What Is Sepsis
•
14 likes•16,419 views
The document discusses various topics related to sepsis including: 1) Definitions of terms like SIRS, sepsis, septic shock, and their associated signs and symptoms. 2) The inflammatory cascades that occur in response to infection and lead to organ dysfunction. 3) How sepsis affects different organs in the body like the brain, heart, lungs, kidneys, and liver. 4) Two theories for the origin of sepsis - the gut origin theory and lung origin theory. 5) The role of activated protein C in reducing thrombin production and inflammation.
Report
Share
Report
Share
![What is Sepsis? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]](https://image.slidesharecdn.com/whatissepsis-090401162009-phpapp02/85/What-Is-Sepsis-1-320.jpg)
![Clinical Approach Scenario 1 ,[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommended
Path physiology of sepsis. SIRS & MOF
The document discusses the pathophysiology of sepsis and multiple organ dysfunction syndrome (MODS). It defines sepsis, SIRS, severe sepsis, and septic shock. Mediators of the septic response include pro-inflammatory and anti-inflammatory factors. Sepsis can lead to organ injury and failure through mechanisms like ischemia, apoptosis, leukocyte-mediated tissue damage, and cytopathic hypoxia. Therapies aim to optimize organ perfusion, control infection, and support dysfunctional organs. Experimental therapies target modulating the host inflammatory response but many past attempts showed little benefit. Evidence-based guidelines incorporate best practices for early recognition, resuscitation, and management of sepsis patients.
Sepsis syndrome
Sepsis syndrome is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. It ranges from sepsis to severe sepsis to septic shock. The pathophysiology involves a complex interaction between pathogens and the host's inflammatory response that results in widespread endothelial damage and microvascular thrombosis leading to multiple organ dysfunction. Management involves early recognition, source control, antibiotics, fluid resuscitation and monitoring for organ dysfunction. Despite treatment, sepsis syndrome remains associated with high morbidity and mortality rates.
Sirs Mods
The document discusses systemic inflammatory response syndrome (SIRS) and its relationship to sepsis. It defines SIRS as a systemic response to various stresses and outlines its diagnostic criteria. SIRS can progress to sepsis if an infection is involved. Sepsis is defined as a systemic response to infection along with signs of organ dysfunction. More severe stages include severe sepsis and septic shock. Risk factors, sources of infection, and specific infectious agents associated with sepsis are also reviewed.
Sepsis, SIRS & Septic Shock
This document summarizes definitions and guidelines for the diagnosis and management of sepsis. It defines sepsis as a clinical syndrome resulting from infection along with systemic inflammatory response syndrome (SIRS). The onset of sepsis focuses on dysregulation of inflammation and can lead to multiple organ dysfunction syndrome (MODS) and high mortality. Diagnostic criteria for sepsis require confirmed or suspected infection along with general, inflammatory, hemodynamic, or organ dysfunction variables. Management of severe sepsis and septic shock prioritizes early supportive care to correct hypoxemia and hypotension, rapid fluid resuscitation, vasopressors if hypotension persists, and control of the septic focus. Early goal-directed resuscitation aims to optimize perfusion parameters like mean
Septic shock
This document provides definitions and guidelines for the management of septic shock. It begins with definitions of terms like SIRS, sepsis, septic shock, and qSOFA. It then discusses the pathophysiology of sepsis, including the host immune response and organ dysfunction. Manifestations across organ systems are outlined. Recommended markers for sepsis diagnosis are described. Treatment protocols emphasize early fluid resuscitation, screening programs, appropriate cultures before antibiotics, initiating broad-spectrum antibiotics within 1 hour, and optimizing antibiotic dosing and duration. Combination empiric therapy for septic shock may be considered but should be de-escalated once infection is controlled.
Sepsis
Systemic inflammatory response syndrome (SIRS) is a clinical syndrome characterized by a dysregulated inflammatory response that can be caused by infectious or noninfectious processes. Sepsis is defined as SIRS caused by a confirmed or suspected infection. As sepsis progresses it can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS). Key aspects of managing sepsis include early identification of infection, administering antibiotics, and supporting vital organ function by correcting hypoxemia, hypotension, and hypoperfusion. Investigations should identify the source of infection and assess organ dysfunction, while priorities of treatment are stabilizing respiration and circulation followed by identifying and treating the underlying infection.
sepsis pharmacotherapy
contents included are introduction, progression of sepsis, clinical presentation, diagnosis, treatment, and prevention of sepsis
Sepsis. dr.vinod kumar
The document provides information on sepsis definitions, pathophysiology, and assessment tools. It discusses:
1) The 1992 and 2001 consensus definitions of sepsis, severe sepsis, and septic shock based on SIRS criteria and organ dysfunction.
2) The key pathophysiological processes in sepsis including dysregulated inflammation, coagulation, fibrinolysis and endothelial dysfunction which can lead to organ failure.
3) Limitations of the SIRS criteria and introduction of newer assessment tools like qSOFA and SOFA score which include clinical variables and lab markers to better predict patient outcomes.
Recommended
Path physiology of sepsis. SIRS & MOF
The document discusses the pathophysiology of sepsis and multiple organ dysfunction syndrome (MODS). It defines sepsis, SIRS, severe sepsis, and septic shock. Mediators of the septic response include pro-inflammatory and anti-inflammatory factors. Sepsis can lead to organ injury and failure through mechanisms like ischemia, apoptosis, leukocyte-mediated tissue damage, and cytopathic hypoxia. Therapies aim to optimize organ perfusion, control infection, and support dysfunctional organs. Experimental therapies target modulating the host inflammatory response but many past attempts showed little benefit. Evidence-based guidelines incorporate best practices for early recognition, resuscitation, and management of sepsis patients.
Sepsis syndrome
Sepsis syndrome is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. It ranges from sepsis to severe sepsis to septic shock. The pathophysiology involves a complex interaction between pathogens and the host's inflammatory response that results in widespread endothelial damage and microvascular thrombosis leading to multiple organ dysfunction. Management involves early recognition, source control, antibiotics, fluid resuscitation and monitoring for organ dysfunction. Despite treatment, sepsis syndrome remains associated with high morbidity and mortality rates.
Sirs Mods
The document discusses systemic inflammatory response syndrome (SIRS) and its relationship to sepsis. It defines SIRS as a systemic response to various stresses and outlines its diagnostic criteria. SIRS can progress to sepsis if an infection is involved. Sepsis is defined as a systemic response to infection along with signs of organ dysfunction. More severe stages include severe sepsis and septic shock. Risk factors, sources of infection, and specific infectious agents associated with sepsis are also reviewed.
