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Utilizing TopolyzerVario & Oculyzer II for 
IROC Science to Innovation AG 
Technoparkstrasse 1 
8005 Zürich 
Tel: +41 43 500 0850 
accurate refractive outcomes 
Michael Mrochen, PhD
VISION - OPTICS - LIGHT 
Content 
• What essential data are required by your ex500? 
• What is different between WFO and T-CAT? 
• A limiting factor: the subjective refraction 
• Accuracy of the TopolyzerVario 
• Accuracy of the Oculyzer II 
• A small pocket guide on: What to use when? 
2
VISION - OPTICS - LIGHT 
What essential data are required by 
your ex500? 
• Ablation profile 
– A map of required tissue removal at each point of the 
cornea 
– It’s based on difference between the pre- and to post-operative 
cornea anterior surface 
– Derived from either modelled or measured anterior 
cornea data 
3
VISION - OPTICS - LIGHT 
What essential data are required by 
your ex500? 
• How to calculate an ablation profile? 
– Assume a preoperative cornea shape (R,Q, Cyl,…) 
– Calculate the postoperative corneal shape based on the 
attempted refractive power change 
– Define to optical zone 
– Calculate the change in corneal height maps within the 
optical zone 
– Define a transition zone 
4 
Preoperative 
Postoperative 
Optical zone
WFO Wavefront Optimized for sphere and cylinder 
T-CAT Topography guided for sphere, cylinder and corneal irregularities 
VISION - OPTICS - LIGHT 
What is different between 
WFO and T-CAT? 
5 
Ex500 
Algorithm 
Manifest Refraction 
Optical zone 
WFO 
Ablation profile 
- Refractive 
predictability 
- Maintain visual 
performance 
Ex500 
Algorithm 
Manifest Refraction 
Optical zone 
T-CAT 
Ablation profile 
- Refractive 
predictability 
- Improve visual 
performance 
Height maps from 
Topolyzer / Oculyzer
Error of refraction (normal eyes) 
60% [43% to 75%] ±0.25 
92% [80% to 98%] ±0.5 
100% [91% to 100%] ±1.0 
VISION - OPTICS - LIGHT 
A limiting factor: 
the subjective refraction 
Error of refraction (irregular cornea) 
25% [18% to 33%] ±0.25 
50% [41% to 58%] ±0.5 
80% [72% to 86%] ±1.0 
Thomas W. Raasch1, Kenneth B. Schechtman2, Larry J. Davis3, Karla Zadnik1 Repeatability of subjective 
refraction in myopic and keratoconic subjects: results ofvector analysis. Ophthal. Physiol. Opt. Vol. 21, No. 
5, pp. 376±383, 2001
VISION - OPTICS - LIGHT 
Accuracy of the TopolyzerVario 
7 
44Edges 
Edge 
Detection
VISION - OPTICS - LIGHT 
Accuracy of the TopolyzerVario 
8 
Eye lashes, lid & nose Corneal irregularities 
Pupil detection Corneal surface / tear film
Degree of light scattering is of clinical relevance 
VISION - OPTICS - LIGHT 
9 
Accuracy of the Oculyzer II
VISION - OPTICS - LIGHT 
Accuracy of the Oculyzer II 
10 
Segmented measurement Motion compensation 
Light scattering
VISION - OPTICS - LIGHT 
Consequences of accuracy 
11 
Uncertainty of topography ~ 2 - 5 microns @ 8 mm 
2 micrometer will result in an uncertainty of 
approximately 0.14 D for an optical zone of 6.5 mm 
2 micrometer will result in an uncertainty of 
approximately 0.98 D for an optical zone of 2.5 mm
VISION - OPTICS - LIGHT 
A small pocket guide on: 
What to use when? 
12 
Manifest 
Refraction 
How much can 
I trust the Rx? 
TopolyzerVario 
Measurement 
Oculyzer II 
Measurement 
Mires of rings 
well detected? 
Yes 
Scheimpflug 
images well 
detected? 
Successful 
Topolyzer or 
Oculyzer 
measurement? 
No 
ex500 
Yes 
No 
Other treatment 
options
VISION - OPTICS - LIGHT 
Summary 
• TopolyzerVario and Oculyzer II are accurate 
measurement devices as demonstrated by experimental 
measurements and clinical studies. 
