The Suzuki reaction is a palladium-catalyzed cross-coupling reaction between boronic acids or esters with organic halides, triflates, or other boron-containing compounds. This reaction occurs under basic conditions and leads to the formation of carbon-carbon single bonds, typically between an aryl or vinyl group and another aryl or vinyl group. It is commonly used to synthesize biaryl compounds. The reaction proceeds through oxidative addition, transmetallation, and reductive elimination steps. Key advantages are mild reaction conditions and availability of boronic acids. The Suzuki reaction has applications in synthesizing pharmaceuticals, agrochemicals, and natural products.

1. SUZUKI REACTION
SUZUKI MIYAURA REACTION
SUZUKI COUPLING REACTION
SUBMITTED BY :
RINSHANA FATHIMA ABDUL AZEEZ
FIRST YEAR M.PHARM
PHARMACEUTICAL CHEMISTRY
AL SHIFA COLLEGE OF PHARMACY
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2. Suzuki reaction is the Pd catalysed cross coupling reaction[1]
between the boronic / organoboronic acids / organoboranes with
organic halides[2], triflates, etc under basic conditions[3] which leads
to the formation of carbon carbon single bonds.[4]
This reaction is commonly used for synthesising biaryl
compounds.
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3. GENERAL SCHEME
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4. STEP 1 - Oxidative Addition - 2 groups adds to the metal.
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MECHANISM

5. STEP 2 - Hydroxide attacks Pd, kicking off X
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6. STEP 3 - Lewis base (OH－) attacks Lewis acid (B)
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The Organo Boron has only 3 bonds around it and it is sp2 hybrised with
an empty p orbital, making it a very good lewis acid.

7. STEP 4 - Transmetallation.
Carbon will attach to a metal that has an electronegativity closer to it.
Electronegativity Values
 C = 2.5
 B = 2.0
 Pd = 2.4

8. STEP 5 - Reductive Elimination - 2 groups are removed from a
metal.
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9. ADVANTAGES
• Mild reaction conditions. (From 20-80℃)
• Commercial availability of many boronic acids.
• The inorganic by-products are easily removed from the reaction
mixture, making the reaction suitable for industrial processes
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10. • Generally aryl halides react sluggishly.
• By-products such as self-coupling products are formed because
of solvent-dissolved oxygen.
DISADVANTAGES
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11. • Development of catalysts facilitating coupling of unreactive aryl
halides.
Eg: Ni catalysts have been used as catalysts for coupling aryl
chlorides, for the following reasons.
 No handling of air or moisture - sensitive material is necessary.
 A wide variety of functional groups are tolerated and
unsymmetrical biaryls are obtained in high yields.
ADVANCEMENTS
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12. • Xenbucin 1, an analgesic drug, was synthesized in 4 steps using two
different routes. The biaryl fragment could successfully be produced
via a Pd/C catalysed Suzuki coupling [5]
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SYNTHETIC APPLICATIONS

13. • Boscalid, a fungicide is prepared via Suzuki reaction.[6]
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14. • In Valsartan, the biaryls can easily be prepared by this reaction. [6]
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15. • The formal total synthesis of Oximidine by G.A.Molander et al. was
done by using this reaction. [4]
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16. • The key step in the total synthesis of Myxalamide A by C.H. Heathcock
et al. was Suzuki Cross-Coupling.
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17. • The natural anti tumour product Epothilone A was synthesized in
the laboratory by J.S. Panek by using the Suzuki Cross Coupling
Reaction.
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18. REFERENCE
1. Jie Jack Li; Name Reactions: A Collection of Detailed Mechanisms and
Synthetic Applications Fifth Edition; Springer Science & Business Media,
30-Jan-2014; Page no. 544
2. Benny K G Theng; Clay Mineral Catalysis of Organic Reactions; CRC
Press, 27-Jul-2018; Page No.2016
3. Ranjit S. Dhillon; Hydroboration and Organic Synthesis : 9-Borabicclo
[3.3.1] nonane (9-BBN); Springer Science & Business Media; 01 - May -
2007; Page No. 523
4. Laszlo Kurti, Barbara Czako; Strategic Applications of Named Reactions
in Organic Synthesis; Elsevier, 29-Apr-2005; Page no. 37
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19. 4. Noora KuulojaTuula KylmäläYoujun XuRobert Franzén; Synthesis of
Xenbucin using Suzuki reaction catalyzed by Pd/C in water; Central
European Journal of Chemistry; September 2008, Volume 6, Issue 3, pp
390–392
5. .A. MAUREEN ROUHI, C&EN WASHINGTON;FINE CHEMICALS Suzuki-
coupling chemistry takes hold in commercial practice, from small-scale
synthesis of screening compounds to industrial production of active
ingredients; American Chemical Society; September 6, 2004 Volume 82,
Number 36 pp. 49-58
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20. THANK YOU
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