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May 2020 presentation about BioWorma, the fungus that traps and kills worm larvae in manure of livestock. Webinar presentation by Chris Lawlor from International Animal Health.

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  1. 1. WHAT IS IT? Duddingtonia flagrans A natural strain of fungus isolated from the environment, found around the world, with application as a biological control for larvae of parasitic nematodes of grazing animals.
  2. 2. WHY DO WE NEED IT? Duddingtonia flagrans • Resistance to anthelmintics is getting worse all the time • Need for reduced reliance on chemicals to control worms. • Emergence of integrated parasite management (IPM) programs.
  3. 3. HOW DO WE USE IT? Duddingtonia flagrans • Firstly complete Faecal Egg Count (FEC) • Based on FEC results, treat the animals with an effective chemical wormer/anthelmintic • Move animals onto low-worm pasture • Administer D. flagrans in daily rations
  4. 4. HOW DOES IT WORK? Duddingtonia flagrans • By feeding a supplement containing inert fungal spores which pass into the manure, having no effect within the animal. • Breaks the parasites’ life cycle by trapping, paralysing and consuming infective larvae within the animal’s manure. • Equally-effective against resistant parasites
  5. 5. • D. flagrans is a natural organism isolated in Australia by CSIRO in early 1990’s • Products are safe for animals, people and the environment • Products are palatable, easy to use and have good shelf life. Duddingtonia flagrans
  6. 6. Duddingtonia flagrans spore
  7. 7. Duddingtonia flagrans Trapping network
  8. 8. Duddingtonia flagrans 8 hours post capture
  9. 9. Duddingtonia flagrans 48 hours post capture
  10. 10. Livamol® is the ideal delivery vehicle for BioWorma®, providing a nutritious base of proteins, energy plus added vitamins and minerals which are important for the development and maintenance of immunity of young, growing and grazing animals. Animals receiving adequate feed, maintaining good condition through good nutrition are better able to cope with parasitism and this has a positive impact on their resistance and resilience to worms.
  12. 12. GOAT TRIALS
  13. 13. SHEEP TRIALS
  14. 14. Commercially, the most important roundworms/nematodes for cattle, sheep & goats are: • Haemonchus spp. - No.1 in the world and occurs in warm and moist regions, mostly mixed infections and occurs globally • Teladorsagia (Ostertagia) spp. - No.1 in the world in temperate climates, mostly mixed infections and occurs globally • Trichostrongylus spp. - Mostly in mixed infections, globally • Nematodirus spp. - Mainly temperate climate, mostly mixed infections, globally • Cooperia spp. - Mainly in warm and moist regions, mostly mixed infections, globally Mixed infections = several worm species, as above infecting the host animal at the same time.
  15. 15. HORSE TRIALS
  16. 16. Commercially, the most important roundworms/nematodes for horses are: •Cyathostomins (small strongyles (small red worms or cyathostomes) - No.1 problem in horses worldwide. Mostly in mixed infections. •Parascaris equorum. Ascarids - A serious problem, particularly for young animals, globally. •Strongylus spp. - One of the most harmful parasites of horses. Mostly in mixed infections. •Strongyloides westeri - A serious threat for young foals, mainly in warm and moist regions, globally. •Trichostrongylus axei - A serious problem worldwide, particularly for young animals. •Habronema spp. - Can be regionally quite important. Found globally. Mixed infections = several worm species as above infecting the host animal at the same time.
  17. 17. EXOTIC ANIMALS Slides courtesy Dr Jim Miller (LSU) & Dr Deidre Fontenot (DAK)
  18. 18. ZOO ANIMALS (a happy customer)
  19. 19. Duddingtonia flagrans reduces the number of gastrointestinal nematodes (GIN) larvae on pasture, which is significantly greater than a chemical wormer can do within the animal (overall averages below): 84% HORSES 81% CATTLE 86% GOATS 68% SHEEP
  20. 20. There is widespread chemical resistance and multi-resistance in production animals (sheep, cattle & goats) including: Haemonchus (Barber’s Pole or wire worm), Teladorsagia (Brown stomach worm), Trichlostronglus (Black Scour or Hair worm), Cooperia spp. (Intestinal Worm), Nematodirus (Thread-necked Worm)
  21. 21. The extent of resistance is best documented in production animals and a recent survey of sheep in Australia (Playford et al., 2014) found widespread resistance in the common sheep parasites (Teladorsagia,Trichostrongylus and Haemonchus) to broad-spectrum anthelmintics: 96% prevalence for benzimidazoles 96% prevalence for levamisole 87% prevalence for ivermectin 77% prevalence for abamectin 54% prevalence for moxidectin
  22. 22. Study published by Meat & Livestock Australia Limited (Lane et al., 2015) estimates the total losses per annum due to internal parasites: • Sheep $A436 million ($US327m/$EU305m) with production losses ranging from $1.29 - $28.29 per animal • Cattle $A93.6 million ($US70m/$EU66m) with production losses ranging from $0.44 - $3.59 per animal • Goats $A2.54 million ($US1.9m/$EU1.8m) with production losses ranging from $0 - $5.34 per animal Separately there is no production loss data for horses but the estimated annual costs of worming ranges from $A15.00 - $120.00 per animal.
