The x86 instruction set architecture began with Intel's 16-bit processors in the 1980s and has since evolved through numerous extensions. It supports multiple execution modes including 16-bit real mode, 32-bit protected mode, and 64-bit long mode. The instruction format includes optional prefixes, opcode bytes, addressing fields, and immediate data. General purpose registers are used for operands along with memory addressing modes. Subsequent x86 architectures, such as AMD64, expanded register sizes and added new instructions while maintaining backwards compatibility.