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Sex-Linked Inheritance
Sex-Linked Inheritance
• It is the inheritance of a trait (phenotype)
that is determined by a gene located on
one of the sex chromosomes
X-Linked Dominant Inheritance
• Dominant gene is carried on the X-gene
• Males – get their X-Chromosome from
their mother
• Females – get their X-Chromosome from
both of their parents
X-Linked Dominant Inheritance
• If the mother is a carrier of the mutated
gene
• 50% of the son or/and daughter will be
affected
• 50% of the son or/and daughter will be
normal
X-Linked Dominant Inheritance
• If the father is a carrier of the mutated
gene
• 100% of his daughter will have the
disorder
• 0% of his son will have the disorder
X-Linked Dominant Inheritance
• If both parents are a carrier of the
mutated gene
• 100% of his daughter will have the
disorder
• 50% of his son will have the disorder
• 50% of his son will be unaffected or
normal
X-Linked Recessive Inheritance
• A mode of inheritance on the X-
Chromosome that causes the phenotype
to be expressed
• Female carriers have only copy of the
gene and usually don’t express the
phenotype
X-Linked Recessive Inheritance
Examples of X-Linked Recessive
Inheritance:
•Color Blindness
•Haemophilia
•Becker’s Muscular Dystrophy
•Hunter’s Syndrome
Y-Linked Inheritance
• Holandric Inheritance
• Y-Chromosome is small and doesn’t
contain numerous genes
• Y-linked diseases or disorder are very
rare
• It occurs between fathers and his son/s

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Sex Linked Inheritance

  • 2. Sex-Linked Inheritance • It is the inheritance of a trait (phenotype) that is determined by a gene located on one of the sex chromosomes
  • 3. X-Linked Dominant Inheritance • Dominant gene is carried on the X-gene • Males – get their X-Chromosome from their mother • Females – get their X-Chromosome from both of their parents
  • 4. X-Linked Dominant Inheritance • If the mother is a carrier of the mutated gene • 50% of the son or/and daughter will be affected • 50% of the son or/and daughter will be normal
  • 5.
  • 6. X-Linked Dominant Inheritance • If the father is a carrier of the mutated gene • 100% of his daughter will have the disorder • 0% of his son will have the disorder
  • 7.
  • 8. X-Linked Dominant Inheritance • If both parents are a carrier of the mutated gene • 100% of his daughter will have the disorder • 50% of his son will have the disorder • 50% of his son will be unaffected or normal
  • 9. X-Linked Recessive Inheritance • A mode of inheritance on the X- Chromosome that causes the phenotype to be expressed • Female carriers have only copy of the gene and usually don’t express the phenotype
  • 10. X-Linked Recessive Inheritance Examples of X-Linked Recessive Inheritance: •Color Blindness •Haemophilia •Becker’s Muscular Dystrophy •Hunter’s Syndrome
  • 11. Y-Linked Inheritance • Holandric Inheritance • Y-Chromosome is small and doesn’t contain numerous genes • Y-linked diseases or disorder are very rare • It occurs between fathers and his son/s