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IOL Master
Moderator: Dr. A.Y.
Yakkundi
Presenter: Dr. Arushi
4th
March ‘15
History
• Theopticsof theeye
representsoneof theoldest
fieldsin ophthalmology
• Thehistory of IOL power
calculation began in 1949
when Sir Harold Ridley
implanted thefirst IOL.
2
Department of Ophthalmology,
JNMC
4th March 2015 3
• Heused thehuman lensashismodel and
selected similar radii of curvatureto createa
biconvex disc whileusing approximately half
thethicknessand weight (∟5 mm thick and 230
mg for thehuman lens).
• Oneof hisoriginal lensesmadeby Rayner, a
23.00 diopter (D), wasmeasured at 8.5 mm in
diameter and 2.4 mm thick, with aweight of
108 g
History
3
4th
March 2015
Department of Ophthalmology,
JNMC
4th March 2015 4
• TheRidley lenswasplaced in theposterior
chamber after ECCE.
• Theanterior capsulectomy of theday wasvery
large, and thuszonular support waspoor. Some
Ridley lensesdislocated into thevitreousbecause
of poor zonular support,
and partially becauseof
their weight, which was
approximately eight
timesthat of
current IOLs.
History
4
4th
March 2015
Department of Ophthalmology,
JNMC
4th March 2015 5
• Becauseof thedifficulty with posterior chamber IOL
placement, pioneering surgeons spent thenext two
decadestrying to find abetter placeto fixatetheIOL.
• TheAC lens, pupil-fixated IOL, iris-fixated IOL, and
iridocapsular IOL were beplaced in largenumbers, only
to return to theposterior chamber in the1970s.
History
5
4th
March 2015
Department of Ophthalmology,
JNMC
4th March 2015 6
• A major breakthrough camein thelateseventieswith
DoctorsBinkhorst and Worst in Europeand Dr. Shearing
in America
• They began putting their implants“in thebag”. Instead of
removing theentirecataract, they scooped out theinside
of thelens, leaving thecapsule, theouter envelopeof the
lensintact.
• They then implanted their lensesinto thiscavity which
gavethelensimplant anatural support system. Success
dramatically improved.
History
6
4th
March 2015
Department of Ophthalmology,
JNMC
4th March 2015 7
• Whilethiswasgoing on, Dr. CharlesKelman, was
developing phacoemulsification, aradically new method
of removing cataracts.
• A small probeispassed into theeye, and ultrasonic
vibrationswereused to break up thecataract into tiny
particles, easily removed through thesmall probe.
• Thisallowed thecataract to beremoved through asmall
opening. Thisleft aproblem: theopening wastoo small to
allow theinsertion of theintraocular lens, so wound had to
beenlarged.
• Enter thefoldableimplant. First madeof silicone, these
lensescould befolded in half, inserted through asmall
opening, and then unfolded insidetheeyeto their original
shape, all thistaking place“within thebag”.
History
7
4th
March 2015
Department of Ophthalmology,
JNMC
• Implant materialsand designscontinued to improve
through thelate20th century and early 21st century.
Implantsweredeveloped that could berolled instead of
just folded, allowing insertion through smaller and smaller
incisions.
• Thenext major leap forward was
thedevelopment of specialty lenses
with opticsthat could allow the
patient to seeboth distanceand
near through thesamelens.
4th March 2015 8
History
8
4th
March 2015
Department of Ophthalmology,
JNMC
4th March 2015 9
• Somepatientshavealargeamount of astigmatism.
• Thisdefect can beoptically corrected with proper glasses.
After cataract surgery, theshapeof thecorneadoesnot
changemuch.
• Therefore, patientswith astigmatism will still need
glassesfor distanceand near to seeclearly.
• Enter the toric implant. Thisimplant isconstructed with
astigmatism of variouspowersbuilt in, and allowsclear
vision, often without
glasses.
History
9
4th
March 2015
Department of Ophthalmology,
JNMC
4th
March 2015
Department of Ophthalmology,
JNMC 10
“Accurateand precisebiometry isoneof thekey
factorsin obtaining agood refractiveoutcome
after cataract surgery.”
An error of only 1.0 mm in
axial length will resultsin a
post-operativerefractive
error of threedioptres
Ocular Biometry
Ophthalmic
Ultrasonography
4th
March 2015
Department of Ophthalmology,
JNMC 11
Non- invasive, efficient and inexpensive
diagnostic tool to detect and differentiatevarious
ocular and orbital pathologies
Indispensibletool for calculation of IOL power,
evaluation of posterior segment behind dense
cataract / vitreoushaemorrhage, diagnosisof
complex vitreoretinal conditionsand the
differentiation of ocular masses
Physics of
Ultrasonography
4th
March 2015
Department of Ophthalmology,
JNMC 12
• Based on propagation, reflection and
attenuation of sound waves
• Ultrasound arehigh frequency sound waves
(> 20,000 kilohertz)
• Thoseused for diagnostic ophthalmic
ultrasound haveafrequency of 7.5 to 12
megahertz
Physics of
Ultrasonography
4th
March 2015
Department of Ophthalmology,
JNMC 13
• Speed of ultrasound dependson medium through
which it passes
• Astheultrasound passesthrough tissues, part of
thewavemay bereflected back towardsthe
probe, thisreflected waveisreferred to asan
echo.
• Echoesareproduced at thejunction of media
with different sound velocities
• Greater thedifferencein thesound velocitesof
themediaat theinterface, stronger istheecho
4th
March 2015
Department of Ophthalmology,
JNMC 14
 Examiner dependent
 Needs high level of skill and expertise
 Dynamic test
A scan ultrasound biometry isacontact method
and isoperator dependent. Experiencehas
shown that excessivecorneal indentation
compressestheeye, in theanterior-toposterior
direction. Thisproducesan artificially short eye,
producing themyopic refractiveresults
Limitation
Measurement of
Corneal Power
• Corneal power accountsfor about 2/3rd
sof
thetotal dioptric power of theeyeand isan
important component of theocular refractive
system.
• If thecorneal power isinaccurate, it will
induceerror propagation and haveprofound
consequenceson theremaining stepsin the
calculation of IOL power.
15
4th
March 2015
Department of Ophthalmology,
JNMC
• Unfortunately calculation of corneal power is
not astraight forward process
• No keratometer measurescorneal power
directly.
• What ismeasured isthesizeof theimage
reflected from theconvex mirror constituted
by thetear film of thecorneal surface
16
Measurement of
Corneal Power
4th
March 2015
Department of Ophthalmology,
JNMC
• A magnification iscalculated from theimage
sizewhich isdirectly related to theradiusof
curvatureof thereflecting corneal surface.
• To do this, thecorneaisnormally assumed to
beasperocylinder,
17
Measurement of
Corneal Power
4th
March 2015
Department of Ophthalmology,
JNMC
18
Measurement of
Corneal Power
Department of Ophthalmology,
JNMC
Measurement of
Axial Length
• Measurement of axial length remainsoneof
themost crucial stepsin IOL power
calculation.
• Asa0.1 mm error isaxial length isequivalent
to an error of abut 0.27 D in thespectacle
plane(assuming normal eye dimensions),
accuracy of within 0.1mm isnecessary
19
4th
March 2015
Department of Ophthalmology,
JNMC
Variable Error Refractive
Error
Corneal Radius 1.0 mm 5.7 D
Axial Length 1.0 mm 2.7 D
Postoperative
AC Depth
1.0 mm 1.5 D
IOL Power 1.0 D 0.67 D
20
• Deviation from themean valuesof different
variablesand corresponding refraction errors
4th
March 2015
Department of Ophthalmology,
JNMC
a = cornea spike
b = anterior lens spike
c = posterior lens spike
d = retinal spike
e = orbital spike
21
Acoustic
Biometry• What isreally
measured by
ultrasound isthe
transit timetaken
by theultrasonic
beam to travel
through theocular
mediawhileit is
deflected from the
internal structures
of theeye.
