Study of vascular endothelial growth factor (vegf) and bcl 2 protein levels in serum and vitreous humor of patients with proliferative diabetic retinopathy
This study examined levels of vascular endothelial growth factor (VEGF) and B-cell lymphoma 2 (Bcl-2) protein in serum and vitreous humor of patients with proliferative diabetic retinopathy compared to non-diabetic controls. VEGF and Bcl-2 levels were significantly higher in the vitreous humor of patients, suggesting they are involved in the pathogenesis of proliferative diabetic retinopathy. While levels did not differ in serum, a positive correlation between serum VEGF and Bcl-2 in patients indicates VEGF may induce pathological angiogenesis partly by up-regulating the anti-apoptotic protein Bcl-2. The study concludes VEGF and Bcl-2 are implicated in proliferative diabetic ret
you can find out all types of VEGF in this ppt and it is about physiological and path-physiological significance of VEGF and its possible targeting manoeuvering
Watch the slideshow: https://youtu.be/TP7iP1HEVps
Learn key concepts:
Hallmarks of cancer, Angiogenic switch, Tumor Angiogenesis
VEGF family i.e ligand and receptors, Effect of VEGF
VEGF Inhibitors or angiogenic
Bevacizumab, Ramucirumab, Ziv-Aflibercept
Angiogenesis is the growth of blood vessels from the existing vasculature. It occurs throughout life in both health and disease, beginning in utero and continuing on through old age.
you can find out all types of VEGF in this ppt and it is about physiological and path-physiological significance of VEGF and its possible targeting manoeuvering
Watch the slideshow: https://youtu.be/TP7iP1HEVps
Learn key concepts:
Hallmarks of cancer, Angiogenic switch, Tumor Angiogenesis
VEGF family i.e ligand and receptors, Effect of VEGF
VEGF Inhibitors or angiogenic
Bevacizumab, Ramucirumab, Ziv-Aflibercept
Angiogenesis is the growth of blood vessels from the existing vasculature. It occurs throughout life in both health and disease, beginning in utero and continuing on through old age.
angiogenesis, anti angiogenic agents, angiogenic mechanism, types of angiogenesis, wound healing, disorders of angiogenesis, tumour angiogenesis, factors of angiogenesis, theurepeutic angiogenesis, father of tumour angiogenesis, terminology of angiogenesis, angiogenesis in health and disease, diabetic retinopathy, retinopathy of prematurity, macular degeneration, rheumatoid arthritis, arteriogenesis, intussusceptive agiogenesis, angioblasts, angiogenesis inhibitors, william harvey, judah folkman, interferon, thromospondin,sprouting angiogenesis, VEGF,FGF, PDGF, matrix metalloproteinases ,
It starts with brief introduction about angiogenesis, history of angiogenesis, types and various stages of angiogenesis, followed by its clinical usage.
Hurdles and new players in the management of chronic heart failure with reduc...Dhritisdiary
Watch the slideshow for a better understanding: https://youtu.be/CsXvS1hA330
1. Learn the standard therapy in HFrEF
2. Learn its challenges
3. Learn the new drugs for HFrEF.
A new form of cancer treatment using drugs called 'angiogenesis inhibitors' that specifically halt new blood vessel growth and starve a tumor by cutting off its blood supply.
Many healthy foods contain bioactive compounds – specific substances that affect the body in certain ways, such as lowering blood pressure or cholesterol or inhibiting angiogenesis.
This PPT includes the details about some cardiovascular diseases and how they are treated using Gene Therapy. It also discuss about the vectors that are used in the process.
Are we using the correct quality goals?Ola Elgaddar
Setting quality goals / specifications is a debatable issue since 1999. I am trying here to show the options and the continuos trials from several professional bodies to reach a consensus in this matter.
