Von Willebrand Disease is the most common hereditary bleeding disorder; roughly 1 in every 100 people suffers from the disease. People who suffer from VWD have blood that does not clot properly.
Normally when a person is injured and starts to bleed, the von Willebrand factor in the blood attaches to small blood cells called platelets. This helps the platelets stick together to form a clot at the site of the injury and stop bleeding. When a person has VWD, the clot might take longer to form or not form the way it should and bleeding might take longer to stop. This can lead to heavy, hard-to-stop bleeding. Although rare, the bleeding can be severe enough to damage joints or internal organs, or even be life-threatening.
http://www.nlm.nih.gov/medlineplus/plateletdisorders.html#cat1
http://www.cdc.gov/ncbddd/vwd/facts.html
Aplastic anemia is one of the stem cell disorder which leads to pancytopenia in the peripheral blood and decrease production of all cell line in bone marrow. it require bone marrow transplantation to cure the patient.
Aplastic anemia is one of the stem cell disorder which leads to pancytopenia in the peripheral blood and decrease production of all cell line in bone marrow. it require bone marrow transplantation to cure the patient.
von Willebrand factor (VWF)is a blood glycoprotein involved in hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura.
Hemophilia is a genetic bleeding disorder in which body loses the ability to stop bleeding due to low levels or absence of proteins known as ‘’clotting factors’’ which are necessary for clotting of blood. Hemophilia leads to excessive bleeding.
von Willebrand factor (VWF)is a blood glycoprotein involved in hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic purpura.
Hemophilia is a genetic bleeding disorder in which body loses the ability to stop bleeding due to low levels or absence of proteins known as ‘’clotting factors’’ which are necessary for clotting of blood. Hemophilia leads to excessive bleeding.
Es el trastorno hemorrágico hereditario más común
Causada por una deficiencia del factor de von Willebrand, que ayuda a las plaquetas de la sangre a aglutinarse y adherirse a las paredes de los vasos sanguíneos, lo cual es necesario para la coagulación normal de la sangre
Inherited bleeding disorders are usually associated with boys and men. But with medical advances, more and more women have been diagnosed with inherited bleeding disorders such as Hemophilia, von Willebrand Disease, Platelet Function Disorders and factor deficiency disorders. This presentation shares about bleeding disorders affecting women. The first part is a report from the WFH World Congress 2014 held in Melbourne by the presenter, My Girls Blood Ambassador from the Philippines, Andrea Echavez. The second part is about inherited bleeding disorders affecting women.
This would give an idea of the various bleeding disorders, associated clotting factors and more specifically management in the dental office of the patients with bleeding disorders
Overweight and obesity are both labels
for ranges of weight that are greater than what is generally
considered healthy for a given height. The terms also identify ranges
of weight that have been shown to increase the likelihood of certain
diseases and other health problems.
Corneal injury describes an injury to the
cornea. The cornea is the crystal clear (transparent) tissue covering the front
of the eye. It works with the lens of the eye to focus images on the retina.
Have you ever had
the "stomach flu?" What you probably had was gastroenteritis - not a
type of flu at all. Gastroenteritis is an inflammation of the lining of the
intestines caused by a virus, bacteria or parasites. Viral gastroenteritis is
the second most common illness in the U.S. It spreads through contaminated food
or water, and contact with an infected person. The best prevention is frequent
hand washing.
Symptoms of
gastroenteritis include diarrhea, abdominal pain, vomiting, headache, fever
and chills. Most people recover with no treatment.
The most common
problem with gastroenteritis is dehydration. This happens if you do not drink
enough fluids to replace what you lose through vomiting and diarrhea. Dehydration
is most common in babies, young children, the elderly and people with weak
immune systems.
Drug addiction is a complex illness characterized by intense and, at times, uncontrollable drug craving, along with compulsive drug seeking and use that persist even in the face of devastating consequences. While the path to drug addiction begins with the voluntary act of taking drugs, over time a person's ability to choose not to do so becomes compromised, and seeking and consuming the drug becomes compulsive. This behavior results largely from the effects of prolonged drug exposure on brain functioning. Addiction is a brain disease that affects multiple brain circuits, including those involved in reward and motivation, learning and memory, and inhibitory control over behavior.
Because drug abuse and addiction have so many dimensions and disrupt so many aspects of an individual's life, treatment is not simple. Effective treatment programs typically incorporate many components, each directed to a particular aspect of the illness and its consequences. Addiction treatment must help the individual stop using drugs, maintain a drug-free lifestyle, and achieve productive functioning in the family, at work, and in society. Because addiction is typically a chronic disease, people cannot simply stop using drugs for a few days and be cured. Most patients require long-term or repeated episodes of care to achieve the ultimate goal of sustained abstinence and recovery of their lives.