Sepsis, SIRS & Septic Shock
This document summarizes definitions and guidelines for the diagnosis and management of sepsis. It defines sepsis as a clinical syndrome resulting from infection along with systemic inflammatory response syndrome (SIRS). The onset of sepsis focuses on dysregulation of inflammation and can lead to multiple organ dysfunction syndrome (MODS) and high mortality. Diagnostic criteria for sepsis require confirmed or suspected infection along with general, inflammatory, hemodynamic, or organ dysfunction variables. Management of severe sepsis and septic shock prioritizes early supportive care to correct hypoxemia and hypotension, rapid fluid resuscitation, vasopressors if hypotension persists, and control of the septic focus. Early goal-directed resuscitation aims to optimize perfusion parameters like mean
Septic shock
This document provides definitions and guidelines for the management of septic shock. It begins with definitions of terms like SIRS, sepsis, septic shock, and qSOFA. It then discusses the pathophysiology of sepsis, including the host immune response and organ dysfunction. Manifestations across organ systems are outlined. Recommended markers for sepsis diagnosis are described. Treatment protocols emphasize early fluid resuscitation, screening programs, appropriate cultures before antibiotics, initiating broad-spectrum antibiotics within 1 hour, and optimizing antibiotic dosing and duration. Combination empiric therapy for septic shock may be considered but should be de-escalated once infection is controlled.
Sepsis
Systemic inflammatory response syndrome (SIRS) is a clinical syndrome characterized by a dysregulated inflammatory response that can be caused by infectious or noninfectious processes. Sepsis is defined as SIRS caused by a confirmed or suspected infection. As sepsis progresses it can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS). Key aspects of managing sepsis include early identification of infection, administering antibiotics, and supporting vital organ function by correcting hypoxemia, hypotension, and hypoperfusion. Investigations should identify the source of infection and assess organ dysfunction, while priorities of treatment are stabilizing respiration and circulation followed by identifying and treating the underlying infection.
sepsis pharmacotherapy
contents included are introduction, progression of sepsis, clinical presentation, diagnosis, treatment, and prevention of sepsis
Sepsis. dr.vinod kumar
The document provides information on sepsis definitions, pathophysiology, and assessment tools. It discusses:
1) The 1992 and 2001 consensus definitions of sepsis, severe sepsis, and septic shock based on SIRS criteria and organ dysfunction.
2) The key pathophysiological processes in sepsis including dysregulated inflammation, coagulation, fibrinolysis and endothelial dysfunction which can lead to organ failure.
3) Limitations of the SIRS criteria and introduction of newer assessment tools like qSOFA and SOFA score which include clinical variables and lab markers to better predict patient outcomes.
Sepsis
Sepsis is a systemic inflammatory response to infection that can lead to organ dysfunction and death. It is a major cause of death in intensive care units. The incidence of sepsis is rising due to an aging population and increased use of invasive medical procedures and devices. Sepsis progresses through a spectrum from systemic inflammatory response syndrome to severe sepsis with organ dysfunction to septic shock with hypotension and perfusion abnormalities if not treated promptly.
Sepsis And Septic Shock
The document discusses concepts related to sepsis, severe sepsis, and septic shock. It provides statistics on the incidence and mortality of these conditions. It also describes the pathophysiology of sepsis, including the roles of inflammation, coagulation abnormalities, and hemodynamic changes. Potential mediators such as cytokines, nitric oxide, and endotoxin are examined in the development of septic shock.
Acute Sepsis - Emergency Management
This powerpoint (ppt) presentation describes in details Pathophysiology and Management of Acute Sepsis in Emergency Department. Acute sepsis has 30% mortality and further more Septic Shock has 50% mortality if untreated. It is the job of Emergency Physician to recognise and treat Sepsis in time.
Septicemia/Sepsis Slides
This document provides information about an upcoming webinar on documenting and coding septicemia and sepsis. The webinar will have three panels on documenting sepsis, coding and audits for sepsis, and appealing denials for sepsis cases. It also includes detailed clinical information on defining and diagnosing sepsis, systemic inflammatory response syndrome, organ dysfunction, and coding guidelines for infectious versus non-infectious causes of sepsis.
Management of sepsis and septic shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The document discusses key concepts of sepsis including that it is a leading cause of death from infection worldwide. It also outlines the reasons for revising previous definitions of sepsis, including advances in understanding its pathobiology and the need to distinguish sepsis from uncomplicated infection. The new Sepsis-3 definitions and clinical criteria for identifying sepsis and septic shock are presented.
Sepsis Updates
This document provides an overview of sepsis, including its definitions, epidemiology, pathophysiology, clinical manifestations, complications, diagnosis, and management. It notes that sepsis is a systemic inflammatory response to infection that can lead to life-threatening organ dysfunction. An estimated 750,000 cases of severe sepsis and septic shock occur annually in the US, with over 200,000 deaths. The pathophysiology involves a complex interplay between the host's immune response and invading pathogens. Diagnosis is challenging as there is no single diagnostic test, but suspected cases should be promptly investigated and treated.
Septic shock sirs and mof
presentation on SIRS septic shock and multiorgan failure,and their corelation together in increasing morbidity and mortalitiy in shocked patient explaning pathophysiology clinical picture and how to manage
Sirs
The document discusses systemic inflammatory response syndrome (SIRS) which can be triggered by infection or non-infectious causes like trauma. SIRS is characterized by changes in vital signs and white blood cell count. If associated with infection, it is called sepsis. Severe sepsis involves organ dysfunction while septic shock requires life support interventions. SIRS leads to an exaggerated inflammatory response that can damage multiple organs and lead to multiple organ dysfunction syndrome (MODS) if not treated promptly with antibiotics, fluids, and other supportive care measures.
Systemic Inflammatory Response Syndrome SIRS and Septicemia
Systemic Inflammatory Response Syndrome SIRS and Septicemia - SOFA score APACHE score MODS Failure DIC
SIRS, MODS, Sepsis
The document discusses a case of sepsis in an elderly woman who presented with urinary tract infection, dehydration, and organ dysfunction and eventually succumbed to her illness. It then provides definitions and descriptions of terms related to systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS). The pathophysiology of sepsis and progression to organ failure is explained as being driven by a dysregulated inflammatory response and endothelial dysfunction leading to tissue hypoperfusion and injury.
Sepsis
The document discusses definitions and classifications of sepsis, severe sepsis, and septic shock according to the ACCP/SCCM. It provides details on the pathogenesis, screening, and goals of early goal directed therapy for severe sepsis and septic shock. The therapy involves early diagnosis, source control, antibiotics within 1 hour, hemodynamic stabilization through fluid resuscitation and vasopressors to achieve certain goals within 6 hours.
Approach to sepsis- a primary physician perspective
1. The document discusses guidelines for the approach to sepsis management, including definitions of sepsis, severe sepsis, septic shock, and clinical impact.
2. It provides recommendations for initial resuscitation, diagnosis and antibiotic therapy, including performing early goal-directed therapy, administering early appropriate antibiotics and fluids, and taking early cultures and lactate levels.
3. Bundles are outlined to be completed within 3 and 6 hours, including measures like administering broad-spectrum antibiotics, fluid resuscitation, vasopressors, and measuring lactate, CVP and ScvO2.
New definition of sepsis... sepsis 3
The document discusses proposed changes to the definitions of sepsis, septic shock, and related terms based on recent evidence and consensus guidelines. It summarizes the new definitions as follows:
1) Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, assessed using a SOFA score ≥ 2 points.
2) Septic shock involves profound circulatory and cellular abnormalities indicated by persisting hypotension requiring vasopressors and serum lactate >2mmol/L, despite adequate fluid resuscitation.
3) Terms like "severe sepsis" are removed, and quick SOFA (qSOFA) criteria are suggested for evaluating sepsis outside the ICU.
