The document discusses the different types of organocopper reagents that can be synthesized depending on the preparation method used: 1) organocopper complexes are produced through the reaction of a copper(I) halide and organolithium, 2) lower-order cuprates result when organocopper complexes are treated with organolithium, 3) lower-order cyanocuprates are similarly derived from organolithium and copper(I) cyanide, and 4) higher-order cyanocuprates are formed through the reaction of two equivalents of organolithium with copper(I) cyanide.

1. PRESENTED BY:
Sana abbas
Bs, Karakoram international university

2. TOPIC:
Synthesis of
organocopper
reagents

3. The
constitution
of
organocoppe
r compounds
depends on
their method
of
preparation:
Organocopper complexes (RCu)
Lower-order cuprates (R2CuLi)
Lower-order cyanocuprates (RCu(CN)Li)
Higher-order cyanocuprates (R2Cu(CN)Li2)

4. Organocopper complexes (RCu)
• (RCu) are produced when a copper(I) halide and organolithium are combined.
• Transmetellation

5. Lower-order cuprates (R2CuLi)
• (R2CuLi, also known as Gilman reagents) result when organocopper complexes are treated
with an equivalent of organolithium.

6. Lower-order cyanocuprates (RCu(CN)Li)
• RCu(CN)Li) are similarly derived from an organolithium compound and copper(I) cyanide

7. Higher-order cyanocuprates (R2Cu(CN)Li2)
• (R2Cu(CN)Li2) are formed upon the reaction of two equivalents of organolithium with copper(I)
cyanide.

8. THE END