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Nanotechnology in dentistry
- 1. Nanotechnology In Dentistry Done by: Karim Aly Haridy,Ahmed Hesham ali ,Ahmed Hatem ,Ahmed Hesham ,Abdelrahman Ahmed Semester Four Under Suprvision of : A.Prof Samah Kamel
- 3. • nanotechnology are the study and application of extremely small things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering. • Nanotechnology is science,and technology conducted at the nanoscale, which is about 1 to 100 nanometers.
- 6. First Nano-anesthesia: New approach to local anesthesia?
- 7. The experimental pilot study evaluated the use of magnet- directed nanoparticles containing the local anesthetic drug ropivacaine (MNP/Ropiv) to produce Magnets Used to Attract Anesthesia-Containing Nanoparticles
- 8. Experiment • The researchers then placed magnets around the ankle of the right paw for 15, 30, or 60 minutes. The goal was to use the magnets to draw the nanoparticles to ankle. Once there, the particles would release the anesthetic, numbing the nerves around the ankle.
- 9. Local anathesia • Millions of active analgesic micron-size dental robots will be in instilled on the patient’s gingiva • After contacting the surface of crown or mucosa , the ambulating nanorobots reach pulp via gingival sulcus , lamina propria ,and dentinal tubules
- 10. Second Nanoparticles used to break up plaque and prevent cavities ?
- 11. ………. So new technique should be implied • The bacteria that live in dental plaque and contribute to tooth decay often resist traditional antimicrobial treatment, as they can "hide" within a sticky biofilm matrix
- 12. What does iron containing nanoparticles does to hydrogen peroxide Iron-containing nanoparticles catalyze activity of Hydrogen peroxide
- 13. 5000 x This Photo by Unknown Author is licensed under CC BY-SA
- 15. filling material with tiny particles made by self-assembly of antimicrobial drugs, designed to stop bacteria in its tracks.
- 16. But here comes the struggle ….. how do you store enough drug within the material to be effective for someone's entire life?
- 18. We know very well that bacteria specifically attack the margins between fillings and the remaining tooth to create cavities
- 19. PROS OF SILICA • organize themselves on a molecule-by-molecule basis to maximize drug density, with enough supply to last years
- 20. • Venkat R. R. Mantha, Harsha K. Nair, Raman Venkataramanan, Yuan Yue Gao, Krzysztof Matyjaszewski, Hongchen Dong, Wenwen Li, Doug Landsittel, Elan Cohen, William R. Lariviere. Nanoanesthesia. Anesthesia & Analgesia, 2014; 1 DOI: 10.1213/ANE.0000000000000175 • Lizeng Gao, Yuan Liu, Dongyeop Kim, Yong Li, Geelsu Hwang, Pratap C. Naha, David P. Cormode, Hyun Koo. Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo. Biomaterials, 2016; 101: 272 DOI: 10.1016/j.biomaterials.2016.05.051 • University of Toronto Faculty of Applied Science & Engineering. "The fight against tooth decay gets help with a new smart material: Team designs new antimicrobial materials to prevent recurrent cavities under fillings." ScienceDaily. ScienceDaily, 30 January 2018. <www.sciencedaily.com/releases/2018/01/180130123800.htm>. References
Editor's Notes
- The researchers then placed magnets around the ankle of the right paw for 15, 30, or 60 minutes. The goal was to use the magnets to draw the nanoparticles to ankle. Once there, the particles would release the anesthetic, numbing the nerves around the ankle. Sensation in the right paw was assessed by comparing the right paw to the left paw, which was not affected. Other groups of rats received standard nerve block, with ropivacaine injected directly into the ankle; or IV injection of ropivacaine alone, not incorporated into nanoparticles. Injection of MNP/Ropiv complexes followed by magnet application produced significant nerve block in the right ankle, similar to a standard nerve block. The left ankle was unaffected.
- A new strategy conceived by University of Pennsylvania researchers took a more sophisticated approach. Instead of simply applying an antibiotic to the teeth, they took advantage of the pH-sensitive and enzyme-like properties of iron-containing nanoparticles to catalyze the activity of hydrogen peroxide, a commonly used natural antiseptic. The activated hydrogen peroxide produced free radicals that were able to simultaneously degrade the biofilm matrix and kill the bacteria within, significantly reducing plaque and preventing the tooth decay, or cavities, in an animal model.
- nanoparticles' reaction with a 1 percent or less hydrogen peroxide solution was remarkably effective at killing bacteria, wiping out more than 99.9 percent of the S. mutans in the biofilm within five minutes, an efficacy more than 5,000 times greater than using hydrogen peroxide alone
- Through this research we discovered a combination of drugs and silica glass that." This discovery of using antimicrobials which self-assemble means the team can pack 50 times as much of the bacteria-fighting drugs into the particles. "We know very well that bacteria specifically attack the margins between fillings and the remaining tooth to create cavities," says Finer. "Giving these materials an antimicrobial supply that will last for years could greatly reduce this problem."