Sepsis 3
The document discusses definitions of systemic inflammatory response syndrome (SIRS), sepsis, septic shock, and new criteria proposed in Sepsis-3. SIRS criteria are nonspecific and can occur with non-infectious conditions. Sepsis is defined as a dysregulated host response to infection leading to organ dysfunction. Septic shock is a subset of sepsis with circulatory and metabolic abnormalities increasing mortality risk. New definitions propose sepsis be defined as a life-threatening organ dysfunction caused by a dysregulated response to infection. Septic shock is defined by hypotension requiring vasopressors and hyperlactatemia above 2 mmol/L despite fluid resuscitation.
Sirs
The document discusses systemic inflammatory response syndrome (SIRS) and defines it as a systemic response to various stresses that includes symptoms like fever, increased heart rate, respiratory rate and white blood cell count. It outlines the progression from infection to bacteremia to sepsis, which involves SIRS criteria and a suspected or proven infection. The stages of sepsis like severe sepsis, septic shock and refractory septic shock are defined based on the presence of organ dysfunction or hypotension.
Sepsis & Septic Shock
The document discusses shock and sepsis. It defines shock as a clinical condition characterized by a fast pulse rate and low blood pressure. The main types of shock discussed are hypovolemic, cardiogenic, septic, anaphylactic, and neurogenic. Sepsis is defined as a life-threatening organ dysfunction caused by the body's response to an infection. As sepsis progresses it can lead to septic shock, which is associated with high mortality. The stages of shock and signs and symptoms of early and late sepsis are also summarized.
Sepsis
Sepsis is a serious medical condition caused by the body's response to an infection. It affects over 750,000 people in the US each year and is one of the top causes of death. Risk factors include intravenous lines, mechanical ventilation, recent surgery, and immunosuppression. The pathophysiology involves the systemic inflammatory response syndrome leading to organ damage and shock. Diagnosis is based on confirming an infection along with signs of altered organ function or tissue hypoperfusion. Treatment involves early antibiotic therapy and fluid resuscitation to treat shock and prevent further organ damage.
Sepsis
This document discusses sepsis, septicemia, and multiple organ dysfunction syndrome (MODS). It defines related terms like bacteremia, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock. It discusses the magnitude of the problem globally and in India. It covers the pathophysiology and most common sources of infection. It also summarizes the Surviving Sepsis Campaign guidelines for management of sepsis and septic shock. Finally, it provides an overview of recent advances and controversies in the field and lists various biomarkers that can be used for diagnosis, prognosis, and stratification of sepsis severity.
Sepsis 3
Latest definition of sepsis, application of qSOFA, latest evidence on treatment of septic shock,role of fluids, role of steroids, isobalance salt solution
Sepsis and Septic shock
This document discusses sepsis and septic shock. It defines severe sepsis as acute organ dysfunction caused by infection, and septic shock as sepsis with hypotension refractory to fluid resuscitation requiring vasopressors. Common infection sites include the respiratory tract, intra-abdominal space, and urinary tract. Gram-positive and gram-negative bacteria, as well as fungi, can cause sepsis. The pathophysiology involves an initial inflammatory response that can lead to organ damage and dysfunction if not controlled. Complications include disseminated intravascular coagulation, acute respiratory distress syndrome, and acute renal failure. Treatment involves identifying and treating the infection source along with early, targeted antimicrobial therapy and organ support.
Sepsis power point presentation
This document provides information on sepsis for EMS providers, including causes and risk factors, signs and symptoms, treatment guidelines, and case studies. Sepsis is a serious condition that can lead to septic shock and organ failure if not treated quickly. The guidelines describe identifying septic patients in the field using specific criteria and initiating fluid resuscitation and transport to the hospital for early goal directed therapy to improve outcomes. Case studies demonstrate application of the guidelines and emphasize importance of early recognition and treatment.
Septic shock
The document outlines septic shock, including its definition, classification, epidemiology, pathogenesis, clinical features, investigation, treatment, complications, prognosis and prevention. Septic shock results from a systemic inflammatory response due to infection and can lead to multiple organ dysfunction. Prompt resuscitation, antibiotics, source control and organ support are crucial for treatment, but mortality remains high, especially in patients with multiple organ dysfunction or failure to respond to therapy. Early recognition and treatment of infection helps reduce risks of septic shock.
More Related Content
What's hot
Sepsis
Sepsis is a systemic inflammatory response to infection that can lead to organ dysfunction and death. It is a major cause of death in intensive care units. The incidence of sepsis is rising due to an aging population and increased use of invasive medical procedures and devices. Sepsis progresses through a spectrum from systemic inflammatory response syndrome to severe sepsis with organ dysfunction to septic shock with hypotension and perfusion abnormalities if not treated promptly.
Sepsis And Septic Shock
The document discusses concepts related to sepsis, severe sepsis, and septic shock. It provides statistics on the incidence and mortality of these conditions. It also describes the pathophysiology of sepsis, including the roles of inflammation, coagulation abnormalities, and hemodynamic changes. Potential mediators such as cytokines, nitric oxide, and endotoxin are examined in the development of septic shock.
Acute Sepsis - Emergency Management
This powerpoint (ppt) presentation describes in details Pathophysiology and Management of Acute Sepsis in Emergency Department. Acute sepsis has 30% mortality and further more Septic Shock has 50% mortality if untreated. It is the job of Emergency Physician to recognise and treat Sepsis in time.
Septicemia/Sepsis Slides
This document provides information about an upcoming webinar on documenting and coding septicemia and sepsis. The webinar will have three panels on documenting sepsis, coding and audits for sepsis, and appealing denials for sepsis cases. It also includes detailed clinical information on defining and diagnosing sepsis, systemic inflammatory response syndrome, organ dysfunction, and coding guidelines for infectious versus non-infectious causes of sepsis.
Management of sepsis and septic shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The document discusses key concepts of sepsis including that it is a leading cause of death from infection worldwide. It also outlines the reasons for revising previous definitions of sepsis, including advances in understanding its pathobiology and the need to distinguish sepsis from uncomplicated infection. The new Sepsis-3 definitions and clinical criteria for identifying sepsis and septic shock are presented.
Sepsis Updates
This document provides an overview of sepsis, including its definitions, epidemiology, pathophysiology, clinical manifestations, complications, diagnosis, and management. It notes that sepsis is a systemic inflammatory response to infection that can lead to life-threatening organ dysfunction. An estimated 750,000 cases of severe sepsis and septic shock occur annually in the US, with over 200,000 deaths. The pathophysiology involves a complex interplay between the host's immune response and invading pathogens. Diagnosis is challenging as there is no single diagnostic test, but suspected cases should be promptly investigated and treated.
Septic shock sirs and mof
presentation on SIRS septic shock and multiorgan failure,and their corelation together in increasing morbidity and mortalitiy in shocked patient explaning pathophysiology clinical picture and how to manage
Sirs
The document discusses systemic inflammatory response syndrome (SIRS) which can be triggered by infection or non-infectious causes like trauma. SIRS is characterized by changes in vital signs and white blood cell count. If associated with infection, it is called sepsis. Severe sepsis involves organ dysfunction while septic shock requires life support interventions. SIRS leads to an exaggerated inflammatory response that can damage multiple organs and lead to multiple organ dysfunction syndrome (MODS) if not treated promptly with antibiotics, fluids, and other supportive care measures.
