This document discusses the assessment and management of patients presenting with vertigo. It outlines various central and peripheral causes of vertigo including vestibular migraine, brainstem ischemia, and BPPV. It also presents a case study of a 32 year old woman presenting with acute onset vertigo following viral symptoms who is assessed as likely having vestibular neuritis. The document recommends using the TiTrATE approach to classify vertigo presentations as episodic or constant, triggered or spontaneous to guide further testing and management. Physical exam findings of nystagmus patterns are also discussed to help differentiate central from peripheral causes of vertigo.
Vertigo is a problem commonly encountered in daily clinical practice.So an uniform approach to a patient with Vertigo is essential to identify the underlying aetiology of Vertigo.
Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Vertigo is a subtype of dizziness in which a patient inappropriately experiences the perception of motion (usually a spinning motion) due to dysfunction of the vestibular system.
1. Identify the difference between vertigo, disequilibrium,, near-syncope, and Undifferentiated dizziness.
2. Identify helpful tests to distinguish peripheral from central vertigo.
3. Understand how to treat different kinds of vertigo
Videonystagmography is also known as VNG, is a most advanced diagnostic test for a balance disorder. Individuals who feel dizzy and face difficulty in maintaining their balance and equilibrium should undergo the videonystagmography diagnostic test.
Vertigo is a problem commonly encountered in daily clinical practice.So an uniform approach to a patient with Vertigo is essential to identify the underlying aetiology of Vertigo.
Perilymph Fistula can be difficult to diagnose as a standalone condition. Post-trauma symptoms such as dizziness, headache, etc. can be linked to other conditions like a traumatic brain injury with a concussion.
Vertigo is a subtype of dizziness in which a patient inappropriately experiences the perception of motion (usually a spinning motion) due to dysfunction of the vestibular system.
1. Identify the difference between vertigo, disequilibrium,, near-syncope, and Undifferentiated dizziness.
2. Identify helpful tests to distinguish peripheral from central vertigo.
3. Understand how to treat different kinds of vertigo
Videonystagmography is also known as VNG, is a most advanced diagnostic test for a balance disorder. Individuals who feel dizzy and face difficulty in maintaining their balance and equilibrium should undergo the videonystagmography diagnostic test.
A review of epilepsy in the elderly, the etiopathogenesis, clinical challenges, diagnosis, use of antiseizure drugs and outcomes. Also the various special considerations in managing elderly patients with epilepsy.
RCVS is usually a benign cerebral vascular dysregulation induced clinico-radiological syndrome presents typically with recurrent thunderclap headache with or without ischemic/hemorrhagic stroke or cerebral edema with vasoconstriction. Various risk factors are responsible for this syndrome.
Death by Neurological Criteria and Organ Donation: Bill KnightSMACC Conference
Bill Knight explains the concept of death by neurological criteria and the complexities surrounding organ donation in such situations.
Bill discusses the process of dying, the definition of death, how to approach the neurologically dead patient and how to consider organ donation.
Death is a complex topic.
Due to advancements in medical technology and processes, the definition of death is a challenging one.
Bill talks at length about the definition of death by the neurological criteria. Dying is an active process, whereas death is an event.
The acceptance of death by the neurological criteria is often challenging as Bill will highlight. Bill talks about the care of the dying or dead patient.
There is a point at which care will transition from supporting the patient to supporting the organs. This is still good care.
There is an alignment of parallel intentions – first and foremost resuscitation of patients and then failing that, proceeding to considering and actioning organ donation. This is important due to the shortage of viable donor organ worldwide.
The donation process itself is complex. Bill provides his thoughts. He insists that an intensivist be involved as this has been shown to increase the number of viable and healthy organs made available.
The timing is also important. Available evidence does not support the need for immediate procurement after brain death. Taking time to optimise perfusion and allow recovery and cardiac function is appropriate and should be done.
Bill also discusses other treatment options at the time of death such as optimising endocrine function.
Finally, Bill will provide some practical considerations when communicating with the dead patient’s family. This involves being clear on your messaging. You are supporting organs, not life.
