Hmp shunt

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  • 1. 2-2-2013
  • 2. LaY Out           Other names Definition Occurence & Tissue Distribution Biomedical Importance Metabolic Pathway Clinical Correlates Regulation Differences with EM Pathway References Acknowledgements 2-2-2013
  • 3. Phosphogluconate Pathway Pentose Cycle Hexose Monophosphate Pathway or Shunt Warburg-Dickens-Lipman Pathway 2-2-2013
  • 4.  The process which brings about oxidation & decarboxylation at C-1 of Glucose 6phosphate, reducing NADP+ to NADPH & producing Pentose Phosphates. 2-2-2013
  • 5. 2-2-2013
  • 6. Liver Lactating Mammary Gland Adrenal Cortex Gonads Adipose Tissue Erythrocytes Lens & Cornea 2-2-2013
  • 7. It has 2 main functions: Provides NADPH Provides PENTOSES Though there is oxidation of Glucose,but it is NOT meant for Energy. 2-2-2013
  • 8.  It 1) 2) has 2 Phases: Oxidative Phase Non-Oxidative Phase 2-2-2013
  • 9. Glucose 6-Phosphate Glucose 6-phosphate NADP+ Dehydrogenase Mg++ NADPH+H 6-phosphogluconolactone 6-phosphoglucolactonase H2O Mg++ H+ 6-phosphogluconate 2-2-2013
  • 10. 6-phosphogluconate 6-phosphogluconate NADP+ Dehydrogenase Mg++ NADPH+H 3-Keto-6-phosphogluconate D-Ribulose 5-phosphate + CO2 2-2-2013
  • 11. D-Ribulose 5-Phosphate Phosphopentose Isomerase D-Ribose 5-phosphate D-Ribose-1-P D-Ribose-1,5-di-P 2-2-2013
  • 12. D-Ribulose-5-P Phosphopentose Epimerase D-Xylulose-5-Phosphate 2-2-2013
  • 13. 2 Particular Enzymes are required: 1)TRANSKETOLASE 2)TRANSALDOLASE 2-2-2013
  • 14. 1) Xylulose-5-P+Ribose-5-P Transketolase TPP Sedoheptolose 7-Phosphate + Glyceraldehyde-3-Phosphate 2-2-2013
  • 15. Sedoheptolose 7-P+G3P Transaldolase Fructose 6-Phosphate + Erythrose 4-Phosphate 2-2-2013
  • 16. 2)Xylulose 5-P+Erythrose 4-P Transketolase TPP Fructose 6-Phosphate +G3P Dihydroxy-acetone-P+G3P Recycles the Pathway Glucose-6-P Fructose-1,6-bi-P Fructose-6-P 2-2-2013
  • 17. G-6-PD deficiency results in: Heamolytic Aneamia Neonatal Kidney Jaundice failure 2-2-2013
  • 18. Mutation in gene coding for G6PD, production of NADPH decreases,low level of reduced glutathione--accumulation of H2O2---RBC’s memb. bursts---Heamolysis. Oxidant group of drugs e.g, Antimalarials,Analgesics,Antipyretics & Sulpha antibiotics. Fava beans. 2-2-2013
  • 19.  Genetically variant form of Transketolase. It can’t bind TPP, affecting “transketolation” reaction.  Symptoms are:  Mental disorders  Severe memory loss  Partial paralysis 2-2-2013
  • 20. Results in: Liver cirrhosis Male infertility 2-2-2013
  • 21. Occurs in 3 ways: a) Ratio of [NADP+][NADPH] _1st Step is Rate-limiting step catalysed by G6PD. b) Increased HMP Shunt on feeding high CHO diet & decreased in Diabetes Mellitus c)HORMONES: Insulin & Thyroid hormones 2-2-2013
  • 22.  Occurs in all tissues  Not a multi cyclic process  NAD+ is H+ acceptor  ATP production  CO2 is never formed EM PATHWAY Occurs in certain special tissues Multi cyclic process NADP+ is H+ acceptor ATP is not produced CO2 is produced HM PATHWAY 2-2-2013
  • 23. Lehninger Principles of Biochemistry 5th edition,Pg.no 558-563 Biochemistry by Thomas M.Devlin 7th edition,Pg.no 648-652 Harper’s Illustrated Biochemistry 29th edition,Pg.no 197-204 Medical Biochemistry by MN.Chatterjea 8th edition,Pg.no 354-360 2-2-2013
  • 24. THANK YOU 2-2-2013