Too often, addiction goes untreated: According to SAMHSA's National Survey on Drug Use and Health (NSDUH), 23.2 million persons (9.4 percent of the U.S. population) aged 12 or older needed treatment for an illicit drug or alcohol use problem in 2007. Of these individuals, 2.4 million (10.4 percent of those who needed treatment) received treatment at a specialty facility (i.e., hospital, drug or alcohol rehabilitation or mental health center). Thus, 20.8 million persons (8.4 percent of the population aged 12 or older) needed treatment for an illicit drug or alcohol use problem but did not receive it. These estimates are similar to those in previous years.
Addiction results when a person ingests a
substance (alcohol, cocaine, or nicotine, for example) or repeatedly takes part
in an activity (gambling) that can be pleasurable, but the continued use of
which becomes compulsive and interferes with everyday life.
Common addictions include:
-- Alcohol abuse
-- Drug abuse
-- Exercise abuse
-- Pornography
-- Gambling
Classic symptoms of addiction include
impaired control over substances/behavior, preoccupation with
substance/behavior, continued use despite consequences, and denial. Behavior
patterns and habits associated with addiction are commonly characterized by the
pursuit of immediate gratification, coupled with negative long-term effects.
Physiological dependence results when the
body is unable to function normally in the absence of the substance or
behavior. This state produces the conditions of tolerance and withdrawl.
Tolerance is the result of the body
requiring larger volumes of the substance or stimulus in order to achieve the
original effects.
Withdrawal is the physical and
psychological symptoms experienced when the body no longer receives the
substance in the same quantities it has become reliant upon.
When winter temperatures drop significantly below normal, staying
warm and safe can become a challenge. Extremely cold temperatures
often accompany a winter storm, so you may have to cope with power failures and icy roads. Although staying indoors as much as possible can help reduce the risk of car crashes and falls on the ice, you may also face indoor hazards.
Many homes will be too cold—either due to a power failure or because the heating system isn't adequate for the weather. When people must use space heaters and fireplaces to stay warm, the risk of household fires increases, as well as the risk of carbon monoxide poisoning.
Exposure to cold temperatures, whether indoors or outside, can cause other serious or life-threatening health problems. Infants and the elderly are particularly at risk, but anyone can be affected. To keep yourself and your family safe, you should know how to prevent cold-related health problems and what to do if a cold-weather health emergency arises. The emergency procedures outlined here are not a substitute for training in first aid. However, these procedures will help you to know when to seek medical care and what to do until help becomes available.
Maintaining a healthy office environment requires attention to chemical hazards, equipment and work station design, physical environment (temperature, humidity, light, noise, ventilation, and space), task design, psychological factors (personal interactions, work pace, job control) and sometimes, chemical or other environmental exposures.
A well-designed office allows each employee to work comfortably without needing to over-reach, sit or stand too long, or use awkward postures (correct ergonomic design). Sometimes, equipment or furniture changes are the best solution to allow employees to work comfortably. On other occasions, the equipment may be satisfactory but the task could be redesigned. For example, studies have shown that those working at computers have less discomfort with short, hourly breaks.
Situations in offices that can lead to injury or illness range from physical hazards (such as cords across walkways, leaving low drawers open, objects falling from overhead) to task-related (speed or repetition, duration, job control, etc.), environmental (chemical or biological sources) or design-related hazards (such as nonadjustable furniture or equipment). Job stress that results when the requirements of the job do not match the capabilities or resources of the worker may also result in illness.
When quitting smoking many people feel the need
for help in the form of a tobacco substitute. There are a wide variety of
different products billed as alternatives to smoking that are supposedly healthier.
The main additive in cigarettes that makes them so addictive is
nicotine. Hence most of the products that aim to replace smoking are nicotine
replacements such as nicotine gum, inhalers, patches and medications.
Other products are sold as smokeless tobacco such as snuff and hookah or as better because they are low yield cigarettes. Not all of these smoking substitutes are
healthy or even better than cigarettes.
Tobacco use can lead to nicotine dependence and serious health problems. Cessation can significantly reduce the risk of suffering from smoking-related diseases. Tobacco dependence is a chronic condition that often requires repeated interventions, but effective treatments and helpful resources exist. Smokers can and do quit smoking. In fact, today there are more former smokers than current smokers.
Small changes can make a big difference in reducing your chances of having alcohol-related problems. Whatever strategies you choose, give them a fair trial. If one approach doesn't work, try something else. But if you haven't made progress in cutting down after 2 to 3 months, consider quitting drinking altogether, seeking professional help, or both.
Here are some strategies to try, and you can add your own at the end. Check off perhaps two or three to try in the next week or two. Then click List my choices, and you can print or email them to yourself.