To reinforce this point, Bill suggests not examining or talking to the patient. He also recommends using all of the available hospital support services.
Similarly, it is best to not introduce the topic of organ donation to the family yourself as the treating clinician. Utilise the Organ Procurement Organisations (or similar services) and get them involved early to speak with the family.
Join Bill Knight in his talk on the North American perspective on Organ Donation, brain death and management of the brain dead donor prior to organ donation.
For more like this, head to our podcast page. #CodaPodcast
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
10. Why do we assess vertiginous patient?
CENTRAL
Vestibular migraine
Brainstem
ischaemia
Cerebellar stroke
Chiari
malformation
MS
Vertebrobasilar TIA
BPPV
Vestibular
neuritis
Labyrinthine
concussion
Menieres
Otitis media
Acoustic neuroma
PERIPHERAL
11. Vertebrobasilar TIA
Non-focal symptoms are more
frequent in patients with
vertebral artery than carotid
artery stenosis
Compter et al
Cerebrovasc Dis. 2013
Transient neurological attack
before vertebrobasilar stroke
Hoshino et al
J Neurol Sci 2013
Transient isolated brainstem
symptoms preceding
posterior circulation stroke: a
population-based study
Paul et al
Lancet Neurol 2013
14. Maggie C
•32 yr old lady, hx vestibular neuritis
•Acute onset vertigo assoc with N&V since waking
•Recent viral symptoms
•Difficult examination due to severe symptoms
•? horizontal torsional nystagmus
•Unsteady on feet
21. NYSTAGMUS
Peripheral
• Unidirectional
• Worse on gaze towards
fast beat
• Fatigueable
• Reversal on visual fixation
• Positional
Central
• Purely torsional
• Purely vertical
• Does NOT suppress
with visual fixation
• Changes direction with
gaze
28. Maggie C’s pathway
•Neurology admit
•Supportive treatment for nausea and vertigo
•Betahistine, cyclizine, ondansetron, haloperidol
•Neurosurg: repeat MRI and F/U in 3/12
•Transferred to OPH Young Adult Rehab
•Transfers 1x assist. Ambulation 1x assist
•DC OPH 6 weeks later
29.
30. References
• David E. Newman-Toker and Jonathan A. Edlow. TiTrATE: A Novel Approach to
Diagnosing Acute Dizziness and Vertigo. Neurol Clin. 2015 Aug; 33(3): 577–599.
• Compter A, Kappelle LJ, Algra A, et al. Nonfocal symptoms are more frequent in
patients with vertebral artery than carotid artery stenosis. Cerebrovasc
Dis. 2013;35(4):378–384.
• Hoshino T, Nagao T, Mizuno S, et al. Transient neurological attack before
vertebrobasilar stroke. J Neurol Sci. 2013;325(1–2):39–42.
• Paul NL, Simoni M, Rothwell PM, et al. Transient isolated brainstem symptoms
preceding posterior circulation stroke: a population-based study. Lancet
Neurol. 2013;12(1):65–71.
• Peter Johns. The HINTS exam. Youtube video accessible on:
https://www.youtube.com/watch?v=1q-VTKPweuk (last accessed July 2017)
• J. H. Pula, D. E. Newman-Toker, J. C. Kattah. Multiple sclerosis as a cause of the
acute vestibular syndrome. J Neurol. June 2013; 260(6):1649–1654
Editor's Notes
Vestibular symptoms – approx 5% ED visits, 1 in 20 patients, that’s 2 patients a week.
In approx 20% - underlying sinister cause
VERTIGO: sensation of self-motion (of head/body) when no self-motion is occurring or the sensation of distorted self-motion during an otherwise normal head movement
PERIPHERAL
CENTRAL
Ischaemia & stroke
Vestibular migraine: dx if >/= 5 attacks with migraine sx in at least half and prev hx migraine like headaches. And Low ABCD2 score.
Chiari malformation: congenital / aquired. F>M. Structural defects cerebullum, herniation into foramen magnum.
MS : demyelinating lesions in the cerebellum, medulla or intra-pontine 8th nerve fascicle. Study Newman Toker 2013: 130 patients with AVS, 4% (7) demyelinating lesions. 5 had other occulomotor signs, 2 didn’t.
