The document consists of a series of questions regarding systemic lupus erythematosus (SLE), focusing on associations with autoantibodies, clinical manifestations, affected organ systems, diagnostic tests, and demographic factors. Key topics include the common autoantibodies linked to SLE, specific symptoms such as malar rash and Raynaud's phenomenon, and factors influencing disease activity and risk. It emphasizes the significance of understanding these elements for the diagnosis and management of SLE.

2. 1. Which autoantibody is most commonly associated with
SLE?
A) Rheumatoid factor
B) Antinuclear antibody
C) Anti-CCP antibody
D) Cryoglobulins

3. 2. Which of the following is NOT a common clinical
manifestation of SLE?
A) Arthritis
B) Vasculitis
C) Optic neuritis
D) Sjogren’s syndrome

4. 3. Which organ system is most commonly affected in SLE?
A) Pulmonary
B) Renal
C) Cardiovascular
D) Neuropsychiatric

5. 4. Which test is used to measure disease activity in SLE?
A) ESR
B) CRP
C) Complement levels
D) ANA titer

6. 5. Malar rash is considered a diagnostic criterion for SLE.
What does it affect?
A) Ears
B) Palms
C) Face
D) Soles of feet

7. 6. Which laboratory finding is associated with active lupus
nephritis?
A) Low complement levels
B) Pyuria
C) Microscopic hematuria
D) Proteinuria

8. 7. What percentage of patients with SLE will develop
neuropsychiatric involvement?
A) 5-10%
B) 10-15%
C) 15-25%
D) Over 25%

9. 8. Which autoantibody is associated with cardiac involvement
in SLE?
A) Anti-Ro
B) Anti-La
C) Anti-RNP
D) Anti-Smith

10. 9. Raynaud’s phenomenon is associated with which specific
autoantibody in SLE?
A) Anti-RO
B) Anti-La
C) Anti-Smith
D) Anti-RNP

11. 10 What group of individuals is
most at risk for lupus?
A Men 15 to 45 years of age
B Women 15 to 45 years of age
C Men 45 to 70 years of age
D Women 45 to 70 years of age

12. 11 Which of the following is
thought to be the prime cause
of SLE?
A)Hormones
B)Environment
C)Genetic factors
D)Immune dysregulation