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Phosphorus /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
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June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
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The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
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Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
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1. Copper: it’s complicated
SUSAN SCHOENIAN
Sheep & Goat Specialist Emeritus
University of Maryland Extension
sschoen@umd.edu | sheepandgoat.com
sheep101.info | wormx.info
2. Importance of
copper in the
diets of sheep
• Copper is one of the most important
trace elements required for normal
body functioning in sheep and other
animals.
• Dietary copper supports bone
formation, wool growth, pigmentation,
healthy nerve function, red blood cell
formation, immune response and
more.
• Copper deficient sheep are more
susceptible to worm infection.
No production benefit to giving
copper to sheep that are not deficient.
3. How much copper do sheep need?
Copper is a trace (or micro) mineral. It is required in very small amounts in the diet.
5 mg/kg DM (NRC, 1975)
1-8.6 mg/kg DM (ARC, 1980)
7-11 mg/kg DM (NRC, 1985)
• Since 2007, equations that use different
absorption coefficients have been used to
estimate copper requirements (mg/day) for
growing lambs, pregnant, and lactating ewes.
• 15 mg/kg is the maximum tolerable amount.
Class and weight
Absorption
coefficient
Lamb, pre-weaning
11 lbs.
22 lbs.
44 lbs.
.90
.53
.20
Lamb post-weaning
Pasture
Feedlot
.045
.06
Ewe
Gestation
Lactation
.06
.045
These all assume normal amounts of Mo and S in
diet; 1-2 mg/kg and 1.5-2.5 g/kg, respectively.
Old recommendations
mg/kg = PPM
4. Copper
absorption: age
• Relatively poor overall,
1.4 to 12.8%.
• However, much higher
among young animals, up
to 90%.
• 70-75% absorption in
newborns versus < 10%
in adults.
5. Copper absorption:
breed
• Between and within breed variation
with regards to copper absorption.
• Some breeds absorb copper more
efficiently than other breeds.
• Individual genetics can affect copper
status of animal.
Most efficient
More susceptible to Cu tox
Intermediate
Least efficient
Less susceptible to Cu tox
Texel
Suffolk
Short-wool breeds
Lowland breeds
Merino
Fine wool
Scottish Blackface
Cheviot
Gotland
Finn sheep
6. Copper absorption: source
• Metallic sources of copper are poorly
absorbed (e.g., copper oxide).
• The water-soluble forms of copper
are more readily absorbed (e.g.,
copper sulfate and copper carbonate).
• Chelated** minerals allow more
efficient absorption and utilization of
minerals.
**Chelated minerals are minerals which are formed
into a chemical compound with some organic
product, often an amino acid, e.g., Zinc-Methionine
and Copper-Lysine.
7. Copper absorption: antagonists
• Availability of copper is
reduced by presence of
antagonists, especially
molybdenum, but also
zinc, iron, and sulfur.
• Antagonists bind with
copper and prevent its
absorption.
• Cu:Mo ratio should be
between 6:1 and 10:1.
8. Sources of copper in sheep diets
• All feedstuffs contain copper.
• Copper levels in forages are
variable and dependent upon
many factors.
• Fresh grasses are poor sources of
copper compared to cured hay.
• Mineral concentrations in forages
vary much more than do protein
and energy concentrations.
• Liming and fertilization can alter
copper content of plants.
Feedstuff Copper, ppm
Barley 7.2
Corn 4.7
Oats 6.8
Wheat middlings 12.1
Beet pulp 16.0
Soybean
(much lower for soy hull pellets)
22.7
Corn gluten 35.1
DDSG 38.4
9. Feedstuffs with high
amounts of copper
• Improperly mixed feeds
• Feeds formulated for other species,
especially pig and poultry.
• Minerals formulated for other species
• Feedstuffs grown on land in which pig
or poultry manure (or sludge) has
been applied or copper-containing
chemicals have been used.
10. Why are sheep so
susceptible to copper
toxicity?
• Sheep are the most susceptible
species to copper poisoning.
• They have low dietary
requirements.
• Their liver cells have a high
affinity for copper.
• They excrete copper into the
bile at a very low rate, leading
to a build-up of copper in the
liver over time.
11. Causes of copper
toxicity in sheep
• Excessive exposure to
copper
• Amount of copper
antagonists in diet.
• Bioavailability of copper
• Stress
12. Excessive exposure to
copper
FEED is the most common source.
1. Feed mixing errors
2. Feeds and minerals formulated for other species
3. Supplements containing copper, e.g., Red Cell.
Other sources
• Pasture fertilized with pig or poultry manure
• Chemicals applied to pasture.