-- Keep track -Keep track of how much you drink. Find a way that works for you, carry drinking tracker cards in your wallet, make check marks on a kitchen calendar, or enter notes in a mobile phone notepad or personal digital assistant. Making note of each drink before you drink it may help you slow down when needed.
-- Count and measure -Know the standard drink sizes so you can count your drinks accurately. Measure drinks at home. Away from home, it can be hard to keep track, especially with mixed drinks, and at times, you may be getting more alcohol than you think. With wine, you may need to ask the host or server not to "top off" a partially filled glass.
-- Set goals -Decide how many days a week you want to drink and how many drinks you'll have on those days. It's a good idea to have some days when you don't drink. Drinkers with the lowest rates of alcohol use disorders stay within the low-risk limits.
-- Pace and space -When you do drink, pace yourself. Sip slowly. Have no more than one standard drink with alcohol per hour. Have "drink spacers"—make every other drink a non-alcoholic one, such as water, soda, or juice.
-- Include food -Don't drink on an empty stomach. Eat some food so the alcohol will be absorbed into your system more slowly.
-- Find alternatives -If drinking has occupied a lot of your time, then fill free time by developing new, healthy activities, hobbies, and relationships, or renewing ones you've missed. If you have counted on alcohol to be more comfortable in social situations, manage moods, or cope with problems, then seek other, healthy ways to deal with those areas of your life.
-- Avoid "triggers." -What triggers your urge to drink? If certain people or places make you drink even when you don't want to, try to avoid them. If certain activities, times of day, or feelings trigger the urge, plan something else to do instead of drinking. If drinking at home is a problem, keep little or no alcohol there.
-- Plan to handle urges -When you cannot avoid a trigger and an urge hits, consider these options: Remind yourself of your reasons for changing (it can help to carry them in writing or store them in an electronic message you can access easily). Or talk things through with someone you trust. Or get involved with a healthy, distracting activity, such as physical exercise or a hobby that doesn't involve drinking. Or, instead of fighting the feeling, accept i
Don't give up
Changing habits such as smoking, overeating, or drinking too much can take a lot of effort, and you may not succeed with the first try. Setbacks are common, but you learn more each time. Each try brings you closer to your goal. Whatever course you choose, give it a fair trial.
If one approach doesn't work, try something else. If a setback happens, get back on track as quickly as possible. In the long run, your chances for success are good.
Research shows that most heavy drinkers, even those with alcoholism, either cut back significantly or quit.
Alcohol withdrawal syndrome is a set of symptoms that people who have a history of alcoholism experience when they stop drinking. People who are casual drinkers rarely have withdrawal symptoms.
People who have gone through withdrawal before are more likely to have withdrawal symptoms each time they quit drinking.
Symptoms of alcohol withdrawal can range from severe to mild, and can include:
-- Insomnia
-- Nightmares
-- Irritability
-- Fatigue
-- Shakes
-- Sweats
-- Anxiety
-- Depression
-- Headaches
-- Decreased appetite
Severe withdrawal symptoms include fever, convulsions and delirium tremens (DTs). Those who experience DTs may become confused, anxious and even have hallucinations. DTs can be very serious if they are not treated by a doctor.
Eat healthy
-- Eat a variety of fruits, vegetables, and whole grains every day.
-- Limit foods and drinks high in calories, sugar, salt, fat, and alcohol.
-- Eat a balanced diet to help keep a healthy weight.
--
Learn the Facts
When you get a preventive medical test,
you're not just doing it for yourself. You're doing it for your family and
loved ones:
-- Men are 24 percent less likely than women
to have visited a doctor within the past year and are 22 percent more likely to
have neglected their cholesterol tests.
-- Men are 28 percent more likely than women
to be hospitalized for congestive heart failure.
-- Men are 32 percent more likely than women
to be hospitalized for long-term complications of diabetes and are more than
twice as likely than women to have a leg or foot amputated due to complications
related to diabetes.
-- Men are 24 percent more likely than women
to be hospitalized for pneumonia that could have been prevented by getting an
immunization.
The single most important way you can take
care of yourself and those you love is to actively take part in your health
care. Educate yourself on health care and participate in decisions with your
doctor. This site will help you get started.
Learn the Facts
When you get a preventive medical test, you're not just doing it for yourself. You're doing it for your family and loved ones:
-- Men are 24 percent less likely than women to have visited a doctor within the past year and are 22 percent more likely to have neglected their cholesterol tests.
-- Men are 28 percent more likely than women to be hospitalized for congestive heart failure.
-- Men are 32 percent more likely than women to be hospitalized for long-term complications of diabetes and are more than twice as likely than women to have a leg or foot amputated due to complications related to diabetes.
-- Men are 24 percent more likely than women to be hospitalized for pneumonia that could have been prevented by getting an immunization.
The single most important way you can take care of yourself and those you love is to actively take part in your health care. Educate yourself on health care and participate in decisions with your doctor. This site will help you get started.
