This presentation is an overview of the description of the 4 stages of the cardiac cycle (atrial diastole, atrial systole, ventricular systole, ventricular diastole) as well as explaining the mechanism of the cardiac cycle.
This presentation is an overview of the description of the 4 stages of the cardiac cycle (atrial diastole, atrial systole, ventricular systole, ventricular diastole) as well as explaining the mechanism of the cardiac cycle.
Cardiovascular physiology for university studentsItsOnyii
A detailed pdf document on cardiovascular physiology for university students including structure and functions of heart, Electrocardiogram, echocardiography, chest and limb leads, Diseases and disorders of the heart.
✓Heart
✓Anatomy of heart
✓Blood circulation
✓Blood Vessels
✓Structure and function of artery, vein and capillaries
✓Elements of conduction system of heart and heart beat
✓Its regulation by nervous system
✓Cardiac output
✓Cardiac cycle
✓Regulation of bood pressure
✓Pulse
✓Electrocardiogram
✓Disorder of heart
Cardiovascular physiology for university studentsItsOnyii
A detailed pdf document on cardiovascular physiology for university students including structure and functions of heart, Electrocardiogram, echocardiography, chest and limb leads, Diseases and disorders of the heart.
✓Heart
✓Anatomy of heart
✓Blood circulation
✓Blood Vessels
✓Structure and function of artery, vein and capillaries
✓Elements of conduction system of heart and heart beat
✓Its regulation by nervous system
✓Cardiac output
✓Cardiac cycle
✓Regulation of bood pressure
✓Pulse
✓Electrocardiogram
✓Disorder of heart
CONDUCTIVE SYSTEM OF HEART .pptx BY MRS. WINCY THIRUMURUGAN .PROFESSOR.NURSIN...WINCY THIRUMURUGAN
MEANING.
The conducting system of the heart consists of cardiac muscle cells and conducting fibers (not nervous tissue) that are specialized for initiating impulses and conducting them rapidly through the heart.
It provides the heart its automatic rhythmic beat.
The purpose is to
Generating rhythmical electrical impulses to cause rhythmical contraction of the heart muscle. Conducting these impulses rapidly throughout the heart.
This pathway is made up of 5 elements:
The sino-atrial (SA) node.
The atrio-ventricular (AV) node.
The bundle of His.
The left and right bundle branches.
The Purkinje fibers.
SINOATRIAL NODE
The sinoatrial (SA) node is a collection of specialized cells (pacemaker cells), and is located in the upper wall of the right atrium, at the junction where the superior vena cava enters.
These pacemaker cells can spontaneously generate electrical impulses. The wave of excitation created by the SA node spreads via gap junctions across both atria, resulting in atrial contraction (atrial systole) – with blood moving from the atria into the ventricles.
The SA node is supraventricular and is sensitive to parasympathetic and sympathetic influence.
The SA node generates impulses and influenced by the Autonomic Nervous System:
Sympathetic nervous system – increases firing rate of the SA node, and thus increases heart rate.
Parasympathetic nervous system – decreases firing rate of the SA node, and thus decreases heart rate
THE INTER NODAL PATHWAYS consist of three bands (anterior, middle, and posterior) that lead directly from the SA node to the next node in the conduction system, the atrioventricular node. The impulse takes approximately 50 m s (milliseconds) to travel between these two nodes.
Bachmann's bundle (BB), also known as the interatrial bundle, myocardial strands connecting the right and left atrial walls and is considered to be the main pathway of interatrial conduction.
THE AV NODEThe AV node is located in the posterior wall of the right atrium immediately behind the tricuspid valve.
Cause of Slow Conduction in the A-V Node
What is the significance of AV nodal delay?
The cardiac impulse does not travel from the atria to the ventricles too rapidly.
It is primarily the AV node and it’s adjacent fibers that delay this transmission into the ventricles
AV BUNDLE OR BUNDLE OF HIS
From the AV node arises a special conducting pathway .
RIGHT AND LEFT BUNDLE BRANCHES
FASCICLE
The right bundle branch contains one fascicle.
The left bundle branch into three fascicles:
The left anterior,
The left posterior, and
The left septal fascicle.
PURKINJE FIBRES
The LT and RT bundle branches divides in turn course sidewise around each ventricular chamber and back toward the base of heart.
The ends of Purkinje fibers penetrate about one third of the way into muscle mass and finally become continuous with cardiac muscle fibers
,abundant with glycogen and extensive gap junctions, rapidly transmit cardiac action potentials in 0.03sec
The heart has four chambers. The two superior receiving chambers are the atria (= entry halls or chambers), and the two inferior pumping chambers are the ventricles (= little bellies).
On the anterior surface of each atrium is a wrinkled pouchlike structure called an auricle
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
3. THE CONDUCTING SYSTEM
• The heart is able to contract on its
own because it contains specialized
cardiac muscle tissue that
spontaneously forms impulses and
transmits them to the myocardium to
initiate contraction.
4.
5. COMPONENTS
• The conducting system of the heart is composed of
the following 5 components:.
1. Sinuatrial node (SA node).
2. Atrioventricular node (AV node).
3. Atrioventricular bundle (of His).
4. Left and right branches of bundle (of His).
5. Subendocardial Purkinje fibres.
6.
7. SINUATRIAL NODE
(SA NODE OR NODE OF KEITH FLACK)
• It is a small horseshoe-shaped mass having
specialized myocardial fibres, situated in the wall
of the right atrium in the upper part of sulcus
terminalis just below the opening of superior vena
cava.
• It is called pacemaker of the heart since it
generates impulses (about 70/minute).
• It initiates the contraction of cardiac muscle
producing heart beat.
