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By Linda Guzman
Preview of Main Points

• What it is?

• Its history

• Pathology – transmission

• Symptoms

• Preventative measures
What is the WNV?


• Flaviviridae family

• Icosahedral envelope – RNA

• 40-60 nm in size
WNV History
• 1937 – West Nile District of Uganda

• Africa, Middle East, Eastern Europe, West
  Asia

• New York City 1999 – First case
WNV History
• 1999 – 62 cases and 7 deaths
WNV 2004
WNV 2011
• Every US state has reported a WNV case
WNV Global
Seasonal Disease

• Active during mosquito breeding season

• Spring till the end of August
Pathology
• Zoonotic
• Replicates in salivary glands
• Culex pipiens mosquito - the common house
  mosquito
Transmission Cycle
Interesting Fact
• Europe – two types of Culex pipien population

• America – mosquito population has evolved

• Spread faster in America
Transmission
• Dead end host
• Per CDC – OK to
 breast feed
• Infected mosquito
 bites a human
Pathology
• Keratinocyte and dendritic
  cell in basal layer
• Dendritic cells travels to
  lymph nodes – 1st virus
  replication
• Epithelial cells of visceral
  organs – 2nd virus replication
Pathology
• Viremia triggers production of proteins &
  enzymes
• Weaken tight junction of BBB
Pathology
• Neurons and glial cells infected
• Triggers cells narcosis = inflammation
• Encephalitis – inflammation of brain
• Meningitis – inflammation of meninges spinal cord
Who’s at Risk?
• Children, elderly,
  compromised immune
  system

• Over 50yo especially over
  75yo – more at risk –
  morbidity and mortality
Symptoms

• 3 to 14 days after infection
• 80% show no symptoms
• 20% show acute symptoms – mild, last couple of
  days
   – Fever, headache, body aches, nausea, vomiting, rash &
     swollen lymph glands
Symptoms
• Out of 20% only 1% show
 severe symptoms
  – Tremors, stiff neck, high fever,
    severe headache, paralysis,
    muscle weakness, confusion,
    convulsion, coma, encephalitis
    or meningitis
Cure?

• There is not cure for WNV

• But there is one for horses

• Best way to protect is prevention
Prevention
• Stay indoors during dusk & dawn hours

• Long sleeves and long pants

• Insect repellent 10-30% DEET - mosquitoes
 can still bite thru thin material
Prevention
• Dispose stagnant water
Works Cited
Byron E. E. Martina, et al. "West Nile Virus: Immunity and Pathogenesis." Viruses (1999-4915) 3.6
    (2011): 811-828. Academic Search Complete. EBSCO. Web. 28 Sept. 2011.
Gerardi, Michael H., and Melvin C. Zimmerman. Wastewater Pathogens. John Wiley & Sons, Inc. (US),
    2005. eBook Collection (EBSCOhost). EBSCO. Web. 28 Sept. 2011.
Hoyle, Brian. "West Nile." Infectious Diseases: In Context. Ed. Brenda Wilmoth Lerner and K. Lee Lerner.
    Vol. 2. Detroit: Gale, 2008. 899-905. Gale Virtual Reference Library. Web.
Quick, Jennifer, and J. P. Saleeby. "The Mighty Mosquito-borne Killer." American Fitness 25.4 (2007):
    26-29. Health Source - Consumer Edition. EBSCO. Web. 29 Sept. 2011.
"West Nile Virus." CRS - Pediatric Advisor (2010): 1. Health Source - Consumer Edition. EBSCO. Web. 29
    Sept. 2011.

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WNV

  • 2. Preview of Main Points • What it is? • Its history • Pathology – transmission • Symptoms • Preventative measures
  • 3. What is the WNV? • Flaviviridae family • Icosahedral envelope – RNA • 40-60 nm in size
  • 4. WNV History • 1937 – West Nile District of Uganda • Africa, Middle East, Eastern Europe, West Asia • New York City 1999 – First case
  • 5. WNV History • 1999 – 62 cases and 7 deaths
  • 7. WNV 2011 • Every US state has reported a WNV case
  • 9. Seasonal Disease • Active during mosquito breeding season • Spring till the end of August
  • 10. Pathology • Zoonotic • Replicates in salivary glands • Culex pipiens mosquito - the common house mosquito
  • 12. Interesting Fact • Europe – two types of Culex pipien population • America – mosquito population has evolved • Spread faster in America
  • 13. Transmission • Dead end host • Per CDC – OK to breast feed • Infected mosquito bites a human
  • 14. Pathology • Keratinocyte and dendritic cell in basal layer • Dendritic cells travels to lymph nodes – 1st virus replication • Epithelial cells of visceral organs – 2nd virus replication
  • 15. Pathology • Viremia triggers production of proteins & enzymes • Weaken tight junction of BBB
  • 16. Pathology • Neurons and glial cells infected • Triggers cells narcosis = inflammation • Encephalitis – inflammation of brain • Meningitis – inflammation of meninges spinal cord
  • 17. Who’s at Risk? • Children, elderly, compromised immune system • Over 50yo especially over 75yo – more at risk – morbidity and mortality
  • 18. Symptoms • 3 to 14 days after infection • 80% show no symptoms • 20% show acute symptoms – mild, last couple of days – Fever, headache, body aches, nausea, vomiting, rash & swollen lymph glands
  • 19. Symptoms • Out of 20% only 1% show severe symptoms – Tremors, stiff neck, high fever, severe headache, paralysis, muscle weakness, confusion, convulsion, coma, encephalitis or meningitis
  • 20. Cure? • There is not cure for WNV • But there is one for horses • Best way to protect is prevention
  • 21. Prevention • Stay indoors during dusk & dawn hours • Long sleeves and long pants • Insect repellent 10-30% DEET - mosquitoes can still bite thru thin material
  • 23. Works Cited Byron E. E. Martina, et al. "West Nile Virus: Immunity and Pathogenesis." Viruses (1999-4915) 3.6 (2011): 811-828. Academic Search Complete. EBSCO. Web. 28 Sept. 2011. Gerardi, Michael H., and Melvin C. Zimmerman. Wastewater Pathogens. John Wiley & Sons, Inc. (US), 2005. eBook Collection (EBSCOhost). EBSCO. Web. 28 Sept. 2011. Hoyle, Brian. "West Nile." Infectious Diseases: In Context. Ed. Brenda Wilmoth Lerner and K. Lee Lerner. Vol. 2. Detroit: Gale, 2008. 899-905. Gale Virtual Reference Library. Web. Quick, Jennifer, and J. P. Saleeby. "The Mighty Mosquito-borne Killer." American Fitness 25.4 (2007): 26-29. Health Source - Consumer Edition. EBSCO. Web. 29 Sept. 2011. "West Nile Virus." CRS - Pediatric Advisor (2010): 1. Health Source - Consumer Edition. EBSCO. Web. 29 Sept. 2011.