Ectrodactyly-ectodermal dysplasia-cleft syndrome is a rare condition characterized by deformities of the hands and feet (ectrodactyly), abnormalities in skin, hair, teeth and nails (ectodermal dysplasia), and cleft lip and/or palate. It can be caused by genetic mutations and affects development of the ectoderm layer in utero. People with this syndrome may experience physical challenges and social isolation due to the visible differences and associated health issues. There is no cure, but treatment aims to address specific symptoms through surgery, dental care, and managing other ectodermal abnormalities.