The circulatory system transports blood throughout the body using blood vessels. Blood carries oxygen, nutrients, hormones and waste products as it circulates from the heart through arteries and veins, with an exchange of substances occurring between blood and body cells in capillaries. Some organisms have a single circulation where blood passes through the heart once, while mammals like humans have a double circulation with blood passing through the heart twice per circuit. Heart disease can be caused by factors like lack of exercise, poor diet, smoking and genetics, and treated through lifestyle changes, medication, procedures like angioplasty, or surgery. The lymphatic system works with the circulatory system to transport lymph and help fight infection.