Systemic Inflammatory Response Syndrome SIRS and Septicemia
Systemic Inflammatory Response Syndrome SIRS and Septicemia - SOFA score APACHE score MODS Failure DIC
SIRS, MODS, Sepsis
The document discusses a case of sepsis in an elderly woman who presented with urinary tract infection, dehydration, and organ dysfunction and eventually succumbed to her illness. It then provides definitions and descriptions of terms related to systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome (MODS). The pathophysiology of sepsis and progression to organ failure is explained as being driven by a dysregulated inflammatory response and endothelial dysfunction leading to tissue hypoperfusion and injury.
Sepsis
The document discusses definitions and classifications of sepsis, severe sepsis, and septic shock according to the ACCP/SCCM. It provides details on the pathogenesis, screening, and goals of early goal directed therapy for severe sepsis and septic shock. The therapy involves early diagnosis, source control, antibiotics within 1 hour, hemodynamic stabilization through fluid resuscitation and vasopressors to achieve certain goals within 6 hours.
Approach to sepsis- a primary physician perspective
1. The document discusses guidelines for the approach to sepsis management, including definitions of sepsis, severe sepsis, septic shock, and clinical impact.
2. It provides recommendations for initial resuscitation, diagnosis and antibiotic therapy, including performing early goal-directed therapy, administering early appropriate antibiotics and fluids, and taking early cultures and lactate levels.
3. Bundles are outlined to be completed within 3 and 6 hours, including measures like administering broad-spectrum antibiotics, fluid resuscitation, vasopressors, and measuring lactate, CVP and ScvO2.
New definition of sepsis... sepsis 3
The document discusses proposed changes to the definitions of sepsis, septic shock, and related terms based on recent evidence and consensus guidelines. It summarizes the new definitions as follows:
1) Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, assessed using a SOFA score ≥ 2 points.
2) Septic shock involves profound circulatory and cellular abnormalities indicated by persisting hypotension requiring vasopressors and serum lactate >2mmol/L, despite adequate fluid resuscitation.
3) Terms like "severe sepsis" are removed, and quick SOFA (qSOFA) criteria are suggested for evaluating sepsis outside the ICU.
Sepsis 3
The document discusses definitions of systemic inflammatory response syndrome (SIRS), sepsis, septic shock, and new criteria proposed in Sepsis-3. SIRS criteria are nonspecific and can occur with non-infectious conditions. Sepsis is defined as a dysregulated host response to infection leading to organ dysfunction. Septic shock is a subset of sepsis with circulatory and metabolic abnormalities increasing mortality risk. New definitions propose sepsis be defined as a life-threatening organ dysfunction caused by a dysregulated response to infection. Septic shock is defined by hypotension requiring vasopressors and hyperlactatemia above 2 mmol/L despite fluid resuscitation.
Sirs
The document discusses systemic inflammatory response syndrome (SIRS) and defines it as a systemic response to various stresses that includes symptoms like fever, increased heart rate, respiratory rate and white blood cell count. It outlines the progression from infection to bacteremia to sepsis, which involves SIRS criteria and a suspected or proven infection. The stages of sepsis like severe sepsis, septic shock and refractory septic shock are defined based on the presence of organ dysfunction or hypotension.
Sepsis & Septic Shock
The document discusses shock and sepsis. It defines shock as a clinical condition characterized by a fast pulse rate and low blood pressure. The main types of shock discussed are hypovolemic, cardiogenic, septic, anaphylactic, and neurogenic. Sepsis is defined as a life-threatening organ dysfunction caused by the body's response to an infection. As sepsis progresses it can lead to septic shock, which is associated with high mortality. The stages of shock and signs and symptoms of early and late sepsis are also summarized.
Sepsis
Sepsis is a serious medical condition caused by the body's response to an infection. It affects over 750,000 people in the US each year and is one of the top causes of death. Risk factors include intravenous lines, mechanical ventilation, recent surgery, and immunosuppression. The pathophysiology involves the systemic inflammatory response syndrome leading to organ damage and shock. Diagnosis is based on confirming an infection along with signs of altered organ function or tissue hypoperfusion. Treatment involves early antibiotic therapy and fluid resuscitation to treat shock and prevent further organ damage.
Sepsis
This document discusses sepsis, septicemia, and multiple organ dysfunction syndrome (MODS). It defines related terms like bacteremia, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock. It discusses the magnitude of the problem globally and in India. It covers the pathophysiology and most common sources of infection. It also summarizes the Surviving Sepsis Campaign guidelines for management of sepsis and septic shock. Finally, it provides an overview of recent advances and controversies in the field and lists various biomarkers that can be used for diagnosis, prognosis, and stratification of sepsis severity.
Sepsis 3
Latest definition of sepsis, application of qSOFA, latest evidence on treatment of septic shock,role of fluids, role of steroids, isobalance salt solution
Sepsis and Septic shock
This document discusses sepsis and septic shock. It defines severe sepsis as acute organ dysfunction caused by infection, and septic shock as sepsis with hypotension refractory to fluid resuscitation requiring vasopressors. Common infection sites include the respiratory tract, intra-abdominal space, and urinary tract. Gram-positive and gram-negative bacteria, as well as fungi, can cause sepsis. The pathophysiology involves an initial inflammatory response that can lead to organ damage and dysfunction if not controlled. Complications include disseminated intravascular coagulation, acute respiratory distress syndrome, and acute renal failure. Treatment involves identifying and treating the infection source along with early, targeted antimicrobial therapy and organ support.
What's hot (20)
Systemic Inflammatory Response Syndrome SIRS and Septicemia
Systemic Inflammatory Response Syndrome SIRS and Septicemia
Approach to sepsis- a primary physician perspective
Approach to sepsis- a primary physician perspective
Viewers also liked
Sepsis power point presentation
This document provides information on sepsis for EMS providers, including causes and risk factors, signs and symptoms, treatment guidelines, and case studies. Sepsis is a serious condition that can lead to septic shock and organ failure if not treated quickly. The guidelines describe identifying septic patients in the field using specific criteria and initiating fluid resuscitation and transport to the hospital for early goal directed therapy to improve outcomes. Case studies demonstrate application of the guidelines and emphasize importance of early recognition and treatment.
Septic shock
The document outlines septic shock, including its definition, classification, epidemiology, pathogenesis, clinical features, investigation, treatment, complications, prognosis and prevention. Septic shock results from a systemic inflammatory response due to infection and can lead to multiple organ dysfunction. Prompt resuscitation, antibiotics, source control and organ support are crucial for treatment, but mortality remains high, especially in patients with multiple organ dysfunction or failure to respond to therapy. Early recognition and treatment of infection helps reduce risks of septic shock.
Sensorimotor interplay in vocal communication
This document discusses sensorimotor interplay in vocal communication. It begins by discussing the significance of communication in society and the evolution of communication from a taxonomic perspective. It then covers human speech, including the history of linguistic studies, the peripheral phonation system, anatomical areas involved in speech perception and production, models of speech, and speech disorders like aphasias.
