Infectious mononucleosis is caused by the Epstein-Barr virus and causes an acute self-limited disease typically in adolescents and young adults. It is characterized by lymphocytosis showing atypical lymphocytes in blood smears, lymphadenopathy, and sometimes splenomegaly. The diagnosis involves detecting atypical lymphocytes in blood, a positive Monospot test, or a rising titer of antibodies to EBV antigens.

1. Infectious
Mononucleosis
Yuzbasheva Nihal 221B

2.  Infectious mononucleosis is an acute, self-limited disease
of adolescents and young adults that is caused by Epstein-
Barr virus (EBV), a member of the herpesvirus family.

6. Atypical lymphocytes in infectious mononucleosis-peripheral blood smear. The
cell on the left is a normal small resting lymphocyte with a compact nucleus
and scant cytoplasm. By contrast, theatypical lymphocyte on the right has
abundant cytoplasm and a large nucleus with dispersed chromatin.

8. LYMPHOADENOPATHY

10. Classification or Reed-Sternberg
Cells

12. Splenomegaly

14. Ultimately, the diagnosis depends on the following findings,
in increasing order of specificity:
(1) lymphocytosis with the characteristic atypical lymphocytes in
the peripheral blood
(2) a positive heterophil reaction (Monospot test),
(3) a rising titer of antibodies specific for EBV antigens (viral
capsid antigens, early antigens, or Epstein-Barr nuclear antigen).

15. X-linked lymphoproliferative
syndrome

16. THANKS FOR
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