• Water is rarely the source.
• Use of copper-containing anthelmintics (copper sulfate)
• Use of copper-containing footbaths
• Monensin (Rumensin®) may predispose sheep to
copper poisoning.
13. How to diagnose copper
toxicity in sheep
• Feed history (not necessarily current feed, as it take
awhile for copper to accumulate in the liver).
• Clinical signs
• Blood work (> 2.0 ppm)
• Necropsy
• Liver and kidney copper levels
Copper liver concentration, dry weight, mg/kg (ppm)
Deficient 0.5 to 4
Adequate 88-350
Toxic 250-400
Source: Sheep & Goat Medicine, 2002
14. Signs of copper
toxicity in sheep
• Weakness
• Wandering
• Trembling
• Head-pressing
• Anorexia
• Jaundice (eye, gums)
• Dark urine
• Shallow breathing
• Dead
15. Treating copper toxicity in sheep
Clinical – hemolytic stage
• Treatments with the Cu antagonists:
Mo and S.
• Ammonium tetrathiomolybdate is
the treatment of choice.
• Oral administration of ammonium
molybdate (100 mg) and sodium
thiosulfate (1 g) for 3 weeks.
• Supportive treatment,
e.g., fluids
• Prognosis usually poor.
• Under advice of veterinarian
Sub-clinical
Copper accumulation phase
• Intervention should focus on prevention.
• Evaluation of feedstuffs
• Molybdenum or thiosulfate supplementation
• Zinc supplementation
• Avoid over
supplementation with
chelated minerals
• Consult nutritionist
17. Risk factors
for copper
deficiency
• Lack of intake of copper.
• Lower copper levels in soils and plants.
• High levels of molybdenum or other antagonists in ration
• Liming of pastures (as soil pH increases, molybdenum is released).
• Seasonal differences of copper content in plants.
• High levels of parasitic (especially barber pole worm) infection
18. Signs of copper
deficiency
in sheep
• Anorexia
• Anemia
• “Steely wool” loss of crimp
• Loss of pigmentation in hair and wool
• Lower wool production
• Staggers
• Swayback in lambs (enzootic ataxia)
• Copper deficiency may impair fertility.
19. How to diagnose copper
deficiency
in sheep
• Swayback in lambs is strongly suggestive;
loss of pigment, not as certain.
• Liver copper concentrations are one of
the best indicators, but not guaranteed.
• Concentration of copper in blood is
unreliable.
• Pasture analysis provides only a rough
guide.
• Copper treatment response is an option.
20. Liver toxicology: mineral screens
Accurate liver mineral ranges for sheep
(ppm wet weight)
Calcium 40-80
Cobalt 0.025-0.085
Copper 25-100
Iron 30-300
Magnesium 120-200
Manganese 2.0-4.4
Molybdenum 0.4-1.7
Selenium 0.25-1.50
Zinc 30-75
Additional liver copper reference ranges
for sheep (ppm wet weight)
Deficient 0.5-4.0
Marginal 5.0-20.0
Adequate 25-100
High 100-500
Toxic 250-1000
21. Treating copper deficiency in sheep
Sub-clinical
• Copper bolus(es)
• Increase copper in diet
• Add feed grade copper to ration
• Supplement copper in salt/mineral
mixture
Clinical
• Give copper injection(s)
• Drench with copper sulfate
• Give copper bolus(es)
CONSULT YOUR VETERINARIAN. YOU NEED TO BE CAREFUL BECAUSE THERE IS A NARROW MARGIN BETWEEN
REQUIREMENT AND TOXICITY!
22. Can I use copper as a dewormer?
• High copper mineral
• Copper sulfate
• Copper oxide wire particles (COWP)
Copper-deficient sheep
may be more
susceptible to
parasitism, but
exceeding dietary
copper requirements
will not help to alleviate
parasite problems, but
rather will put sheep at
risk for copper toxicity.
24. • Remember copper is
complicated!
• Don’t listen to your neighbors,
friends, or Facebook.
• Test your soils and feeds to
determine risk of copper
deficiency or toxicity.
• Test livers to determine copper
status of animals.
• Don’t add copper to diet
without knowing status of
animals and farm.
• Work with a nutritionist if you
think you have a problem.
Preventing
issues with
copper on
your farm
25. Thank you.
Comments?
Questions?
SUSAN SCHOENIAN
Sheep & Goat Specialist Emeritus
University of Maryland Extension
sschoen@umd.edu
www.sheepandgoat.com
www.sheep101.info
www.wormx.info
Facebook @ MDSmallRuminant
Flickr @ /baalands