Pathology of Infectious Mononucleosis (Epstein-Barr Virus)

1. Infectious
Mononucleosis
Yuzbasheva Nihal 221B

2.  Infectious mononucleosis is an acute, self-limited disease
of adolescents and young adults that is caused by Epstein-
Barr virus (EBV), a member of the herpesvirus family.

6. Atypical lymphocytes in infectious mononucleosis-peripheral blood smear. The
cell on the left is a normal small resting lymphocyte with a compact nucleus
and scant cytoplasm. By contrast, theatypical lymphocyte on the right has
abundant cytoplasm and a large nucleus with dispersed chromatin.

8. LYMPHOADENOPATHY

10. Classification or Reed-Sternberg
Cells

12. Splenomegaly

14. Ultimately, the diagnosis depends on the following findings,
in increasing order of specificity:
(1) lymphocytosis with the characteristic atypical lymphocytes in
the peripheral blood
(2) a positive heterophil reaction (Monospot test),
(3) a rising titer of antibodies specific for EBV antigens (viral
capsid antigens, early antigens, or Epstein-Barr nuclear antigen).

15. X-linked lymphoproliferative
syndrome

16. THANKS FOR
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