Vetebrobasilar TIAS: proven that isolated episodes dizzines / vertigo = TIAs, often preceed post circ stroke. 3 papers 2013,
Menieres: episodic vertigo associated with tinnitus, aural fullness, SNHL. Usually starts aged 20-40yrs. Disruption endolymph.
BPPV: episodic vertigo triggered by changes in position. Episodes last seconds-minutes. Calcium crystals within endolymph in canals. F>M. middle aged – elderly.
Vestibular Neuritis: post viral / viral inflammation of vestibular portion 8th CN. Acute onset, CONSTANT symptoms, severe, gait instability. Usually lasts 1-2 days then gradual recovery.
Acoustic Neuroma: neuroma aka vestibular schwannoma is a benign primary intracranial tumor of the myelin-forming cells of the vestibular portion of 8th cranial nerve. Hearing loss, tinnitus + vestibular symptoms
(Images from: http://www.dizziness-and-balance.com/disorders/tumors/acoustic_neuroma/tests.html)
PERIPHERAL
CENTRAL
Ischaemia: risk factors. If trauma consider DISSECTION.
Stroke: aneurysm, AVM
Vestibular migraine: dx if >/= 5 attacks + migraine sx in at least half and prev hx migraine like headaches. And Low ABCD2 score.
Compter A, Kappelle LJ, Algra A, et al. Nonfocal symptoms are more frequent in patients with vertebral artery than carotid artery stenosis. Cerebrovasc Dis. 2013;35(4):378–384.
Hoshino T, Nagao T, Mizuno S, et al. Transient neurological attack before vertebrobasilar stroke. J Neurol Sci. 2013;325(1–2):39–42.
Paul NL, Simoni M, Rothwell PM, et al. Transient isolated brainstem symptoms preceding posterior circulation stroke: a population-based study. Lancet Neurol. 2013;12(1):65–71.
Vetebrobasilar TIAS: proven that isolated episodes dizzines / vertigo = TIAs, often preceed post circ stroke. 3 papers 2013,
Two MS plaques in cerebellar white matter.
NOT a common presentation for MS BUT within vestibular symptoms a significant number do have MS… see study below
MS : demyelinating lesions in the cerebellum, medulla or intra-pontine 8th nerve fascicle. Study Newman Toker 2013: 130 patients with AVS, 4% (7) demyelinating lesions. 5 had other occulomotor signs, 2 didn’t.
(image: Dizziness and Multiple Sclerosis (MS) Timothy C. Hain, accessed 25/7/2017)
TITRATE study
Triggers vs exacerbating factors. Important to differentiate
Episodic VERTIGO, note nausea may continue between episodes
L/S BP: check it is not hypoperfusion secondary to postural BP drop causing symptoms
DHP – will often EXACERBATE vestibular neuritis / stroke, but don’t confuse that with triggering an attack.
Peter Johns
Next morning, unfortunately her symptoms had got worse. Now unable to mobilise without frame, despite tx overnight onging vertigo N&V
O/E nystagmus at rest, bi-directional, torsional, past pointing
So she went off to the CT scanning
Torsional nystagmus
CT brain: Acute 14 x 14 x 13 mm parenchymal haematoma centred on the left middle cerebellar peduncle
This may reflect an underlying lesion such as a cavernoma.
CTA: No arteriovenous malformation or aneurysm is identified on CTA.
MRI: Acute left middle cerebellar peduncle haemorrhage with adjacent developmental venous anomaly suggesting an underlying cavernoma as the cause for haemorrhage. The haemorrhage has mildly increased in size since 12/06/2017.
Sporadically or familial pattern
M=F, aged 30 to 40 years
Dilated, thin walled capillaries that lack elastic fibers and smooth muscle
Women more commonly present with haemorrhage and neurologic deficits
Management:
Observation
Surgical resection if progressive neurologic deficit, intractable epilepsy or recurrent hemorrhage
Important case in reminding to expect unexpected
Importance of good examination skills, despite patient Sx / personal stuff