Photoreceptors in the retina called rods and cones detect light and initiate visual signals. Rods are more light-sensitive and do not distinguish color, while cones provide color vision and are concentrated in the fovea. Rhodopsin is the visual pigment in rods that absorbs light and triggers a signal transduction pathway, resulting in photoreceptor cell hyperpolarization. Rods and cones synapse with bipolar cells, which then synapse with ganglion cells that form the optic nerve. Color vision is mediated by three types of cone cells containing unique photopsins detected by the brain. Colorblindness results from a deficiency in one or more photopsins.