Von Willebrand disease is the most common inherited bleeding disorder, caused by mutations that impair the function or production of von Willebrand factor. There are three main types - type 1 is characterized by a quantitative deficiency, type 2 involves qualitative defects, and type 3 is the rarest form with extremely low von Willebrand factor levels. Patients typically present with mucocutaneous bleeding or bleeding after trauma or surgery. Diagnosis involves testing von Willebrand factor antigen levels, activity, and multimers. Treatment options include desmopressin, von Willebrand factor replacement, antifibrinolytics, and adjuvant therapies depending on severity and bleeding history.