Care of the patient in severe sepsis septic shock nursing inservice 2012
This document discusses sepsis, including definitions, risk factors, signs and symptoms, and a nurse's responsibilities. It presents several case studies of patients with possible sepsis and asks the reader to identify signs of organ dysfunction and determine if/when sepsis should be declared. It emphasizes the importance of early recognition and treatment of sepsis, including administering IV fluids and antibiotics, obtaining blood cultures and lactate levels, and improving communication among staff.
Major Case Presentation Septic Shock
This document discusses the pharmacotherapy of septic shock. It begins with a case presentation of a 59-year-old female admitted with septic shock secondary to pyelonephritis. It then covers the epidemiology, pathogenesis, diagnosis, goals of treatment which include identifying the infection source and providing hemodynamic support. Therapeutic alternatives discussed in detail include antimicrobial therapy, hemodynamic monitoring, fluids, inotropes and vasopressors.
REVIEW OF HEMODYNAMIC MONITORING
1. Clinical examination alone is not sufficient to assess hemodynamic status in critically ill patients as individual vital signs do not reflect overall status.
2. Arterial lines can be used to monitor blood pressure, heart rate, and derive parameters like cardiac output but waveforms require interpretation and may be affected by various artifacts.
3. Pulmonary artery catheters can measure central venous and pulmonary artery pressures as well as cardiac output but have potential complications and their use remains controversial with no proven benefits shown in large trials.
Chapter 3 (microbiology) 8th edition
This document summarizes key aspects of cell structure and function in bacteria and archaea. It describes the two domains of prokaryotes: eubacteria and archaea. It then discusses bacterial cell morphology, size, cell membranes, cell walls, inclusion bodies, DNA arrangement, plasmids, peptidoglycan composition, and differences between gram-positive and gram-negative cell walls. The document provides an overview of the essential components and structures that define bacterial and archaeal cell organization and physiology.
Sepsis
This document provides guidelines for the management of severe sepsis and septic shock. It discusses definitions of sepsis, systemic inflammatory response syndrome, and septic shock. It outlines initial resuscitation goals including fluid resuscitation, vasopressors, inotropic therapy, and goals for central venous pressure, mean arterial pressure, urine output, and central venous or mixed venous oxygen saturation. It provides recommendations on antibiotic therapy, source control, steroids, activated protein C, transfusion thresholds, glucose control, renal replacement therapy, stress ulcer prophylaxis, and implementing a sepsis resuscitation bundle.
Multi organ dysfunction syndrome
The document discusses sepsis, SIRS, and MODS (multiple organ dysfunction syndrome). It defines sepsis as the systemic response to infection, SIRS as the inflammatory response to various insults, and MODS as altered organ function in an acutely ill patient that cannot be maintained without intervention. The relationships between sepsis, SIRS, and MODS are explained, along with their pathogenesis and potential complications like respiratory distress and multi-organ failure. Risk factors, diagnosis, management goals, and nursing interventions are also outlined.
Sepsis
Enumerates the latest advancements in the management of sepsis and the search into its pathophysiology.
Sepsis updates 2016
This document summarizes the key points of the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). It discusses why new definitions were needed, the process used to develop the definitions, and the main changes and recommendations. The new definitions focus on organ dysfunction rather than inflammation. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock involves circulatory and metabolic abnormalities requiring vasopressors and showing elevated lactate. The quick SOFA (qSOFA) score is recommended outside the ICU to help identify potential sepsis.
Viewers also liked (11)
Care of the patient in severe sepsis septic shock nursing inservice 2012
Care of the patient in severe sepsis septic shock nursing inservice 2012
Similar to What Is Sepsis
shock.ppt3333333333333333333333333333333
Shock results from the failure of the cardiovascular system to provide sufficient blood circulation.
To maintain circulatory homeostasis the following mechanisms must be present –
1. a functioning of heart to circulate blood .
A sufficient amount of blood volume .
The capability of the vascular system , accommodating blood flow to the capillaries and returning to the right side of the heart.
shock
The document discusses different types of shock including hypovolumic, cardiogenic, septic, anaphylactic, and neurogenic shock. It defines shock as systemic hypoperfusion caused by reduced cardiac output or effective circulatory blood volume. Key signs are hypotension, tissue hypoperfusion, cellular hypoxia, and potential end organ dysfunction. Management involves treating the underlying cause, restoring circulating volume, providing vasoactive drugs and oxygenation support, and monitoring for multiple organ failure in intensive care. Prognosis depends on the shock type and duration, with septic and cardiogenic shock having higher mortality risks.
sepsis.pptx
This document discusses sepsis, including definitions, pathophysiology, clinical features, diagnosis, and management. It defines sepsis as a life-threatening condition caused by a dysregulated immune response to infection leading to organ dysfunction. The pathophysiology involves a dysregulated inflammatory response and coagulation system. Signs and symptoms may include altered vital signs and organ dysfunction. Diagnosis involves identifying infection source through cultures and biomarkers. Treatment involves prompt antibiotics, fluid resuscitation, and supportive care based on Surviving Sepsis Campaign guidelines.
shock.pptx
This document discusses different types of shock including hypovolemic, cardiogenic, septic, anaphylactic, and neurogenic shock. It defines shock as systemic hypoperfusion caused by reduced cardiac output or effective circulatory volume. Key signs are hypotension, tissue hypoperfusion, and end organ dysfunction. The stages of shock are described as initial non-progressive, progressive, and irreversible. Treatment involves restoring blood volume, vasoactive drugs, treating the underlying cause, and intensive care management to prevent multi-organ failure. Prognosis depends on the type and duration of shock.
Systamic infalmatory response syndrome sirs
The document discusses the immune system response to cardiopulmonary bypass (CPB). It describes how CPB activates both the innate and adaptive immune systems, resulting in systemic inflammatory response syndrome (SIRS). Contact with foreign surfaces and other insults during CPB trigger complement activation and release of cytokines that promote inflammation. This leads to activation of leukocytes, endothelium, platelets, and coagulation/fibrinolysis pathways. The clinical manifestations of SIRS, including fever, organ dysfunction and increased infection risk, are described. Therapeutic strategies aim to minimize the immune system activation and inflammatory response caused by CPB.
2. Shock.pptx
This document discusses shock, specifically defining it as a life-threatening condition characterized by reduced circulating blood volume and inadequate tissue perfusion. It describes the basics of cellular injury in shock and lists the main types as hypovolemic, cardiogenic, septic/toxic, and anaphylactic. The pathogenesis of shock involves reduced blood volume, reduced oxygen delivery, and toxins from cellular injury. Specific details are provided on the pathogenesis of hypovolemic, cardiogenic, and septic shock, focusing on inflammatory responses, endothelial activation/injury, and induction of procoagulant states in septic shock.
Shock
Circulatory shock occurs when blood volume is displaced in the vasculature, causing hypovolemia and decreased cardiac output. There are three main types: septic shock (caused by infection), neurogenic shock (caused by loss of sympathetic tone), and anaphylactic shock (caused by allergic reaction). Septic shock is the most common and results from an immune response to infection that causes widespread vasodilation and capillary leakage. Treatment involves identifying and treating the infection, restoring intravascular volume, and providing supportive care.
Sepsis
Sepsis is a generalized infection caused by bacteria entering the bloodstream and overwhelming the body's defenses. It can result from various infections or invasive medical procedures. Key factors in its pathogenesis include bacterial toxins that trigger an overproduction of cytokines, which cause systemic inflammatory response and multi-organ dysfunction. Treatment involves identifying and treating the infection source, administering antibiotics and other measures to support organ function, and modulating the immune response.
