Oral Bioavailability = 0.7
Calculate LD?
39. Dr.RameshBhandari
Concept of Clearance
Clearance determines the maintenance
dose (MD) that is required to obtain a
given steady-state serum concentration
(Css).
MD = Css.Cl
40. Dr.RameshBhandari How does Clearance influence
Dp
ss
According to definition,
Steady state is said to exist when:
Rate of Drug Administration = Rate of drug elimination
41. Dr.RameshBhandari
Rearranging equation of Cl,
Dp = Rate of drug Elimination
Cl
Applying steady state in above Cl equation,
Dp
ss = Rate of drug Elimination at steady state
Cl
42. Dr.RameshBhandari Applying steady state in above Cl equation,
Dp
ss = R0 (Rate of drug administration = rate of drug elimination)
Cl
Maintenance dose = amount of drug taken at regular
intervals
Dosing interval = Time between MDs
Bioavailability = fraction of dose absorbed in systemic
circulation
43. Dr.RameshBhandari
Rate of drug administration = Amount of drug delivered to the systemic circulation
Time
R0 = B x MD
DI
Then substituting value of R0 in steady state equation of Cl,
Dp
ss = B x MD
DI x Cl
Hence, Dp
ss wont depend on absolute value of MD and DI
but it will depend on ratio of MD and DI