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SECRETIONS
OF
GASTRO INTESTINAL TRACT
SALIVARY SECRETION
SALIVARY GLANDS
Major salivary glands
1. Parotid,
2. Submandibular, and
3. Sublingual glands.
Minor salivary glands
1. Labial glands
2. Buccal gland
3. Glossopalatine gland
4. Palatine glands
5. Lingual glands
New type of SALIVARY GLANDS
Tubarial Glands
SALIVARY GLANDS
PAROTID GLAND
 Largest gland
 Located anterior and Inferior to the Ear
 Partially overlying the Masseter muscle
 Produces 25-30 % of saliva
 Conducted through the Parotid Duct to the Oral cavity.
SUB MANDIBULAR GLAND
 Inferior to the body of the Mandible
 Produce most of the saliva (60-70 %)
 Ducts open through a Papilla in the floor of the mouth
 lateral to the Lingual Frenulum
SUBLINGUAL GLAND
 Inferior to the tongue
 each gland has multiple tiny sublingual ducts
 Open on to the Inferior surface of the oral cavity
 contribute on 3-5% of total saliva
TYPES OF CELLS IN SALIVARY GLANDS
1.MUCUS CELLS/ ACCINI
2.SEROUS CELLS/ ACCINI
NERVE SUPPLY TO PAROTID SUBMANDIBULAR &
SUBLINGUAL GLANDS
SSN FACIAL NERVE NERVOUS INTERMEDIUS CTN
SUBMANDIBULAR AND SUBLINGUAL GLANDS SUBMANDIBULAR GANGLION
ISN CN IX
TYM. BR OF CN IX
OTIC GANGLION
PAROTID GLAND
MECHANISM OF FORMATION OF SALIVA
1. Primary secretion
2. Modification of saliva
MECHANISM OF FORMATION OF SALIVA
PRIMARY SECETION
•FORMED BY TRANSUDATION (Pressure filtration)
•ISOTONIC TO PLASMA
•MODIFIED AS SOON AS THEY SECRETED
FLOW RATE OF SALIVA
CEPHALIC PHASE SECRETION OF SALIVA BEFORE
ENTRY OF FOOD
CONDITIONAL REFLEX
BUCCAL PHASE PRESENCE OF FOOD IN THE
MOUTH [(+) BUCCAL
RECEPTORS]
UNCONDITIONAL REFLEX&
PARTIALLY REGULATED BY
APETITE CENTRE
OESOPHAGEAL PHASE PASSING OF FOOD THROUGH
OESOPHAGUS
STIMULATION OF SALIVARY
GLANDS
GASTRIC PHASE PRESENCE OF FOOD IN
STOMACH
IRRITANT FOODS IN
STOMACH (VOMITING)
INTESTINAL PHASE FOOD IN INTESTINE IRRITANT FOOD IN UPPER
INTESTINE
PHASES OF SALIVARY SECRETION
PHASES OF SALIVARY SECRETION
Cephalic Phase
Food
(Before entering)
Condition reflex
(Sight, Smell etc.,)
Secretion of Saliva
GASTRIC PHASE
Food (Mouth)
(+) Buccal Receptors
Secretion of Saliva
 An Unconditioned reflex.
 Partially regulated by Appetite Centre.
Esophageal
Phase
Food passing
through
Esophagus
(+) Salivary
Glands
Gastric Phase &
Intestinal Phase
Presence of Food in
Stomach& Intestine
(Irritants)
salivation before
Vomitting
ESOPHAGEAL PHASE GASTRIC AND INTESTINAL
PHASES
APPLIED PHYSIOLOGY
1. Xerostomia: consistant decrease in salivary secretion/
absence on salivary secretion
2. Sialorrhoea : salivary secretion is increased
3. Sialolithiasis : Stone is formed in the ducts
GASTRIC SECRETION
STOMACH- ANATOMY
HISTOLOGY OF STOMACH
1. Serosal layer – outermost
2. Muscular layer
3. Submucosal layer
4. Mucosal layer
GASTRIC GLANDS
NAME OF THE GLAND THE CARDIAC
GLANDS
THE OXYNTIC
GLANDS
PYLORIC
GLANDS
LOCATION Below LES Fundus Pyloric antral
region
GLAND CONTAINS Mucous secreting
cells
Oxyntic cells Mucous neck
cells
SECRETION Mucous &
Bicarbonate
HCL & IF mucous
THE OXYNTIC GLAND
CELL TYPES MUCOUS
NECK CELLS
OXYNTIC &
PEPTIC CELLS
CHIEF /
PEPTIC CELLS
ENDOCRINE
CELLS
LOCATION NECK REGION
OF THE GLAND
BODY PART OF
THE GLAND
BASE OF THE
GLAND
ANTRAL
REGION
SECRETION MUCOUS AND
BICARBONATE
HCL & IF PEPSIONOGEN HISTAMINE
FUNCTION PROTECTION
OF GASTRIC
EPITHELIUM
HCL : PROTEIN
BREAKDOWN
IF: VIT.B12
ABSORPTION
CONVERSION
TO ACTIVE
PEPSIN
+ CAUSES ACID
SECRETION
FACTORS INFLUENCING HCL SECRETION-
hormonal regulation
PHASES OF GASTRIC SECRETION

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SALIVARY SECRETION AND GASTRIC.pptx

  • 3. SALIVARY GLANDS Major salivary glands 1. Parotid, 2. Submandibular, and 3. Sublingual glands. Minor salivary glands 1. Labial glands 2. Buccal gland 3. Glossopalatine gland 4. Palatine glands 5. Lingual glands New type of SALIVARY GLANDS Tubarial Glands
  • 5. PAROTID GLAND  Largest gland  Located anterior and Inferior to the Ear  Partially overlying the Masseter muscle  Produces 25-30 % of saliva  Conducted through the Parotid Duct to the Oral cavity.