This was an oral presentation in the first international conference of the Chemical Pathology Department, Medical Research Institute, Alexandria University - February 2016
Harmonization of Laboratory Indicators, 09 03-2017Ola Elgaddar
Most of Medical labs are having KPIs to monitor their performance and enhance process improvement. This presentation discusses in short the IFCC attempts to reach a consensus and harmonize medical labs quality indicators.
angiogenesis, anti angiogenic agents, angiogenic mechanism, types of angiogenesis, wound healing, disorders of angiogenesis, tumour angiogenesis, factors of angiogenesis, theurepeutic angiogenesis, father of tumour angiogenesis, terminology of angiogenesis, angiogenesis in health and disease, diabetic retinopathy, retinopathy of prematurity, macular degeneration, rheumatoid arthritis, arteriogenesis, intussusceptive agiogenesis, angioblasts, angiogenesis inhibitors, william harvey, judah folkman, interferon, thromospondin,sprouting angiogenesis, VEGF,FGF, PDGF, matrix metalloproteinases ,
It starts with brief introduction about angiogenesis, history of angiogenesis, types and various stages of angiogenesis, followed by its clinical usage.
Hurdles and new players in the management of chronic heart failure with reduc...Dhritisdiary
Watch the slideshow for a better understanding: https://youtu.be/CsXvS1hA330
1. Learn the standard therapy in HFrEF
2. Learn its challenges
3. Learn the new drugs for HFrEF.
A new form of cancer treatment using drugs called 'angiogenesis inhibitors' that specifically halt new blood vessel growth and starve a tumor by cutting off its blood supply.
Many healthy foods contain bioactive compounds – specific substances that affect the body in certain ways, such as lowering blood pressure or cholesterol or inhibiting angiogenesis.
This PPT includes the details about some cardiovascular diseases and how they are treated using Gene Therapy. It also discuss about the vectors that are used in the process.
Are we using the correct quality goals?Ola Elgaddar
Setting quality goals / specifications is a debatable issue since 1999. I am trying here to show the options and the continuos trials from several professional bodies to reach a consensus in this matter.
This was an oral presentation in the first international conference of the Chemical Pathology Department, Medical Research Institute, Alexandria University - February 2016
Harmonization of Laboratory Indicators, 09 03-2017Ola Elgaddar
Most of Medical labs are having KPIs to monitor their performance and enhance process improvement. This presentation discusses in short the IFCC attempts to reach a consensus and harmonize medical labs quality indicators.
This is the first one of a series of lectures about the "Cell". I am here introducing some basic principles about the cell structure, types, histology and biochemistry
The forth lecture about the "Cell".
Here, I am discussing the several signaling pathways.....It is highly dependent on the 3rd lecture; Receptors.
Enjoy :)
ELISA is one of the commonly used laboratory techniques. As it is a multi-step manual technique, every step should be carefully monitored. Here is a short presentation on the common things that should be considered when using ELISA.
Strategic planning, Ola Elgaddar, 12 12-2016Ola Elgaddar
A simple introduction to the basic concepts of strategic planning addressing anyone who works in any organization, aiming at elucidating some vague terms like strategy, environmental scanning, mission, vision,......!!
It is very important to every employee, who is a bit away from decision makers in his organization, to know the basic concepts at least.
Laboratory diagnosis of H. Pylori infection, Ola ElgaddarOla Elgaddar
A short presentation for the different laboratory techniques used in diagnosing Helicobacter Pylori infection. A special focus is given for the diagnostic performance of every test.
Congenital adrenal hyperplasia, Ola Elgaddar, 2012
Similar to Study of vascular endothelial growth factor (vegf) and bcl 2 protein levels in serum and vitreous humor of patients with proliferative diabetic retinopathy
The aim of this work is to illustrate a difficult diagnostic in vitamin B12 deficiency because of using of multivitamin preparations to a patient with unknown etiology of anemia. History Patient: a 70 year old engineer, following 8 years vegetable – dietary, was admitted to the county hospital, in neurology department, with diagnostic of poli-radiculonevrites, received in ward the treatment with milgama (containing 250 micro-gram multivitamin). After a lipotimia status the patient was transferred to cardiology department. Laboratory examinations showed in peripheral blood: Hb = 6 3 g/dl; Ht = 18.8%; RBC= 290.000/mm³; PLT. = 214000/mm³; WBC = 5300/³mm; Ret. = 3, 7%; Erythrocytes indices = normal values; ESR = 38 mm/h, moderate increase and serum iron decreased, 36 microgram/dl value. On blood smear in optic microscopy was registered: Band = 5% (with nucleus in ring!!!), differential count being normally with aspect flags on Coulter HMX Analyzer with 22 parameters: neutrophilia, lymphopenia, anemia. To microscopic examination of slide from bone morrow, have occurred the hyperplasic series of erythrocytes ~ 45%, deficiency of erythropoiesis, poly-cromathopil and acidophil erythroblasts with megaloblastic character, large metamielocytes and giant band forms. Macrocytes and ovalocytes where also presented. Biopsy results from gastric mucosa showed lesions of chronic gastritis, non-atrophic epithelium. Conclusions: Megaloblastosis appears in some time with vitamin B12 deficiently in bone morrow but no in peripheral blood because of administration of multivitamin drugs, deleting haematological shape of megaloblastic anemia.
