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EMBRYOLOGY

Neural Tube
           By
      Dr. Dalia Saleh
Second Week
 Epiblast
 Hypoblast
 Amniotic cavity
 Yolk sac cavity




               Dr. Dalia Saleh (Anatomy Dept)
Third Week
Primitive node
Primitive streak
Intra embryonic
mesoderm
Notochord




                   Dr. Dalia Saleh (Anatomy Dept)
Neural Tube
 Arises from the ectoderm
 overlying the notochord

 Gives rise to the brain and
 spinal cord




                 Dr. Dalia Saleh (Anatomy Dept)
Neural Tube Formation

 The notochord induces the
 ectoderm above it which
 thickens to form the neural
 plate




                 Dr. Dalia Saleh (Anatomy Dept)
Neural Tube Formation

 The neural plate folds to
 form neural groove with
 prominent neural folds
 The neural folds approach
 each other with deepening
 of the neural groove




                 Dr. Dalia Saleh (Anatomy Dept)
Neural Tube Formation

The neural folds fuse and a
neural tube is formed

The tube, then, separates
from the overlying ectoderm




                 Dr. Dalia Saleh (Anatomy Dept)
Neural Tube Closure

 Closure of the neural tube
 begins in the future neck region
 (4th somite).

 Then, proceeds cranially and
 caudally.




                  Dr. Dalia Saleh (Anatomy Dept)
Neural Tube Closure
The most cranial and caudal ends
of the tubes still open as
•   Anterior neuropore
•   Posterior neuropore
The anterior pore will close @ day
25 the posterior @ day 27
The lumen of the tube
ventricles of the brain and central
canal of spinal cord
                   Dr. Dalia Saleh (Anatomy Dept)
Development of the Brain

3 primary vesicles @ 4th week:
  Prosencephalon

  Mesencephalon

  Rhombencephalon




                    Dr. Dalia Saleh (Anatomy Dept)
Development of the Brain
5 secondary vesicles @ 6th week:
  Prosencephalon
    Telencephalon

    Diencephalon

  Mesencephalon

  Rhombencephalon
    Metencephalon

    Mylencephalon



                    Dr. Dalia Saleh (Anatomy Dept)
Development of the Spinal Cord
The cells of the neural tube migrate to form the mantle
layer   gray matter which differentiates into

  An alar plate, mostly sensory neurons

  A basal plate, mostly motor neurons.

  Separated by sulcuc limitans




                    Dr. Dalia Saleh (Anatomy Dept)
Development of the Spinal Cord
The cells of the mantle layer have axons which
collect in the marginal layer                   white matter




                    Dr. Dalia Saleh (Anatomy Dept)
Histogenesis of the Spinal Cord
First, the neural tube is
lined by neuroepithelial
cells

They then divide to give:
  Neuroblasts     apolar,
  unipolar, bipolar, multipolar

  Glioblasts    astrocytes,
  oligodendrocytes

  Ependymocytes

                        Dr. Dalia Saleh (Anatomy Dept)
Neural Crest Cells

 Originate from cells of
 neural folds.

 Lie between the neural
 tube and surface
 ectoderm.



                    Dr. Dalia Saleh (Anatomy Dept)
Neural Crest Cells
They, then, migrate to new locations                   many
derivatives


                  G
                  G   A M E
                      A M E                      S
                                                 S
Ganglion cells (DRG, Cranial sensory, Autonomic)
Arachnoid and pia maters
Melanocytes, Mesenchyme of the pharyngeal arches
Enteric ganglia
Schwann cells, Suprarenal medulla cells


                      Dr. Dalia Saleh (Anatomy Dept)
Tissues around The Spinal Cord
 Neural crest      pia and
 arachnoid maters
 Mesderom
   Microglial cells
   Mesenchyma        dura
   mater
   Somites     become
   vertebrae.




