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The document summarizes the results of a study on the effects of CIRCOVAC vaccination on reproductive parameters in sows. The study was a blinded, controlled, randomized trial conducted on 3 German farms with a total of 250 vaccinated and 89 control sows. The results showed that vaccinated sows had significantly more live born and weaned piglets per sow than control sows. Specifically, vaccinated sows had 1.4 more live born piglets and 0.7 more weaned piglets per sow. Over the course of a year, vaccinated sows weaned 1.6 more piglets on average than control sows. The study confirms field experiences showing benefits of PCV2 sow vaccination on reproductive
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The document discusses managing PCV2 infection in gilts through vaccination. It presents results from several farms that show vaccinating gilts against PCV2 with Circovac led to improved acclimatization of gilts, reduced clinical signs, increased weight gain, higher farrowing weights, more total born piglets, and better reproductive parameters compared to non-vaccinated gilts. Field studies demonstrate significant breeding performance improvements after gilt vaccination against PCV2.
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The document discusses managing PCV2 infection in gilts through vaccination. It presents results from several farms that show vaccinating gilts against PCV2 with Circovac led to improved acclimatization of gilts, reduced clinical signs, increased weight gain, higher farrowing weights, more total born piglets, and better reproductive parameters compared to non-vaccinated gilts. Field studies demonstrate significant breeding performance improvements after gilt vaccination against PCV2.
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The document discusses managing PCV2 infection in gilts through vaccination. It presents results from several farms that show vaccinating gilts against PCV2 with Circovac led to improved acclimatization of gilts, reduced clinical signs, increased weight gain, higher farrowing weights, and increased total born piglets compared to non-vaccinated gilts. Field studies demonstrate PCV2 vaccination of gilts and sows can significantly improve reproductive performance.
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This study evaluated the efficacy of Circovac® vaccination in piglets on an Austrian farm with a history of PCV2 infection. 1105 piglets were randomly allocated to a vaccinated or control group. Vaccinated piglets showed significantly higher average daily weight gain, lower rates of wasting and mortality compared to controls. Laboratory results found vaccination reduced PCV2 viremia and shedding over time, lowering viral pressure on the farm. The study demonstrated Circovac® vaccination effectively improved piglet performance and health.
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PCV2 is highly prevalent in swine herds worldwide. The document summarizes research showing that:
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3) The farrowing environment is thoroughly contaminated with PCV2, exposing growing piglets to constant viral challenge from the sow and environment.
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This document provides a historical overview and summary of porcine circovirus type 2 (PCV2) and postweaning multisystemic wasting syndrome (PMWS). It discusses the discovery and characterization of PCV2 and PMWS in the 1990s. It also summarizes research on PCV2 transmission routes, the role of various factors in PMWS development, diagnostics methods, prevention and control strategies including vaccination.
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In this downloadable slideset, expert faculty members Andrew Carr, MBBS, MD, FRACP, FRCPA; Daniel R. Kuritzkes, MD; and Ian M. Sanne, MBBCH, FCP(SA), review key studies presented at the 2016 International AIDS Conference.
Format: Microsoft PowerPoint (.ppt)
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Dr. Mike Roof - Impact of Porcine Reproductive & Respiratory Syndrome (PRRS) ...
1) A study examined the impact of vaccination with Ingelvac PRRS MLV on pigs challenged with varying doses of wild-type PRRSV.
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CIRCOVAC is an inactivated PCV2a strain vaccine for pigs. Studies show that vaccinating piglets with CIRCOVAC reduces PCV2 virus load and lesions in lymphoid tissues, decreases faecal shedding of the virus, and lowers mortality and wasting. Vaccination also leads to improved weight gain and growth performance from weaning to slaughter.
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The one-step RT-qPCR assay developed by Exopol S.L. was able to detect a wide variety of ruminant pestiviruses with excellent specificity and good sensitivity down to 102 copies per reaction. Testing on 272 clinical samples identified BVDV/BDV in 17.1% of cattle and 16.7% of sheep samples, with most positive cases in reproductive swabs and blood/serum. The assay provides a reliable and sensitive diagnostic tool for routine detection of pestiviruses in ruminants.
