Ten principles underlying good publication practices.
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Dotting the i's and crossing the t's in bringing a drug/device to market, means understanding the plethora of regulations involved in designing, executing, and communicating the results from a clinical trial. Experts in publication planning have collaborated in order to clarify the process for all stakeholders. DISCLAIMER: Please note that this infographic is best viewed by changing the PowerPoint slide size to 11" x 6". Otherwise, the images will appear to overlap.
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The research question is the most crucial element of any academic paper and the first and most important stage in the publication process. A paper with results that are unoriginal, predictable, or trivial is less likely to be published.Research ethics
This document discusses key ethical considerations in research including informed consent, privacy, confidentiality, potential harms, and benefits. It addresses ethics committees that review proposed research methodology and adherence to ethical codes. Key principles of ethical research are protecting participants, voluntary participation with informed consent, and following national laws. The document also examines ethical issues around vulnerable groups, deception, incentives, and how to respond to ethical dilemmas that may arise during a study.
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This document provides an introduction to a course on health policy and systems research (HPSR). It outlines the importance of studying health systems and how they can be improved through research. The course aims to help students identify relevant research questions in health policy and systems, select appropriate research strategies, and understand how to support the use of research evidence in decision-making. Key topics that will be addressed include different research purposes, study designs, ensuring rigor, and engaging with policymakers. The overall goal is for participants to gain skills in conducting and applying HPSR to strengthen health systems.ihpsrppt1latestdec2014-150121003700-conversion-gate01 (1).pdf
This document provides an introduction to a course on health policy and systems research (HPSR). It outlines the importance of studying health systems and how they can be improved through research. The course aims to help students identify relevant research questions in health policy and systems, select appropriate research strategies, and understand how to support the use of research evidence in decision-making. Key topics that will be addressed include formulating research questions, different research designs and study types, ensuring rigorous research, and facilitating the use of research findings.
Writingahealthresearchproposal
This document provides guidance on writing a health research proposal. It discusses key components such as the problem statement, objectives, methodology, and ethics. The methodology section should define the study design, variables, participants and sampling. It emphasizes that proposals require clear objectives, detailed methodology, and consideration of ethics. Well-defined proposals are needed to obtain funding and regulatory approval, and to allow other researchers to replicate the study.
Research proposal
Research proposals are documents prepared before a research project begins that describe the proposed research problem, its significance, and planned procedures. They help researchers clarify their thinking and ensure research questions and methods are sufficiently refined. Proposals also allow others to provide feedback to improve the study's design and potential contribution. Students preparing proposals for a dissertation or thesis should carefully choose an advisor and committee who can offer guidance throughout the research process.
Apa manual presentation
This document provides an overview of writing for behavioral and social science publications. It discusses the main types of research articles, including empirical studies, literature reviews, theoretical articles, methodological articles, and case studies. It also outlines important ethical standards for publication, such as ensuring accurate reporting of results, protecting research participants, managing conflicts of interest, determining authorship, and maintaining intellectual property rights. Guidelines are provided for retaining data, avoiding plagiarism, and obtaining proper permissions and approvals. The document concludes with a checklist for authors to ensure compliance with ethical standards.
Unit 2
This document discusses various ethical issues in scientific research, including intellectual honesty, research integrity, scientific misconduct such as falsification and plagiarism. It addresses principles like duty to society, informed consent, and protecting research participants. Forms of problematic publishing are defined, like duplicate/overlapping publications and "salami slicing" research. Selective reporting or misrepresenting data to bias results undermines reproducibility. Upholding integrity requires monitoring at the individual researcher, work group and institutional levels.
,ffid; ,ffiffit#.$ObjectivesnL. Describe the three basic.docx
This document discusses writing research reports. It begins by outlining the primary goals of research reports, which include advancing scientific knowledge, shaping social policy, and organizing social action through participatory action research. It then discusses the writing process and some of the challenges involved, emphasizing that writing is an iterative process that requires starting early and allowing time for revisions. Key points made include that research reports should communicate discoveries to intended audiences, that some researchers seek to explicitly influence policy or social change, and that participatory research involves stakeholders throughout the research and reporting process. Ethical reporting and avoiding plagiarism are also addressed. The document provides guidance on successful writing principles and outlines different publication outlets for research.
A guide to clinical research writing on public health for clinical researcher...
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Lesson-2-The-Characteristics-Process-and-Ethics-of-Research.pptx
Lesson-2-The-Characteristics-Process-and-Ethics-of-Research.pptx
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ihpsrppt1latestdec2014-150121003700-conversion-gate01 (1).pdf
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A guide to clinical research writing on public health for clinical researcher...