• Measurements of each device can be affected differently 
by the condition of the patient’s eye. 
• Raw data checks are required to assure accurate 
measurements. 
• Consequences can be irregular ablations or poor 
refractive predictability 
13

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Utilizing topolyzer vario & oculyzer ii for accurate refractive

  • 1. We focus your ideas Utilizing TopolyzerVario & Oculyzer II for IROC Science to Innovation AG Technoparkstrasse 1 8005 Zürich Tel: +41 43 500 0850 accurate refractive outcomes Michael Mrochen, PhD
  • 2. VISION - OPTICS - LIGHT Content • What essential data are required by your ex500? • What is different between WFO and T-CAT? • A limiting factor: the subjective refraction • Accuracy of the TopolyzerVario • Accuracy of the Oculyzer II • A small pocket guide on: What to use when? 2
  • 3. VISION - OPTICS - LIGHT What essential data are required by your ex500? • Ablation profile – A map of required tissue removal at each point of the cornea – It’s based on difference between the pre- and to post-operative cornea anterior surface – Derived from either modelled or measured anterior cornea data 3
  • 4. VISION - OPTICS - LIGHT What essential data are required by your ex500? • How to calculate an ablation profile? – Assume a preoperative cornea shape (R,Q, Cyl,…) – Calculate the postoperative corneal shape based on the attempted refractive power change – Define to optical zone – Calculate the change in corneal height maps within the optical zone – Define a transition zone 4 Preoperative Postoperative Optical zone
  • 5. WFO Wavefront Optimized for sphere and cylinder T-CAT Topography guided for sphere, cylinder and corneal irregularities VISION - OPTICS - LIGHT What is different between WFO and T-CAT? 5 Ex500 Algorithm Manifest Refraction Optical zone WFO Ablation profile - Refractive predictability - Maintain visual performance Ex500 Algorithm Manifest Refraction Optical zone T-CAT Ablation profile - Refractive predictability - Improve visual performance Height maps from Topolyzer / Oculyzer
  • 6. Error of refraction (normal eyes) 60% [43% to 75%] ±0.25 92% [80% to 98%] ±0.5 100% [91% to 100%] ±1.0 VISION - OPTICS - LIGHT A limiting factor: the subjective refraction Error of refraction (irregular cornea) 25% [18% to 33%] ±0.25 50% [41% to 58%] ±0.5 80% [72% to 86%] ±1.0 Thomas W. Raasch1, Kenneth B. Schechtman2, Larry J. Davis3, Karla Zadnik1 Repeatability of subjective refraction in myopic and keratoconic subjects: results ofvector analysis. Ophthal. Physiol. Opt. Vol. 21, No. 5, pp. 376±383, 2001
  • 7. VISION - OPTICS - LIGHT Accuracy of the TopolyzerVario 7 44Edges Edge Detection
  • 8. VISION - OPTICS - LIGHT Accuracy of the TopolyzerVario 8 Eye lashes, lid & nose Corneal irregularities Pupil detection Corneal surface / tear film
  • 9. Degree of light scattering is of clinical relevance VISION - OPTICS - LIGHT 9 Accuracy of the Oculyzer II
  • 10. VISION - OPTICS - LIGHT Accuracy of the Oculyzer II 10 Segmented measurement Motion compensation Light scattering
  • 11. VISION - OPTICS - LIGHT Consequences of accuracy 11 Uncertainty of topography ~ 2 - 5 microns @ 8 mm 2 micrometer will result in an uncertainty of approximately 0.14 D for an optical zone of 6.5 mm 2 micrometer will result in an uncertainty of approximately 0.98 D for an optical zone of 2.5 mm
  • 12. VISION - OPTICS - LIGHT A small pocket guide on: What to use when? 12 Manifest Refraction How much can I trust the Rx? TopolyzerVario Measurement Oculyzer II Measurement Mires of rings well detected? Yes Scheimpflug images well detected? Successful Topolyzer or Oculyzer measurement? No ex500 Yes No Other treatment options
  • 13. VISION - OPTICS - LIGHT Summary • TopolyzerVario and Oculyzer II are accurate measurement devices as demonstrated by experimental measurements and clinical studies. • Measurements of each device can be affected differently by the condition of the patient’s eye. • Raw data checks are required to assure accurate measurements. • Consequences can be irregular ablations or poor refractive predictability 13