4th
March 2015
22
Acoustic
Biometry• Thebest signal isobtained when the
ultrasonic beam strikesasurfaceat normal
incidencethat givesriseto asteep spikeon
theechogram
• With good alignment along theocular axis,
it ispossibleto detect acorneal signal
(sometimesadoublespike), the front and
back surfacesof thelensand theretinaat
thesametime
4th
March 2015
Department of Ophthalmology,
JNMC
• The‘retinal’ spikeisgenerally assumed to
ariseat theinternal limiting membraneof the
retina
• Thismay call for correction to account for
retinal thicknesswhen thereadingsareto be
used in an IOL power formula.
• It isimportant to know thevelocity of
ultrasound in order to calculatethedistances
in question
23
Acoustic
Biometry
4th
March 2015
Department of Ophthalmology,
JNMC
• For thenormal phakic eye, velocity is
generally assumed to be1532/second for the
anterior chamber and vitreousand
1641m/second for thelens(Jansson & Knock)
• In an averageeye, thisisequivalent to 1550
m/second for thewholeeye.
• However, if weassumeaconstant lens
thickness, thisaveragevelocity islower in a
long eyeand higher in ashort eye, and should
becorrected to obtain an unbiased prediction
in theseunusual eyes
24
4th
March 2015
Thepitfallsof ultrasound measurementsare
numerous
•Readingsshould becoaxial with theocular axis
•Thisrequiresasteep spikefrom theretinaas
well asgood spikesfrom theanterior and
posterior surfacesof thelens
25
Acoustic
Biometry
limitations
• Someeyesdo not haveperfectly parallel
structures, however,
• readingscan bedifficult to obtain in eyeswith
densecataracts
• and eyeswith posterior staphyloma.
• Careshould betaken not to indent thecornea
if contact measurementsareused .
• For thisreason immersion readingsare
generally considered moreaccuratethan
contact measurements
26
Acoustic
Biometry
limitations
4th
March 2015
27
Optical
Biometry
4th
March 2015
Department of Ophthalmology,
JNMC
• Theintroduction of optical biometry using
partial coherenceinterferometry significantly
improved theaccuracy with which axial
length can bemeasured.
• Thefact that theretinal pigment epithelium is
theend– point of an optical measurement,
whereastheinterfacebetween thevitreous
and theneuro retinaistheendpoint of an
ultrasonic measurement, makesmeasurements
by PCLI longer than thosetaken with
ultrasound
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March 2015
OPTICAL
BIOMETRY
29
• However, just asdistancemeasurementstaken
with ultrasound aredependent on theassumed
ultrasound velocity, optical biometry is
dependent on theassumed group refractive
indicesof thephakic eye.
• Theindicesused by theZeissIOL Master
wereestimated by Haigisand werepartly
based on extrapolated data.
4th
March 2015
30
Optical Biometry –
Uses Optical Low-Coherence Reflectometry,
a similar technology that is used in OCT
devices. This technology results in highly
accurate measurements of the eye using
light in comparison to sound. The added
benefit is that this technology is also non
contact and can be performed with the
patient sitting comfortably in a chair without
the need for any topical anaesthesia, and
without the risk of damage to the cornea.
4th
March 2015
Department of Ophthalmology,
JNMC
Principle of Michelson
Interferometer
Xiaoyu Ding
Albert Michelson (1852~1931)
thefirst American scientist to
receiveaNobel prize, invented
theoptical interferometer.
TheMichelson interferometer has
been widely used for over a
century to makeprecise
measurementsof wavelengths
and distances.
Albert Michelson
31
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March 2015
Principle of Michelson
Interferometer
A Michelson Interferometer for use on an optical table
Xiaoyu Ding
1)Separation
2)Recombination
3)Interference
32
4th
March 2015
Department of Ophthalmology,
JNMC
33
IOL master employstheprincipleof optical
coherencebiometry (OCB)
It usespartially coherent infrared light beamsof
780nm diodelaser light emitted issplit up into two
beamsin aMichelson interferometer onemirror of
theinterferometer isfixed and theother ismoved at
constant speed making onebeam out of phasewith
theother. Both beamsareprojected in theyeand get
reflected at corneaand retina.
Thelight reflected from thecorneainterfereswith
that reflected by theretinaastheoptical pathsof
both thebeamsareequal
4th
March 2015
Department of Ophthalmology,
JNMC
34
Thisinterferenceproducesalight and dark band
pattern which isdetected by aphoto detector
Thesignalsareamplified, filtered and recorded
asafunction of theposition of theinterferometer
mirror.
An optical encoder isused to convert the
measurementsinto axial length measurements
In interferometer, theeyeneedsto beabsolutely
stableso asnot to disturb interferencepatterns
4th
March 2015
Department of Ophthalmology,
JNMC
The Down Side
Sinceoptical Biometry useslight
thereisahigher probability of the
“scatter” effect. Meaning that if the
light beam isreflected prior to the
RPE then thesignal returning to the
devicesensor will bevery weak if
detected at all. Thiswill result in low
SNR. Patientswith DensePSC,
ExtremeCorneal Abnormalities, or
WhiteCataractsarevery tough to
measure.
35
4th
March 2015
Department of Ophthalmology,
JNMC
IOL Master (Carl Zeiss)
Lenstar LS 900 (Haag-Streit)
Manufacturers
36
4th
March 2015
Department of Ophthalmology,
JNMC
IOL Master
A combined biometry instrument. It measures
parametersof thehuman eyeneeded for
intraocular lenscalculation.
37
4th
March 2015
Department of Ophthalmology,
JNMC
4th
March 2015
Department of Ophthalmology,
JNMC 38
1.Joystick with
release button
2.Display
3.Red eye
level marks
4.Lock knob
5.Connector
panel
6.Mouse
connector
7.Keyboard
connector
8.keyboard
PAR
TS
Department of Ophthalmology,
4th
March 2015
Department of Ophthalmology,
JNMC 39
1.DVD Drive
2.Adjustment
of headrest
3.Chin rest
4.Holding
pins for paper
pads
5.Forehead
rest
6. aperture
for diode
laser
PAR
TS
Department of Ophthalmology,
IOL Master
4th
March 2015
Department of Ophthalmology,
JNMC 40
It measuresquickly and precisely :
1. Axial length
2. Corneal curvature
3. Anterior chamber depth (ACD)
4. White-To-White(optional)
5. IOL power
It measures quickly and precisely
Axial length : Based on partial coherence interferometry
( Michelson interferometer)
Corneal curvature is determined by measuring the distance
between reflected light images.
ACD : as the distance between the optical sections of the
crystalline lens and the cornea produced by lateral slit
illumination.
White to white is determined from the image of the iris.
IOL power calculation : by software incorporating
internationally accepted calculation formulae.
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4th
March 2015
How do we operate
IOLmaster ?
After switching on the device, patient manager screen will
appear
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March 2015
Screen layout
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March 2015
Axial length
measurement(alm)Activate the axial length measurement mode by clicking on
ALM icon.
Switching to ALM mode will automatically change the
magnification ratio: a smaller section of the eye becomes
visible with the reflection of the alignment light and a
vertical line.
The patient should look at the red fixation point in the
center . A crosshair with a circle in the middle will appear
on the display.
Fine align the device so that the reflection of the alignment
44
4th
March 2015
Department of Ophthalmology,
JNMC
Note : The patient should be asked if he or she sees the
fixation point. If the patient fails to fixate properly, the visual
axis will not be correctly recognized, which may result in
measuring errors.
In the case of poor visual acuity/high ametropia (> 4 D) it is
advisable to measure through the spectacles. If the
procedure is followed correctly, no measuring errors will be
produced. Measurements should not be taken while a
patient is wearing contact lenses, as this will result in
measuring errors.
The corresponding display field next to the video image will
show the measured axial length.