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Pancreatic Cancer
The passing of some legendary figures in 2020 such as Jeopardy host, Alex Trebek, and Supreme Court Justice, Ruth Bader Ginsburg, serves as a reminder of how far we have yet to go in the fight against pancreatic cancer. This disease is estimated to be the second-leading cause of cancer deaths by 2030. This quick primer is for anyone unfamiliar with the condition to serve as a starting point for his or her research. Strength and peace!
Management thyroid cancer_v1
Information about thyroid cancer on this infographic was obtained from public sources. It is not meant to be a substitute for medical advice.
Cancer vaccines 20_july2020
This is a brief overview of the evolving field of prophylactic and therapeutic cancer vaccines.
Cancer vaccines are active immunotherapies. As seen in the accompanying figure, the distinction from passive immunotherapies is based on different mechanisms of action. Passive immunotherapies and adoptive T-cell transfer, for example, are made/modified outside of the body.
Once inside the body they can compensate for missing or deficient functions. Active immunotherapies, on the other hand, stimulate effector functions in vivo. What this means, is that the patient’s immune system can respond to the challenge and be stimulated to mediate effector cells that defend the body in an immune response. Examples of active immunotherapies include peptide, dendritic cell, and allogeneic whole-cell vaccines.
COVID Treatment Infographics
There are literally hundreds of ongoing trials in search for a COVID-19 cure/treatment. The search for a vaccine deserves its own infographic. In the meantime, here are a few approaches by scientists worldwide to treat this complex disease. Stay tuned for further updates
Basics you need to know about heart disease and stents
Stents are small mesh tubes used to keep arteries, blood vessels, and ureters open. During coronary artery disease, arteries in the heart become narrowed or blocked by plaque, reducing blood flow and oxygen to the heart. Doctors may place a stent in an artery to prevent collapse or improve blood flow. Stents are placed using imaging and a method called percutaneous coronary intervention (PCI) or coronary angioplasty. When deciding between open heart surgery or PCI to treat coronary artery disease, doctors consider the complexity of the blockages and patient preferences, with more complex cases sometimes better suited for surgery and simpler cases often having equivalent outcomes with either approach.
Introduction to cancer vaccines
This intro is geared towards interested novices who wish to find a resource that can serve as a starting point for further self-study. This is not meant to replace a doctor's advice. Please approach a medical professional for any health condition.
Gastroesophageal disease (GERD) in Adults
Gastroesophageal reflux disease (GERD) affects at least 20% of Westerners and is characterized by heartburn and acid regurgitation. GERD occurs when the lower esophageal sphincter weakens, allowing stomach acid to flow back into the esophagus. Treatment involves lifestyle changes and over-the-counter or prescription medications like proton pump inhibitors to reduce acid production. For cases that do not respond well to medication, surgical procedures may be considered to strengthen the lower esophageal sphincter. Long-term use of proton pump inhibitors can potentially lead to side effects like bone fractures or pneumonia. Future research aims to develop new therapies targeting incomplete responders to proton pump inhibitors to improve treatment of GER
Could CDK12 mutations guide immune checkpoint inhibitor use?
Certain mutations in genes like CDK12 may cause prostate cancers to be more amenable to immune checkpoint inhibitor treatment. A subtype of metastatic castration-resistant prostate cancer with CDK12 variants has been identified that has high levels of neoantigens recognized by the immune system as foreign, as well as greater T-cell infiltration. These CDK12-variant prostate cancers may have higher response rates to PD-1 inhibitors than other genomic subtypes of prostate cancer. Pending clinical trial results, CDK12-variant prostate cancer may become the second defined tumor subtype able to be treated with PD-1 inhibitors.
Cytomegalovirus infection in critically ill patients: Focus on HSCT recipients
Medline Plus has this to say about bone marrow transplants (here used interchangeably to refer to hematopoietic stem cell transplantation [HSCT]): “Bone marrow is the soft, fatty tissue inside your bones. The bone marrow produces blood cells. Stem cells are immature cells in the bone marrow that give rise to all of your different blood cells.” According to the literature, HSCT has become a standard of care for hematologic malignancies, congenital or acquired disorders of the hematopoietic system, and it is also applied as a therapeutic option in some of the solid tumors.
Here, I have provided a brief overview of CMV, with a focus on HSCT recipients. DISCLAIMER: Extracted research data from ongoing clinical trials are subject to change. This is not a substitute for medical advice. Please consult your doctor for any medical condition.