Shock and its management
Shock and its management is summarized as follows:
1. Shock is a life-threatening condition characterized by inadequate tissue perfusion due to reduced circulating blood volume or cardiac output.
2. Shock is classified as hypovolemic, cardiogenic, septic, traumatic, neurogenic, or hypoadrenal based on etiology.
3. The pathophysiology involves reduced circulating volume, impaired tissue oxygenation, and release of inflammatory mediators, progressing from compensated to decompensated to irreversible stages if left untreated.
RHEUMATOID ARTHRITIS BY DR BASHIR AHMED DAR ASSOCIATE PROFESSOR MEDICINE SOPO...
RHEUMATOID ARTHRITIS BY DR BASHIR AHMED DAR ASSOCIATE PROFESSOR MEDICINE SOPO...Prof Dr Bashir Ahmed Dar
This document discusses rheumatoid arthritis (RA), an autoimmune disorder where the immune system attacks the synovial membrane of joints. It describes the etiology and pathogenesis of RA, including the role of cytokines like IL-1 and TNF-α in causing inflammation and joint damage. Symptoms of RA include stiffness, swelling and pain in small joints of hands and feet typically in a symmetrical pattern. Long-term RA can lead to joint deformities and loss of function. The document also covers diagnostic criteria, epidemiology, microscopic findings, and treatment of RA.1578185 - McGraw-Hill Professional ©CHAPTER 141Sepsis an
1578185 - McGraw-Hill Professional ©
CHAPTER 141
Sepsis and Shock
Kevin Felner, MD
Robert L. Smith, MD
Key Clinical Questions
What is the definition of systemic inflammatory response syndrome (SIRS) and
how do you differentiate SIRS from sepsis, severe sepsis, and septic shock?
Which patients presenting with sepsis need admission to the intensive care unit
(ICU)?
Which septic patients require invasive monitoring (arterial catheter, central venous
catheter)?
What interventions in the treatment of sepsis improve mortality?
Which septic patients deserve empiric steroids as part of the therapeutic
regimen?
INTRODUCTION
Sepsis is a clinical syndrome that complicates severe infection and is characterized by
systemic inflammation and widespread tissue injury. The incidence and number of sepsis-
1578185 - McGraw-Hill Professional ©
related deaths has increased yearly from 1979 to 2009 with a combined peak of both
primary and secondary sepsis in 2009 greater than 1 million patients in the United States;
and sepsis is the ninth most common cause of death in the United States. Despite the
rising number of cases, earlier identification of sepsis and improved intensive medical
care has been shown to reduce the overall mortality rate to approximately 17.9%. Severity
is correlated with mortality (Table 141-1).
TABLE 141-1 Sepsis Syndromes, Definitions, and Mortality Risk
Syndrome Definition
Approximate
Mortality
Systemic
inflammatory
response syndrome
(SIRS)
At least two of the following four clinical
features:
1. Temperature >38°C or <36°C
2. Heart rate >90 beats/min
3. Respiratory rate >20 breaths/min or
PaCO2 <32 mm Hg
4. White blood cell (WBC) count >12,000
cells/mm3, or <4000 cells/mm3, or >10%
immature (band) forms
10%
Sepsis SIRS criteria plus a culture-proven infection
or presumed presence of an infection
20%
Severe sepsis Sepsis plus presence of one or more organ
dysfunctions including:
• Pulmonary dysfunction (eg, acute
respiratory distress syndrome)
• Cardiac dysfunction
• Renal dysfunction
• Hepatic dysfunction
• Neurologic dysfunction (altered
sensorium)
• Hematologic dysfunction (eg,
disseminated intravascular coagulation
[DIC], thrombocytopenia)
• Lactic acidosis (indicating end-organ
hypoperfusion)
20%-40%
Septic shock Sepsis and refractory hypotension with
mean systemic blood pressure lower than
65 mm Hg unresponsive to crystalloid fluid
challenge of 20-40 cc/kg
40%-60%
Initially successful shock resuscitation may still be associated with considerable
morbidity and mortality. Multiple organ dysfunction syndrome (MODS) refers to severe
1578185 - McGraw-Hill Professional ©
acquired dysfunction of at least two organ systems lasting at least 24 to 48 hours in the
setting of sepsis, trauma, burns, or severe inflammatory conditions so that homeostasis
cannot be maintained without intervention. Mortality is directly correlated with the number
of dysfunctional organs and the duration of dysfunction (Table 1 ...
1578185 - McGraw-Hill Professional ©CHAPTER 141Sepsis an
1578185 - McGraw-Hill Professional ©
CHAPTER 141
Sepsis and Shock
Kevin Felner, MD
Robert L. Smith, MD
Key Clinical Questions
What is the definition of systemic inflammatory response syndrome (SIRS) and
how do you differentiate SIRS from sepsis, severe sepsis, and septic shock?
Which patients presenting with sepsis need admission to the intensive care unit
(ICU)?
Which septic patients require invasive monitoring (arterial catheter, central venous
catheter)?
What interventions in the treatment of sepsis improve mortality?
Which septic patients deserve empiric steroids as part of the therapeutic
regimen?
INTRODUCTION
Sepsis is a clinical syndrome that complicates severe infection and is characterized by
systemic inflammation and widespread tissue injury. The incidence and number of sepsis-
1578185 - McGraw-Hill Professional ©
related deaths has increased yearly from 1979 to 2009 with a combined peak of both
primary and secondary sepsis in 2009 greater than 1 million patients in the United States;
and sepsis is the ninth most common cause of death in the United States. Despite the
rising number of cases, earlier identification of sepsis and improved intensive medical
care has been shown to reduce the overall mortality rate to approximately 17.9%. Severity
is correlated with mortality (Table 141-1).
TABLE 141-1 Sepsis Syndromes, Definitions, and Mortality Risk
Syndrome Definition
Approximate
Mortality
Systemic
inflammatory
response syndrome
(SIRS)
At least two of the following four clinical
features:
1. Temperature >38°C or <36°C
2. Heart rate >90 beats/min
3. Respiratory rate >20 breaths/min or
PaCO2 <32 mm Hg
4. White blood cell (WBC) count >12,000
cells/mm3, or <4000 cells/mm3, or >10%
immature (band) forms
10%
Sepsis SIRS criteria plus a culture-proven infection
or presumed presence of an infection
20%
Severe sepsis Sepsis plus presence of one or more organ
dysfunctions including:
• Pulmonary dysfunction (eg, acute
respiratory distress syndrome)
• Cardiac dysfunction
• Renal dysfunction
• Hepatic dysfunction
• Neurologic dysfunction (altered
sensorium)
• Hematologic dysfunction (eg,
disseminated intravascular coagulation
[DIC], thrombocytopenia)
• Lactic acidosis (indicating end-organ
hypoperfusion)
20%-40%
Septic shock Sepsis and refractory hypotension with
mean systemic blood pressure lower than
65 mm Hg unresponsive to crystalloid fluid
challenge of 20-40 cc/kg
40%-60%
Initially successful shock resuscitation may still be associated with considerable
morbidity and mortality. Multiple organ dysfunction syndrome (MODS) refers to severe
1578185 - McGraw-Hill Professional ©
acquired dysfunction of at least two organ systems lasting at least 24 to 48 hours in the
setting of sepsis, trauma, burns, or severe inflammatory conditions so that homeostasis
cannot be maintained without intervention. Mortality is directly correlated with the number
of dysfunctional organs and the duration of dysfunction (Table 1 ...
