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HYDROCEPHALUS
GBONEME S.E
FINAL YEAR, MEDICAL STUDENT, CMUL
Outline
• Introduction
• Epidemiology
• Relevant Anatomy
• Etiology
• Classification and Pathogenesis
• Clinical Features
• Management
Introduction
• Hydrocephalus is of major importance as it is commonly
noticed in children, as well as after a traumatic brain injury
• Hydrocephalus can be defined as the abnormal collection of
cerebrospinal fluid within the ventricles of the brain either
due to over production of CSF, obstruction of flow, or
decreased absorption.
Epidemiology
• Hydrocephalus occurs in approximately every 1 in 500
children.
• It has equal sex predilection (i.e. a ratio of 1:1)
• No racial predilection.
• Also occurs after Head Injury.
Relevant Anatomy
Relevant Anatomy Contd
• CSF is produced by the choriod plexuses of the ventricles.
• It flows from the Lateral ventricles (2) to the 3rd ventricle via
the FORAMEN OF MONROE (2) then flows into the 4th
ventricle via the AQUEDUCT of SYLVIUS.
• From the 4th Ventricle, it flows into the CISTERNS via the
lateral FORAMEN OF LUSCHKA (2) and the median FORAMEN
OF MAGENDIE (1)
Relevant Anatomy Contd
• CSF from the foramen of Luschka flows into the pontine
cistern, then the lumbar cistern
• CSF from the foramen of Magendie flows into the superior
cistern.
• CSF from the lumbar cistern and superior cistern join and flow
into the SUBARACHNOID SPACE.
• There, they are then absorbed by the arachnoid villi
granulations.
Relevant Anatomy Contd
• Absorbed CSF flows to the CONFLUENCE OF SINUS and drains
into venous blood via the STRAIGHT SINUS.
Etiology
• Grouped into CONGENITAL and ACQUIRED
• CONGENITAL
Aqueduct of Sylvius stenosis
Arnold Chiari II malformation
Stenosis of any of the foramina
Dandy walker syndrome
Fetal and Neonatal infections e.g Toxoplasmosis
Etiology Contd
• ACQUIRED
Trauma
Infection- Bacterial meningitis, ventriculitis
Neoplasms – Choriod Papilloma
Hemorrhage – Intracranial hemorrhage
Classification
• Can broadly be classified as Obstructing (Non communicating)
and Communicating.
• Non communicating: Flow of CSF is blocked along one or
more of the narrow pathways in the ventricular system
• Communicating: Flow is not blocked within the ventricular
system, however it can be blocked after it exits the ventricular
system.
Clinical Features
• Hydrocephalus in Infants:
1. Failure to thrive
2. Failure to achieve milestones
3. Distended scalp veins
4. Increased skull circumference
5. Lethargy
6. Vomiting
7. Sun setting of eyes (due to 3rd ventricle compression on the
superior colliculus)
8. Tense and Bulging fontanelle
Clinical Features contd
• Hydrocephalus in Adults
1. Headaches – Usually in the morning, due to raised ICP due
to CO2 retention, causing vasodilatation. Raised ICP causes
compression of pain sensitive dura.
2. Vomiting, (projectile) also in the morning, relieves the
headache. Occurs due to compression of the
Chemoreceptor trigger zone.
3. Drowsiness
4. Papilloedema - Optic disc edema
5. Cushings Triad – Hypertension, Bradycardia, Cheyne stokes
breathing (A late sign)
Managment
• Investigations
1. Plain X-RAY (although phased out, but may show Copper
beating appearance of the skull).
Investigations contd
• CT Scan:
• Investigation of choice. Shows the size of the ventricles as well
as the underlying cause and the degree of mass effect.
• Other investigations
• Full Blood Count – may indicate Infection (raised WBC)
• Also necessary for surgery work up
• Electrolyte, Urea, Creatinine – Baseline, work up for surgery
DANDYWALKERSYNDROME
CREDIT: Medscape
CTscanshowingenlargementofthelateralventriclesontheleft
andmickeymousesignontheright
CREDIT: medicinembbs.blogspot.com
Treatment
• Treatment is SURGICAL. Treat the underlying cause
Treatment contd
• Redirect CSF flow using Shunts
1. Ventriculoperitoneal – most common
2. Ventriculoatrial
3. Lumboperitioneal
4. Ventriculopleural
• Endoscopic third ventriculostomy
Complication
• VP shunt comes with quite a number of complications.