  • 6. SUB MANDIBULAR GLAND  Inferior to the body of the Mandible  Produce most of the saliva (60-70 %)  Ducts open through a Papilla in the floor of the mouth  lateral to the Lingual Frenulum
  • 7. SUBLINGUAL GLAND  Inferior to the tongue  each gland has multiple tiny sublingual ducts  Open on to the Inferior surface of the oral cavity  contribute on 3-5% of total saliva
  • 8.
  • 9. TYPES OF CELLS IN SALIVARY GLANDS 1.MUCUS CELLS/ ACCINI 2.SEROUS CELLS/ ACCINI
  • 10. NERVE SUPPLY TO PAROTID SUBMANDIBULAR & SUBLINGUAL GLANDS SSN FACIAL NERVE NERVOUS INTERMEDIUS CTN SUBMANDIBULAR AND SUBLINGUAL GLANDS SUBMANDIBULAR GANGLION ISN CN IX TYM. BR OF CN IX OTIC GANGLION PAROTID GLAND
  • 11.
  • 12.
  • 13.
  • 14. MECHANISM OF FORMATION OF SALIVA 1. Primary secretion 2. Modification of saliva
  • 15. MECHANISM OF FORMATION OF SALIVA PRIMARY SECETION •FORMED BY TRANSUDATION (Pressure filtration) •ISOTONIC TO PLASMA •MODIFIED AS SOON AS THEY SECRETED
  • 16.
  • 17. FLOW RATE OF SALIVA
  • 18. CEPHALIC PHASE SECRETION OF SALIVA BEFORE ENTRY OF FOOD CONDITIONAL REFLEX BUCCAL PHASE PRESENCE OF FOOD IN THE MOUTH [(+) BUCCAL RECEPTORS] UNCONDITIONAL REFLEX& PARTIALLY REGULATED BY APETITE CENTRE OESOPHAGEAL PHASE PASSING OF FOOD THROUGH OESOPHAGUS STIMULATION OF SALIVARY GLANDS GASTRIC PHASE PRESENCE OF FOOD IN STOMACH IRRITANT FOODS IN STOMACH (VOMITING) INTESTINAL PHASE FOOD IN INTESTINE IRRITANT FOOD IN UPPER INTESTINE PHASES OF SALIVARY SECRETION
  • 19. PHASES OF SALIVARY SECRETION Cephalic Phase Food (Before entering) Condition reflex (Sight, Smell etc.,) Secretion of Saliva
  • 20. GASTRIC PHASE Food (Mouth) (+) Buccal Receptors Secretion of Saliva  An Unconditioned reflex.  Partially regulated by Appetite Centre.
  • 21. Esophageal Phase Food passing through Esophagus (+) Salivary Glands Gastric Phase & Intestinal Phase Presence of Food in Stomach& Intestine (Irritants) salivation before Vomitting ESOPHAGEAL PHASE GASTRIC AND INTESTINAL PHASES
  • 22. APPLIED PHYSIOLOGY 1. Xerostomia: consistant decrease in salivary secretion/ absence on salivary secretion 2. Sialorrhoea : salivary secretion is increased 3. Sialolithiasis : Stone is formed in the ducts
  • 24. STOMACH- ANATOMY HISTOLOGY OF STOMACH 1. Serosal layer – outermost 2. Muscular layer 3. Submucosal layer 4. Mucosal layer
  • 25.
  • 26. GASTRIC GLANDS NAME OF THE GLAND THE CARDIAC GLANDS THE OXYNTIC GLANDS PYLORIC GLANDS LOCATION Below LES Fundus Pyloric antral region GLAND CONTAINS Mucous secreting cells Oxyntic cells Mucous neck cells SECRETION Mucous & Bicarbonate HCL & IF mucous
  • 27. THE OXYNTIC GLAND CELL TYPES MUCOUS NECK CELLS OXYNTIC & PEPTIC CELLS CHIEF / PEPTIC CELLS ENDOCRINE CELLS LOCATION NECK REGION OF THE GLAND BODY PART OF THE GLAND BASE OF THE GLAND ANTRAL REGION SECRETION MUCOUS AND BICARBONATE HCL & IF PEPSIONOGEN HISTAMINE FUNCTION PROTECTION OF GASTRIC EPITHELIUM HCL : PROTEIN BREAKDOWN IF: VIT.B12 ABSORPTION CONVERSION TO ACTIVE PEPSIN + CAUSES ACID SECRETION
  • 28.
  • 29.
  • 30. FACTORS INFLUENCING HCL SECRETION- hormonal regulation
  • 31. PHASES OF GASTRIC SECRETION