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2. History
• 65 years male patient presented with non
healing ulcer on anterolateral aspect of right
thigh since 6 months.
• Gradual increase in size was noted. Wide
local surgical excision done.
• Mass measuring 3 cm in diameter & surgical
resection of 16x6x2 cm. received.
16. Discussion
• Eccrine porocarcinoma (EPC) represents 0.005%
of all malignant epithelial neoplasms.
• Majority patients older, peak incidence 67 yrs.
• M=F, a slight predominance in women.
• 20% of EPC recur after excision,
• 20% have nodal metastasis,
• 12% develop distant metastasis.
• Patients with metastasis have a high mortality
rate
17. Histogenesis
• Forms in the intraepidermic ductal portion of
the sweat gland.
• Etiology remains unknown (EPC arises from
malignant transformation of Eccrine
Poroma).
• Diagnosis of EPC requires clinical,
histopathological and IHC characterization.
18. Prognosis
• Histological findings that predict the worse
prognosis are
- lymphovascular invasion,
- mitotic index of >14 mitotic cells/hpf
- tumoral depth of more than 7 mm.
• No standard therapeutic protocol for EPC.
• Wide excision with clear margins (HPE)
is treatment of choice.
• Infiltrative tumour margin has influence on local
recurrence.
19. References
1. Murilo de Almeida Luz,I Daniel Cury Ogata,II Marcos Flávio Gomes Montenegro
eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging
cases CLINICS 2010;65(7):739-42
2. Ugo Marone, Corrado Caracò, Anna Maria Anniciello, Gianluca Di Monta
Metastatic eccrine porocarcinoma: report of a case and review of the literature
Marone et al. World Journal of Surgical Oncology 2011, 9:32
3. Harish S. Permi & Shubha P. Bhat Kishan Prasad H. L. Eccrine Porocarcinoma of
Scalp: An Uncommon Tumor at an Unusual Site Indian J Surg Oncol (April–June
2011) 2(2):145–147
