SHORTEST AND PRECISE REVIEW OF LITERATURE ON CLOBAZAM ROLE IN FEBRILE SEIZURES

1. CLOBAZAM in FEBRILE SEIZURE
PROPHYLAXIS
DR SHAILESH MEHTA
MD PEDIATRICS

2. EVIDENCE BASED FACTS
• Cochrane meta- analysis and ILAE don’t support
use of CLOBAZAM in febrile seizures.
Cochrane Database of Systematic Reviews 2017,
Issue 2. Art. No.: CD003031.
included 40 articles describing 30 randomised
trials with 4256 randomised participants
RESULT: CLOBAZAM INEFFECTIVE
• Most studies in favour have sample size 25-70
patients only
Indian J Pediatr (2011) 78:38–40
Manreza et al,Arq Neuropsiquiatr 1997;55(4)
Rose et al, Indian J Pediatr 2005;72(1)

3. RESCUE VS PROPHYLAXIS
RESCUE- IF SEIZURE MORE THAN 15 MIN
DIAZEPAMI.V./ RECTAL-0.3- 0.5MG /KG/DOSE
MIDAZOLAM INTRANASAL-0.2MG/KG/DOSE
CLOBAZAM- NOT USED
Cochrane Database of Systematic Reviews 2017, Issue 2. Art.
No.: CD003031
Lancet 2005,;366:205-10
PROPHYLAXIS-
NO MORE USED- PHENOBARB, VALPARIN
DIAZEPAM(ORAL) – 0.3 MG/KG/DOSE 12 HOURLY
TILL AFEBRILE FOR 24 HRS
CLOBAZAM(ORAL)- 0.5 MG/KG/DOSE- 12HOURLY- FOR 48HRS