45
Axial length
measurement
4th
March 2015
Department of Ophthalmology,
JNMC
The IOL Master requires five measurements to be taken.
The message Measure again will thus appear. Only then
will the composite signal be calculated and displayed as a
blue measurement curve following the red individual
measuring signal.
With stronger lens opacities, it may be advisable to defocus
the device. Defocusing and shifting the reflection within the
circle will have no effect on the result, because
interferometric axial length measurement is completely
independent of distance.
46
Axial length
measurement
4th
March 2015
Department of Ophthalmology,
JNMC
Axial Length Modes
1.Phakic
2.Pseudophakic
3.Aphakic
4.Silicone filled eyes
47
Axial length
measurement
4th
March 2015
Department of Ophthalmology,
JNMC
 IOLMaster produces a primary maxima (narrow, well-defined,
centered peak identified by a circle above it), secondary
maxima (discrete lower peaks, sometimes disappearing into
the baseline), and a baseline (which is low and even, but may
become high and uneven with decreasing signal-to-noise ratio
(SNR)).
Triple peak
curve
SNR categories :SNR is a measure of accuracy and
decreases with increasing cataract density.
The SNR is automatically analyzed while the system is
internally calculating the axial length from the interference
signal.
SNR display at GREEN  reading is valid.
SNR display at YELLOW  reading is uncertain
SNR display at RED reading should not be used
49
Axial length
measurement
4th
March 2015
Department of Ophthalmology,
JNMC
Keratometric
measurementAsk the patient to relax and look at the fixation
light. If the patient cannot see the fixation light,
he or she should look straight ahead into the
device.
When adjusting the device, make sure that all 6
peripheral points are visible and located in the
field between the two auxiliary circles, as
closely as possible to the center of the display.
The images of the measuring marks on the
display must be optimally focused by varying
the distance between patient and device.
50
4th
March 2015
Department of Ophthalmology,
JNMC
Focus points
51
TheIOLMaster
reflectssix pointsof
light, arranged in a2.3
mm diameter
hexagonal pattern
(measured by digital
callipers), from the
air/tear film interface.
Theseparation of
oppositepairsof lights
ismeasured
objectively by the
instrument’sinternal
softwareand the
toroidal surface
curvaturescalculated
from threefixed
meridians
Keratometric
measurement
Department of Ophthalmology,
JNMC
Acd measurement
Ask the patient to relax and look at the fixation
light. If the patient cannot see the fixation light, he
or she should look straight ahead into the device.
When the anterior chamber depth mode is turned
on, the system automatically activates the lateral
slit illumination. The illumination always originates
from a temporal direction.
An image similar to that of a slit lamp (optical
section through the anterior segment of the eye) is
visible on the display. Align the device to the
patient’s eye by lateral adjustment using the
joystick until:
52
4th
March 2015
The image of the anterior crystalline lens is visible in the
pupil.
The image of the fixation point may not lie in the image of
the lens or cornea.
53
Acd measurement
4th
March 2015
Department of Ophthalmology,
JNMC
54
4th
March 2015
Measuring errors
The"Error" messagemay havetwo basic
causes:
• Theresultsof thefiveinternal individual
measurementsvary by morethan 0.15 mm (very
rare), or
• Theimagesproduced (optical sections) do not
contain relevant structures(normally without the
edgeof thecrystallinelens) or disturbancesare
preventing their detection.
55
Acd measurement
4th
March 2015
Department of Ophthalmology,
JNMC
Ask the patient to relax and look at the fixation light.
Focus on the iris, not on the light spots.
After the image has been taken, the operator should check
if the software has correctly detected the edge of the iris. If
the circle segments drawn in the image do not define the
iris correctly, the result must be discarded.
56
WTW
measurement
4th
March 2015
Department of Ophthalmology,
JNMC
57
4th
March 2015
Department of Ophthalmology,
JNMC
Once all measurements have been taken (depending on
the IOL calculation formula), options can be generated for
intraocular lenses to be implanted.
Start the calculation by: clicking on IOL
Click on the appropriate tab to select the desired formula.
The IOL Haigis, HofferQ, Holladay, SRK II, and SRKÂŽ/T
formulae are implemented as standards.
After refractive corneal surgery the Haigis-L formulae may
be selected.
58
IOL
CALCULATION
4th
March 2015
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March 2015
result
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Measuring ranges Axial length : 14 – 40 mm
Corneal radii : 5 – 10 mm
Depth of anterior chamber : 1.5 – 6.5 mm
White-to-white : 8 – 16 mm
formulas SRKÂŽ II, SRKÂŽ/T, Holladay, Hoffer Q, Haigis
Haigis-L for IOL calculation for eyes after
myopic/hyperopic LASIK/PRK/LASEK
Optimization of IOL constants
Line voltage 100 – 240 V +/– 10% (self sensing)
Line frequency 50 – 60 Hz
Power consumption max. 90 VA
Technical data
61
4th
March 2015
Department of Ophthalmology,
JNMC
62
Biometry Formulas
4th
March 2015
Department of Ophthalmology,
JNMC
IOL Formulas
1st
Generation – The first theoretical formula
(based on Geometric Optics as applied to
schematic eye models) was developed in 1967.
These formulas were very primitive and usually
resulted in large amounts of post-cataract surgery
refractive errors. (Regression)
63
4th
March 2015
Department of Ophthalmology,
JNMC
IOL formulas
1st
generation
•Most are based on regression formula developed
by Sander ,Retzlaff & Kraff
•Known as SRK formula.
•P = A - 2.5(L) - 0.9(K)
•P=lens implant power for emetropia
•L= Axial length (mm)
•K=average keratometric reading (diopters)
•A= lens constant
64
4th
March 2015
Department of Ophthalmology,
JNMC
IOL formulas
2nd
Generation – With an extreme need for
increased IOL Calculation, the second generation
formulas (Hoffer, SRK II) listed manual
correction factors for long or short eyes. (These
formulas are now considered obsolete.)
(Regression)
65
4th
March 2015
Department of Ophthalmology,
JNMC
IOL formulas
• IOL FORMULA 2nd
generation
• SRK II formula
• modification of SRK
• works on ELP
• P = A1 – 2.5L – 0.9K
66
4th
March 2015
Department of Ophthalmology,
JNMC
IOL formulas
3rd
Generation – In 1988 Dr. Holladay published
a formula (Holladay I)that predicted the AC
Depth on the basis of K Height and the distance
from the iris plane to the IOL optical plane called
the “Surgeon Factor”. This change in the physics
greatly increased the visual outcomes for Cataract
Surgery. This generation also includes the
SRK/T and Hoffer Q.
4th
Generation – Consist of Holladay II as well as
the modern post-refractive formulas
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IOL formulas
• IOL FORMULA 3rd
generation
• Third generation formulas-
• SRK/T -very long eyes >26mm
• Holladay I -long eyes 24-26 mm
• HofferQ -Short eyes<22mm
68
4th
March 2015
Department of Ophthalmology,
JNMC
IOL formulas
• IOL FORMULA 4th
generation
• Holladay II
• Haigis formula-
• d = a0 + (a1 * ACD) + (a2 * AL)
• ACD is the measured anterior chamber depth
• AL is the axial length of the eye
• The a0, a1 and a2 constants are set by optimizing
• a set of surgeon- and IOL-specific outcomes for a wide
• range of ALs and ACDs.
• SRK/T formula — uses "A-constant“
• Holladay 1 formula — uses "Surgeon Factor“
• Holladay 2 formula — uses "Anterior Chamber Depth“
• Hoffer Q formula — uses "Anterior Chamber Depth"
69
4th
March 2015
Department of Ophthalmology,
JNMC
IOL formulas
• When capsular tear does not allow bag
placement of the lens → change IOL
power for sulcus placement
• >=28.5 D Decrease by 1.5 D
• +17 To 28 D Decrease by 1.0 D
• +9 To 17 D Decrease by 0.5 D
• <+ 9 D
70
4th
March 2015
Department of Ophthalmology,
JNMC
LensConstants
A-Constants are used with all IOL formulas, and
are determined by the anticipated position within
the eye.