20150918 C.Izzi - 22q11.2 Microdeletion Syndrome: Understanding the Emerging...Roberto Scarafia
22q11.2 Microdeletion Syndrome:
Understanding the Emerging
Importance of this Syndrome
Dr.ssa Claudia Izzi
Centro di Diagnosi Prenatale
Dipartimento Ostetrico-Ginecologico
Azienda Spedali Civili di Brescia
SICKELE CELL DISEASE MODULE 3 SEJOJO.pptx TO BE PRESENTED. IN TRAININGS.pptxSEJOJO PHAAROE
Sickle cell anemia is a genetic disorder whereby red blood cells are abnormally shaped, causing problems with the flow of blood through the body as well as transport of oxygen throughout the body
inheritance is Autosomal because its a blood disorder and systemic disorder
its caused by mutation on B-chain of the globulin chain , where red blood cells (RBCs) become sickle/crescent shaped
Cells get destroyed in narrowed thin blood capillaries , RE system and cause anaemia Blockage in thin layers body
Abstract—Cataract is the main cause of blinding and Diabetes Mallitus (DM) is the one of major cause of early cataract. Patents of DM has poor So this study is aimed to assess the corneal endothelial cell count in patients of DM (Type 2)after phecoemulsification and intra-ocular lens implantation. This study was conducted on 66 patients of cataract, out of which 33 patients with and 33 without DM (Type 2). Both groups underwent pre operative investigation and ophthalmological assessment and then undergo phacoemulsification done by same surgeon. After phacoemulsification all cases were followed up on 1st day ,1st week,1 month and 3 months and Uncorrected visual acquity (UCVA), Best corrected visual acquity (BCVA),corneal thickness, endothelial cell count and morphometric analysis were recorded. Both groups parameters were compared with unpaired 't' test. At the end of 3 months it was found that the mean endothelial cell loss in Group A(Diabetic) was 6.9% ± 0.6 and in Group B (control) was 2.4% ± 0.3 suggesting that the corneal endothelium in diabetic patients is under metabolic stress, and weaker against mechanical loads, such as phacoemulsification, than that in non-diabetic subjects. Despite good glycemic control and no corneal abnormalities before surgery. Endothelium in diabetic subjects is more vulnerable to surgical trauma and has a lower capability in the process of repair. These findings should be considered when planning cataract surgery in patients with diabetes.
1. Bio preservation of Red Cell Components 2. CULTURED RBCs 3. solvent plasmaDrShinyKajal
1. Bio preservation of Red Cell Components
2. CULTURED RBCs
3. Solvent plasma
Hypothermic storage
Cryopreservation
Lyophilization
Desiccated RBCs
Three major sources of cells are under consideration:
circulating stem and progenitor cells from adults or from cord blood
immortalized progenitors
pluripotent stem cells.
Immortalized Progenitors
LIQUID CULTURE METHODS- by the SED (stem cell factor (SCF), erythropoietin, and dexamethasone) and STIF cocktails (stem cell factor, thombopoietin, insulin-like growth factor-2, fibroblast growth factor-2)
ENUCLEATION- separation of extruded nuclei from cRBCs
SCALING UP- using cord blood CD34+ cells in bioreactors
and treated for 4 h with TNBP (tri-nitrobutylphosphate)solvent and with Triton X-100 detergent
UAEU - CMHS - Hematology-Oncology Course - MMH 302 - HONC 320. Education material for medical students - It cover basic principles of hematology and oncology, including CAR-T and gene editing. It can be used for study and review. It illustrates main principles of hematology and oncology.