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This field study compared the effects of Vaxxitek HVT+IBD vaccine versus an intermediate IBD vaccine on broiler production performance and meat quality in Eastern Spain. The study involved 24 farms randomly divided into two groups, with 12 farms vaccinating birds with Vaxxitek and 12 farms vaccinating with the intermediate vaccine. Results showed that birds vaccinated with Vaxxitek had significantly higher average daily gain, lower feed conversion ratio, lower mortality rates, and lower early production losses compared to birds vaccinated with the intermediate vaccine. Vaxxitek also provided a slight improvement in breast muscle color quality.
VAXXITEK HVT + IBD - Field Study - Brazil - Merial
This document summarizes the field experience of using Vaxxitek HVT+IBD vaccine in broilers in Copacol Parana, Brazil over 6 months and 450 flocks totaling 7.2 million birds. The experimental group received a single dose of Vaxxitek HVT+IBD in ovo, while the standard program used Marek's disease vaccine in ovo and two intermediate IBD vaccines by drinking water. Results showed the Vaxxitek group had lower mortality, slightly better feed conversion ratio, older age, lower condemnation rates, and higher body weight compared to the standard program. Vaxxitek provides benefits of improved production performance and lower condemnation rates.
VAXXITEK HVT + IBD - Field Study - Egypt - Merial
This document summarizes the results of a field study comparing the use of VAXXITEK HVT+IBD vaccine to a standard IBD vaccination program in commercial broilers in Egypt. Three consecutive cycles of 155,000 broilers were given either the VAXXITEK vaccine at day-of-hatch or the standard IBD program involving live IBD vaccines at day-of-hatch and day 14. The VAXXITEK vaccine provided equivalent protection against vvIBD as the standard program while improving performance parameters such as 10 points lower early postmortem inspection condemnation, higher livability, heavier body weight, and better feed conversion rate, resulting in an economic benefit of $0.245/kg body weight.
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Oakland Farm Eggs Ltd. is the largest producer of colony eggs in the UK, rearing over 2 million pullets per year. They were experiencing problems with variable chick quality, poor flock uniformity, high Marek's disease challenge, and severe IBD infections causing 30% mortality. They administered 4 live hot IBD vaccinations but saw variable egg production. In 2010, they started vaccinating flocks with Vaxxitek HVT+IBD which improved overall bird health, achieved good uniform body weights, and allowed removal of the 4 on-farm live IBD vaccinations. Data from 2012 showed improved bodyweights, uniformity and laying performance since adopting the Vaxxitek vaccination.
VAXXITEK HVT + IBD - Field Study - France - Merial
A field study was conducted in France to compare the laying performance of commercial brown layers vaccinated with Vaxxitek HVT+IBD versus controls vaccinated with a live intermediate IBD vaccine. Over 250 birds per group were reared on a pullet and layer farm and housed in enriched cages. Results showed that the Vaxxitek group had a 3.88 egg/hen higher laying rate and higher average egg weight than the controls. Growth was also improved in the Vaxxitek group as they had a higher body weight at 5 weeks of age. In conclusion, Vaxxitek vaccination benefits included higher pullet weight at point of lay, improved laying performance and egg quality.
Apvs2013 09 vosloo et al.-o1 manisa efficacy vs viet fmd strain in pig
This study tested the efficacy of an O1 Manisa high potency vaccine against challenge with the O/Vietnam/2010 strain in pigs. Pigs were vaccinated 4 and 7 days prior to challenge. Most vaccinated pigs were protected from clinical disease at both timepoints. Virus RNA was detected in nasal secretions of vaccinated pigs for shorter durations than in unvaccinated controls. Vaccinated pigs shed insufficient virus to infect direct contact pigs. The vaccine decreased virus excretion and transmission, suggesting it could help control disease outbreaks when used with biosecurity measures.
Apvs2013 04 kagawa et al.-importance of continuation of pcv2 sow vaccination ...
1) This case report describes a 120-sow farm in Japan that implemented PCV2 vaccination of sows in 2008 and saw a reduction in post-weaning mortality without vaccinating piglets.
2) After sow vaccination, the farm's post-weaning mortality rate decreased substantially from around 20% to an average of 5.2% in 2012, though it fluctuated due to other disease issues.
3) Testing showed that PCV2 viral loads decreased after sow vaccination such that the virus was not detected in pigs of any age three years after vaccination began. Continued sow vaccination provided strong immunity and global protection across the farm.