Surgeon Factor – is used with the first Holladay
formula, and is determined by the distance from
the Iris plane to the Optical plane of the implant.
Effective Lens Position (ELP) is used for the
Holladay II formula, and is based on the depth of
the AC following Cataract surgery with the new
IOL in place. 71
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March 2015
Typesof Formulas
Regression formulas are based upon mathematical
analysis of a large sampling of post-operative results. 
The most familiar regression formula is the SRK
formula. The basic SRK formula  works well for eyes in
the "average" measurement range; 22.5 to 25.0 mm in
axial length, with certain combinations of K readings. 
The formula does not work well for "long" (>25 mm) or
"short" (<22.5 mm) eyes. 
Advantage - relatively simple to calculate.  A factor
can be added to a simple regression formula to
compensate for a long or a short eye
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Typesof Formulas
Theoretical formulas are optical formulas based on the
optical properties of the eye.  They do a better job of
predicting post-op outcomes for long and short eyes.
73
4th
March 2015
Department of Ophthalmology,
JNMC
Formula Requirements
Haigis Hoffer Q SRK/2 SRK/T HOLLADAY 1 HOLLADAY 2 Olsen
Axial Length YES YES YES YES YES YES YES
ACD YES NO NO NO NO YES* YES
Keratometry YES YES YES YES YES YES YES
Lens Thickness NO NO NO NO NO YES YES
Corneal Thickness NO NO NO NO NO NO NO
White to White NO NO NO NO NO YES YES
Pupil Size NO NO NO NO NO NO NO
Visual Axis NO NO NO NO NO NO NO
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4th
March 2015
Department of Ophthalmology,
JNMC
Formula Preferences
75
4th
March 2015
Short Eyes (<22.0mm) Hoffer Q / Holladay 2
Average Eyes (22.1-
24.4mm)
Hoffer Q /
Holladay I / SRK/T
Medium-Long Eyes
(24.5-25.9mm
Holladay I / Hoffer Q
Long Eyes (25.0mm +) SRK/T / Holladay I
(Holladay II All eye
lengths.)
(Haigis All eye lengths
w/o optimization)
Post-Refractive Surgery Patient
One of the most challenging problems facing modern
Cataract Surgery is the Post-Refractive patient. Following
refractive surgery (RK, PRK, LASIK, ect) accurate K
readings cannot be obtained from topography, automated
or manual keratometry because the central cornea has
been flattened causing the mires of the measuring device
to measure roughly 4.5mm versus 3.0mm for which they
were designed. This causes erroneous K readings
compromising the effectiveness of all modern IOL
formulas.
76
4th
March 2015
Department of Ophthalmology,
JNMC
Post Refractive Formulas
Haigis L - The Haigis-L formula offers predictable outcomes
after laser refractive surgery for myopia based only on current
measurements without refractive history.)
Masket Method - The Masket Method of post-LASIK corneal
power estimation is a postoperative regression method developed
by Samuel Masket and Clinical History Method – Is usable when
both the pre-op and post-op Keratometry values are known.
Contact Lens Method - The Contact Lens Method, originally
outlined by Dr. Holladay is considered a helpful way to estimate
the average central corneal power following radial keratotomy.
This technique required a special PMMA contact lens, of a known
base curve and power.
77
4th
March 2015
4th
March 2015
Shammas – Used when no pre-op data is available such as
refraction and keratometry.
Double K SRK/T – Utilizes pre-op refraction and keratometry
Post Refractive Formulas
78
4th
March 2015
Department of Ophthalmology,
JNMC
Advantages
#  Learned very quickly (User Friendly)
#  Extensiveintegrated safety features
#  Non-contact measurements.
# It givesthetruerefractivelength than anatomical
axial length
79
4th
March 2015
Department of Ophthalmology,
JNMC
Advantages
# Accuracy of IOL Master is0.02 Âľm which is
operator independent
# It isupright, non contact, ultrahigh resiltuion
biometry
# Highly ametropic patient can wear glasseswhile
sitting on theIOL master which aidsin fixation
# It hastheadvantageof measuring foveain cases
of posterior staphyloma
80
4th
March 2015
Department of Ophthalmology,
JNMC
Limitations
# Cannot measureaxial length in media
opacitieslikecorneal opacities, dense
cataract, nuclear sclerosisgradeIV, posterior
Polar Cataract
# Cannot measureaxial length in casesof
vitreoushaemmorrhage
# Difficulty in measuring axial lengthsin
infants, small children and mentally
handicapped patients
# Patientswith poor fixation
81
4th
March 2015
Department of Ophthalmology,
JNMC
Do not throw away old ultrasound
machine
Immersion
ultrasound
IOL
master
Posterior staphyloma
Silicone oil
Pseudophakia
4++brunescent lens
Central PSC plaque
Vitreous hemorrhage
Central corneal scar
Difficult
Difficult
Variable
•Yes
•Yes
•Yes
•Yes
•Yes
•Yes
•Yes
No
No
No
No
Lenstar 900
4th March 2015 Department of Ophthalmology,
JNMC
83
4th
March 2015
Lenstar 900
Lenstar featuresauniquedual zonekeratometer with a
total of 32 marker pointson two concentric ringsof 1.65
and 2.3 mm in diameter for improved refractive
outcomeswith toric lense.
84
4th
March 2015
Lenstar 900
It hasbeen complemented with
an optional T-Conetopography
add-on and an optional toric
surgery planning platform.
TheT-ConeenablestheLenstar
to providetruePlacido
topograph of thecentral 6 mm
optical zone.
Thetoric surgery planning
platform allowsplanning and
optimization of thesurgical
85
4th
March 2015
Lenstar 900
• Thetoric planner showstheimplantation axis, the
incision location and user-defined guiding meridiansin
thereal patient image.
• Incision optimization toolsallow for preciseplacement
of theincision to minimizetheresidual astigmatism
based on thesurgically induced astigmatism.
• Planning of theoperation on real eyeimagesallowsthe
user to definerecognizable, additional guiding linesto
anatomical landmarksin theintraoperativeview.
• They either serveasabaselinepoint for the
intraoperativeorientation or asafallback strategy if
external marking isnot successful.
• Theplanning sketch can easily beprinted and hung near
themicroscope
86
4th
March 2015
• The LENSTAR LS 900 ® measures:
¡¡ Axial eye length
¡¡ Corneal thickness
¡¡ Anterior chamber depth
¡¡ Aqueous depth
¡¡ Lens thickness
¡¡ Radii of curvature of flat and
steep meridian
¡¡ Axis of the flat meridian
¡¡White-to-white distance
¡¡ Pupil diameter4th March 2015 Department of Ophthalmology,
JNMC
87
Lenstar 900
4th
March 2015
88
Olsen formula
calculatesthepostoperativelens
position asafraction of the
crystallinelensthicknessand the
ACD.
Thisapproach allowsaccurate
calculation of thelensposition
independent of thecorneal status
of theeye.
Thelensposition isthen used to
calculatetheIOL power based
on ray tracing, thesame
technology that physicistsuseto
design telescopesand camera
4th
March 2015
Post -refractive IOL
calculation
4th March 2015 Department of Ophthalmology,
JNMC
89
• ShammasNo-History and Masket – for
premium results
• TheLenstar EyeSuitesoftwareprovides
theuser with acomprehensiveset of
cutting-edgeIOL calculation formulae
for normal eyes. IOL Power calculation
in patientswith prior LASIK or PRK,
presenting with no history, iseasily
achieved with theon-board Shammas
No-History method.
• If thechangein refraction isknown, then
theMasket and modified Masket
formulaemay also beused.