Cancer immunotherapies from the perspectives of oncology nurses
This presentation, tailored for oncology nurses, provides an overview of immunotherapy classes, how they work, and how key side effects are typically managed. (Disclaimer: Content is based on peer-reviewed literature; however, it is not a substitute for medical advice. Please consult your doctor)
Triple-Negative Breast Cancer: 2018 Status Update
Up to 20% of all invasive female breast cancer diagnoses are defined by the clinically significant absence of three hormone receptors i.e., ER, PR and HER2. This group of highly heterogeneous tumors exhibit aggressive growth patterns and are known as TNBCs. Although most TNBCs are ductal carcinomas (no special types), the identification of specific histologic/molecular subtypes potentially open up further modes of treatment for a disease that has thus far mainly been treated with cytotoxic chemotherapies. Biologic features in tumor subsets that carry such implications include BRCA pathway inhibition, increased tumor infiltrating lymphocytes (TILs), detection of other biomarkers paving the way for immunotherapies such as elevated PD-L1 expression and AR expression. Here, is some of the relevant information about TNBCs.
Disclaimer: This deck is meant to provide a springboard to interested readers who wish to look for materials to discuss with a doctor and is not a substitute for expert advice. Information was culled from the Internet and sources cited in the deck.
Prostate cancer 2018: A brief overview
Advances in risk assessment, differential diagnosis between aggressive and non-aggressive tumors, and the development of novel/optimized treatment for advanced disease are discussed.
This slide deck is made available for patients/caregivers. It is not a substitute for seeking medical help. Please check original sources listed in the deck and consult your physician for the latest information and advice.
The State of Mental Health as We Know it
The document discusses the state of mental health in the United States. It notes that in 2018, mental health issues among youth worsened while access to services increased, though over half of mentally ill Americans do not receive treatment. While 2017 saw breakthroughs in areas like genetics and technology that could help reduce doctor visits, translating these discoveries into public health plans is urgently needed, as indicated by statistics on conditions like schizophrenia, bipolar disorder, and anxiety disorders. According to the CDC, around 1 in 5 American adults experiences a mental illness each year, resulting in over $193 billion in lost earnings annually due to serious cases.
HIV Vaccines
Before the discovery of highly active antiretroviral therapy (HAART), acquired immunodeficiency syndrome – the final stage of human immunodeficiency virus (HIV) infection – spelled cancers and death. HIV destroys a type of white blood cell, the CD4+ T cell, which leaves the body vulnerable to other opportunistic infections and complications. Human challenges and triumphs in the age of AIDS are now embedded in our collective memories and captured in 2016 statistics from the World Health Organization. AIDS deaths have declined by 47% since 2005, according to a Los Angeles Times Article. Additionally, more than half of the 36.7 million people across the globe that are living with HIV (in 2016) are also receiving ART.
This points to the transformation of an often-fatal disease into a chronic condition. Today, only 1.1 million people in the USA are estimated to be infected with HIV. However, 1 in 7 Americans do not know their HIV status. Moreover, global treatment gains have been offset by knowledge of geographic “hot spots,” gender gaps in terms of access and care, delays in starting treatment, variable adherence ART, and the development of resistance to drugs. Even if an implicit public health goal of containing clinical sequelae in every HIV-infected individual is accomplished, the burden of exposure to years of ART may take a long-term socioeconomic toll on each patient. Therefore, researchers continue to search for ways to aid the public in the prevention of getting HIV/AIDS in the first place or, failing that, to facilitate a timely cure.
One strategy in a multipronged public health program against the stealth pathogen continues to be the development of preventive/therapeutic vaccines. Currently, there are no approved HIV vaccines, but promising research is underway.
Sources:
1. US Centers for Disease Control and Prevention (https://www.cdc.gov/hiv/statistics/overview/ataglance.html)
2. World Health Organization
3. Los Angeles Times
Immunology for Beginners
This "cheat sheet" is meant to assist people not trained in biology to understand basic concepts they may encounter when reading articles about the latest research developments in cancer, infectious diseases, and immunology. Enjoy!
The Vaccine Debate
Vaccines are designed to elicit an immune response against the particular microbe or bits of the microbe from which the vaccine is made. This idea dates back several centuries, when British surgeon, Edward Jenner developed the first vaccine against a lethal infectious disease, small pox. Between the 18th century and now, more than 65 products have been approved which, together with public health and other developments, have contributed to the tapering and, in some cases, eradication of infectious diseases that used to kill millions. The problem is that the design is based on the physical attributes of the microbe. So, one person might be infected with virus x, which mutates rapidly to become 10 or more different strains. So, between approval and reaching the public, effectiveness may drop or wane over time. The sheer logistics of designing a trial means that follow-up periods are not long enough to account for every possible safety issue. Nevertheless, they remain our go-to defense for lethal infections, such as Ebola, and ones that reduce productivity. In other cases, timely inoculations may protect against the risk of developing specific cancers later in life. They have also contributed to the fact that most people are not at home sick with polio or some of the other ancient plagues.