Similar to Study of vascular endothelial growth factor (vegf) and bcl 2 protein levels in serum and vitreous humor of patients with proliferative diabetic retinopathy (20)
Enhancing Laboratory Leadership through Financial Management Skills.pptxOla Elgaddar
In our recent presentation titled 'Strengthening Lab Leadership through Financial Management,' we explored how financial skills can enhance lab management. Attendees discovered practical ways to leverage financial tools for more effective resource allocation and sustainable growth. The session showcased how mastering financial management can streamline lab operations and improve overall leadership performance.
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A presentation in the Annual meeting of the Egyptian American Scholars (AEAS) in Cairo 2015.
I am trying here to describe, in short, from my point of view as a laboratorian, the points that we need to discuss with clinicians. Both groups should share some terms and definitions and should see things from the same perspective!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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This document describes the acute management of AV block.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...
Study of vascular endothelial growth factor (vegf) and bcl 2 protein levels in serum and vitreous humor of patients with proliferative diabetic retinopathy
1. STUDY OF VASCULAR ENDOTHELIAL
GROWTH FACTOR (VEGF)
AND BCL-2 PROTEIN LEVELS
IN SERUM AND VITREOUS HUMOR
Of PATIENTS WITH
PROLIFERATIVE DIABETIC
RETINOPATHY
by
Ola Hussein Aly Elgaddar
2. ADVISORS
Prof. Dr. Ahmad Mohamad Zaki
Professor of Chemical Pathology
Medical Research Institute
Alexandria University
Prof. Dr. Ahmad Magdy Bedda
Professor of Ophthalmology
Faculty of Medicine
Alexandria University
Dr. Amel Abd El-Fattah Kamel
Assistant Professor of Chemical Pathology
Medical Research Institute
Alexandria University
Dr. Hoda Ali El-Attar
Assistant Professor of Chemical Pathology
Medical Research Institute
Alexandria University
5. DR is a devastating microvascular complication
of diabetes mellitus.
It is considered the leading cause for adult
blindness.
Its prevalence among diabetic patients in Egypt
is 42%.
Risk factors includes: poor glycemic control,
duration
of
diabetes,
hypertension,
hyperlipidemia and proteinuria.
6. DR can be classified into:
Early non-proliferative diabetic
retinopathy
Advanced non-proliferative diabetic
retinopathy
Proliferative diabetic retinopathy
8.
Hypoxia occurring early in the course of DR
triggers the release of several growth
factors
that
promote
retinal
neovascularization.
Among these growth factors are:
Insulin-like growth factor-I (IGF-I)
Basic fibroblast growth factor (bFGF)
Hepatocyte growth factor (HGF)
Vascular endothelial growth factor (VEGF)
9. VASCULAR ENDOTHELIAL
GROWTH FACTOR (VEGF)
VEGF-A is a 34- to 42-kDa dimeric
glycoprotein.
It is a member of the VEGF family that
currently comprises seven members;
VEGF-A (hereafter referred to as VEGF),
VEGF-B, VEGF-C, VEGF-D, VEGF-E,
VEGF-F, and placental growth factor (PlGF)
11. ACTIVITIES OF VEGF
A. Mitogenesis, angiogenesis, and endothelial
cell survival.
B. Stimulatory effect on bone marrow cells and
hematopoiesis.
C. Enhancement of vascular permeability.
12. REGULATION OF
VEGF PRODUCTION
I) Hypoxia:
The main stimulus
II) Growth factors & hormones:
TNF- α, bFGF, TGF-ß, PDGF,Ang-1, Ang-2,
IGF-1, IL-1 and IL-6
TSH, ACTH, estrogens & progestins
PlGF,
III) Glucose:
Hyperglycemia or hypoglycemia???
14. VEGF IN PATHOLOGICAL
CONDITIONS
A) Solid & hematological tumors:
As in Lung, breast, renal, ovarian and
intracranial tumors as well as in some
lymphomas and leukemias.