4th
March 2015
Optical Biometer Properties
90
Feature Device
IOL Master Lenstar
Axial Length X X
White to White X X
Keratometry X X
ACD X X
Pachymetry X
Lens Thickness X
Retinal
Thickness
X
Pupillometry X
Visual Axis X
4th
March 2015
Summary
With state of the art technology
and modern IOL calculation
formulas, excellent refractive
outcomes can be achieved after
IOL implantation in challenging
eyes, that approach the
benchmarks postulated for
91
4th
March 2015
Department of Ophthalmology,
JNMC
08/22/15 01:46 PM Dept. of Ophthalmology, JNMC 92

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Iol master

  • 1. IOL Master Moderator: Dr. A.Y. Yakkundi Presenter: Dr. Arushi 4th March ‘15
  • 2. History • Theopticsof theeye representsoneof theoldest fieldsin ophthalmology • Thehistory of IOL power calculation began in 1949 when Sir Harold Ridley implanted thefirst IOL. 2 Department of Ophthalmology, JNMC
  • 3. 4th March 2015 3 • Heused thehuman lensashismodel and selected similar radii of curvatureto createa biconvex disc whileusing approximately half thethicknessand weight (∟5 mm thick and 230 mg for thehuman lens). • Oneof hisoriginal lensesmadeby Rayner, a 23.00 diopter (D), wasmeasured at 8.5 mm in diameter and 2.4 mm thick, with aweight of 108 g History 3 4th March 2015 Department of Ophthalmology, JNMC
  • 4. 4th March 2015 4 • TheRidley lenswasplaced in theposterior chamber after ECCE. • Theanterior capsulectomy of theday wasvery large, and thuszonular support waspoor. Some Ridley lensesdislocated into thevitreousbecause of poor zonular support, and partially becauseof their weight, which was approximately eight timesthat of current IOLs. History 4 4th March 2015 Department of Ophthalmology, JNMC
  • 5. 4th March 2015 5 • Becauseof thedifficulty with posterior chamber IOL placement, pioneering surgeons spent thenext two decadestrying to find abetter placeto fixatetheIOL. • TheAC lens, pupil-fixated IOL, iris-fixated IOL, and iridocapsular IOL were beplaced in largenumbers, only to return to theposterior chamber in the1970s. History 5 4th March 2015 Department of Ophthalmology, JNMC
  • 6. 4th March 2015 6 • A major breakthrough camein thelateseventieswith DoctorsBinkhorst and Worst in Europeand Dr. Shearing in America • They began putting their implants“in thebag”. Instead of removing theentirecataract, they scooped out theinside of thelens, leaving thecapsule, theouter envelopeof the lensintact. • They then implanted their lensesinto thiscavity which gavethelensimplant anatural support system. Success dramatically improved. History 6 4th March 2015 Department of Ophthalmology, JNMC
  • 7. 4th March 2015 7 • Whilethiswasgoing on, Dr. CharlesKelman, was developing phacoemulsification, aradically new method of removing cataracts. • A small probeispassed into theeye, and ultrasonic vibrationswereused to break up thecataract into tiny particles, easily removed through thesmall probe. • Thisallowed thecataract to beremoved through asmall opening. Thisleft aproblem: theopening wastoo small to allow theinsertion of theintraocular lens, so wound had to beenlarged. • Enter thefoldableimplant. First madeof silicone, these lensescould befolded in half, inserted through asmall opening, and then unfolded insidetheeyeto their original shape, all thistaking place“within thebag”. History 7 4th March 2015 Department of Ophthalmology, JNMC
  • 8. • Implant materialsand designscontinued to improve through thelate20th century and early 21st century. Implantsweredeveloped that could berolled instead of just folded, allowing insertion through smaller and smaller incisions. • Thenext major leap forward was thedevelopment of specialty lenses with opticsthat could allow the patient to seeboth distanceand near through thesamelens. 4th March 2015 8 History 8 4th March 2015 Department of Ophthalmology, JNMC
  • 9. 4th March 2015 9 • Somepatientshavealargeamount of astigmatism. • Thisdefect can beoptically corrected with proper glasses. After cataract surgery, theshapeof thecorneadoesnot changemuch. • Therefore, patientswith astigmatism will still need glassesfor distanceand near to seeclearly. • Enter the toric implant. Thisimplant isconstructed with astigmatism of variouspowersbuilt in, and allowsclear vision, often without glasses. History 9 4th March 2015 Department of Ophthalmology, JNMC
  • 10. 4th March 2015 Department of Ophthalmology, JNMC 10 “Accurateand precisebiometry isoneof thekey factorsin obtaining agood refractiveoutcome after cataract surgery.” An error of only 1.0 mm in axial length will resultsin a post-operativerefractive error of threedioptres Ocular Biometry
  • 11. Ophthalmic Ultrasonography 4th March 2015 Department of Ophthalmology, JNMC 11 Non- invasive, efficient and inexpensive diagnostic tool to detect and differentiatevarious ocular and orbital pathologies Indispensibletool for calculation of IOL power, evaluation of posterior segment behind dense cataract / vitreoushaemorrhage, diagnosisof complex vitreoretinal conditionsand the differentiation of ocular masses
  • 12. Physics of Ultrasonography 4th March 2015 Department of Ophthalmology, JNMC 12 • Based on propagation, reflection and attenuation of sound waves • Ultrasound arehigh frequency sound waves (> 20,000 kilohertz) • Thoseused for diagnostic ophthalmic ultrasound haveafrequency of 7.5 to 12 megahertz
  • 13. Physics of Ultrasonography 4th March 2015 Department of Ophthalmology, JNMC 13 • Speed of ultrasound dependson medium through which it passes • Astheultrasound passesthrough tissues, part of thewavemay bereflected back towardsthe probe, thisreflected waveisreferred to asan echo. • Echoesareproduced at thejunction of media with different sound velocities • Greater thedifferencein thesound velocitesof themediaat theinterface, stronger istheecho
  • 14. 4th March 2015 Department of Ophthalmology, JNMC 14  Examiner dependent  Needs high level of skill and expertise  Dynamic test A scan ultrasound biometry isacontact method and isoperator dependent. Experiencehas shown that excessivecorneal indentation compressestheeye, in theanterior-toposterior direction. Thisproducesan artificially short eye, producing themyopic refractiveresults Limitation
  • 15. Measurement of Corneal Power • Corneal power accountsfor about 2/3rd sof thetotal dioptric power of theeyeand isan important component of theocular refractive system. • If thecorneal power isinaccurate, it will induceerror propagation and haveprofound consequenceson theremaining stepsin the calculation of IOL power. 15 4th March 2015 Department of Ophthalmology, JNMC
  • 16. • Unfortunately calculation of corneal power is not astraight forward process • No keratometer measurescorneal power directly. • What ismeasured isthesizeof theimage reflected from theconvex mirror constituted by thetear film of thecorneal surface 16 Measurement of Corneal Power 4th March 2015 Department of Ophthalmology, JNMC
  • 17. • A magnification iscalculated from theimage sizewhich isdirectly related to theradiusof curvatureof thereflecting corneal surface. • To do this, thecorneaisnormally assumed to beasperocylinder, 17 Measurement of Corneal Power 4th March 2015 Department of Ophthalmology, JNMC
  • 19. Measurement of Axial Length • Measurement of axial length remainsoneof themost crucial stepsin IOL power calculation. • Asa0.1 mm error isaxial length isequivalent to an error of abut 0.27 D in thespectacle plane(assuming normal eye dimensions), accuracy of within 0.1mm isnecessary 19 4th March 2015 Department of Ophthalmology, JNMC
  • 20. Variable Error Refractive Error Corneal Radius 1.0 mm 5.7 D Axial Length 1.0 mm 2.7 D Postoperative AC Depth 1.0 mm 1.5 D IOL Power 1.0 D 0.67 D 20 • Deviation from themean valuesof different variablesand corresponding refraction errors 4th March 2015 Department of Ophthalmology, JNMC