Chapat et al.-orf1 et orf2 cmi with CIRCOVAC vaccination in sows
This study assessed the cell-mediated immune response against PCV2 ORF1 and ORF2 proteins in pigs vaccinated with an inactivated PCV2 vaccine. The results showed that vaccination induced gamma interferon production against both ORF1 and ORF2, primed pigs for interleukin-2 secretion after challenge, and stimulated antibody responses. In contrast, unvaccinated pigs only developed immune responses after challenge. The cellular immune response detected is expected to contribute to reduced PCV2 replication in vaccinated pigs. This highlights the importance of including both ORF1 and ORF2 in PCV2 vaccine design.
Apvs2013 02 merdy et al.-comparison circovac vs competitors on adwg mortality...
This document reviews 9 publications that compare the efficacy of CIRCOVAC, an inactivated PCV2 vaccine, to 3 competitor vaccines in reducing mortality and improving average daily weight gain in piglets. The studies found that CIRCOVAC was at least as effective as the competitor vaccines in decreasing mortality rates from weaning to slaughter by 3.16-8.5% and increasing average daily weight gain by 633-800 grams per day. In conclusion, CIRCOVAC vaccination in piglets performed as well or better than other PCV2 vaccines in improving production parameters.
Apvs2013 01 merdy et al.-circovac pmr calculation
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Apvs2013 10 lee et al.-trypanosomiasis in pigs in malaysia
This document summarizes an outbreak of trypanosomiasis in pigs in Malaysia. Nearly 40-50% of sows and boars on a 1,000 sow farm showed symptoms of pyrexia, anorexia, abortions and skin hemorrhages. Laboratory testing found trypanosomes in the pigs' blood and confirmed the presence of Trypanosoma evansi via PCR testing. Treatment with diminazine aceturate and isometamidium chloride resulted in clinical improvement and reduced mortality. The outbreak was likely caused by transmission of T. evansi from cattle and buffalo in nearby palm oil plantations by tabanid flies present on the pig farm.
Apvs2013 08 tee et al.-csf test kit comparison
This study evaluated 4 commercial ELISA test kits for detecting antibodies to classical swine fever (CSF) by testing them on 6 standard serum samples. Test kit B detected antibodies in all samples, including those from pigs infected less than 21 days. Test kits S and I failed to detect antibodies in samples from pigs infected less than 21 days. The sensitivities of the test kits ranged from 60% to 100%. The performance of the test kits may depend on factors like the antigen used and the cut-off points designed for screening versus detection of true positives. More studies are needed to evaluate the test kits' ability to detect antibodies in pigs vaccinated for CSF.
Apvs2013 07 tonelli and galuppini- serological survey of akipor mixed with gr...
This document summarizes a serological survey of Aujeszky's disease vaccination in an Italian pig herd. The herd vaccinated gilts, sows, growers, and fatteners using a vaccine called AKIPOR 6.3 mixed with another vaccine. Blood samples from gilts, sows, and fatteners showed high antibody levels against Aujeszky's disease, indicating the mixed vaccination program was effective at maintaining immunity. The survey results demonstrated that mixing AKIPOR 6.3 with an influenza vaccine did not negatively impact the potency of the Aujeszky's disease component of the vaccine.
Salvini et al.-Introduction of prssv vaccination with PROGRESSIS® in an itali...
This document summarizes a case report on the effects of introducing PRSSv vaccination with Progressis in addition to existing PCV2 vaccination with Circovac in an Italian pig farm. Key results included an improvement in the farrowing rate from 82.8% to over 90% after introducing Progressis vaccination for gilts and sows. Other positive impacts were a steady increase in litter size from 13.26 to 15.01 piglets born alive per litter between 2010-2012, and an increase in piglets weaned per sow from 24.87 to 27.42 over the same period despite lengthening the reproductive cycle. The case report concluded that PRSSv vaccination with Progressis was an effective tool to help improve
Apvs2013 06 castellan et al.-clinical case report of h1 n1pdm in italy
This document summarizes a clinical case report of an outbreak of pandemic H1N1 influenza virus (H1N1pdm) in an Italian pig farm between July 2012 and March 2013. The farm experienced increased respiratory disease and mortality in post-weaned pigs, testing confirmed the presence of H1N1pdm virus. A vaccination program was implemented using an inactivated trivalent swine influenza vaccine. Following vaccination of sows and piglets, clinical signs reduced and virus detection decreased, controlling the H1N1pdm outbreak.