However, anti-infective vaccines are typically given to healthy children and people on the basis that it will not make them sick or that it will reduce the risk of premature death. Because vaccines need to be preserved, properly stored and kept free of other contamination before it reaches many distribution sites, other ingredients are added to the mix. And some people, especially those with weakened immune systems, may have severe/life-threatening allergies to additives or a contaminated batch.
So, one in a million complications/deaths is one in a million too many. To this end, I have compiled a summary culled from various sources, to foster a positive dialogue towards improvements.
Management of Diabetes and Heart Disease
This document discusses the link between diabetes and cardiovascular disease. It provides guidance on screening and managing both conditions, including maintaining optimal blood sugar levels, treating risk factors like high blood pressure and cholesterol, and adopting a healthy lifestyle. Close monitoring of patients can help prevent diabetes-related complications like heart attack, stroke, and peripheral artery disease. While intensive glucose control shows long-term cardiovascular benefits in type 1 diabetes, the evidence in type 2 diabetes is more mixed and depends on individual patient factors.
The Management of Lupus
The management of this chronic autoimmune condition that predominantly affects younger females will depend on the severity, disease type,and affected organs. Publicly available resources, including information from the American College of Rheumatology, were used for this infographic.
Please consult a doctor for specific medical advice.
Health insurance coverage in the United States
This is the second part of my contributions to the ongoing health insurance coverage conversation in the USA. Data geeks are advised to visit the Kaiser Family Foundation site for a state-by-state breakdown of insured and uninsured demographics as of 2015. Other information was obtained under Creative Commons License from the CDC, Wikipedia, and additional listed sources.
Management of Prostate Cancer
Basic information for discussion with a healthcare professional is provided here together with some background:
• An enlargement or the presence of tumors in the gland below a man’s bladder that produces fluid for semen ie, the prostate, may suggest benign prostatic hyperplasia (BPH) or prostate cancer
o Almost 8% of new cancer cases worldwide are attributed to this highly curable disease (proportion of patients surviving after 5 years = 98.9%)
o In the USA alone, prostate cancer is the most common non-skin cancer, diagnosed more often in African-American (1 in 5 cases) than white men (1 in 6 cases)
o Prostate cancer is strongly correlated with age, starting at about 50 years old and rising over the ensuing decades
o While debates over under- or over-treatment of prostate cancer continue, it is clear that management of the disease costs the USA an aggregate annual loss in productivity of $3.0 billion
o Moreover, prostate cancer is the third-leading cause of cancer-related deaths in the USA, mainly due to advanced or metastatic disease
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Healthy Eating Habits:
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Ten principles underlying good publication practices.
- 1. 10. All authors and contributors should disclose any relationships or potential competing interests relating to the research and its publication or presentation. 1. Design and results of all clinical trials should be reported in a complete, accurate, balanced, transparent, and timely manner. 3. Journal and congress requirements should be followed, especially ethical guidelines on originality and avoiding redundancy (that is, duplicate publication) 4. Publication planning and development should be a collaboration among all persons involved (for example, clinicians, statisticians, researchers, and publication professionals, including medical writers) and reflect the collaborative nature of research and the range of skills required to conduct, analyze, interpret, and report research findings. 8. Author lists and contributorship statements should accurately reflect all substantial intellectual contributions to the research, data analyses, and publication or presentation development. Relevant contributions from persons who did not qualify as authors should also be disclosed. 7. The authors should take responsibility for the way in which research findings are presented and published, be fully involved at all stages of publication and presentation development, and be willing to take public responsibility for all aspects of the work. 6. All authors should have access to relevant aggregated study data and other information (for example, the study protocol) required to understand and report research findings. 5. Rights, roles, requirements, and responsibilities of all contributors (that is, authors and any nonauthor contributors) should be 2. Reporting and publication processes should follow applicable laws (for example, Food and Drug Administration Amendments Act of 2007) and guidelines. 9. The role of the sponsor in the design, execution, analysis, reporting, and funding (if applicable) of the research should be fully disclosed in all publications and presentations of the findings. Any involvement by persons or organizations with an interest (financial or nonfinancial) in the findings should also be disclosed. 1. Battisti WP, Wager E, Baltzer L, et al.: Annals of Internal Medicine 2015, 163(6):461-464.