Inflammation
This document provides an overview of inflammation, including its definition, history, types (acute and chronic), classical signs, vascular and cellular events, chemical mediators, and outcomes. Inflammation is defined as a protective response to injury or infection that involves increased blood flow, blood vessel permeability, and the migration of white blood cells. The classical signs of inflammation are heat, redness, swelling, pain, and loss of function. Key events in acute inflammation include increased vascular permeability, chemotaxis of white blood cells, phagocytosis of pathogens, and the release of chemical mediators like histamine and cytokines. Chronic inflammation is long-lasting inflammation that involves ongoing tissue damage and repair. Systemic inflammatory response syndrome (SIRS)
Septic shock e-Medicine Article
This document provides an overview of septic shock, including definitions, pathophysiology, and classifications. It defines key terms like sepsis, severe sepsis, septic shock, and systemic inflammatory response syndrome (SIRS). Septic shock is a type of distributive shock caused by excessive activation of the host's immune response to infection, leading to widespread inflammation and vascular dysfunction. Mediators like cytokines and bacterial components play a role in initiating sepsis and the associated hyperdynamic circulatory response. Organ dysfunction and failure can occur as a result of impaired perfusion and coagulation abnormalities.
Inflammation (dr.ahsan)patho.docx
Inflammation is the body's protective response to injury or infection. It involves vascular changes like vasodilation and increased permeability that allow fluid proteins and immune cells to move from blood vessels into injured tissues. Acute inflammation occurs immediately after injury and lasts a few days at most. It is characterized by neutrophil accumulation and involves vascular changes and fluid exudation that cause swelling. Neutrophils migrate to injury sites through a process involving rolling, adhesion and chemotaxis in response to chemical signals, and then phagocytose and destroy pathogens through enzymatic lysis before undergoing apoptosis.
Approach to a patient with shock
Shock, its types and approach to a patient presenting with shock and its management.
Source: Harrison's book of medicine 19th and 20th edition.
SIRS.ppt
1. Systemic inflammatory response syndrome (SIRS) is a clinical syndrome characterized by generalized inflammation in organs remote from the initial insult, caused by deregulated inflammation.
2. SIRS can be triggered by infectious processes like sepsis or non-infectious insults and is characterized by fever, hypotension, tachycardia, tachypnea, and leukocytosis.
3. Untreated, SIRS can lead to multiple organ dysfunction syndrome (MODS) through the massive release of pro-inflammatory mediators, resulting in organ damage and extremely high mortality rates.
Shock
Shock is a state of impaired tissue perfusion that can result from low cardiac output or reduced circulating blood volume. There are several types of shock, including cardiogenic shock from heart failure, hypovolemic shock from fluid loss, and septic shock caused by the body's inflammatory response to infection. Septic shock is characterized by endothelial cell activation, tissue edema, blood clotting abnormalities, and metabolic disturbances that can lead to multiple organ failure and death. The pathogenesis involves an overactive inflammatory response triggered by microbial components that activate immune cells and cause widespread vascular leakage, hypotension, and tissue hypoxia. This can progress to organ dysfunction and failure if not corrected.
ALTERACIONES EN LA DISFUNCION MULTIORGANICA.pdf
Sepsis is a life-threatening condition defined as organ dysfunction caused by a dysregulated immune response to infection. The immune response causes widespread vascular and microcirculatory dysfunction that leads to global hypoperfusion and injury of multiple organs. This results in organ failures of the kidneys, liver, lungs, heart, brain, and blood system - known as multiple organ failure - which determines whether the patient recovers or dies from the infection. While early treatment of the infection and restoring circulation are important, sepsis has heterogeneous pathophysiology that has made directly intervening on its mechanisms unsuccessful. Improved public health strategies and novel technologies are needed to better treat sepsis and reduce its high global burden.
Shock
Shock is characterized by systemic hypoperfusion of tissues due to diminished cardiac output or reduced circulating blood volume. Prolonged shock leads to irreversible tissue injury and can be fatal if left untreated. There are several types of shock including cardiogenic, hypovolemic, septic, neurogenic, and anaphylactic shock. Septic shock results from vasodilation and blood pooling due to the immune response to infection, which can cause organ dysfunction if not corrected. Shock progresses through initial compensatory, progressive, and irreversible stages that can lead to cell injury and death without treatment.
Similar to What Is Sepsis (20)
RHEUMATOID ARTHRITIS BY DR BASHIR AHMED DAR ASSOCIATE PROFESSOR MEDICINE SOPO...
RHEUMATOID ARTHRITIS BY DR BASHIR AHMED DAR ASSOCIATE PROFESSOR MEDICINE SOPO...
1578185 - McGraw-Hill Professional ©CHAPTER 141Sepsis an
1578185 - McGraw-Hill Professional ©CHAPTER 141Sepsis an
1578185 - McGraw-Hill Professional ©CHAPTER 141Sepsis an
1578185 - McGraw-Hill Professional ©CHAPTER 141Sepsis an
More from Husni Ajaj
Atls Introduction
This document discusses Advanced Trauma Life Support (ATLS), a protocol for trauma care. It outlines the history and growth of ATLS since its introduction in 1988. While ATLS protocols align well with recommendations from reviews of trauma care, the document calls for strengthening ATLS training requirements and ensuring protocols fit current local practice. The future of ATLS would benefit from formal introduction into postgraduate medical education and commitment to ongoing skills retention.
Conduct Of Local Anesthesia Technique And Complication
This document discusses regional anesthesia techniques and their complications. It covers the advantages of regional anesthesia, how local anesthetics work, different types of regional blocks including spinal, epidural, brachial plexus and others. It describes the physiology of neuroaxial blocks and their effects. Complications of various blocks like hypotension, post dural puncture headache are explained. Contraindications and techniques for specific blocks are also outlined.
Perioperative Management Of Liver Tranplant Patients1
The document discusses perioperative management of liver transplant patients. It covers indications for liver transplantation including various etiologies of end-stage liver disease. It also discusses selection criteria using MELD scoring and preoperative management of complications associated with liver disease. Post-operative complications are outlined including right pleural effusion, renal failure, electrolyte issues, and biliary leaks. Induction of immunosuppression with triple therapy is also summarized.
Neuropathic Pain Dr.Husni
The document discusses neuropathic pain and its treatment. It defines neuropathic pain as pain initiated or caused by primary lesions or dysfunction in the nervous system. Some examples of neuropathic pain given are postherpetic neuralgia, diabetic peripheral neuropathy, and post-surgical neuropathy. The document outlines approaches to diagnosing neuropathic pain, including listening to the patient's description of their pain, looking for sensory abnormalities, and locating the region of pain to a neuroanatomical area. It discusses treating neuropathic pain with topical medications, systemic medications like anticonvulsants, antidepressants and opioids.
