The SlipChip is a simple lab-on-a-chip system that can perform many reactions in parallel in a small volume. It is used to demonstrate digital PCR, which can quantify DNA over a large concentration range by loading samples into wells and counting the number of wells that test positive. The SlipChip allows running multiple digital PCR experiments simultaneously on different sections of the chip, improving quantification accuracy and dynamic range. Examples show detecting pathogens in blood and simultaneously measuring viral loads of HCV and HIV. The system is flexible and its applications are limited only by the assays designed for it. Feedback is sought on potential clinical and research uses.