                    Dr. Dalia Saleh (Anatomy Dept)
Dr. Dalia Saleh (Anatomy Dept)
Spinal Cord Positioning
@ 3rd month       same length as
  vertebral canal

@ Birth      Spinal cord
  terminates at 3rd lumbar
  vertebra

@ Adult    spinal cord
  terminates at the level of L1


                      Dr. Dalia Saleh (Anatomy Dept)

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Spinal Cord Dev

  • 1. EMBRYOLOGY Neural Tube By Dr. Dalia Saleh
  • 2. Second Week Epiblast Hypoblast Amniotic cavity Yolk sac cavity Dr. Dalia Saleh (Anatomy Dept)
  • 3. Third Week Primitive node Primitive streak Intra embryonic mesoderm Notochord Dr. Dalia Saleh (Anatomy Dept)
  • 4. Neural Tube Arises from the ectoderm overlying the notochord Gives rise to the brain and spinal cord Dr. Dalia Saleh (Anatomy Dept)
  • 5. Neural Tube Formation The notochord induces the ectoderm above it which thickens to form the neural plate Dr. Dalia Saleh (Anatomy Dept)
  • 6. Neural Tube Formation The neural plate folds to form neural groove with prominent neural folds The neural folds approach each other with deepening of the neural groove Dr. Dalia Saleh (Anatomy Dept)
  • 7. Neural Tube Formation The neural folds fuse and a neural tube is formed The tube, then, separates from the overlying ectoderm Dr. Dalia Saleh (Anatomy Dept)
  • 8. Neural Tube Closure Closure of the neural tube begins in the future neck region (4th somite). Then, proceeds cranially and caudally. Dr. Dalia Saleh (Anatomy Dept)
  • 9. Neural Tube Closure The most cranial and caudal ends of the tubes still open as • Anterior neuropore • Posterior neuropore The anterior pore will close @ day 25 the posterior @ day 27 The lumen of the tube ventricles of the brain and central canal of spinal cord Dr. Dalia Saleh (Anatomy Dept)
  • 10. Development of the Brain 3 primary vesicles @ 4th week: Prosencephalon Mesencephalon Rhombencephalon Dr. Dalia Saleh (Anatomy Dept)
  • 11. Development of the Brain 5 secondary vesicles @ 6th week: Prosencephalon Telencephalon Diencephalon Mesencephalon Rhombencephalon Metencephalon Mylencephalon Dr. Dalia Saleh (Anatomy Dept)
  • 12. Development of the Spinal Cord The cells of the neural tube migrate to form the mantle layer gray matter which differentiates into An alar plate, mostly sensory neurons A basal plate, mostly motor neurons. Separated by sulcuc limitans Dr. Dalia Saleh (Anatomy Dept)
  • 13. Development of the Spinal Cord The cells of the mantle layer have axons which collect in the marginal layer white matter Dr. Dalia Saleh (Anatomy Dept)
  • 14. Histogenesis of the Spinal Cord First, the neural tube is lined by neuroepithelial cells They then divide to give: Neuroblasts apolar, unipolar, bipolar, multipolar Glioblasts astrocytes, oligodendrocytes Ependymocytes Dr. Dalia Saleh (Anatomy Dept)
  • 15. Neural Crest Cells Originate from cells of neural folds. Lie between the neural tube and surface ectoderm. Dr. Dalia Saleh (Anatomy Dept)
  • 16. Neural Crest Cells They, then, migrate to new locations many derivatives G G A M E A M E S S Ganglion cells (DRG, Cranial sensory, Autonomic) Arachnoid and pia maters Melanocytes, Mesenchyme of the pharyngeal arches Enteric ganglia Schwann cells, Suprarenal medulla cells Dr. Dalia Saleh (Anatomy Dept)
  • 17. Tissues around The Spinal Cord Neural crest pia and arachnoid maters Mesderom Microglial cells Mesenchyma dura mater Somites become vertebrae. Dr. Dalia Saleh (Anatomy Dept)
  • 18. Dr. Dalia Saleh (Anatomy Dept)
  • 19. Spinal Cord Positioning @ 3rd month same length as vertebral canal @ Birth Spinal cord terminates at 3rd lumbar vertebra @ Adult spinal cord terminates at the level of L1 Dr. Dalia Saleh (Anatomy Dept)