• 1. The shunt can fail
• 2. Blockage of the shunt can occur
• 3. Infections may arise
Thank You.

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Hydrocephalus Lecture Note (Congenital and Acquired)

  • 2. Outline • Introduction • Epidemiology • Relevant Anatomy • Etiology • Classification and Pathogenesis • Clinical Features • Management
  • 3. Introduction • Hydrocephalus is of major importance as it is commonly noticed in children, as well as after a traumatic brain injury • Hydrocephalus can be defined as the abnormal collection of cerebrospinal fluid within the ventricles of the brain either due to over production of CSF, obstruction of flow, or decreased absorption.
  • 4. Epidemiology • Hydrocephalus occurs in approximately every 1 in 500 children. • It has equal sex predilection (i.e. a ratio of 1:1) • No racial predilection. • Also occurs after Head Injury.
  • 6. Relevant Anatomy Contd • CSF is produced by the choriod plexuses of the ventricles. • It flows from the Lateral ventricles (2) to the 3rd ventricle via the FORAMEN OF MONROE (2) then flows into the 4th ventricle via the AQUEDUCT of SYLVIUS. • From the 4th Ventricle, it flows into the CISTERNS via the lateral FORAMEN OF LUSCHKA (2) and the median FORAMEN OF MAGENDIE (1)
  • 7. Relevant Anatomy Contd • CSF from the foramen of Luschka flows into the pontine cistern, then the lumbar cistern • CSF from the foramen of Magendie flows into the superior cistern. • CSF from the lumbar cistern and superior cistern join and flow into the SUBARACHNOID SPACE. • There, they are then absorbed by the arachnoid villi granulations.
  • 8. Relevant Anatomy Contd • Absorbed CSF flows to the CONFLUENCE OF SINUS and drains into venous blood via the STRAIGHT SINUS.
  • 9. Etiology • Grouped into CONGENITAL and ACQUIRED • CONGENITAL Aqueduct of Sylvius stenosis Arnold Chiari II malformation Stenosis of any of the foramina Dandy walker syndrome Fetal and Neonatal infections e.g Toxoplasmosis
  • 10. Etiology Contd • ACQUIRED Trauma Infection- Bacterial meningitis, ventriculitis Neoplasms – Choriod Papilloma Hemorrhage – Intracranial hemorrhage
  • 11. Classification • Can broadly be classified as Obstructing (Non communicating) and Communicating. • Non communicating: Flow of CSF is blocked along one or more of the narrow pathways in the ventricular system • Communicating: Flow is not blocked within the ventricular system, however it can be blocked after it exits the ventricular system.
  • 12. Clinical Features • Hydrocephalus in Infants: 1. Failure to thrive 2. Failure to achieve milestones 3. Distended scalp veins 4. Increased skull circumference 5. Lethargy 6. Vomiting 7. Sun setting of eyes (due to 3rd ventricle compression on the superior colliculus) 8. Tense and Bulging fontanelle
  • 13. Clinical Features contd • Hydrocephalus in Adults 1. Headaches – Usually in the morning, due to raised ICP due to CO2 retention, causing vasodilatation. Raised ICP causes compression of pain sensitive dura. 2. Vomiting, (projectile) also in the morning, relieves the headache. Occurs due to compression of the Chemoreceptor trigger zone. 3. Drowsiness 4. Papilloedema - Optic disc edema 5. Cushings Triad – Hypertension, Bradycardia, Cheyne stokes breathing (A late sign)
  • 14. Managment • Investigations 1. Plain X-RAY (although phased out, but may show Copper beating appearance of the skull).
  • 15. Investigations contd • CT Scan: • Investigation of choice. Shows the size of the ventricles as well as the underlying cause and the degree of mass effect. • Other investigations • Full Blood Count – may indicate Infection (raised WBC) • Also necessary for surgery work up • Electrolyte, Urea, Creatinine – Baseline, work up for surgery
  • 18. Treatment • Treatment is SURGICAL. Treat the underlying cause
  • 19. Treatment contd • Redirect CSF flow using Shunts 1. Ventriculoperitoneal – most common 2. Ventriculoatrial 3. Lumboperitioneal 4. Ventriculopleural • Endoscopic third ventriculostomy
  • 20. Complication • VP shunt comes with quite a number of complications. • 1. The shunt can fail • 2. Blockage of the shunt can occur • 3. Infections may arise