0
2-2-2013
LaY Out












Other names
Definition
Occurence & Tissue Distribution
Biomedical Importance
Metabolic Pathw...
Phosphogluconate Pathway
Pentose Cycle
Hexose Monophosphate Pathway or Shunt

Warburg-Dickens-Lipman Pathway

2-2-2013
 The

process which brings
about oxidation &
decarboxylation at C-1 of
Glucose 6phosphate, reducing NADP+
to NADPH & prod...
2-2-2013
Liver
Lactating Mammary Gland
Adrenal Cortex
Gonads
Adipose Tissue
Erythrocytes
Lens & Cornea

2-2-2013
It has 2 main functions:
Provides NADPH
Provides PENTOSES
Though there is oxidation of
Glucose,but it is NOT meant for
...
 It
1)

2)

has 2 Phases:
Oxidative Phase
Non-Oxidative Phase

2-2-2013
Glucose 6-Phosphate
Glucose 6-phosphate NADP+
Dehydrogenase
Mg++

NADPH+H

6-phosphogluconolactone
6-phosphoglucolactonase...
6-phosphogluconate
6-phosphogluconate NADP+
Dehydrogenase Mg++
NADPH+H
3-Keto-6-phosphogluconate
D-Ribulose 5-phosphate + ...
D-Ribulose 5-Phosphate
Phosphopentose
Isomerase

D-Ribose 5-phosphate

D-Ribose-1-P

D-Ribose-1,5-di-P
2-2-2013
D-Ribulose-5-P
Phosphopentose
Epimerase

D-Xylulose-5-Phosphate

2-2-2013
2 Particular Enzymes are
required:
1)TRANSKETOLASE
2)TRANSALDOLASE

2-2-2013
1)

Xylulose-5-P+Ribose-5-P

Transketolase

TPP

Sedoheptolose 7-Phosphate +
Glyceraldehyde-3-Phosphate

2-2-2013
Sedoheptolose 7-P+G3P
Transaldolase

Fructose 6-Phosphate
+
Erythrose 4-Phosphate

2-2-2013
2)Xylulose 5-P+Erythrose 4-P
Transketolase
TPP

Fructose 6-Phosphate +G3P
Dihydroxy-acetone-P+G3P

Recycles
the Pathway
Gl...
G-6-PD deficiency results in:
Heamolytic Aneamia
Neonatal
Kidney

Jaundice

failure

2-2-2013
Mutation

in gene coding for G6PD,
production of NADPH decreases,low
level of reduced glutathione--accumulation of H2O2--...
 Genetically

variant form of
Transketolase. It can’t bind
TPP, affecting “transketolation”
reaction.

 Symptoms

are:
...
Results in:
Liver cirrhosis
Male

infertility

2-2-2013
Occurs in 3 ways:
a) Ratio of [NADP+][NADPH]
_1st Step is Rate-limiting step catalysed by
G6PD.
b) Increased

HMP Shunt on...
 Occurs

in all

tissues
 Not a multi cyclic
process
 NAD+ is H+
acceptor
 ATP production
 CO2 is never
formed

EM PA...
Lehninger

Principles of Biochemistry
5th edition,Pg.no 558-563
Biochemistry by Thomas M.Devlin
7th edition,Pg.no 648-65...
THANK
YOU
2-2-2013
Upcoming SlideShare
Loading in...5
×

Hmp shunt

2,584

Published on

For study purpose only.

