Systemic lupus erythematosus is an autoimmune disease where the immune system attacks its own tissues. It commonly causes joint pain, rashes, and fatigue. It can also affect major organs like the kidneys, heart, and lungs. Treatment focuses on relieving symptoms by reducing inflammation with medications like corticosteroids and hydroxychloroquine.
Common dermatologic disorders systemic lupus erythematosusDr. Faramarz Didar
SLE or lupus is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body.
The immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage.SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system.
Characteristic facial rash of SLE is a butterfly rash which spread from one side of nose to other side.
It is very important to diagnose this Rash and SLE in patients who attend a cosmetic Clinic in order to solve their facial disfiguration. SLE butterfly facial rash is resistant to treatment by variety of cosmetic procedures like ablative and non-ablative laser, IPL , chemical peel and PRP. The diagnosis of SLE and systemic treatment od this disease is paramount to cosmetic approach. Cosmetic practitioner should have a broad knowledge of dermatological disorder and relevant approach to them.
Common dermatologic disorders systemic lupus erythematosusDr. Faramarz Didar
SLE or lupus is a systemic autoimmune disease (or autoimmune connective tissue disease) that can affect any part of the body.
The immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage.SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system.
Characteristic facial rash of SLE is a butterfly rash which spread from one side of nose to other side.
It is very important to diagnose this Rash and SLE in patients who attend a cosmetic Clinic in order to solve their facial disfiguration. SLE butterfly facial rash is resistant to treatment by variety of cosmetic procedures like ablative and non-ablative laser, IPL , chemical peel and PRP. The diagnosis of SLE and systemic treatment od this disease is paramount to cosmetic approach. Cosmetic practitioner should have a broad knowledge of dermatological disorder and relevant approach to them.
Sebuah edukasi pasien tentang lupus, meliputi berbagai aspek yang patut diketahui, agar pasien dan keluarganya tidak larut dalam fase denial dan bargaining yang berkepanjangan
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease. The immune system attacks the body’s cell and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidney and nervous system.
Over 40 different genes predispose to SLE.
Characterized by remission and exacerbation.
Lupus erythematosus (LE) is an autoimmune connective tissue disorder that can affect one or several organs. Circulating autoantibodies and immune complexes are due to loss of normal immune tolerance and are pathogenic. Clinical features of LE are highly variable. LE nearly always affects the skin to some degree.
Lupus update for rhem fellows wramc 2014 talkDonald Thomas
Update about the diagnosis and management of systemic lupus erythematosus (SLE) from the past several years. This includes the SLICC revision classification criteria for SLE, importance of using ANA by immunofluorescence instead of solid assays, appearance of autoantibodies many years before SLE diagnosis, the need for using Plaquenil along with immunosuppressant medications, importance of correcting vitamin D levels, avoiding lupus triggers (UV light, tobacco, sulfa), proper dosing of Plaquenil (hydroxychloroquine), the proper screening tests for anti-malarial retinopathy, including Gardasil and Prevnar PCV-13 at important vaccines, and the use of IM steroids for flares.
Sebuah edukasi pasien tentang lupus, meliputi berbagai aspek yang patut diketahui, agar pasien dan keluarganya tidak larut dalam fase denial dan bargaining yang berkepanjangan
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease. The immune system attacks the body’s cell and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidney and nervous system.
Over 40 different genes predispose to SLE.
Characterized by remission and exacerbation.
Lupus erythematosus (LE) is an autoimmune connective tissue disorder that can affect one or several organs. Circulating autoantibodies and immune complexes are due to loss of normal immune tolerance and are pathogenic. Clinical features of LE are highly variable. LE nearly always affects the skin to some degree.
Lupus update for rhem fellows wramc 2014 talkDonald Thomas
Update about the diagnosis and management of systemic lupus erythematosus (SLE) from the past several years. This includes the SLICC revision classification criteria for SLE, importance of using ANA by immunofluorescence instead of solid assays, appearance of autoantibodies many years before SLE diagnosis, the need for using Plaquenil along with immunosuppressant medications, importance of correcting vitamin D levels, avoiding lupus triggers (UV light, tobacco, sulfa), proper dosing of Plaquenil (hydroxychloroquine), the proper screening tests for anti-malarial retinopathy, including Gardasil and Prevnar PCV-13 at important vaccines, and the use of IM steroids for flares.
Arthritis (Rheumatoid Arthritis, Osteoarthritis, Gout)
PPT contains content for UG healthcare students.
Elaborated topics referred from Nursing books, Orthopedics books, and some live cases from the department.
Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body.
No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African-American, Hispanic-American, and Native-American women - have a higher risk for some autoimmune diseases.
There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling.
The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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2. A chronic inflammatory condition caused by an
autoimmune disease. An autoimmune disease
occurs when the body's tissues are attacked by
its own immune system. Patients with lupus
have unusual antibodies in their blood that are
targeted against their own body tissues.