Surgion sweming in blood pool Central Hospital
The document discusses guidelines for managing warfarin therapy and reversing its anticoagulant effects. It covers warfarin pharmacokinetics, risk factors for bleeding, general principles for maintaining therapeutic INR levels, and approaches for reversing anticoagulation effects through administering vitamin K or prothrombin complex concentrates. It also provides guidance on pre- and post-operative management of anticoagulation for patients undergoing invasive procedures, including recommendations for bridging therapy based on thromboembolism risk.
Ventilatory support
The document discusses various topics related to mechanical ventilation including:
1. Ventilation strategies for acute respiratory distress syndrome (ARDS) including low tidal volumes, optimal positive end-expiratory pressure, and prone positioning.
2. Ventilation modes and settings should be tailored to the individual patient's condition and aim to prevent ventilator-induced lung injury.
3. Non-invasive ventilation can be considered for certain patients with COPD or asthma to avoid intubation if criteria are met.
Cardiac arrest
The document discusses cardiovascular disease and cardiopulmonary resuscitation (CPR). It states that cardiovascular disease is the leading cause of death worldwide, with over 50% of deaths due to cardiovascular issues. It also notes that CPR training can help save lives by intervening in cases of heart attack, stroke, or choking. The CPR training program covered in the document teaches techniques for adults, children, and infants, including demonstrations of CPR, the Heimlich maneuver, and first aid basics.
Airway Manegement
The document discusses various airway management techniques and equipment for dealing with difficult airway situations. It covers anatomical factors that can cause difficulties, techniques like awake intubation using local anesthesia, and options like bougies, laryngeal mask airways, fiberoptic intubation, retrograde intubation, and cricothyrotomy devices. It also describes the contents of an airway management cart and algorithms for dealing with difficult airways.
More from Husni Ajaj (8)
Conduct Of Local Anesthesia Technique And Complication
Conduct Of Local Anesthesia Technique And Complication
Perioperative Management Of Liver Tranplant Patients1
Perioperative Management Of Liver Tranplant Patients1
Recently uploaded
How to Make a Field Mandatory in Odoo 17
In Odoo, making a field required can be done through both Python code and XML views. When you set the required attribute to True in Python code, it makes the field required across all views where it's used. Conversely, when you set the required attribute in XML views, it makes the field required only in the context of that particular view.
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশের অর্থনৈতিক সমীক্ষা ২০২৪ [Bangladesh Economic Review 2024 Bangla.pdf] কম্পিউটার , ট্যাব ও স্মার্ট ফোন ভার্সন সহ সম্পূর্ণ বাংলা ই-বুক বা pdf বই " সুচিপত্র ...বুকমার্ক মেনু 🔖 ও হাইপার লিংক মেনু 📝👆 যুক্ত ..
আমাদের সবার জন্য খুব খুব গুরুত্বপূর্ণ একটি বই ..বিসিএস, ব্যাংক, ইউনিভার্সিটি ভর্তি ও যে কোন প্রতিযোগিতা মূলক পরীক্ষার জন্য এর খুব ইম্পরট্যান্ট একটি বিষয় ...তাছাড়া বাংলাদেশের সাম্প্রতিক যে কোন ডাটা বা তথ্য এই বইতে পাবেন ...
তাই একজন নাগরিক হিসাবে এই তথ্য গুলো আপনার জানা প্রয়োজন ...।
বিসিএস ও ব্যাংক এর লিখিত পরীক্ষা ...+এছাড়া মাধ্যমিক ও উচ্চমাধ্যমিকের স্টুডেন্টদের জন্য অনেক কাজে আসবে ...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...Nguyen Thanh Tu Collection
https://app.box.com/s/y977uz6bpd3af4qsebv7r9b7s21935vdHindi varnamala | hindi alphabet PPT.pdf
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
Temple of Asclepius in Thrace. Excavation results
The temple and the sanctuary around were dedicated to Asklepios Zmidrenus. This name has been known since 1875 when an inscription dedicated to him was discovered in Rome. The inscription is dated in 227 AD and was left by soldiers originating from the city of Philippopolis (modern Plovdiv).
The History of Stoke Newington Street Names
Presented at the Stoke Newington Literary Festival on 9th June 2024
www.StokeNewingtonHistory.com
How to Setup Warehouse & Location in Odoo 17 Inventory
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
BÀI TẬP BỔ TRỢ TIẾNG ANH LỚP 9 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2024-2025 - ...
BÀI TẬP BỔ TRỢ TIẾNG ANH LỚP 9 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2024-2025 - ...Nguyen Thanh Tu Collection
https://app.box.com/s/tacvl9ekroe9hqupdnjruiypvm9rdaneANATOMY AND BIOMECHANICS OF HIP JOINT.pdf
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
Constructing Your Course Container for Effective Communication
Communicating effectively and consistently with students can help them feel at ease during their learning experience and provide the instructor with a communication trail to track the course's progress. This workshop will take you through constructing an engaging course container to facilitate effective communication.
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Main Java[All of the Base Concepts}.docx
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.
Recently uploaded (20)
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
বাংলাদেশ অর্থনৈতিক সমীক্ষা (Economic Review) ২০২৪ UJS App.pdf
Liberal Approach to the Study of Indian Politics.pdf
Liberal Approach to the Study of Indian Politics.pdf
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
BÀI TẬP BỔ TRỢ TIẾNG ANH 8 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2023-2024 (CÓ FI...
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
NEWSPAPERS - QUESTION 1 - REVISION POWERPOINT.pptx
How to Setup Warehouse & Location in Odoo 17 Inventory
How to Setup Warehouse & Location in Odoo 17 Inventory
BÀI TẬP BỔ TRỢ TIẾNG ANH LỚP 9 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2024-2025 - ...
BÀI TẬP BỔ TRỢ TIẾNG ANH LỚP 9 CẢ NĂM - GLOBAL SUCCESS - NĂM HỌC 2024-2025 - ...
Constructing Your Course Container for Effective Communication
Constructing Your Course Container for Effective Communication
Pengantar Penggunaan Flutter - Dart programming language1.pptx
Pengantar Penggunaan Flutter - Dart programming language1.pptx
B. Ed Syllabus for babasaheb ambedkar education university.pdf
B. Ed Syllabus for babasaheb ambedkar education university.pdf
What Is Sepsis
- 17. What is Sepsis? Multi-Organ Failure How does sepsis effect the various organs of the body?
- 45. Proposed Algorithm for the Management of Hyperdynamic Shock Hypotension/Hypoperfusion Cardiac Index Cardiac Index (CI<4.5 l/min/m ) (CI>4.5 L/min/m ) 2 2 Preload (EDV) Preload Preload Preload (PAOP<15 mmHg) (PAOP>15) (PAOP<15) (PAOP>15) Volume Inotrope Volume Inotrope Vasopressor
- 69. Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock Dellinger, et al Crit Care Med 32:858-73, 2004. Recommendations (not based on expert opinion): Human activated protein C is recommended in patients with a high risk of death. After resolution of hypoperfusion and in the absence of CAD, acute hemorrhage or lactic acidosis, transfusion of rbc’s should only be done to maintain hemoglobin > 7 gm/dl.
- 70. Vasopressors Volume Expansion Inotropes “ It’s déjà vu all over again!” Therapy of Shock