Vila et al. Improvement of herd performance parameters after sow and piglet v...
This document summarizes the results of a case study conducted on a 2,700 sow farm in Bulgaria that implemented a full herd vaccination program against PCV2 using CIRCOVAC. The program involved vaccinating piglets at 28-30 days and sows. Results showed improvements in herd performance parameters, including increased litter size from 13 to 17.8 total born piglets, decreased days to 100kg by 5.3 days, improved daily weight gain, and stabilized health status by decreasing gastric ulcers and respiratory signs. The owner considers CIRCOVAC vaccination as a key tool for farm management and competitiveness.
Aasv2014 daresta et al. comparative pcv2 fetal protection-poster
This study evaluated the protective effects of two PCV2 vaccines (Vaccine A and Vaccine B) against fetal PCV2 infection in pigs. Gilts were vaccinated with one of the vaccines or unvaccinated as controls. After artificial insemination with PCV2-spiked semen, fetuses, placentas, and amniotic fluid were tested for PCV2. Vaccine A significantly reduced PCV2 positivity in fetuses compared to unvaccinated controls, but Vaccine B increased PCV2 positivity in placentas and amniotic fluid. The results suggest Vaccine A may better protect against subclinical fetal PCV2 infection than Vaccine B.
Aasv2014 callen et al. vaccination compliance to pcv2 using a dth test
This document describes two trials that tested a delayed type hypersensitivity (DTH) test to detect compliance with PCV2 vaccination. In the first trial, vaccinated pigs all showed a significant skin reaction to antigen injection, while 50% of unvaccinated pigs reacted. The reaction was strongest 20-24 hours after injection. Histology confirmed a type IV DTH response. The second trial found nearly all pigs vaccinated with CIRCOVAC reacted, while only 25% of those vaccinated with another PCV2 vaccine reacted. The DTH test shows potential as a practical way to check compliance with CIRCOVAC vaccination. Further studies are needed to improve specificity and standardize the technique in field conditions.
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This document contains an abstract from a conference on Porcine Circovirus diseases. The abstract describes a field study comparing the effectiveness of three different PCV2 piglet vaccines (CIRCOVAC, Vaccine A, and Vaccine B) on a large Russian farm. Over 4,000 piglets were randomly assigned to receive one of the three vaccines and were monitored for average daily weight gain and mortality in the post-weaning and finisher stages. The results showed CIRCOVAC and Vaccine A performed similarly in terms of weight gain and mortality, while Vaccine B results were slightly lower. The study demonstrates the ability of CIRCOVAC to control PCV2 under field conditions in Russia comparable to another leading
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03 thais vila
- 1. CIRCOVAC benefits on reproductive parameters Thaïs VILA, DVM MERIAL – Swine Technical Director EMEA
- 8. Results Low incidence of PCV2 infection (similar between groups) Mortality related to PMWS Lesion score at necropsy PCR Inguinal lymph nodes lesions Increase of serum antibodies level in sows, gilts and offspring provided by vaccination Serology and viremia in sows and offsprings Vaccinated group: 8.7% Control group: 9.5% Global mortality in offsprings
- 9. Results: live born piglets + 1.4 piglet / sow * p=0.007 14.0 1.0 3.4 10.1* 40 19.0 6.0 2.1 11.5* 124 Cycle 2 15.0 1.0 2.7 10.2 54 18.0 2.0 2.4 10.6 155 Cycle 1 Max Min N Max Min N Control CIRCOVAC
- 10. Results: weaned piglets/sow + 0.7 piglet / sow + 1.6 weaned / sow / year * p=0.027 13.0 1.0 3.3 8.6* 40 14.0 3.0 1.8 9.8* 124 Cycle 2 12.0 1.0 2.3 8.9 54 17.0 1.0 2.4 9.2 155 Cycle 1 Max Min N Max Min N Control CIRCOVAC
- 12. CIRCOVAC benefits at all stages
- 13. Thank you!
Editor's Notes
- Farm by farm analysis: Statistically significant difference in favour of the vaccinated group of sows for reproduction cycle 2 in farm A (p=0.011) and farm C (p=0.010)