When you get a preventive medical test, you're not just doing it for yourself. You're doing it for your family and loved ones:
Men are 24 percent less likely than women to have visited a doctor within the past year and are 22 percent more likely to have neglected their cholesterol tests.
Men are 28 percent more likely than women to be hospitalized for congestive heart failure.
Men are 32 percent more likely than women to be hospitalized for long-term complications of diabetes and are more than twice as likely than women to have a leg or foot amputated due to complications related to diabetes.
Men are 24 percent more likely than women to be hospitalized for pneumonia that could have been prevented by getting an immunization.
The single most important way you can take care of yourself and those you love is to actively take part in your health care. Educate yourself on health care and participate in decisions with your doctor. This site will help you get started.
Cancer screening is an essential part of preventative health screening for women of all ages. Here you can read about screening for breast and gynecological cancers.
Injury is the #1 killer of children and teens in the United States. In 2009, more than 9,000 youth age 0-19 died from unintentional injuries in the United States. Millions more children suffer injuries requiring treatment in the emergency department. Leading causes of child injury include motor vehicle crashes, suffocation, drowning, poisoning, fires, and falls.1 Child injury is predictable and preventable. It is also among the most under-recognized public health problems facing our country today.
Progress has been made in preventing child injury. Child injury death rates have decreased 29% in the last decade.2 Yet injury is still the leading cause of death for children and teens. More can be done to keep our children safe.
Shiatsu is a physical therapy that supports
and strengthens the body’s natural ability to heal and balance itself. It works
on the whole person - not just a physical body, but also a psychological,
emotional and spiritual being.
Shiatsu originated in Japan from traditional
Chinese medicine, with influences from more recent Western therapies. Although
shiatsu means ‘finger pressure’ in Japanese, in practise a practitioner uses
touch, comfortable pressure and manipulative techniques to adjust the body’s
physical structure and balance its energy flow. It is a deeply relaxing
experience and regular treatments can alleviate stress and illness and maintain
health and well-being.
2. 1
Overview
Von Willebrand Disease is the most
common hereditary bleeding disorder; roughly 1 in
every 100 people suffers from the disease. People
who suffer from VWD have blood that does not
clot properly.
3. 2
Overview
Normally when a person is injured and starts to
bleed, the von Willebrand factor in the blood
attaches to small blood cells called platelets. This
helps the platelets stick together to form a clot at
the site of the injury and stop bleeding. When a
person has VWD, the clot might take longer to
form or not form the way it should and bleeding
might take longer to stop. This can lead to heavy,
hard-to-stop bleeding. Although rare, the bleeding
can be severe enough to damage joints or internal
organ
5. 4
Symptoms
Primary symptoms of Von Willebrand Disease
include:
-- abnormal or heavy menstrual bleeding
-- bleeding of the gums
-- easy bruising
6. 5
Symptoms
-- frequent or hard-to-stop nosebleeds
-- skin rash
Note: Most women with heavy or prolonged
menstrual bleeding do not have Von Willebrand
Disease.
http://www.nlm.nih.gov/medlineplus/plateletdisor
ders.html#cat1
7. 6
Diagnosis
Von Willebrand Disease may be hard to diagnose
because low von Willebrand factors and bleeding
do not always mean you have von Willebrand
disease.
Tests may be done to diagnose this disease
include:
-- Bleeding time
8. 7
Diagnosis
-- Blood typing
-- Factor VII level
-- Platelet aggregation test
-- Platelet count
-- Ristocetin cofactor test
10. 9
Treatment
**For milder forms of VWD**
: Treatment may include DDAVP (desamino-8-
arginine vasopressin), which is used to raise von
Willebrand factor and reduce the chances of
bleeding. DDAVP is injected into a vein and works
to force the body to release more VWF into the
blood. (DDAVP does not work for all types of von
Willebrand disease, however, so a doctor should
check to determine which type of the disease you
have. )
11. 10
Treatment
**For milder forms of VWD**
A high-strength nasal spray called Stimate is often
used to treat mild forms of VWD. It works to boost
the levels of VWF and factor VIII in the blood. **
**For severe forms of VWD: **
12. 11
Treatment
** **
Drugs like Humate P, Alphanate, and Koate DVI are
injected into a vein in the arm to replace the
missing factor in the blood.
http://www.cdc.gov/ncbddd/vwd/facts.html
13. 12
Causes
Most people who have VWD are born with it. The
disease is almost always inherited from a parent to
a child.
14. 13
Causes
While uncommon, it is possible for a person to get
VWD without a family history of the disease. This
happens when a "spontaneous mutation" in a
person's genes occurs. Rarely, a person's own
immune system can destroy his or her VWF, often
as a result of a medication or another disease.
National Heart Lung and Blood Institute
