Hemophilia is a genetic bleeding disorder in which body loses the ability to stop bleeding due to low levels or absence of proteins known as ‘’clotting factors’’ which are necessary for clotting of blood. Hemophilia leads to excessive bleeding.

1. HEMOPHILIA
CAUSES | SYMPTOMS | DIAGNOSIS |
TREATMENT

2. INTRODUCTION TO HEMOPHILIA
 X-linked congeital bleeding disordercaused by a
deficiency of coagulation factor VIII (in helophilia A) or
factor IX (in hemophilia B).
 The deficienccy is the result fo mutation of the
respective clotting factor genes. F8 and F9 genes
 Frequency of approximately one in 10,000 births

3.  Hemophilia A is more common than hemophilia B.
representing 80-85% of the total hemophilia population
 Hemophilia generally affects makes on the maternal side
 However, both f8 and f9 genes are prone to new
mutations. and as many as 1/3 of all cases are the result
of spontaneous mutation where there is no prior family
history.
CONTINUE:-
INTRODUCTION TO HEMOPHILIA

4. SYMPTOMS OF HEMOPHILIA
The main signs and symptoms of Hemophilia depend
upon the type of bleeding. The bleeding may be internal or
external. Internal bleeding due to Hemophilia causes more
complications than external bleeding.
Symptoms of Internal Bleeding are:
 Blood in the urine or excreta
 Bleeding in the intestine, stomach or kidneys
 Bleeding in the knees, elbows, and other joints

5. CONTINUE SYMPTOMS OF
HEMOPHILIA
Symptoms of External Bleeding are:
 Excessive bleeding from minor injury
 Bleeding of gums
 Nose bleeding
Symptoms of Bleeding in the brain are:
 Frequent vomiting
 Blurred vision
 Extreme weakness in arms and legs
 Fatigue
 Convulsions

6. DIAGNOSIS OF HEMOPHILIA
 The most common method for diagnosing Hemophilia is
a blood test.
 The sample of blood taken from your vein indicates the
factors responsible for Hemophilia.
 The blood test measures the amount of plasma present
in your blood the low level of plasma in the blood
indicates the severity of this bleeding disorder.

7. TREATMENTS FOR HEMOPHILIA
The treatment of this disease depends upon the type of
Hemophilia a patient has. The treatment of each type of
Hemophilia varies according to its type.
 The treatment of Hemophilia A focuses on the hormone
called, Desmopressin. This hormone is given as an
injection in the patient’s vein. The Desmopressin
hormone restores the factors important for clotting of
blood.

8. CONTINUE TREATMENT FOR
HEMOPHILIA
 Hemophilia B is treated by infusing donor’s blood into
the patient’s body, which lacks clotting factors. The
clotting factors present the donor’s blood promotes the
process of clotting of blood.
 Hemophilia C occurs due to the lack of plasma count in
the body. Therefore, plasma infusion is done into the
blood to combat the excessive bleeding.

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