This document discusses mining single nucleotide polymorphisms (SNPs) from public sequence databases. It defines SNPs as single nucleotide variations that can occur between individuals. The document describes a software tool called AutoSNP that can be used to find likely SNPs by aligning and clustering EST sequences downloaded from public databases. It marks up polymorphisms supported by at least two independent sequences to filter out sequencing errors. AutoSNP results are output to HTML reports. The document concludes that grid technology could help deliver real-time alignments and SNP detection for any query sequence submitted by a user.