8. Sinoatrial Node
• The rate at which the SA node generates
impulses is influenced by the autonomic
nervous system:
• Sympathetic nervous system – increases
firing rate of the SA node, and thus increases
heart rate.
• Parasympathetic nervous system – decreases
firing rate of the SA node, and thus decreases
heart rate.
9. SA NODE
• The flow of impulses causes contraction of the
atria from superior to inferior, forcing blood
into the ventricles. At the same time, the
impulses are carried to the atrioventricular
node (AV node).
• There is a brief time delay as the impulses
pass slowly through the AV node, which
allows time for the ventricles to fill with
blood.
10.
11. ATRIOVENTRICULAR NODE (AV
NODE/NODE OF TAWARA)
• It is smaller compared to the SA
node.
– located in the right atrium near the
junction with the interventricular
septum near the opening of the
coronary sinus.
• It conducts the cardiac impulse to the
ventricle by the atrioventricular bundle.
12. Atrioventricular Node
• After the electrical impulses spread across the
atria, they converge at the AV node.
• The AV node acts to delay the impulses by
approximately 120ms, to ensure the atria
have enough time to fully eject blood into the
ventricles before ventricular systole.
• The wave of excitation then passes from the
atrioventricular node into the atrioventricular
bundle.
13.
14. ATRIOVENTRICULAR BUNDLE (OF HIS)
• It begins from AV node, crosses the AV ring and
runs along the inferior part of the membranous part
of the interventricular septum where it divides into
the right and left branches extending inferiorly to
the interventricular septum and superior to the
lateral walls of the ventricles.
• Since the skeleton (fibrous framework) of the heart
separates the muscles of atria from the muscles of
the ventricles, the bundle of His is the only means
of conducting impulses from the atria to the
ventricles.
15. Atrioventricular Bundle
• The atrioventricular bundle (bundle of His) is a
continuation of the specialized tissue of the AV node,
and serves to transmit the electrical impulse from the
AV node to the Purkinje fibres of the ventricles.
• It descends down the membranous part of the
interventricular septum, before dividing into two main
bundles:
• Right bundle branch – conducts the impulse to the
Purkinje fibres of the right ventricle
• Left bundle branch – conducts the impulse to the
Purkinje fibres of the left ventricle.
16. LEFT AND RIGHT BRANCHES OF THE
BUNDLE (OF HIS)
• The right branch enters down the right side of the
interventricular septum and after that becomes
subendocardial on the right side of the septum.
• A large part of it continues in the septomarginal
trabeculum (moderator band) to reach the anterior
papillary muscle and anterior wall of the ventricle.
Its Purkinje fibres then spread out underneath the
endocardium.
• The left branch descends on the left side of the
ventricular septum, divides into Purkinje fibres that
are distributed to the septum and left ventricle.
21. Purkinje Fibres
• The Purkinje fibres (sub-endocardial plexus of
conduction cells) are a network of specialized cells.
They are abundant with glycogen and have extensive
gap junctions.
• These cells are located in the subendocardial surface of
the ventricular walls, and are able to rapidly transmit
cardiac action potentials from the atrioventricular
bundle to the myocardium of the ventricles.
– This rapid conduction allows coordinated ventricular
contraction (ventricular systole) and blood is moved from
the right and left ventricles to the pulmonary artery and
aorta respectively.
22. Overview of Heart Conduction
• The sequence of electrical events during one full
contraction of the heart muscle:
• An excitation signal (an action potential) is created by
the sinoatrial (SA) node.
• The wave of excitation spreads across the atria, causing
them to contract.
• Upon reaching the atrioventricular (AV) node, the
signal is delayed.
• It is then conducted into the bundle of His, down the
interventricular septum.
• The bundle of His and the Purkinje fibres spread the
wave impulses along the ventricles, causing them to
contract.
23. Clinical Relevance: Artificial
Pacemaker
• An artificial pacemaker is a small electrical device
commonly fitted to monitor and correct heart rate
and rhythm. It is inserted into the chest under the
left clavicle, with wires connected to the heart via
the venous system.
• The most common indication for a pacemaker
is bradycardia. Once inserted, the pacemaker
monitors the heart rate, and only fires if the rate
becomes too slow. Pacemakers can also be used to
treat some tachycardias, certain types of heart
block and other rhythm abnormalities.
24. ARTERIAL SUPPLY OF THE
CONDUCTING SYSTEM
• The whole of the conducting system
of the heart is provided by the right
coronary artery with the exception of
a part of the left branch of the AV
bundle that is provided by the left
coronary artery.
25. CONDUCTING SYSTEM DEFECTS
• The defect/damage of conducting system causes
cardiac arrhythmias.
• If the AV bundle fails to conduct normal impulses, there
takes place alteration in the rhythmic contraction of the
ventricles (arrhythmias). If complete bundle block takes
place there is complete dissociation in the rate of
contraction of atria and ventricles. The common cause
of defective conduction via AV bundle
is atherosclerosis of the coronary arteries which leads
to diminished blood supply to the conducting system.
• The rapid pulse is referred to as tachycardia, the slow
pulse is named bradycardia on the other hand irregular
pulse is named arrhythmia.
26. Bundle of KENT
• Conduction from the atria to the ventricles normally
occurs via the AV- node-His-Purkinje system.
• Patients with a preexcitation syndrome have an
additional or alternative pathway, known as an
accessory pathway, which directly connects the atria
and ventricle and bypasses the AV node.
• AV conduction through an accessory pathway (most
commonly a direct AV connection) results in the earlier
activation of the ventricles than if the impulse had
traveled through the AV node; hence causes proxysmal
atrial tachycardia.