Presentation by Vish Nene at the 12th Biennial Conference of the Society for Tropical Veterinary Medicine (STVM) and the VIII International Conference on Ticks and Tick-borne Pathogens (TTP-8) Cape Town, South Africa 24 to 29 August 2014.

1. Current and future animal vaccine
research activities at ILRI
Vish Nene
8 International Congress on Ticks and Tick-Borne Pathogens (TTP8)
and 12 Biennial Conference, South Africa, 24-29 August 2014

2. Priority diseases targeted by the ILRI Vaccine
Biosciences group
Vaccines save lives and livestock and contribute to food security
and poverty alleviation
 African swine fever (ASF) – swine
 African disease threatens the global $150 billion/year pig industry
 Contagious bovine pleuropneumonia (CBPP) – cattle
 Regional losses to CBPP amount to ~ $60 million/year
 East Coast fever (ECF) – cattle
 Regional losses exceed $300 million/year; kills ~ 1million cattle/year
 Peste des petits ruminants (PPR) – small ruminants
 Losses in Kenya alone amount to ~ $13 million/year
 Rift Valley Fever (RVF) – small ruminants, cattle and human
 2006/7 outbreak in Kenya cost ~ $30 million
o 309 human cases in Kenya, Somalia and Tanzania; 140 deaths
 Diagnostics are key components of a vaccine program
 New and more user-friendly tests – evidence based control programs

3. ILRI’s vaccine R & D pathway to impact
Disease selec on Lead vaccine molecules Vaccine op miza on Scaled-up produc on Delivery
Target product profile Phase I, II, III trials Regulatory processes Con nued monitoring
 ILRI’s comparative advantage is mainly in the discovery phase to proof-of-principle
under laboratory and field conditions.
 Different entry points in pathway depending on disease targeted for control.
 Improvement of existing vaccines
 Development of subunit vaccines
 Laboratory and field based diagnostics
Marke ng
Market
assessment
Proof-of-principle
laboratory/field
Clinical
development
Manufacturing
Product development Research partnerships partnerships
NARS, Universi es, ARIs, Regional and
sub-regional R&D organiza ons, PPP
PPP, Private sector, Regional networks, FAO, OIE, PANVAC,
AU-IBAR, NARs, NGOs

4. ILVAC – planting the orchard (ilvac.net)
Vaccines are difficult to make and take time
BASIC RESEARCH
Increase our knowledge base
“Knowledge lays the founda on
for science & innova on”
APPLIED RESEARCH
Develop new vaccines & diagnos cs
“Vaccines are highly effec ve an -
disease interven ons”
u Study host-pathogen interac ons
u Map immune responses to infec on
u Characterize pathogen virulence
u Inves gate disease epidemiology
u Dissect pathogen biology &
diversity
u Iden fy candidate vaccine and
diagnos c molecules
u Assess candidate vaccine molecules
u Assess a enuated pathogens
u Thermo-stabilize vaccines
u Develop easy to use diagnos c tools
u Assess different vaccina on
systems
u Facilitate transla on of research
outputs to commercial products

5. ILVAC - vaccine technologies (ilvac.net)
Establish key principles in livestock vaccinology and capacity
ILVAC – a vaccine pla orm
An body technologies
Cellular technologies
Vaccine formula ons
Genomic technologies
Diagnos c technologies
Contagious bovine
pleuropneumonia
East Coast fever
African swine fever
Consor a for research & product development and capacity development
Private sector
GALVmed
CRPs
NARS
Inter-gov
agencies
Improved vaccines and
diagnos c tools
Peste des pe s ruminants
Ri Valley fever
Infec ous disease research:
primary & applied

6. The ILRI Vaccine Biosciences group

7. Better lives through livestock
ilri.org
The presentation has a Creative Commons licence. You are free to re-use or distribute this work, provided credit is given to ILRI.