  • 21. a = cornea spike b = anterior lens spike c = posterior lens spike d = retinal spike e = orbital spike 21 Acoustic Biometry• What isreally measured by ultrasound isthe transit timetaken by theultrasonic beam to travel through theocular mediawhileit is deflected from the internal structures of theeye. 4th March 2015
  • 22. 22 Acoustic Biometry• Thebest signal isobtained when the ultrasonic beam strikesasurfaceat normal incidencethat givesriseto asteep spikeon theechogram • With good alignment along theocular axis, it ispossibleto detect acorneal signal (sometimesadoublespike), the front and back surfacesof thelensand theretinaat thesametime 4th March 2015 Department of Ophthalmology, JNMC
  • 23. • The‘retinal’ spikeisgenerally assumed to ariseat theinternal limiting membraneof the retina • Thismay call for correction to account for retinal thicknesswhen thereadingsareto be used in an IOL power formula. • It isimportant to know thevelocity of ultrasound in order to calculatethedistances in question 23 Acoustic Biometry 4th March 2015 Department of Ophthalmology, JNMC
  • 24. • For thenormal phakic eye, velocity is generally assumed to be1532/second for the anterior chamber and vitreousand 1641m/second for thelens(Jansson & Knock) • In an averageeye, thisisequivalent to 1550 m/second for thewholeeye. • However, if weassumeaconstant lens thickness, thisaveragevelocity islower in a long eyeand higher in ashort eye, and should becorrected to obtain an unbiased prediction in theseunusual eyes 24 4th March 2015
  • 25. Thepitfallsof ultrasound measurementsare numerous •Readingsshould becoaxial with theocular axis •Thisrequiresasteep spikefrom theretinaas well asgood spikesfrom theanterior and posterior surfacesof thelens 25 Acoustic Biometry limitations
  • 26. • Someeyesdo not haveperfectly parallel structures, however, • readingscan bedifficult to obtain in eyeswith densecataracts • and eyeswith posterior staphyloma. • Careshould betaken not to indent thecornea if contact measurementsareused . • For thisreason immersion readingsare generally considered moreaccuratethan contact measurements 26 Acoustic Biometry limitations 4th March 2015
  • 28. • Theintroduction of optical biometry using partial coherenceinterferometry significantly improved theaccuracy with which axial length can bemeasured. • Thefact that theretinal pigment epithelium is theend– point of an optical measurement, whereastheinterfacebetween thevitreous and theneuro retinaistheendpoint of an ultrasonic measurement, makesmeasurements by PCLI longer than thosetaken with ultrasound 28 4th March 2015
  • 29. OPTICAL BIOMETRY 29 • However, just asdistancemeasurementstaken with ultrasound aredependent on theassumed ultrasound velocity, optical biometry is dependent on theassumed group refractive indicesof thephakic eye. • Theindicesused by theZeissIOL Master wereestimated by Haigisand werepartly based on extrapolated data. 4th March 2015
  • 30. 30 Optical Biometry – Uses Optical Low-Coherence Reflectometry, a similar technology that is used in OCT devices. This technology results in highly accurate measurements of the eye using light in comparison to sound. The added benefit is that this technology is also non contact and can be performed with the patient sitting comfortably in a chair without the need for any topical anaesthesia, and without the risk of damage to the cornea. 4th March 2015 Department of Ophthalmology, JNMC
  • 31. Principle of Michelson Interferometer Xiaoyu Ding Albert Michelson (1852~1931) thefirst American scientist to receiveaNobel prize, invented theoptical interferometer. TheMichelson interferometer has been widely used for over a century to makeprecise measurementsof wavelengths and distances. Albert Michelson 31 4th March 2015
  • 32. Principle of Michelson Interferometer A Michelson Interferometer for use on an optical table Xiaoyu Ding 1)Separation 2)Recombination 3)Interference 32 4th March 2015 Department of Ophthalmology, JNMC
  • 33. 33 IOL master employstheprincipleof optical coherencebiometry (OCB) It usespartially coherent infrared light beamsof 780nm diodelaser light emitted issplit up into two beamsin aMichelson interferometer onemirror of theinterferometer isfixed and theother ismoved at constant speed making onebeam out of phasewith theother. Both beamsareprojected in theyeand get reflected at corneaand retina. Thelight reflected from thecorneainterfereswith that reflected by theretinaastheoptical pathsof both thebeamsareequal 4th March 2015 Department of Ophthalmology, JNMC
  • 34. 34 Thisinterferenceproducesalight and dark band pattern which isdetected by aphoto detector Thesignalsareamplified, filtered and recorded asafunction of theposition of theinterferometer mirror. An optical encoder isused to convert the measurementsinto axial length measurements In interferometer, theeyeneedsto beabsolutely stableso asnot to disturb interferencepatterns 4th March 2015 Department of Ophthalmology, JNMC
  • 35. The Down Side Sinceoptical Biometry useslight thereisahigher probability of the “scatter” effect. Meaning that if the light beam isreflected prior to the RPE then thesignal returning to the devicesensor will bevery weak if detected at all. Thiswill result in low SNR. Patientswith DensePSC, ExtremeCorneal Abnormalities, or WhiteCataractsarevery tough to measure. 35 4th March 2015 Department of Ophthalmology, JNMC
  • 36. IOL Master (Carl Zeiss) Lenstar LS 900 (Haag-Streit) Manufacturers 36 4th March 2015 Department of Ophthalmology, JNMC
  • 37. IOL Master A combined biometry instrument. It measures parametersof thehuman eyeneeded for intraocular lenscalculation. 37 4th March 2015 Department of Ophthalmology, JNMC
  • 38. 4th March 2015 Department of Ophthalmology, JNMC 38 1.Joystick with release button 2.Display 3.Red eye level marks 4.Lock knob 5.Connector panel 6.Mouse connector 7.Keyboard connector 8.keyboard PAR TS Department of Ophthalmology,
  • 39. 4th March 2015 Department of Ophthalmology, JNMC 39 1.DVD Drive 2.Adjustment of headrest 3.Chin rest 4.Holding pins for paper pads 5.Forehead rest 6. aperture for diode laser PAR TS Department of Ophthalmology,
  • 40. IOL Master 4th March 2015 Department of Ophthalmology, JNMC 40 It measuresquickly and precisely : 1. Axial length 2. Corneal curvature 3. Anterior chamber depth (ACD) 4. White-To-White(optional) 5. IOL power
  • 41. It measures quickly and precisely Axial length : Based on partial coherence interferometry ( Michelson interferometer) Corneal curvature is determined by measuring the distance between reflected light images. ACD : as the distance between the optical sections of the crystalline lens and the cornea produced by lateral slit illumination. White to white is determined from the image of the iris. IOL power calculation : by software incorporating internationally accepted calculation formulae. 41 4th March 2015
  • 42. How do we operate IOLmaster ? After switching on the device, patient manager screen will appear 42 4th March 2015
  • 44. Axial length measurement(alm)Activate the axial length measurement mode by clicking on ALM icon. Switching to ALM mode will automatically change the magnification ratio: a smaller section of the eye becomes visible with the reflection of the alignment light and a vertical line. The patient should look at the red fixation point in the center . A crosshair with a circle in the middle will appear on the display. Fine align the device so that the reflection of the alignment 44 4th March 2015 Department of Ophthalmology, JNMC
  • 45. Note : The patient should be asked if he or she sees the fixation point. If the patient fails to fixate properly, the visual axis will not be correctly recognized, which may result in measuring errors. In the case of poor visual acuity/high ametropia (> 4 D) it is advisable to measure through the spectacles. If the procedure is followed correctly, no measuring errors will be produced. Measurements should not be taken while a patient is wearing contact lenses, as this will result in measuring errors. The corresponding display field next to the video image will show the measured axial length. 45 Axial length measurement 4th March 2015 Department of Ophthalmology, JNMC
  • 46. The IOL Master requires five measurements to be taken. The message Measure again will thus appear. Only then will the composite signal be calculated and displayed as a blue measurement curve following the red individual measuring signal. With stronger lens opacities, it may be advisable to defocus the device. Defocusing and shifting the reflection within the circle will have no effect on the result, because interferometric axial length measurement is completely independent of distance. 46 Axial length measurement 4th March 2015 Department of Ophthalmology, JNMC
  • 47. Axial Length Modes 1.Phakic 2.Pseudophakic 3.Aphakic 4.Silicone filled eyes 47 Axial length measurement 4th March 2015 Department of Ophthalmology, JNMC
  • 48.  IOLMaster produces a primary maxima (narrow, well-defined, centered peak identified by a circle above it), secondary maxima (discrete lower peaks, sometimes disappearing into the baseline), and a baseline (which is low and even, but may become high and uneven with decreasing signal-to-noise ratio (SNR)). Triple peak curve
  • 49. SNR categories :SNR is a measure of accuracy and decreases with increasing cataract density. The SNR is automatically analyzed while the system is internally calculating the axial length from the interference signal. SNR display at GREEN  reading is valid. SNR display at YELLOW  reading is uncertain SNR display at RED reading should not be used 49 Axial length measurement 4th March 2015 Department of Ophthalmology, JNMC
  • 50. Keratometric measurementAsk the patient to relax and look at the fixation light. If the patient cannot see the fixation light, he or she should look straight ahead into the device. When adjusting the device, make sure that all 6 peripheral points are visible and located in the field between the two auxiliary circles, as closely as possible to the center of the display. The images of the measuring marks on the display must be optimally focused by varying the distance between patient and device. 50 4th March 2015 Department of Ophthalmology, JNMC
  • 51. Focus points 51 TheIOLMaster reflectssix pointsof light, arranged in a2.3 mm diameter hexagonal pattern (measured by digital callipers), from the air/tear film interface. Theseparation of oppositepairsof lights ismeasured objectively by the instrument’sinternal softwareand the toroidal surface curvaturescalculated from threefixed meridians Keratometric measurement Department of Ophthalmology, JNMC
  • 52. Acd measurement Ask the patient to relax and look at the fixation light. If the patient cannot see the fixation light, he or she should look straight ahead into the device. When the anterior chamber depth mode is turned on, the system automatically activates the lateral slit illumination. The illumination always originates from a temporal direction. An image similar to that of a slit lamp (optical section through the anterior segment of the eye) is visible on the display. Align the device to the patient’s eye by lateral adjustment using the joystick until: 52 4th March 2015
  • 53. The image of the anterior crystalline lens is visible in the pupil. The image of the fixation point may not lie in the image of the lens or cornea. 53 Acd measurement 4th March 2015 Department of Ophthalmology, JNMC
  • 55. Measuring errors The"Error" messagemay havetwo basic causes: • Theresultsof thefiveinternal individual measurementsvary by morethan 0.15 mm (very rare), or • Theimagesproduced (optical sections) do not contain relevant structures(normally without the edgeof thecrystallinelens) or disturbancesare preventing their detection. 55 Acd measurement 4th March 2015 Department of Ophthalmology, JNMC
  • 56. Ask the patient to relax and look at the fixation light. Focus on the iris, not on the light spots. After the image has been taken, the operator should check if the software has correctly detected the edge of the iris. If the circle segments drawn in the image do not define the iris correctly, the result must be discarded. 56 WTW measurement 4th March 2015 Department of Ophthalmology, JNMC
  • 57. 57 4th March 2015 Department of Ophthalmology, JNMC
  • 58. Once all measurements have been taken (depending on the IOL calculation formula), options can be generated for intraocular lenses to be implanted. Start the calculation by: clicking on IOL Click on the appropriate tab to select the desired formula. The IOL Haigis, HofferQ, Holladay, SRK II, and SRKÂŽ/T formulae are implemented as standards. After refractive corneal surgery the Haigis-L formulae may be selected. 58 IOL CALCULATION 4th March 2015
  • 61. Measuring ranges Axial length : 14 – 40 mm Corneal radii : 5 – 10 mm Depth of anterior chamber : 1.5 – 6.5 mm White-to-white : 8 – 16 mm formulas SRKÂŽ II, SRKÂŽ/T, Holladay, Hoffer Q, Haigis Haigis-L for IOL calculation for eyes after myopic/hyperopic LASIK/PRK/LASEK Optimization of IOL constants Line voltage 100 – 240 V +/– 10% (self sensing) Line frequency 50 – 60 Hz Power consumption max. 90 VA Technical data 61 4th March 2015 Department of Ophthalmology, JNMC
  • 63. IOL Formulas 1st Generation – The first theoretical formula (based on Geometric Optics as applied to schematic eye models) was developed in 1967. These formulas were very primitive and usually resulted in large amounts of post-cataract surgery refractive errors. (Regression) 63 4th March 2015 Department of Ophthalmology, JNMC
  • 64. IOL formulas 1st generation •Most are based on regression formula developed by Sander ,Retzlaff & Kraff •Known as SRK formula. •P = A - 2.5(L) - 0.9(K) •P=lens implant power for emetropia •L= Axial length (mm) •K=average keratometric reading (diopters) •A= lens constant 64 4th March 2015 Department of Ophthalmology, JNMC
  • 65. IOL formulas 2nd Generation – With an extreme need for increased IOL Calculation, the second generation formulas (Hoffer, SRK II) listed manual correction factors for long or short eyes. (These formulas are now considered obsolete.) (Regression) 65 4th March 2015 Department of Ophthalmology, JNMC
  • 66. IOL formulas • IOL FORMULA 2nd generation • SRK II formula • modification of SRK • works on ELP • P = A1 – 2.5L – 0.9K 66 4th March 2015 Department of Ophthalmology, JNMC
  • 67. IOL formulas 3rd Generation – In 1988 Dr. Holladay published a formula (Holladay I)that predicted the AC Depth on the basis of K Height and the distance from the iris plane to the IOL optical plane called the “Surgeon Factor”. This change in the physics greatly increased the visual outcomes for Cataract Surgery. This generation also includes the SRK/T and Hoffer Q. 4th Generation – Consist of Holladay II as well as the modern post-refractive formulas 67 4th March 2015
  • 68. IOL formulas • IOL FORMULA 3rd generation • Third generation formulas- • SRK/T -very long eyes >26mm • Holladay I -long eyes 24-26 mm • HofferQ -Short eyes<22mm 68 4th March 2015 Department of Ophthalmology, JNMC
  • 69. IOL formulas • IOL FORMULA 4th generation • Holladay II • Haigis formula- • d = a0 + (a1 * ACD) + (a2 * AL) • ACD is the measured anterior chamber depth • AL is the axial length of the eye • The a0, a1 and a2 constants are set by optimizing • a set of surgeon- and IOL-specific outcomes for a wide • range of ALs and ACDs. • SRK/T formula — uses "A-constant“ • Holladay 1 formula — uses "Surgeon Factor“ • Holladay 2 formula — uses "Anterior Chamber Depth“ • Hoffer Q formula — uses "Anterior Chamber Depth" 69 4th March 2015 Department of Ophthalmology, JNMC
  • 70. IOL formulas • When capsular tear does not allow bag placement of the lens → change IOL power for sulcus placement • >=28.5 D Decrease by 1.5 D • +17 To 28 D Decrease by 1.0 D • +9 To 17 D Decrease by 0.5 D • <+ 9 D 70 4th March 2015 Department of Ophthalmology, JNMC
  • 71. LensConstants A-Constants are used with all IOL formulas, and are determined by the anticipated position within the eye. Surgeon Factor – is used with the first Holladay formula, and is determined by the distance from the Iris plane to the Optical plane of the implant. Effective Lens Position (ELP) is used for the Holladay II formula, and is based on the depth of the AC following Cataract surgery with the new IOL in place. 71 4th March 2015
  • 72. Typesof Formulas Regression formulas are based upon mathematical analysis of a large sampling of post-operative results.  The most familiar regression formula is the SRK formula. The basic SRK formula  works well for eyes in the "average" measurement range; 22.5 to 25.0 mm in axial length, with certain combinations of K readings.  The formula does not work well for "long" (>25 mm) or "short" (<22.5 mm) eyes.  Advantage - relatively simple to calculate.  A factor can be added to a simple regression formula to compensate for a long or a short eye 72 4th March 2015
  • 73. Typesof Formulas Theoretical formulas are optical formulas based on the optical properties of the eye.  They do a better job of predicting post-op outcomes for long and short eyes. 73 4th March 2015 Department of Ophthalmology, JNMC
  • 74. Formula Requirements Haigis Hoffer Q SRK/2 SRK/T HOLLADAY 1 HOLLADAY 2 Olsen Axial Length YES YES YES YES YES YES YES ACD YES NO NO NO NO YES* YES Keratometry YES YES YES YES YES YES YES Lens Thickness NO NO NO NO NO YES YES Corneal Thickness NO NO NO NO NO NO NO White to White NO NO NO NO NO YES YES Pupil Size NO NO NO NO NO NO NO Visual Axis NO NO NO NO NO NO NO 74 4th March 2015 Department of Ophthalmology, JNMC
  • 75. Formula Preferences 75 4th March 2015 Short Eyes (<22.0mm) Hoffer Q / Holladay 2 Average Eyes (22.1- 24.4mm) Hoffer Q / Holladay I / SRK/T Medium-Long Eyes (24.5-25.9mm Holladay I / Hoffer Q Long Eyes (25.0mm +) SRK/T / Holladay I (Holladay II All eye lengths.) (Haigis All eye lengths w/o optimization)
  • 76. Post-Refractive Surgery Patient One of the most challenging problems facing modern Cataract Surgery is the Post-Refractive patient. Following refractive surgery (RK, PRK, LASIK, ect) accurate K readings cannot be obtained from topography, automated or manual keratometry because the central cornea has been flattened causing the mires of the measuring device to measure roughly 4.5mm versus 3.0mm for which they were designed. This causes erroneous K readings compromising the effectiveness of all modern IOL formulas. 76 4th March 2015 Department of Ophthalmology, JNMC
  • 77. Post Refractive Formulas Haigis L - The Haigis-L formula offers predictable outcomes after laser refractive surgery for myopia based only on current measurements without refractive history.) Masket Method - The Masket Method of post-LASIK corneal power estimation is a postoperative regression method developed by Samuel Masket and Clinical History Method – Is usable when both the pre-op and post-op Keratometry values are known. Contact Lens Method - The Contact Lens Method, originally outlined by Dr. Holladay is considered a helpful way to estimate the average central corneal power following radial keratotomy. This technique required a special PMMA contact lens, of a known base curve and power. 77 4th March 2015 4th March 2015
  • 78. Shammas – Used when no pre-op data is available such as refraction and keratometry. Double K SRK/T – Utilizes pre-op refraction and keratometry Post Refractive Formulas 78 4th March 2015 Department of Ophthalmology, JNMC
  • 79. Advantages #  Learned very quickly (User Friendly) #  Extensiveintegrated safety features #  Non-contact measurements. # It givesthetruerefractivelength than anatomical axial length 79 4th March 2015 Department of Ophthalmology, JNMC
  • 80. Advantages # Accuracy of IOL Master is0.02 Âľm which is operator independent # It isupright, non contact, ultrahigh resiltuion biometry # Highly ametropic patient can wear glasseswhile sitting on theIOL master which aidsin fixation # It hastheadvantageof measuring foveain cases of posterior staphyloma 80 4th March 2015 Department of Ophthalmology, JNMC
  • 81. Limitations # Cannot measureaxial length in media opacitieslikecorneal opacities, dense cataract, nuclear sclerosisgradeIV, posterior Polar Cataract # Cannot measureaxial length in casesof vitreoushaemmorrhage # Difficulty in measuring axial lengthsin infants, small children and mentally handicapped patients # Patientswith poor fixation 81 4th March 2015 Department of Ophthalmology, JNMC
  • 82. Do not throw away old ultrasound machine Immersion ultrasound IOL master Posterior staphyloma Silicone oil Pseudophakia 4++brunescent lens Central PSC plaque Vitreous hemorrhage Central corneal scar Difficult Difficult Variable •Yes •Yes •Yes •Yes •Yes •Yes •Yes No No No No
  • 83. Lenstar 900 4th March 2015 Department of Ophthalmology, JNMC 83 4th March 2015
  • 84. Lenstar 900 Lenstar featuresauniquedual zonekeratometer with a total of 32 marker pointson two concentric ringsof 1.65 and 2.3 mm in diameter for improved refractive outcomeswith toric lense. 84 4th March 2015
  • 85. Lenstar 900 It hasbeen complemented with an optional T-Conetopography add-on and an optional toric surgery planning platform. TheT-ConeenablestheLenstar to providetruePlacido topograph of thecentral 6 mm optical zone. Thetoric surgery planning platform allowsplanning and optimization of thesurgical 85 4th March 2015
  • 86. Lenstar 900 • Thetoric planner showstheimplantation axis, the incision location and user-defined guiding meridiansin thereal patient image. • Incision optimization toolsallow for preciseplacement of theincision to minimizetheresidual astigmatism based on thesurgically induced astigmatism. • Planning of theoperation on real eyeimagesallowsthe user to definerecognizable, additional guiding linesto anatomical landmarksin theintraoperativeview. • They either serveasabaselinepoint for the intraoperativeorientation or asafallback strategy if external marking isnot successful. • Theplanning sketch can easily beprinted and hung near themicroscope 86 4th March 2015
  • 87. • The LENSTAR LS 900 ÂŽ measures: ¡¡ Axial eye length ¡¡ Corneal thickness ¡¡ Anterior chamber depth ¡¡ Aqueous depth ¡¡ Lens thickness ¡¡ Radii of curvature of flat and steep meridian ¡¡ Axis of the flat meridian ¡¡White-to-white distance ¡¡ Pupil diameter4th March 2015 Department of Ophthalmology, JNMC 87 Lenstar 900 4th March 2015
  • 88. 88 Olsen formula calculatesthepostoperativelens position asafraction of the crystallinelensthicknessand the ACD. Thisapproach allowsaccurate calculation of thelensposition independent of thecorneal status of theeye. Thelensposition isthen used to calculatetheIOL power based on ray tracing, thesame technology that physicistsuseto design telescopesand camera 4th March 2015
  • 89. Post -refractive IOL calculation 4th March 2015 Department of Ophthalmology, JNMC 89 • ShammasNo-History and Masket – for premium results • TheLenstar EyeSuitesoftwareprovides theuser with acomprehensiveset of cutting-edgeIOL calculation formulae for normal eyes. IOL Power calculation in patientswith prior LASIK or PRK, presenting with no history, iseasily achieved with theon-board Shammas No-History method. • If thechangein refraction isknown, then theMasket and modified Masket formulaemay also beused. 4th March 2015
  • 90. Optical Biometer Properties 90 Feature Device IOL Master Lenstar Axial Length X X White to White X X Keratometry X X ACD X X Pachymetry X Lens Thickness X Retinal Thickness X Pupillometry X Visual Axis X 4th March 2015
  • 91. Summary With state of the art technology and modern IOL calculation formulas, excellent refractive outcomes can be achieved after IOL implantation in challenging eyes, that approach the benchmarks postulated for 91 4th March 2015 Department of Ophthalmology, JNMC
  • 92. 08/22/15 01:46 PM Dept. of Ophthalmology, JNMC 92