Published in: Education
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
2,584
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
205
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Transcript of "Hmp shunt "

  1. 1. 2-2-2013
  2. 2. LaY Out           Other names Definition Occurence & Tissue Distribution Biomedical Importance Metabolic Pathway Clinical Correlates Regulation Differences with EM Pathway References Acknowledgements 2-2-2013
  3. 3. Phosphogluconate Pathway Pentose Cycle Hexose Monophosphate Pathway or Shunt Warburg-Dickens-Lipman Pathway 2-2-2013
  4. 4.  The process which brings about oxidation & decarboxylation at C-1 of Glucose 6phosphate, reducing NADP+ to NADPH & producing Pentose Phosphates. 2-2-2013
  5. 5. 2-2-2013
  6. 6. Liver Lactating Mammary Gland Adrenal Cortex Gonads Adipose Tissue Erythrocytes Lens & Cornea 2-2-2013
  7. 7. It has 2 main functions: Provides NADPH Provides PENTOSES Though there is oxidation of Glucose,but it is NOT meant for Energy. 2-2-2013
  8. 8.  It 1) 2) has 2 Phases: Oxidative Phase Non-Oxidative Phase 2-2-2013
  9. 9. Glucose 6-Phosphate Glucose 6-phosphate NADP+ Dehydrogenase Mg++ NADPH+H 6-phosphogluconolactone 6-phosphoglucolactonase H2O Mg++ H+ 6-phosphogluconate 2-2-2013
  10. 10. 6-phosphogluconate 6-phosphogluconate NADP+ Dehydrogenase Mg++ NADPH+H 3-Keto-6-phosphogluconate D-Ribulose 5-phosphate + CO2 2-2-2013
  11. 11. D-Ribulose 5-Phosphate Phosphopentose Isomerase D-Ribose 5-phosphate D-Ribose-1-P D-Ribose-1,5-di-P 2-2-2013
  12. 12. D-Ribulose-5-P Phosphopentose Epimerase D-Xylulose-5-Phosphate 2-2-2013
  13. 13. 2 Particular Enzymes are required: 1)TRANSKETOLASE 2)TRANSALDOLASE 2-2-2013
  14. 14. 1) Xylulose-5-P+Ribose-5-P Transketolase TPP Sedoheptolose 7-Phosphate + Glyceraldehyde-3-Phosphate 2-2-2013
  15. 15. Sedoheptolose 7-P+G3P Transaldolase Fructose 6-Phosphate + Erythrose 4-Phosphate 2-2-2013
  16. 16. 2)Xylulose 5-P+Erythrose 4-P Transketolase TPP Fructose 6-Phosphate +G3P Dihydroxy-acetone-P+G3P Recycles the Pathway Glucose-6-P Fructose-1,6-bi-P Fructose-6-P 2-2-2013
  17. 17. G-6-PD deficiency results in: Heamolytic Aneamia Neonatal Kidney Jaundice failure 2-2-2013
  18. 18. Mutation in gene coding for G6PD, production of NADPH decreases,low level of reduced glutathione--accumulation of H2O2---RBC’s memb. bursts---Heamolysis. Oxidant group of drugs e.g, Antimalarials,Analgesics,Antipyretics & Sulpha antibiotics. Fava beans. 2-2-2013
  19. 19.  Genetically variant form of Transketolase. It can’t bind TPP, affecting “transketolation” reaction.  Symptoms are:  Mental disorders  Severe memory loss  Partial paralysis 2-2-2013
  20. 20. Results in: Liver cirrhosis Male infertility 2-2-2013
  21. 21. Occurs in 3 ways: a) Ratio of [NADP+][NADPH] _1st Step is Rate-limiting step catalysed by G6PD. b) Increased HMP Shunt on feeding high CHO diet & decreased in Diabetes Mellitus c)HORMONES: Insulin & Thyroid hormones 2-2-2013
  22. 22.  Occurs in all tissues  Not a multi cyclic process  NAD+ is H+ acceptor  ATP production  CO2 is never formed EM PATHWAY Occurs in certain special tissues Multi cyclic process NADP+ is H+ acceptor ATP is not produced CO2 is produced HM PATHWAY 2-2-2013
  23. 23. Lehninger Principles of Biochemistry 5th edition,Pg.no 558-563 Biochemistry by Thomas M.Devlin 7th edition,Pg.no 648-652 Harper’s Illustrated Biochemistry 29th edition,Pg.no 197-204 Medical Biochemistry by MN.Chatterjea 8th edition,Pg.no 354-360 2-2-2013
  24. 24. THANK YOU 2-2-2013
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×