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ANAPHYLAXIS
PRESENTER: DR.SOHAN BISWAS,
DNB JR-2
INTERNAL MEDICINE
• Anaphylaxis is an acute, life-threatening hypersensitivity disorder,
defined as a generalized, rapidly evolving, multi-systemic allergic
reaction.
• Without treatment, anaphylaxis is often fatal due to its rapid
progression to respiratory collapse.
• Anaphylaxis is most often a rapidly evolving presentation, usually
within one hour of exposure.
• Roughly half of the anaphylactic-related fatalities occur within this
first hour; therefore, the first hour after the initial symptom onset is the
most crucial for treatment.
• It is important to note that the more rapid the onset and progression of
symptoms, the more severe the disease process.
• Morbidity and mortality are most often related to loss of airway and
distributive shock.
Anaphylactic reactions can also present in a biphasic manner in up to
20% of cases.
Even after successful management of the initial presenting symptoms,
there can be a recurrence of symptoms peaking 8 to 11 hours after the
initial reaction, therefore the potentially fatal second reaction should not
be dismissed after treatment of the initial reaction.
• In adults and adolescents, 2 L of normal saline are usually administered initially;
more may be required in severe cases.
• Children should receive boluses of 10 to 20 mL per kg until hypotension is
controlled.
• Even in the presence of upper airway obstruction, placing a patient in the recumbent
position with the lower extremities raised is preferred over elevating the head of the
patient's bed, because the vascular collapse during anaphylaxis can be devastating
• Reaction severity is not a predictor of biphasic reactions.
• Ten hours of observation is probably adequate in most situations, but some
investigators recommend a minimum of 24 hours
THANK YOU

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ANAPHYLAXIS BY DR.SOHAN BISWAS,MBBS,DNB(INTERNAL MEDICINE) RESIDENT.pptx

  • 2. • Anaphylaxis is an acute, life-threatening hypersensitivity disorder, defined as a generalized, rapidly evolving, multi-systemic allergic reaction. • Without treatment, anaphylaxis is often fatal due to its rapid progression to respiratory collapse.
  • 3.
  • 4.
  • 5.
  • 6. • Anaphylaxis is most often a rapidly evolving presentation, usually within one hour of exposure. • Roughly half of the anaphylactic-related fatalities occur within this first hour; therefore, the first hour after the initial symptom onset is the most crucial for treatment. • It is important to note that the more rapid the onset and progression of symptoms, the more severe the disease process. • Morbidity and mortality are most often related to loss of airway and distributive shock.
  • 7. Anaphylactic reactions can also present in a biphasic manner in up to 20% of cases. Even after successful management of the initial presenting symptoms, there can be a recurrence of symptoms peaking 8 to 11 hours after the initial reaction, therefore the potentially fatal second reaction should not be dismissed after treatment of the initial reaction.
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23. • In adults and adolescents, 2 L of normal saline are usually administered initially; more may be required in severe cases. • Children should receive boluses of 10 to 20 mL per kg until hypotension is controlled. • Even in the presence of upper airway obstruction, placing a patient in the recumbent position with the lower extremities raised is preferred over elevating the head of the patient's bed, because the vascular collapse during anaphylaxis can be devastating
  • 24. • Reaction severity is not a predictor of biphasic reactions. • Ten hours of observation is probably adequate in most situations, but some investigators recommend a minimum of 24 hours