In these tumors, VEGF Induces Bcl-2 production
thus increasing tumor cells survival.
15. B) Intraocular neovascular syndromes:
Like Diabetes mellitus, occlusion of central retinal
vein and neonatal prematurity.
Retinal ischemia is the main stimulus for VEGF
production in such conditions.
In the eye, VEGF is produced by retinal
pericytes, endothelial cells and glial cells.
It
leads
to
ocular
neovascularization,
hemorrhages and vascular permeability, which
results in visual impairment/blindness.
19. BCL-2 PROTEIN
Bcl-2 is the founding antiapoptotic member
of this family of proteins.
It is a 25 KDa protein.
It is a membrane protein that is localized
to the outer mitochondrial membrane,
endoplasmic reticulum membrane, and
nuclear envelope.
20. Normally, it is expressed in cells and
tissues characterized by apoptotic turn
over, like:
Lymphoid germinal center.
Proliferative precursor cells in the bone
marrow.
Glandular epithelium of the breast, thyroid
& prostate.
21. Pathologically, Bcl-2 is over expressed in
many malignant & non-malignant conditions:
Malignant
• B- Cell lymphoma
• Ovarian cancer
• HCC
• Malignant melanoma
• Breast cancer
• Colorectal cancer
• Lung cancer
• Kaposi sarcoma
Non-malignant
• Epilepsy
• Endometriosis
• Liver cirrhosis
• Multiple sclerosis
22. The mechanisms by which Bcl-2
suppresses apoptosis
1) Blocking the release of cytochrome- c from the
mitochondria to the cytosol.
2) Inhibition of the proapoptotic effects of the Bcl-2
family proteins (e.g., Bax and Bak).
3) Maintenance of sufficient Ca++ in the
sarcoplasmic/endoplasmic
reticulum
and
mitochondria.
4) Direct antioxidant activity.
23. So……
Is there a role for VEGF and Bcl-2
in the pathogenesis of PDR?
Is it possible that the angiogenic
effect of VEGF in PDR is via Bcl-2
up regulation?
25. This study aimed at evaluating the
levels of VEGF and Bcl-2 protein
in the serum and vitreous humor
of patients with proliferative
diabetic retinopathy
27. 40 subjects were included in the
present study divided as follow:
Patients group
25 subjects with PDR
Undergoing vitrectomy
Control group
15 non-diabetic subjects
Undergoing vitrectomy
29. To all studied subjects the following
was done:
I) Full clinical examination.
II) Laboratory investigations:
Preliminary tests in serum.
(F.B.G, RFTs, lipid profile & aminotransferases
activities)
Measurement of glycated hemoglobin (Hb A1C)
by resin chromatography technique.
Estimation of serum and vitreous humor levels
of both VEGF & Bcl-2 by ELISA technique.
31. VITREOUS HUMOR
A clear avascular gel which occupies the
posterior compartment of the eye.
It has the following composition:
Water (99%)
Network of collagen fibrils
Large molecules of hyaluronic acid
Peripheral cells (hyalocytes)
Inorganic salts, sugar and ascorbic acid
•
•
•
•
•
42. From the present study the following
could be concluded:
1) Levels of
VEGF and Bcl-2 were
significantly higher in the vitreous
humor of patients with PDR when
compared to their corresponding levels
in the control group suggesting that both
factors are incriminated in the pathogenesis
of this disease.
43. 2) VEGF
and Bcl-2 did not show any
statistical difference in the serum of the
studied groups. This finding may support
the hypothesis that their increased levels
in the vitreous is probably attributed to
intraocular synthesis, in response to local
retinal hypoxia, rather than to serum filtration.
44. 3) A significant positive correlation was
found between serum Bcl-2 and serum
VEGF in the proliferative diabetic
retinopathy patients. This might suggest
that the role of VEGF in inducing
pathological angiogenesis in PDR might be
in part due to up regulation of the antiapoptotic protein Bcl-2.
46. VEGF together with Bcl-2 will hopefully lead
to the discovery of new targets for future
therapy
for
proliferative diabetic
retinopathy as well as other diseases with a
neovascular component.