3. Inate Susceptibility
•HLA type
•Immunoregulatory genes
•Hormonal levels
•Complement levels
Environmental Stimuli
•UV exposure
•Microbial response
•Medication
Autoimmune Proliferation
•Hyperactive B-cell/T-cell
activation
•High ratio of CDA;CD8 T-cells
•Defective immune complex
clearance
•Impaired tolerance
Autoantibody
Production
•Apoptosis and self
exposure
•Self-recognition
•Foreign-Ab cross
reaction
4. fever, rash, arthritis, alopecia, and renal
involvement
Symptoms Occurrence
Achy joints (arthralgia) 95%
Fever more than 38 degrees C 90%
Rheumatoid arthritis 90%
Prolonged or extreme fatigue 81%
Skin rashes 74%
Anaemia 71%
Kindey involvement 50%
Pain in the chest on deep breathing
(pleurisy)
45%
5. Find out more about Asthma TreatmentSystemic Lupus Erythematosus
6.
7. Affects 85% of patients with SLE
50% of patients have anemia
Between 34 - 42% of patients have
antiphospholipid syndrome (APS)
Patients who have APS have a high incidence
of blood clots
Blood clotting puts patients at higher risk for
stroke and pulmonary embolism
8.
9. • Heart disease is primary cause of death in lupus
patients
• Atherosclerosis, or plaque buildup in the arteries
• High blood pressure, most likely because of
kidney injury and corticosteroid treatments
• Heart failure
• Pericarditis, an inflammation of the tissue
surrounding the heart
• Myocarditis, an inflammation of the heart muscle
itself (rare)
10. Affects 50% of patients
Poor kidney function (mild) and kidney failure
(severe) may result from this damage.
Serious complications occur in 30% of patients
12. Difficult to diagnose
No single diagnostic marker; identified
through a combination of clinal and laboratory
criteria
Early diagnosis is important as it reduces
morbidity and mortality (lupus nephritis)
13. 4 of 11 clinical and laboratory criteria must be met
Antinuclear antibody titer is the primary laboratory
test
Antinuclear antibody titer of 1:40 and characteristic
multiorgan system involvement can be diagnosed
with systemic lupus erythematosus without
additional testing
Patients with an antibody titer of 1:40 who fail to
meet full clinical criteria should undergo additional
testing: including tests for antibody to
doublestranded DNA antigen and antibody to Sm
nuclear antigen.
14. • No cure
• Treatment goal: relieve symptoms and protect organs by
decreasing inflammation and/or the level of autoimmune
activity in the body.
• Treatment options:
Rest/Sleep
Nonsteriodal anti-inflammatory drugs (taken with
medication to prevent ulcers)
Corticosteriods (more potent than NSAIDs in reducing
inflammation)
Hydroxychloroquine (anti-malarial)
Cytotoxic drugs (immunosuppressive medications)
15. Anaphylactic shock is a severe, potentially life-
threatening allergic reaction. It can occur
within seconds or minutes of exposure to
allergen.
16.
17. Skin: 90 %of episodes
⁻ Generalized hives.
⁻ Itching or flushing.
⁻ Swollen lips-tongue-uvula.
⁻ Per-orbital edema.
Respiratory: 70 % of
episodes
⁻ Nasal discharge and
congestion.
⁻ Change in voice quality.
⁻ Sensation of throat closure
or choking.
⁻ Tridor or wheeze.
⁻ Shortness of breath and
cough.
Gastrointestinal: 45% of
episodes
⁻ Nausea.
⁻ Vomiting.
⁻ Diarrhea.
⁻ Crampy abdominal pain.
Cardiovascular: 45 % of
episodes
⁻ Hypotonia (collapse).
⁻ Syncope.
⁻ Dizziness.
⁻ Tachycardia.
⁻ hypotension.
18. Serum or plasma total tryptase
normal range 1 to 11.4 ng/mL
Plasma histamine
We don’t rely on
laboratory
findings on such
cases only clinical
presentation
19. Epinphrin
IM 0.3mg , 1:1000
IV 0.15mg , 1:10,000
Antihestsmin
Corticosteroid
Bronchodilator
Oxygen
Fluids and vasopressors, why?
21. It is a form of arthritis that is long-lasting (chronic) and most
often affects the spine.
It affects joints in the spine and the sacroilium in the pelvis,
causing eventualComplete fusion results in a complete rigidity of
the spine, a condition known as bamboospine
AS is a systemic rheumatic disease and is one of the
seronegative spondyloarthropathies AS is a systemic
rheumatic disease and is one of the seronegative
spondyloarthropathies
22. mild to severe back and buttock pain that is often
worse in the early morning hours.
-This pain usually gets better with
activity. Continued inflammation of the:
-ligaments,
-tendons,
-joint capsules (soft tissues surrounding the
joint),
-and joints of the spine
-cause the spine to fuse together (ankylose) as the
joints and disc spaces are replaced by bone.
-leading to less motion in the neck and
low back
23. a blood test for the HLA-B27 gene
X-ray
-which show characteristic spinal changes
and sacroiliitis
tomography and magnetic resonance imaging
of the sacroiliac joints
Schober's test
-a useful clinical measure of flexion of the
lumbar spine performed during examination.
25. Treatment:-
No cure is known for AS!
treatments and medications are available to reduce
symptoms and pain.
Surgical Management:
may include OSTEOTOMY for marked deformities of
the hip/spine.
occasionally, hip or knee ARTHROPLASTY is used.
- if there is severe arthritis of those joints.
Editor's Notes
Although the specific cause of SLE is unknown, multiple genetic predispositions and gene-environment interactions have been identified (see chart below). This complex situation perhaps explains the variable clinical manifestations in persons with SLE.