An introduction of West Nile Virus, including west nile virus symptoms,transmission,prevention,and treatment.

1. West Nile Virus

2.  West Nile virus commonly spreads to people by
mosquito bites.
 Found in Africa, Europe, the Middle East, North
America and West Asia.
 Occur during mosquito season, which starts in the
summer and continues through fall.

3.  West Nile Virus is a member of the flavivirus genus and belongs to the Japanese
encephalitis antigenic complex of the family Flaviviridae.

4. Serology
 Japanese encephalitis serocomplex
1. West Nile Virus
2. Japanese Encephalitis Virus
3. St Louis Encephalitis Virus
 Only lineage 1 and 2 West Nile Viruses have
Been associated with significant outbreaks in humans.

5. Transmission Cycles

6. No symptoms/conditions
West Nile Fever
Fever, Headache, Fatigue,
Body Aches, nausea, vomiting,
skin rash
West Nile Encephalitis
High Fever, Severe Headache, Stiff
Neck, Disorientation, Stupor,
Coma, Tremors, Convulsions,
Muslce weakness
79%
20%
1%
Signs and symptoms

7. Viral Structure
Ribbon diagram of the crystal structure of WNV E
ectodomain residues 1–400 colored by domain: DI
(red), DII (yellow), and DIII (blue). The fusion loop
(residues 98–110) is shown in green;
Pseudoatomic cryo EM
reconstruction model of the
mature WNV virion;
Pseudoatomic cryo EM
reconstruction model of
the immature WNV virion.

8. Diagnosis
 IgG antibody - ELISA;
 IgM antibody - ELISA;
 Neutralisation assays;
 Viral detection - RT-PCR;
 Virus isolation by cell culture.

9. Treatment

10. Prevention

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