  23. 23. Did you know: It has been estimated 10% of the parasite population is within the host animal vs 90% is on the pasture. Duddingtonia flagrans
  24. 24. • If 10% of worms are within the animal and a wormer is 95% (?) effective: 10 x 0.95% = 9.5% reduction • If 90% worms are on pasture and Df is 70% effective: 90% x 0.70 = 63% (7 times more) via manure Duddingtonia flagrans
  25. 25. The Duddingtonia project THINGS WE’VE HAD TO CONSIDER (Overnight success)  Optimisation of spore production:  Dosage & delivery:  Product formulation & manufacturing:  Shelf life studies:  Efficacy trials (GCP):  Safety studies in target animals (GCP):  Residue studies (GLP) and exposure models:  DNA fingerprinting and genome:  Culture collection lodgement:  Toxicology studies in lab animals (GLP):  Physical testing (GLP):  Environmental safety:  Intellectual Property:  Submission to Regulators DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE ONGOING
  26. 26. Active Constituents: Each gram contains: a minimum of 500,0000 chlamydospores Daily feeding rates: 6g/100kg bodyweight USA 0.1 oz/each 100lbs bodyweight Available: Veterinarians, Premixers and Feedmills Withholding periods: Meat & Milk: 0 days Packsizes: 2kg,7.5kg,15kg, 25kg USA – 15lbs and 30lbs pails
  27. 27. Active Constituents: Each gram contains: a minimum of 30,000 chlamydospores Daily feeding rates: 100g/100kg bodyweight USA 1.6 oz/each 100lbs bodyweight Available: Stores & End users (farmers etc) Withholding periods: Meat & Milk: 0 days Packsizes: 7.5kg and 15kg pails USA – 15lbs and 30lbs pails
  28. 28. 1.Treat animals with a suitable oral, injectable, or pour-on wormer/anthelmintic to rid the animals of worms, then begin administration of BioWorma®. 2. Move the treated animals onto low worm pasture (that is, pasture that has not been grazed by the same animal species for a minimum of 6 weeks). 3. The most worm-susceptible are young animals (from 3 months up to 18-24 months of age) and periparturient females (last month of pregnancy and while producing milk), as they are the most likely to have less resistance to worm infestation due to low immunity. Do not underestimate pasture contamination by adult stock, even animals with low fecal egg counts (FECs), considering the volume of fecal material adult stock place on pasture. 4. Thoroughly mix BioWorma® with feed, feed supplements, premixes or concentrates, and commence daily administration of the resultant mixture to minimize pasture infectivity and maintain the low worm status of the animals.
  29. 29. 5. BioWorma® will begin to work within the first day and may be fed continuously when warm, moist climatic conditions are conducive to parasitic nematode activity. 6. BioWorma® is for use during periods when conditions are conducive to larval development and transmission onto pasture at temperatures above 40° Fahrenheit (5° Celsius). 7. Use BioWorma® in conjunction with the specified worm management strategy for your area by contacting your Veterinarian, Animal Health Advisor or Government Advisory groups for a strategic Integrated Parasite Management (IPM) plan. It is important to consider the principles of refugia. 8. Periodically check the worm burden and monitor the effectiveness of the worm management system. Options include fecal egg counts (FECs), the fecal egg count reduction test (FECRT) and/or identifying worm species by using fecal larval cultures (FLCs). Re-treatment with an effective chemical wormer may be indicated (consult your Veterinarian).
  30. 30. More Information: