บรรยายในการประชุมวิชาการ Korat Hand and Reconstructive Surgery Day ครั้งที่ 3 "Update for Musculoskeletal Problems in Upper Extremities"
วันศุกร์ที่ 16 ธันวาคม 2559 ณ ห้องประชุมหลวงพ่อพุธ ฐานิโย อาคารเฉลิมพระเกีบรติ โรงพยาบาลมหาราชนครราชสีมา
บรรยายในการประชุมวิชาการ Korat Hand and Reconstructive Surgery Day ครั้งที่ 3 "Update for Musculoskeletal Problems in Upper Extremities"
วันศุกร์ที่ 16 ธันวาคม 2559 ณ ห้องประชุมหลวงพ่อพุธ ฐานิโย อาคารเฉลิมพระเกีบรติ โรงพยาบาลมหาราชนครราชสีมา
Soft tissue sarcomas, treatment (surgical, radiation, chemotherapy)Joseph A. Di Como MD
A PowerPoint presentation for medical professionals regarding soft tissue sarcomas, likely most helpful to surgical residents and medical students. Gist tumors, liposarcomas, retroperitoneal sarcomas extremity, breast sarcoma and vascular sarcomas
Alberto Pappo, MD, St. Jude Children’s Hospital, Memphis TN
Presented at the 2010 Texas Adolescent and Young Adult Oncology Conference hosted by Methodist Healthcare-San Antonio. October 2010.
retroperitoneal tumors esp. retroperitoneal sarcoma is most challenging condition to treat in retroperitoneal region inspite of using all treatment modalities.here is brief description of its management acc. to nccn , and other text book ref.
Soft tissue sarcomas, treatment (surgical, radiation, chemotherapy)Joseph A. Di Como MD
A PowerPoint presentation for medical professionals regarding soft tissue sarcomas, likely most helpful to surgical residents and medical students. Gist tumors, liposarcomas, retroperitoneal sarcomas extremity, breast sarcoma and vascular sarcomas
Alberto Pappo, MD, St. Jude Children’s Hospital, Memphis TN
Presented at the 2010 Texas Adolescent and Young Adult Oncology Conference hosted by Methodist Healthcare-San Antonio. October 2010.
retroperitoneal tumors esp. retroperitoneal sarcoma is most challenging condition to treat in retroperitoneal region inspite of using all treatment modalities.here is brief description of its management acc. to nccn , and other text book ref.
Hibernoma is a rare, painless, and benign soft tissue tumor arising from brown fat cells. We present a 28 year old gentleman with a large and tender left anterior neck swelling associated with restricted left shoulder movement for one week duration after he was involved in a motor vehicle accident. Due to the nature of the injury and presentation, it was unexpected to fi nd a well encapsulated fat density suggestive of lipoma from Computed Tomography (CT) scan. Surgical exploration and excision were performed, and the histopathological examination of the excised mass noted to be hibernoma. Patient recovered well and regained full shoulder movement post operatively.
This case illustrated the importance of having broad differentials when approaching patients with post traumatic neck swelling.
Significance of vascular endothelial growth factor and CD31 and morphometric analysis of microvessel density by CD31 receptor expression as an adjuvant tool in diagnosis of psoriatic lesions of skin
Significance of vascular endothelial growth factor and CD31 and morphometric analysis of microvessel density by CD31 receptor expression as an adjuvant tool in diagnosis of psoriatic lesions of skin
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
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4. Microscopy (Biopsy no: 3021/18)
Sections studied shows tumor composed of lobules, sheets of pleomorphic
spindle shaped cells.
4x
40x
5. Microscopy (Biopsy no: 3021/18)
Section studied shows many round to ovoid cells with abundant cytoplasm with
hyperchromatic to vesicular nucleus and prominent nucleoli separated by
hyalinised stroma, infiltrating adjacent fat tissue.
40x
9. Impression (Biopsy no: 3021/18)
• Biopsy from right forearm (outside block and slide) shows
features consistent with epitheloid sarcoma.
• Immunohistochemistry (IHC)
– Epithelial Membrane Antigen (EMA) and Cytokeratin (CK)
are strongly positive within tumor cells.
– Vimentin is also strongly positive suggestive of epitheloid
sarcoma.
– Smooth Muscle Actin (SMA) is negative within tumor cells.
10. Patient details
• Age/Sex : 53 Years / Female
• Hospital OP/ IP No: A18399814
• FNAC no: 304/18
• Site of FNAC : Right axillary lymph node (USG Guided)
• Date of FNA : 07-12-2018
• Date of Report : 10-12-2018
• Clinical Diagnosis : Soft tissue sarcoma right forearm
• Nature of aspirate : Blood mixed aspirate
11. Impression FNAC no: 304/18
USG guided FNAC right axillary lymph node showed features of
reactive lymphoid hyperplasia.
12. Patient details
• Age/Sex : 53 Years / Female
• Hospital OP/ IP No: A18399814
• FNAC no: 317/18
• Site of FNAC : Swelling on right palm
• Date of FNA : 31-12-2018
• Date of Report : 01-01-2019
• Clinical Diagnosis : Soft tissue sarcoma right forearm
• Previous FNAC - FNAC no: 304/18 :USG guided FNAC right axillary
lymph node shows features of reactive lymphoid hyperplasia.
• Nature of aspirate : Blood mixed aspirate
13. Microscopy (FNAC no: 317/18)
•Sparse to moderately cellular smears showing loose clusters and discrete cells
with anaplastic morphology.
•Individual cells have round to oval shaped hyperchromatic nuclei with
moderate amount of eosinophilic cytoplasm showing epithelioid morphology
in a hemorrhagic background.
40x
14. Impression (FNAC no: 317/18)
FNAC from right palm shows cytological features of a malignant
soft tissue sarcoma.
15. Patient details
• Age/Sex : 53 Years / Female
• Hospital OP/ IP No: A18399814
• Biopsy no: 74-75/18
• Date of Receiving Specimen : 09-012-2019
• Date of Report : 22-01-2019
• Clinical Diagnosis : Soft tissue sarcoma right forearm
• Previous Biopsy : Biopsy from right forearm mass shows
features of epithelioid sarcoma (reported outside)
• Nature of Specimen : Wide local Excision biopsy forearm
.
16. Gross Examination (Biopsy no:74/19)
Biopsy no: 74/19
Container labelled A as wide local
excision specimen
• Received skin with underlying
soft tissue, muscles and
tendons altogether measuring
17 x 5.5 x 4 cm.
• Elliptical skin piece attached
measures 12 x 4.5 cm.
• Attached linear tendon (distal
end) measures 5 cm in length.
17. Gross Examination (Biopsy no:74/19)
• The cut surface through the
skin revealed ill defined grey
white tumor with infiltrating
margins measuring
7.5 x 3.5cm.
18. Gross Examination
• Tumor is
– 8 cm away from distal
margin (tip of tendon)
– 2 cm away from proximal
margin
– 1 cm away from skin
(anterior margin)
– 3 cm from medial margin
– 2 cm from lateral margin.
• Grossly, the tumor
involves the deep resected
margin .
19. Gross Examination (Biopsy no:74/19)
• Also identified a solid nodule
measuring 1.5 x 1 cm, lying
within the tendon sheath, 2 cm
from the distal margin.
• Tumor nodule in the tendon
sheath is 5cms from the
proximal larger soft tissue
tumor.
Also noted median nerve (portion
of distal end of median nerve
with long suture) measuring
2.5cms from the soft tissue
tumor.
20. Microscopy (Biopsy no:74/19)
Sections studied shows lobules, nests and sheets of epithelioid cells with intervening
fibro-collagenous tissue and skeletal muscle fibres.
4x
40x
10x
21. Microscopy (Biopsy no:74/19)
Sections studied individual epithelioid cells with epithelioid cells with eosinophilic to
clear cytoplasm and high grade bizzare nuclear pleomorphism.
4x
40x
22. Microscopy (Biopsy no:74/19)
Sections studied shows areas of many congested blood vessels surrounded by tumor
cells, with wide areas of necrosis, atypical mitosis and dense lymphocytic infiltration.
4x
10x
40x
10x
10x
24. Microscopy (Biopsy no:74/19)
Section studied shows adjacent another tumor nodule close to the distal margin
shows similar features with deep resected margin involvement.
10x 40x
25. Microscopy (Biopsy no:74/19)
Sections studied from
• proximal margin (includes skin, soft tissue and muscle) is
free of tumor.
• distal surgical margin (includes skin, underlying soft tissue,
muscle and tendon) is free of tumor.
• Section studied from distal resection margin (includes skin,
soft tissue, muscle and tendons) is free of tumor.
• medial and lateral surgical resected margins (including,
skin, muscle and tendon) are all free of tumor.
• skin, fibromuscular, neurovascular and collagenous tissues
are all free of tumor.
• attached median nerve is free of tumor.
26. Gross Examination (Biopsy no:75/19)
Container labelled B as median nerve
•Received single linear tissue bit measuring 2.5cm in length.
•Grossly - unremarkable
•All embedded in one block.
27. Final Impression
• Wide local excision from Right forearm shows
features consistent with high grade epithelioid
sarcoma (multi-centric).
• A differential diagnosis of epithelioid variant of
angiosarcoma has to be considered.
• Deep resected margin involved by the tumor.
• Proximal and distal fibromuscular and tendon
margins are free of tumor.
• Median nerve sent separately in another
container is free of tumor.
28. Summary
• PROCEDURE: Wide local excision.
• ANATOMIC SITE: Right forearm - flexor compartment.
• LOCALITY: Right side.
• Details of previous biopsy: Outside & 3021/18: Epithelioid sarcoma.
• Measurement of specimen: 17X5.5X7cms.
• Measurement of tumor : Proximal larger tumor measures 7.5x3.5 cms. Distal
smaller tumor nodule measures 1.5x1.0 cm.
• Distance from tumor to margin:- Proximal margin - 2 cms. Distal margin - 8 cms
.Medial margin- 3cms. Lateral margin - 2cms. Deep resected margin is involved
by tumor.
• Lymph nodes: Not submitted.
• tumor site : Soft tissue underlying the Right forearm flexor compartment.
• HISTOLOGICAL TYPE: Epithelioid sarcoma
• Vascular invasion- Not seen
• Bone invasion- Not seen
• Grade : High grade.
30. Salient Features
• Predilection for the distal extremities of young adults.
• Nodular growth pattern with central necrosis may superficially
mimic a granulomatous process.
• Uniform epithelioid cells with mild nuclear atypia and
eosinophilic cytoplasm.
• Proximal-type epithelioid sarcoma arises in the pelvis and
perineum and shows large cell morphology with marked
cytologic atypia.
• Diffusely positive for epithelial membrane antigen, keratins; 50%
CD34.
• Loss of INI1 expression is a characteristic finding.
• Protracted clinical course, with late recurrences and metastases.
• Proximal-type epithelioid sarcoma has a more aggressive course.
32. Prognostic Factors
Potential adverse prognostic factors in epithelioid sarcoma include
• Advanced age (>75 years)
• Male sex
• Large tumor size (>5 cm)
• Deep or proximal location
• Presence of tumor necrosis
• Nuclear pleomorphism
• High mitotic activity
• Vascular or nerve invasion
• Inadequate excision
• Multiple local recurrences
• Regional lymph node metastases at diagnosis